428 results match your criteria regions pcg


A virtual reality meditative intervention modulates pain and the pain neuromatrix in patients with opioid use disorder.

Pain Med 2021 May 6. Epub 2021 May 6.

Department of Psychiatry and Behavioral Neurosciences, Wayne State University.

Objective: Standard-of-care for opioid use disorder (OUD) includes medication and counseling. However, there is an unmet need for complementary approaches to treat OUD patients coping with pain; furthermore, few studies have probed neurobiological features of pain or its management during OUD treatment. This preliminary study examines neurobiological and behavioral effects of a virtual reality-based meditative intervention in patients undergoing methadone maintenance treatment (MMT). Read More

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Integrating Structural and Functional Interhemispheric Brain Connectivity of Gait Freezing in Parkinson's Disease.

Front Neurol 2021 15;12:609866. Epub 2021 Apr 15.

Department of Radiology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China.

Freezing of gait (FOG) has devastating consequences for patients with Parkinson's disease (PD), but the underlying pathophysiological mechanism is unclear. This was investigated in the present study by integrated structural and functional connectivity analyses of PD patients with or without FOG (PD FOG+ and PD FOG-, respectively) and healthy control (HC) subjects. We performed resting-state functional magnetic resonance imaging (fMRI) and diffusion tensor imaging of 24 PD FOG+ patients, 37 PD FOG- patients, and 24 HCs. Read More

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Single-cell CUT&Tag analysis of chromatin modifications in differentiation and tumor progression.

Nat Biotechnol 2021 Apr 12. Epub 2021 Apr 12.

Brotman-Baty Institute for Precision Medicine, University of Washington, Seattle, WA, USA.

Methods for quantifying gene expression and chromatin accessibility in single cells are well established, but single-cell analysis of chromatin regions with specific histone modifications has been technically challenging. In this study, we adapted the CUT&Tag method to scalable nanowell and droplet-based single-cell platforms to profile chromatin landscapes in single cells (scCUT&Tag) from complex tissues and during the differentiation of human embryonic stem cells. We focused on profiling polycomb group (PcG) silenced regions marked by histone H3 Lys27 trimethylation (H3K27me3) in single cells as an orthogonal approach to chromatin accessibility for identifying cell states. Read More

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Comparative mitochondrial genomics of sponge-dwelling snapping shrimps in the genus Synalpheus: Exploring differences between eusocial and non-eusocial species and insights into phylogenetic relationships in caridean shrimps.

Gene 2021 Jun 31;786:145624. Epub 2021 Mar 31.

Department of Biological Sciences, 132 Long Hall, Clemson University, Clemson, SC 29634, USA; Smithsonian Marine Station at Fort Pierce, 701 Seaway Drive, Fort Pierce, Florida 34949, USA; Departamento de Biología Marina, Facultad de Ciencias del Mar, Universidad Católica del Norte, Larrondo 1281, Coquimbo, Chile. Electronic address:

The genus Synalpheus is a cosmopolitan clade of marine shrimps found in most tropical regions. Species in this genus exhibit a range of social organizations, including pair-forming, communal breeding, and eusociality, the latter only known to have evolved within this genus in the marine realm. This study examines the complete mitochondrial genomes of seven species of Synalpheus and explores differences between eusocial and non-eusocial species considering that eusociality has been shown before to affect the strength of purifying selection in mitochondrial protein coding genes. Read More

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The complete chloroplast genome of a distylous-homostylous species, (Primulaceae).

Mitochondrial DNA B Resour 2021 Feb 8;6(2):393-394. Epub 2021 Feb 8.

Department of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guizhou, China.

F. H. Chen & C. Read More

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February 2021

Genome-wide occupancy of Arabidopsis SWI/SNF chromatin remodeler SPLAYED provides insights into its interplay with its close homolog BRAHMA and Polycomb proteins.

Plant J 2021 Apr 17;106(1):200-213. Epub 2021 Mar 17.

Agriculture and Agri-Food Canada, London Research and Development Centre, London, Ontario, Canada.

