774,611 results match your criteria regression analysis

Disparities in Trial of Labor among Women with Twin Gestations in the United States.

Am J Perinatol 2021 Apr 20. Epub 2021 Apr 20.

Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

Objective:  The aim of the study is to examine clinical and demographic factors associated with trial of labor (TOL) among women with twin gestations eligible for a vaginal delivery.

Study Design:  This was a population-based cohort study of women giving birth to twin gestations in the United States (2012-2014). Inclusion criteria for the analysis included live births greater than 23 weeks' gestation and a cephalic presenting twin. Read More

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Latency Period after Preterm Premature Rupture of Membranes: Singletons versus Twins.

Am J Perinatol 2021 Apr 20. Epub 2021 Apr 20.

Department of Obstetrics and Gynecology, New York Presbyterian Hospital-Columbia University Irving Medical Center, New York, New York.

Objective:  Several studies have evaluated the differences in duration of latency and clinical outcomes between singleton and twin pregnancies after preterm premature rupture of membranes (PPROM); however, these data are limited to single-institution analyses and based on small sample sizes. The aim of this study was to assess differences in latency and clinical outcomes in singletons versus twin gestations affected by PPROM in a large, diverse cohort of women.

Study Design:  This is a secondary analysis of a multicenter trial of magnesium for neuroprotection in women at high risk of preterm birth. Read More

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Crucial Music Components Needed for Speech Perception Enhancement of Pediatric Cochlear Implant Users: A Systematic Review and Meta-Analysis.

Audiol Neurootol 2021 Apr 20:1-25. Epub 2021 Apr 20.

Research Institute of Hearing Enhancement, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea.

Background: Although many clinicians have attempted music training for the hearing-impaired children, no specific effects have yet been reported for individual music components. This paper seeks to discover specific music components that help in improving speech perception of children with cochlear implants (CI) and to identify the effective training periods and methods needed for each component.

Method: While assessing 5 electronic databases, that is, ScienceDirect, Scopus, PubMed, CINAHL, and Web of Science, 1,638 articles were found initially. Read More

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Tuberculosis in Myasthenia Gravis patients on immunosuppressive therapy in a high-risk area: Implications for preventative therapy.

J Neurol Sci 2021 Apr 17;425:117447. Epub 2021 Apr 17.

Division of Neurology, Department of Medicine, University of Cape Town, Cape Town, South Africa; Neurology Research Group, UCT Neuroscience Institute, University of Cape Town, Cape Town, South Africa. Electronic address:

Data regarding the risk of tuberculosis (TB) in myasthenia gravis (MG) patients receiving immunosuppressive therapy is limited, and the benefit of TB preventative therapy in these patients is uncertain. We audited observational data collected at an MG clinic in South Africa over a ~ 10-year period, of cases who received immunosuppressive therapy. The total time that the cohort was at risk (patient-years) was used as the denominator to calculate TB incidence after immunosuppressive therapy initiation. Read More

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Association between long-term exposure to fine particulate matter and diabetic retinopathy among diabetic patients: A national cross-sectional study in China.

Environ Int 2021 Apr 17;154:106568. Epub 2021 Apr 17.

Department of Ophthalmology, Tianjin Medical University General Hospital, Tianjin 300052, China; Tianjin Medical University, Tianjin 300070, China. Electronic address:

Background: While the relationship between ambient air pollution and diabetes mellitus has recently been reported, data on the association between fine particulate matter (PM) and diabetic complications are limited, especially in microvascular diseases such as diabetic retinopathy.

Objectives: To investigate the associations between long-term exposure to PM and the prevalence of diabetic retinopathy in adult diabetic patients in rural China.

Methods: The study population was based on the Rural Epidemiology for Glaucoma in China (REG-China), a national cross-sectional survey conducted in rural China. Read More

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A novel nomogram for predicting the risk of epilepsy occurrence after operative in gliomas patients without preoperative epilepsy history.

Epilepsy Res 2021 Apr 14;174:106641. Epub 2021 Apr 14.

Department of Radiotherapy, The First Affiliated Hospital of Wenzhou Medical University, WenZhou, China. Electronic address:

Objective: Epilepsy is a common complication in glioma patients after undergoing brain tumor surgery combined with chemotherapy and/or radiotherapy. Whether antiepileptic drug prophylaxis could be used in these patients remains an open question. The purpose of this study was to produce a model for predicting the risk of epilepsy occurrence in such patients. Read More

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Potential alcohol use disorder among MSM in Ireland - Findings from the European MSM internet survey (EMIS 2017).

