853,432 results match your criteria regression analysis


Adherence and Persistence to Single-Inhaler Versus Multiple-Inhaler Triple Therapy for Asthma Management.

J Allergy Clin Immunol Pract 2022 Jun 22. Epub 2022 Jun 22.

GlaxoSmithKline, Research Triangle Park, NC, USA.

Background: Treatment guidelines recommend triple therapy for patients with asthma who remain uncontrolled on inhaled corticosteroid/long-acting β-agonist therapy. Previously, triple therapy was only available via multiple inhalers. Single-inhaler fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) is approved as maintenance treatment for asthma; however, real-world information on adherence and persistence is limited. Read More

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Conflicts of Interest among Patients: Do They Exist and Can They Bias Patient-Reported Outcome Measures? A Survey of Shoulder and Elbow Patients.

J Shoulder Elbow Surg 2022 Jun 22. Epub 2022 Jun 22.

Hannover Medical School Trauma Department Carl-Neuberg-Str. 1, 30625 Hannover, Germany.

Background: Potential conflicts of interest (COI) are common among physicians and may bias physician-reported outcome assessment in orthopedic research. It is unclear whether patients have COI and if this COI could affect patient-reported outcome measures (PROMs). The purposes of this study were to investigate (1) existence of COIs among patients and (2) their potential to bias PROMs with a pseudonymized survey among consecutive shoulder and elbow patients. Read More

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Impact of Interfacility Transfer of Ruptured Abdominal Aortic Aneurysm Patients.

J Vasc Surg 2022 Jun 22. Epub 2022 Jun 22.

Division of Vascular Surgery and Endovascular Therapy, Department of Surgery, Case Western Reserve University School of Medicine/University Hospitals, Cleveland Medical Center, Cleveland, OH. Electronic address:

Objectives: Interfacility transfer (IT) of patients with ruptured (r) abdominal aortic aneurysm (AAA) occurs not infrequently for a higher level of care. This study evaluates using contemporary administrative database the impact of IT on mortality after rAAA repair.

Methods: Healthcare Cost and Utilization Project Database for NY (2016) and NJ/MD/FL (2016-2017) were queried using ICD-10 edition to identify patients who underwent open and endovascular repair of AAA. Read More

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Association of Lymph Node Sampling and Clinical Volume in Lobectomy for Non-Small Cell Lung Cancer.

Ann Thorac Surg 2022 Jun 22. Epub 2022 Jun 22.

Division of Thoracic Surgery, Massachusetts General Hospital, Boston MA.

Background: Sampling ≥10 lymph nodes during lobectomy for non-small cell lung cancer (NSCLC) is a current surveillance metric and potential quality metric of American College of Surgeons Commission on Cancer. We sought to determine guideline adherence and its relationship to hospital lobectomy volume within the Society of Thoracic Surgeons General Thoracic Surgery Database (STS-GTSD).

Methods: Participant-centers providing elective lobectomy for NSCLC within the STS-GTSD (2012-2019) were divided into tertiles according to annual volume. Read More

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Reduced fetal growth velocity and weight loss are associated with adverse perinatal outcome in fetuses at risk of growth restriction.

Am J Obstet Gynecol 2022 Jun 22. Epub 2022 Jun 22.

Institute of Developmental and Reproductive Biology, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK; Department of Fetal Medicine, Queen Charlotte's and Chelsea Hospital, Imperial College NHS Trust, London, UK. Electronic address:

Background: While fetal size is associated with adverse perinatal outcome, the relationship between fetal growth velocity and adverse perinatal outcome is unclear.

Objectives: To evaluate the relationship between fetal growth velocity and signs of cerebral blood flow redistribution, and their association with birthweight and adverse perinatal outcome.

Study Design: Secondary analysis of the TRUFFLE 2 multicentre observational prospective feasibility study of fetuses at risk of fetal growth restriction between 32 and 36 weeks (n=856) evaluated by ultrasound biometry and umbilical and middle cerebral artery Doppler. Read More

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Environmental exposure to per- and polyfluoroalkyl substances and sleep disturbance in pregnant women: A prospective cohort study.

Sci Total Environ 2022 Jun 22:156869. Epub 2022 Jun 22.

Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai 200092, China; School of Public Health, Shanghai Jiao Tong University School of Medicine, 227 South Chongqing Road, Shanghai 200052, China. Electronic address:

Previous studies on the association between exposure to per- and polyfluoroalkyl substances (PFAS) and sleep patterns in pregnant women are limited. This cohort study aims to assess the associations between PFAS and sleep quality in pregnant women. Of the 4127 women who participated in the Shanghai Birth Cohort, 3174, 3070, and 2887 women in their first, second, and third trimesters of gestation, respectively, were included in our analysis. Read More

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Impact of Smoking on Visual Field Progression in a Long-term Clinical Follow-up.

Ophthalmology 2022 Jun 22. Epub 2022 Jun 22.

Hamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, CA, United States. Electronic address:

Purpose: To investigate the effect of smoking on the rates of progressive visual field damage over time in glaucoma.

Design: Retrospective cohort study.

Participants: A total of 511 eyes of 354 patients with glaucoma followed from multicenter glaucoma registries. Read More

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Neosporosis in sheep: a systematic review and meta-analysis of global seroprevalence and related risk factors.

Acta Trop 2022 Jun 22:106569. Epub 2022 Jun 22.

Laboratorio de Molecular Farming y Vacunas, INTECH, CONICET-UNSAM, Chascomús, Argentina. Electronic address:

Neosporosis is recognized as the main cause of abortions in cattle worldwide and there is an increasing concern about its role in ovine reproductive losses; however, epidemiological studies regarding neosporosis in sheep are still limited. This meta-analysis aimed to estimate the global pooled seroprevalence and associated risk factors of ovine neosporosis. In the current report, a comprehensive strategy of search and data collection from 7 worldwide databases was performed. Read More

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Long COVID symptoms in SARS-CoV-2-positive children aged 0-14 years and matched controls in Denmark (LongCOVIDKidsDK): a national, cross-sectional study.

Lancet Child Adolesc Health 2022 Jun 22. Epub 2022 Jun 22.

Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

Background: After the acute phase of SARS-CoV-2 infection, children can develop long COVID symptoms. We aimed to investigate the prevalence of long-lasting symptoms, the duration and intensity of symptoms, quality of life, number of sick days and absences from daycare or school, and psychological and social outcomes in children aged 0-14 years who had been infected with SARS-CoV-2 relative to controls with no history of SARS-CoV-2 infection.

Methods: A nationwide cross-sectional study was conducted including children with a confirmed SARS-CoV-2-positive PCR test (cases) and matched controls from Danish national registers. Read More

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Motor features associated with cognition in non-demented individuals with essential tremor.

J Neurol Sci 2022 Jun 16;439:120323. Epub 2022 Jun 16.

Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA. Electronic address:

Introduction: Essential tremor (ET) is a clinically heterogeneous disease characterized by motor and non-motor features, including cognitive impairment. In a cross-sectional analysis, we determined whether the presence and severity of motor features of ET are associated with cognitive performance.

Methods: Participants enrolled in a study that used motor and neuropsychological measures to characterize a cohort of ET subjects. Read More

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Association between trajectories of problematic mobile phone use and chronotype among Chinese college students.

Addict Behav 2022 Jun 9;134:107398. Epub 2022 Jun 9.

Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei 230032, Anhui, China; MOE Key Laboratory of Population Health Across Life Cycle, No 81 Meishan Road, Hefei 230032, Anhui, China; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, No 81 Meishan Road, Hefei 230032, Anhui, China; Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University, China. Electronic address:

Aims: This study aimed to describe the prevalence of problematic mobile phone use (PMPU) and chronotype among Chinese college students, estimate PMPU development trajectories, and further examine the effect of PMPU trajectories on chronotype.

Design: In a stratified cluster sampling design, PMPU and chronotype were evaluated in 999 college students from two universities in a 2-year prospective investigation from April 2019 to April 2021, and an investigation was conducted every six months (time 1 ∼ time 5, T1 ∼ T5).

Participants: N = 999 college students (mean age at T1: 18. Read More

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Association between patient age and pediatric cardiac arrest recognition by emergency medical dispatchers.

Am J Emerg Med 2022 Jun 2;58:275-280. Epub 2022 Jun 2.

Department of Emergency Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Republic of Korea; Laboratory of Emergency Medical Services, Seoul National University Hospital Biomedical Research Institute, Republic of Korea.

Background: Dispatcher-assisted cardiopulmonary resuscitation (DA-CPR) is an important prognostic factor in pediatric out-of-hospital cardiac arrest (OHCA). The recognition of cardiac arrest by dispatcher is a key factor for successful DA-CPR. In this study, we evaluated the association between pediatric age and dispatcher recognition. Read More

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Is premature ovarian insufficiency associated with mortality? A three-decade follow-up cohort.