Drug Alcohol Depend 2021 Apr 14;223:108698. Epub 2021 Apr 14.

School of Public Health, University College Cork, Cork, T12 XF62, Ireland; Department of Public Health HSE-South, St. Finbarr's Hospital, Cork, T12XH60, Ireland. Electronic address:

Background: Alcohol consumption is a major public health concern in Ireland. Alcohol use disorder (AUD) disproportionately affects men who have sex with men (MSM). However, little is known about the prevalence of AUD in this group in Ireland specifically, and the characteristics of MSM who may struggle with this. Read More

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Identification and validation of autophagy-related prognostic signature for head and neck squamous cell carcinoma.

Transl Oncol 2021 Apr 17;14(7):101094. Epub 2021 Apr 17.

Department of Otorhinolaryngology-Head and Neck Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430000, China. Electronic address:

Background: Many studies have demonstrated that autophagy plays a significant role in regulating tumor growth and progression. However, the effect of autophagy-related genes (ARGs) on the prognosis have rarely been analyzed in head and neck squamous cell carcinoma (HNSCC).

Methods: We obtained differentially expressed ARGs from HNSCC mRNA data in The Cancer Genome Atlas (TCGA) database. Read More

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Independent and combined associations of urinary heavy metals exposure and serum sex hormones among adults in NHANES 2013-2016.

Environ Pollut 2021 Apr 8;281:117097. Epub 2021 Apr 8.

State Key Laboratory of Reproductive Medicine, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China; Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, 211166, China. Electronic address:

Accumulating evidences indicated that heavy metals may disrupt human sex hormones. However, the combined effects of heavy metals on sex hormones remain to be clarified. To explore the independent and combined associations between heavy metal exposure and serum sex hormones among adults, data of 2728 adults from the National Health and Nutrition Examination Survey (NHANES) was applied. Read More

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Movement compensations during a step ascent task are associated with stair climbing performance in people with multiple sclerosis.

Gait Posture 2021 Apr 15;87:27-32. Epub 2021 Apr 15.

Department of Physical Medicine and Rehabilitation, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Department of Neurology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

Background: The biomechanical mechanisms underlying stair climbing limitations are poorly understood in people with multiple sclerosis (MS).

Research Questions: Are trunk and pelvis motion and lower extremity joint moments during step ascent different between MS and control groups? Are step ascent biomechanics and stair climbing performance associated in people with MS?

Methods: 20 people with MS (49 ± 12 years, EDSS range: 1.5-5. Read More

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Establishing Clinically Significant Outcomes of the PROMIS Upper Extremity Questionnaire after Primary Reverse Total Shoulder Arthroplasty.

J Shoulder Elbow Surg 2021 Apr 17. Epub 2021 Apr 17.

Midwest Orthopaedics at Rush, Chicago, IL, USA. Electronic address:

Background: and Hypothesis: Since its introduction, the Patient Reported Outcome Measurement Information System Upper Extremity (PROMIS UE) assessment has been increasingly used in shoulder arthroplasty outcome measurement. However, determination of clinically significant outcomes using PROMIS UE has yet to be investigated following reverse total shoulder arthroplasty (RTSA). We hypothesized that we could establish clinically significant outcomes of the PROMIS UE outcome assessment in patients undergoing primary RTSA and identify significant baseline patient factors associated with achievement of these measures. Read More

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Neutrophil-to-Lymphocyte Ratio is superior to other leucocyte-based ratios as a prognostic predictor in radiosurgically treated non-small cell lung cancer brain metastases patients under immunotherapy or targeted therapy.

World Neurosurg 2021 Apr 17. Epub 2021 Apr 17.

Department of Neurosurgery, Medical University of Vienna, Vienna, Austria. Electronic address:

Objective: The predictive value of pre-radiosurgery leucocyte-based prognostic ratios was investigated in a selected cohort of non-small cell lung cancer patients (NSCLC) patients with radiosurgically treated brain metastases (BM) and concomitant immunotherapy (IT) or targeted therapy (TT).

Methods: We performed a retrospective analysis of 166 NSCLC BM patients treated with Gamma Knife Radiosurgery. The Neutrophil-to-Lymphocyte Ratio (NLR), Platelet-to-Lymphocyte Ratio (PLR), and Lymphocyte-to-Monocyte Ratio (LMR) were assessed within 14 days prior to radiosurgical treatment. Read More

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Adverse associations of sedentary behavior with cancer incidence and all-cause mortality: A prospective cohort study: Sedentary behavior, cancer and mortality.

J Sport Health Sci 2021 Apr 17. Epub 2021 Apr 17.

Key Laboratory of Cardiovascular Epidemiology, Chinese Academy of Medical Sciences, Beijing 100037, China; Department of Epidemiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China; School of Medicine, Southern University of Science and Technology, Shenzhen 518055, China. Electronic address:

Background: Inconsistent results have been reported in developed countries for relationships between sedentary behavior and cancer incidence and mortality, but evidence from the Chinese population is scarce. This study aimed to investigate such relationships in large Chinese population-based prospective cohorts and to explore the joint effect and interaction of sedentary behavior and moderate-to-vigorous physical activity (MVPA) on these relationships.

Methods: We included 95,319 Chinese adults without cancer from 3 large cohorts and assessed their sedentary behavior and physical activity with a unified questionnaire. Read More

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The potential for mid-treatment albumin-bilirubin (ALBI) score to individualize liver stereotactic body radiation therapy.

Int J Radiat Oncol Biol Phys 2021 Apr 17. Epub 2021 Apr 17.

University of Michigan Department of Radiation Oncology, Ann Arbor, Michigan.

Purpose/objective(s): Our individualized functional response adaptive approach to liver stereotactic body radiation therapy (SBRT) with assessment of indocyanine green (ICG) retention at baseline and mid-treatment to detect subclinical changes in liver function, permitting dose adjustment, has decreased toxicity while preserving efficacy. We hypothesized that assessment of the Albumin-Bilirubin (ALBI) score at baseline and mid-treatment would allow for more practical identification of patients at risk for treatment-related toxicity (TRT).

Methods And Materials: Patients with HCC were treated on three prospective IRB approved trials utilizing baseline and mid-treatment ICG to deliver individualized functional response adaptive liver SBRT. Read More

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Pain is the Primary Factor Associated with Satisfaction with Symptoms for New Patients Presenting to the Orthopaedic Clinic.

Arthroscopy 2021 Apr 17. Epub 2021 Apr 17.

Department of Orthopaedic Surgery, Henry Ford Health System, 2799 W. Grand Blvd, Detroit, MI 48202 USA. Electronic address:

Purpose: The purpose of the current study was to: (1) determine the percentage of new orthopaedic patients reporting their symptoms to be acceptable at presentation, as measured by the Patient Acceptable Symptom State (PASS) question and (2) evaluate whether patient-reported outcome measures (PROMs), including Patient-Reported Outcome Measurement Information System (PROMIS) Physical Function (PF) or Upper Extremity (UE), Pain Interference (PI), and Depression (D), or sociodemographic factors are associated with acceptable symptoms at presentation.

Methods: Between 2/7/2020-3/16/2020, new orthopaedic patients who completed PROMs were identified. Patient records were reviewed for those who also completed the patient acceptable symptom state (PASS) question, a yes/no question about whether a patient's current symptom state is satisfactory. Read More

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Survival and lung transplant outcomes for individuals with advanced cystic fibrosis lung disease in the United States and Canada: an analysis of national registries.

Chest 2021 Apr 17. Epub 2021 Apr 17.

Div. of Respirology, St. Michael's Hospital, Toronto, Canada; Keenan Research Centre, Li Ka Shing Knowledge Institute of St Michael's Hospital, Toronto, Ontario, Canada; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.

Background: Understanding how health outcomes differ for cystic fibrosis (CF) patients with advanced lung disease in the United States (US) compared to Canada has health policy implications.

Research Question: What are rates of lung transplant (LTx) and rates of death without LTx in the US and Canada among individuals with forced expiratory volume in 1 second (FEV) <40% predicted?