Maturitas 2022 Jun 13;163:82-87. Epub 2022 Jun 13.

Quilín Clinic, Faculty of Medicine, University of Chile, Santiago de Chile, Chile.

Objective: To evaluate the association between premature ovarian insufficiency (POI) and mortality.

Materials And Methods: This was a secondary analysis of a long-term cohort of Chilean women who received preventive health care between 1990 and 1993. The exposure variable was POI and the outcome was death, and follow-up time was 30 years. Read More

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Spatiotemporal footprints of odor compounds in megacity's food waste streams and policy implication.

J Hazard Mater 2022 Jun 20;437:129423. Epub 2022 Jun 20.

Shanghai Engineering Research Center of Biotransformation of Organic Solid Waste, School of Ecological and Environmental Sciences, East China Normal University, Shanghai 200241, China; Shanghai Key Lab for Urban Ecological Processes and Eco-Restoration, School of Ecological and Environmental Sciences, East China Normal University, Shanghai 200241, China; Shanghai Institute of Pollution Control and Ecological Security, Shanghai 200092, China; Engineering Research Center for Nanophotonics & Advanced Instrument, Ministry of Education, East China Normal University, Shanghai 200241, China. Electronic address:

Odor pollution is one of the most critical issues in food waste (FW) recycling and has significant implications for human health. However, knowledge of their occurrence and spatiotemporally dynamic in urban FW streams is limited, making it not conducive to implement targeted odor management. This work followed the occurrence of 81 odor compounds (OCs) in nine FW-air environments along the Shanghai's FW streams for one year. Read More

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A predictive model based on liquid biopsy for non-small cell lung cancer to assess patient's prognosis: Development and application.

Tissue Cell 2022 Jun 14;77:101854. Epub 2022 Jun 14.

Department of Respiratory, Hwa Mei Hospital, University of Chinese Academy of Sciences, China; Ningbo Institute of Life and Health Industry, University of Chinese Academy of Sciences, China.

Background And Objective: Improving ability to predict the prognosis of patients with progressive lung cancer is an important task in the era of precision medicine. Here, a predictive model based on liquid biopsy for non-small cell lung cancer (NSCLC) was established to improve prognosis prediction in patients with progressive NSCLC.

Methods: Clinical data and blood samples of 500 eligible patients were collected and screened from the electronic case database and blood sample center of Hwa Mei Hospital, University of Chinese Academy of Sciences and Ningbo Institute of Life and Health Industry, University of Chinese Academy of Sciences. Read More

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Trajectories of parental and peer supply of alcohol in adolescence and associations with later alcohol consumption and harms: A prospective cohort study.

Drug Alcohol Depend 2022 Jun 11;237:109533. Epub 2022 Jun 11.

National Drug & Alcohol Research Centre, UNSW Sydney, NSW 2052, Australia; School of Psychology, University of Tasmania, Hobart, TAS 7000, Australia.

Background: Supply of alcohol to adolescents is associated with increased alcohol consumption and harms including alcohol use disorder (AUD). We aimed to identify: (1) trajectories of alcohol supply to adolescents; (2) sociodemographic characteristics associated with supply trajectory; (3) patterns of alcohol consumption by supply trajectory; and (4) supply trajectory associations with adverse alcohol outcomes.

Methods: We used Australian longitudinal survey data (N = 1813) to model latent trajectories of parent and peer alcohol supply over five annual follow-ups (Waves 2-6; M 13. Read More

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Relationship between lithium carbonate and the risk of Parkinson-like events in patients with bipolar disorders: A multivariate analysis using the Japanese adverse drug event report database.

Psychiatry Res 2022 Jun 19;314:114687. Epub 2022 Jun 19.

School of Pharmacy, Aichi Gakuin University, 1-100, Kusumoto, Chikusa, Nagoya 464-8650, Japan.

The present study attempted to identify risk factors for Parkinson-like events using the Japanese adverse drug event report database. A total of 3521 patients with bipolar disorders were extracted from the database, and Parkinson-like events were detected in 111 (3.15%) using the standardized Medical Dictionary for Regulatory Activities queries. Read More

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Development of symptomatic pelvic organ prolapse over 10 years of mid-life follow-up is affected by occupational lifting and/or pushing for parous women.

Maturitas 2022 Jun 9;164:9-14. Epub 2022 Jun 9.