Study Design: and Methods: Retrospective population-based cohort study, 2005-2016, using the US CF Foundation, United Network for Organ Sharing, and Canadian CF registries. Individuals with CF and ≥2 FEV measurements <40% predicted within a 5-year period, age ≥6 years, without prior LTx were included. Read More

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Elastase Activity from Pseudomonas aeruginosa Respiratory Isolates and ICU Mortality.

Chest 2021 Apr 17. Epub 2021 Apr 17.

Acute Lung Injury Center of Excellence, Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA;; Vascular Medicine Institute, University of Pittsburgh, Pittsburgh PA USA. Electronic address:

Background: Pseudomonas aeruginosa (PA) is a common cause of respiratory infection and morbidity. Pseudomonas elastase is an important virulence factor regulated by the lasR gene. Whether PA elastase activity is associated with worse clinical outcomes in ICU patients is unknown. Read More

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The Fate of Proximal Junctional Vertebral Fractures after Long-Segment Spinal Fixation : Are There Predictable Radiologic Characteristics for Revision surgery?

J Korean Neurosurg Soc 2021 Apr 21. Epub 2021 Apr 21.

Department of Neurosurgery, Gangnam Severance Hospital, Spine and Spinal Cord Institute, Yonsei University College of Medicine, Seoul, Korea.

Objective: To investigate the radiographic characteristics of the uppermost instrumented vertebrae (UIV) and UIV+1 compression fractures that are predictive of revision surgery following long-segment spinal fixation.

Methods: A total 27 patients who presented newly developed compression fracture at UIV, UIV+1 after long segment spinal fixation (minimum 5 vertebral bodies, lowest instrumented vertebra of L5 or distal) were reviewed retrospectively. Patients were divided into two groups according to following management : revisional surgery (group A, n=13) and conservative care (group B, n=14). Read More

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Early ultrasound evaluation identifies excellent responders to neoadjuvant systemic therapy among patients with triple-negative breast cancer.

Cancer 2021 Apr 20. Epub 2021 Apr 20.

Department of Breast Imaging, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Background: Heterogeneity exists in the response of triple-negative breast cancer (TNBC) to standard anthracycline (AC)/taxane-based neoadjuvant systemic therapy (NAST), with 40% to 50% of patients having a pathologic complete response (pCR) to therapy. Early assessment of the imaging response during NAST may identify a subset of TNBCs that are likely to have a pCR upon completion of treatment. The authors aimed to evaluate the performance of early ultrasound (US) after 2 cycles of neoadjuvant NAST in identifying excellent responders to NAST among patients with TNBC. Read More

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A matter of size? Health-related quality of life after radical prostatectomy for patients with giant prostates.

Prostate 2021 Jun;81(8):443-451

Department of Urology, University Hospital Großhadern, Ludwig-Maximilians-University Munich, Munich, Germany.

Background: Evidence regarding the impact of giant prostate volume (PV) on outcome after radical prostatectomy (RP) is controversial with a lack of evidence on the impact of PV on health-related quality of life (HRQOL). We aimed to assess the impact of giant PV on HRQOL and functional outcomes for men with prostate cancer (PC) undergoing RP.

Methods: Giant PV was defined based on the 95th percentile of PV measured by specimen weight of 3929 patients that underwent RP between 2013 and 2018 in a large tertiary care center. Read More

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Genetically proxied morning chronotype was associated with a reduced risk of prostate cancer.

Sleep 2021 Apr 20. Epub 2021 Apr 20.

Department of Epidemiology and Biostatistics, School of Public Health, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.

Study Objectives: Observational epidemiological studies have suggested that chronotype may play a role in the pathogenesis and progression of prostate cancer. However, whether there is a causal association remains unknown. The aim of the present study was to examine the potential causal relationship between chronotype and prostate cancer risk using a Mendelian randomization (MR) design. Read More

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Cornea donation process and tissue quality for transplantation.

PLoS One 2021 20;16(4):e0249927. Epub 2021 Apr 20.

Nursing Department, Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.

Introduction: The quality of the corneal tissue can be influenced by several factors inherent to the recipient, donor, and to the donation and transplantation process. The donated corneal tissue can be classified by its quality as excellent, good, regular, bad, or unacceptable for transplantation, evaluating it in a slit lamp.

Objective: To analyze the relationship between the clinical and sociodemographic variables of the donors and the donation process and the classification of the quality of the corneal tissue collected for transplantation. Read More

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Nomophobia in Lebanon: Scale validation and association with psychological aspects.

PLoS One 2021 20;16(4):e0249890. Epub 2021 Apr 20.

INSPECT-LB: National Institute of Public Health, Clinical Epidemiology and Toxicology, Beirut, Lebanon.

Objectives: Nomophobia, an abbreviation of "No mobile phone phobia", is characterized by the illogical fear of being detached from the mobile phone or unable to use it. Research have provided evidence of an association between increased cellular phone use and multiple health issues, such as anxiety, depression, insomnia, and others. To our knowledge, there are no Lebanese studies about nomophobia, despite the high incorporation rate of mobile phones in Lebanon and the likelihood of suffering from anxiety, depression, and other conditions due to nomophobic attitudes. Read More

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Prevalence and associated factors of hemorrhoids among adult patients visiting the surgical outpatient department in the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia.

PLoS One 2021 20;16(4):e0249736. Epub 2021 Apr 20.

Department of Human Anatomy, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Introduction: Hemorrhoidal disease is a very common benign anorectal disease. It affects millions of people around the world, and represent a major medical and socioeconomic problem. However, studies that determine the magnitude and risk factors are limited. Read More

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Effects of combined decision-support and performance-based incentives on reported client satisfaction with maternal health services in primary facilities: A quasi-experimental study in the Upper East Region of Ghana.

PLoS One 2021 20;16(4):e0249778. Epub 2021 Apr 20.

National University of Singapore, Saw Swee Hock School of Public Health, Singapore, Singapore.

Background: Computerized decision-support systems (CDSS) and performance-based incentives (PBIs) have potential to contribute to client satisfaction with health services. However, rigorous evidence is lacking on the effectiveness of these strategies in lower-income countries such as Ghana. This study aimed to determine the effect of a combined CDSS-PBI intervention on client satisfaction with maternal health services in primary facilities in the Upper East Region of Ghana. Read More

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Mapping internet literacy skills of digital natives: A developing country perspective.

PLoS One 2021 20;16(4):e0249495. Epub 2021 Apr 20.

Minhaj University Lahore, Lahore, Pakistan.

Over the last three decades, Information and Communication Technologies (ICTs) have changed the world in all walks of life. It has not only influenced the ways of human communication but also changed the way of learning. However, to utilize the facility of the Internet in effective manners, people need a certain set of skills called "Internet Literacy Skills". Read More

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Large Individual Bilateral Differences in Tibial Torsion Impact Accurate Contralateral Templating and the Evaluation of Rotational Malalignment.

J Orthop Trauma 2021 Apr 19. Epub 2021 Apr 19.

Keck School of Medicine of USC, Los Angeles, CA, USA Department of Orthopaedic Surgery, Keck School of Medicine of USC, Los Angeles, CA, USA Department of Orthopaedics, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Objective: To determine individual bilateral differences (IBDs) in tibial torsion in a diverse population.

Methods: Computed tomography scans of uninjured bilateral tibiae were used to determine tibial torsion and IBDs in torsion using four measurement methods. Age, sex, and self-identified race/ethnicity were also recorded for each subject. Read More

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Insurance Status and Ethnicity Impact Health Disparities in Rates of Advance Directives in Trauma.

Am Surg 2021 Apr 20:31348211011115. Epub 2021 Apr 20.

Division of Trauma and Critical Care and Acute Care Surgery, Department of Surgery, 22957Duke University Medical Center, Durham, NC, USA.

Introduction: Advanced directives (ADs) provide a framework from which families may understand patient's wishes. However, end-of-life planning may not be prioritized by everyone. This analysis aimed to determine what populations have ADs and how they affected trauma outcomes. Read More

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Rising Incidence of Childhood Intussusception in Ontario: A Population-Based Study From 1997-2016.

Am Surg 2021 Apr 20:31348211011139. Epub 2021 Apr 20.

Department of General Surgery, 9978Queen's University, Kingston, Canada.

Background: Intussusception is the most common cause of bowel obstruction in children aged 3 months to 6 years of age. We sought to describe patterns of incident childhood intussusception.

Methods: A retrospective longitudinal cohort study utilizing population-based health administrative data and a validated case definition was used to identify patients <18 years of age treated for intussusception between January 1, 1997 and December 31, 2016 in Ontario, Canada. Read More

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