Department of Obstetrics & Gynecology, University of Calgary, 4th floor, North Tower, Foothills Hospital, 1403-29 Street NW, Calgary, Alberta T2N 2T9, Canada; Department of Community Health Sciences, University of Calgary, 3D10, 3280 Hospital Drive NW, Calgary, Alberta T2N 4Z6, Canada.

Objective: To document the risk of new-onset symptomatic pelvic organ prolapse (POP) among perimenopausal women and examine whether occupational lifting and/or pushing is a risk factor in the development of POP over a 10-year follow-up window.

Study Design: Secondary analysis of prospective, longitudinal data from the Study of Women's Health Across the Nation (SWAN) cohort study.

Main Outcome Measures: We analyzed women with current employment at the start of SWAN who were followed annually during mid-life. Read More

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Caring for a child with an eating disorder: Understanding differences among mothers and fathers of adolescent and adult children.

Eur Eat Disord Rev 2022 Jun 25. Epub 2022 Jun 25.

Laurentian University, Sudbury, Ontario, Canada.

Objective: This study investigated treatment-engagement fears, self-efficacy, and accommodating and enabling in mothers and fathers of adolescent and adult children with eating disorders.

Methods: This study involved a secondary analysis of pre-treatment data from a subsample of 143 parents (95 mothers; 48 fathers) from a Canada-wide multi-site study. Parents completed the Caregiver Traps Scale, Parents Versus Anorexia Scale, and the Accommodation and Enabling Scale for Eating Disorders. Read More

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Imputation of the major histocompatibility complex region identifies major independent variants associated with bullous pemphigoid and dermatomyositis in Han Chinese.

J Dermatol 2022 Jun 25. Epub 2022 Jun 25.

Department of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

As autoimmune skin diseases, both bullous pemphigoid (BP) and dermatomyositis (DM) show significant associations with the major histocompatibility complex (MHC) region. In fact, the coexistence of BP and DM has been previously reported. Therefore, we hypothesized that there may be a potential genetic correlation between BP and DM. Read More

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Maternal and Perinatal Risk Factors for Infantile Hemangioma: A Matched Case-Control Study with a Large Sample Size.

Dermatol Ther (Heidelb) 2022 Jun 25. Epub 2022 Jun 25.

Division of Oncology, Department of Pediatric Surgery, West China Hospital of Sichuan University, 37 Guo-Xue-Xiang, Chengdu, 610041, China.

Introduction: Infantile hemangioma (IH) is the most common benign tumor in infancy, but information about its pathogenesis is limited. The aim of this study was to determine maternal and perinatal risk factors for IH.

Methods: A total of 1033 IH patients were enrolled in the study between 2017 and 2020. Read More

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Sensitivity analysis of greenhouse gas emissions at farm level: case study of grain and cash crops.

Environ Sci Pollut Res Int 2022 Jun 25. Epub 2022 Jun 25.

Department of Civil and Architectural Engineering, University of Wyoming, Laramie, WY, 13 82071, USA.

Sensitivity analysis is useful to downgrade/upgrade the number of inputs to limit greenhouse emissions and enhance crop yield. The primary data from the 300 rice (grain crop) and 300 cotton (cash crop) farmers were gathered in face-to-face interviews by applying a multistage random sampling technique using a well-structured pretested questionnaire. Energy use efficiency was estimated with data envelopment analysis (DEA) model, and a second-stage regression analysis was conducted by applying Cobb-Douglas production function to evaluate the influencing factors affecting. Read More

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Parent-Child Discrepancy in Educational Aspirations and Depressive Symptoms in Early Adolescence: A Longitudinal Study.

J Youth Adolesc 2022 Jun 25. Epub 2022 Jun 25.

Collaborative Innovation Center of Assessment toward Basic Education Quality, Beijing Normal University, No.19, Xinjiekouwai St, Haidian District, Beijing, 100875, P.R. China.

Adolescents may have educational aspirations that are different from their parents' educational aspirations for them, and such discrepancy may affect adolescents' psychological adjustment. This longitudinal study examined how parent-child discrepancy in educational aspirations relate to depressive symptoms in early adolescents, both concurrently and prospectively, when controlling for parents' depressive symptoms. Moreover, parent and child gender differences in the effects were explored. Read More

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Pulmonary Atresia with Intact Ventricular Septum: Midterm Outcomes from a Multicenter Cohort.

Pediatr Cardiol 2022 Jun 25. Epub 2022 Jun 25.

Division of Cardiology, Department of Pediatrics, Shawn Jenkins Children's Hospital, Medical University of South Carolina, Charleston, SC, USA.

Contemporary multicenter data regarding midterm outcomes for neonates with pulmonary atresia with intact ventricular septum are lacking. We sought to describe outcomes in a contemporary multicenter cohort, determine factors associated with end-states, and evaluate the effect of right ventricular coronary dependency and coronary atresia on transplant-free survival. Neonates treated during 2009-2019 in 19 United States centers were reviewed. Read More

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Expression pattern and prognostic potential of histamine receptors in epithelial ovarian cancer.

J Cancer Res Clin Oncol 2022 Jun 25. Epub 2022 Jun 25.

Department of Gynecology and Obstetrics, University Hospital, LMU Munich, Munich, Germany.

Purpose: Despite recent advances in the treatment of ovarian cancer (OC), long-term remissions remain scarce. For a targeted approach, prognostic markers are indispensable for predicting survival and treatment response. Given their association with multiple hallmarks of cancer, histamine receptors (HR) are emerging as promising candidates. Read More

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Repeated neurofilament light chain measurements did not capture Riluzole therapeutic effect in amyotrophic lateral sclerosis patients.

CNS Neurosci Ther 2022 Jun 25. Epub 2022 Jun 25.

LBPC-PPC, Univ Montpellier, CHU Montpellier, INSERM, INM Montpellier, Montpellier, France.

Background: Little is known about the influence of Riluzole on serum neurofilament light chain (sNfL) levels, a biomarker of prognosis in amyotrophic lateral sclerosis (ALS), and variations with time of sNfL concentrations are controversial.

Methods: Sera from ALS patients (n = 141) and controls (n = 33) were collected at inclusion (sNfL1) and second visit (sNfL2, mean delay 10.4 ± 8. Read More

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Use of α1-Adrenoceptor Antagonists Tamsulosin and Alfuzosin and The Risk of Alzheimer's Disease.

Pharmacoepidemiol Drug Saf 2022 Jun 25. Epub 2022 Jun 25.

School of Pharmacy, University of Eastern Finland, Kuopio, Finland.

Purpose: Tamsulosin has been associated with dementia, but the results have been inconsistent. Concerns have been raised about using exposure assessment time too close to the outcome. We investigated the association between use of α1-adrenoceptor antagonists indicated for benign prostate hyperplasia and risk of Alzheimer's disease (AD) using different exposure windows. Read More

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Association between urinary polycyclic aromatic hydrocarbon metabolites and diabetes mellitus among the US population: a cross-sectional study.

Int Health 2022 Jun 25. Epub 2022 Jun 25.

Department of Toxicology and Occupational health, College of Public Health, Zhengzhou University, Zhengzhou 450001, China.

Background: The primary aim of this study is to examine the association between urinary polycyclic aromatic hydrocarbons (PAHs) and diabetes mellitus (DM) among the US population.

Methods: We used data from the National Health and Nutritional Examination Survey 2003-16, which is a nationally representative population-based survey of the US non-institutionalized population. Logistic regression analysis was performed to evaluate the association between urinary PAHs and the prevalence of DM using odds ratios (ORs) and 95% confidence intervals (CIs). Read More

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Polygenic risk score for ACE-inhibitor-associated cough based on the discovery of new genetic loci.

Eur Heart J 2022 Jun 25. Epub 2022 Jun 25.

Laboratory for Molecular Cardiology, Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Building 9312, Henrik Harpestrengs Vej 4C, 2100 Copenhagen, Denmark.

Aims: To search for sequence variants associated with ACEi discontinuation and to test their association with ACEi-associated adverse drug reactions (ADRs).

Methods And Results: A genome-wide association study (GWAS) on ACEi discontinuation was conducted, including 33 959 ACEi-discontinuers and 44 041 controls. Cases were defined as persons who switched from an ACEi treatment to an angiotensin receptor blocker. Read More

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The prevalence of anxiety and depression in patients with ostomy: A systematic review and meta-analysis Short title: The prevalence of anxiety and depression in ostomy.

Psychooncology 2022 Jun 25. Epub 2022 Jun 25.

Nursing Care Research Center (NCRC), School of Nursing and Midwifery, Iran University of Medical Sciences, Tehran, Iran.

Aim: The prevalence of anxiety and depression in patients with ostomy is reported differently. The aim of this systematic review and meta-analysis is to estimate the global prevalence of anxiety and depression in patients with ostomy.

Method: A systematic search of Embase, Proquest, Scopus, PubMed and Web of Science (ISI) databases was conducted from January 1990 up to May 5th, 2021. Read More

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