SPLAYED (SYD) is a SWItch/Sucrose Non-Fermentable (SWI/SNF)-type chromatin remodeler identified in Arabidopsis thaliana (Arabidopsis). It is believed to play both redundant and differential roles with its closest homolog BRAHMA (BRM) in diverse plant growth and development processes. To better understand how SYD functions, we profiled the genome-wide occupancy of SYD and its impact on the global transcriptome and trimethylation of histone H3 on lysine 27 (H3K27me3). Read More

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Structural and functional underpinnings of precentral abnormalities in amyotrophic lateral sclerosis.

Eur J Neurol 2021 May 1;28(5):1528-1536. Epub 2021 Feb 1.

Department of Radiology, Chongqing University Cancer Hospital, Chongqing Cancer Institute, and Chongqing Cancer Hospital, Chongqing, China.

Background And Purpose: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by the loss of both upper and lower motor neurons. Studies using various magnetic resonance imaging (MRI) analytical approaches have consistently identified significant precentral abnormalities in ALS, whereas their structural and functional underpinnings remain poorly understood.

Methods: Using cortical thickness, fractional anisotropy (FA), and effective connectivity, we performed a multimodal MRI study to examine the structural and functional alterations associated with precentral abnormalities in patients with ALS (n = 60) compared with healthy controls (n = 60). Read More

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Preliminary Study of Subclinical Brain Alterations in Patients With Asymptomatic Carotid Vulnerable Plaques Using Intravoxel Incoherent Motion Imaging by Voxelwise Comparison: A Study of Whole-Brain Imaging Measures.

Front Neurosci 2020 15;14:562830. Epub 2020 Dec 15.

Department of Radiology, Xiangya Hospital, Central South University, Changsha, China.

Objective: To preliminarily explore subclinical brain alterations in an asymptomatic carotid vulnerable plaque group based on intravoxel incoherent motion (IVIM) imaging through voxelwise comparison in the whole brain.

Materials And Methods: Forty-nine elderly participants underwent multi--value DWI, of whom 24 participants with asymptomatic carotid vulnerable plaques and <50% stenosis served as the test group, while the rest served as the healthy control group. After fitting the double-exponential model, slow ADC (Ds) and the fraction of fast ADC () values of the whole brain were obtained, which then were compared in a voxelwise manner by two-sample -test. Read More

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December 2020

The complete plastome of , an extremely endangered species in the Qinghai-Tibet Plateau.

Mitochondrial DNA B Resour 2020 Nov 13;5(3):3727-3729. Epub 2020 Nov 13.

Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China.

is an extremely endangered species in the Qinghai-Tibet Plateau. Based on the second-generation high-throughput genome sequencing, we assembled the plastome of this species. The length of the total plastome is 152,324 bp with a typical quadripartite structure including a large single-copy region of 83,708 bp, a small single-copy region of 29,882 bp and two reverse repeat regions of 19,367 bp respectively. Read More

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November 2020

Characterization of the complete chloroplast genome of (Betulaceae), a critically endangered limestone birch.

Mitochondrial DNA B Resour 2020 27;5(3):2166-2167. Epub 2020 May 27.

The University of Tokyo Chichibu Forest, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Chichibu, Japan.

is a critically endangered limestone birch confined to the Chichibu and Kitakami mountains in central and northeastern Japan, respectively. In this study, we assembled and characterized the complete chloroplast genome of . The whole chloroplast genome was 160,791 bp in length, consisting of a large single-copy (LSC) region of 89,504 bp and a small single-copy (SSC) region of 19,175 bp, separated by a pair of inverted repeat (IR) regions of 26,056 bp. Read More

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Characterization of the complete chloroplast genome of (Araliaceae) as an herb in China.

Authors:
Zhuo Tian

Mitochondrial DNA B Resour 2020 20;5(3):2133-2134. Epub 2020 May 20.

College of Information Technology, Jilin Agricultural University, Changchun, China.

is a highly valued woody herb medicinal plant belonging to the family Araliaceae, which is also the popular edible plant in China. In this paper, the chloroplast genome of was completed. The complete chloroplast genome of was 156,768 bp in length as a circle. Read More

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Characterization of the complete chloroplast genome of , one of the traditional Chinese medicines in China.

Mitochondrial DNA B Resour 2020 28;5(2):1202-1203. Epub 2020 Feb 28.

Basic Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.

is a common and annual the Traditional Chinese Medicine for many years in China. In this study, we presented the complete chloroplast genome of . The chloroplast genome size was 151,897 bp in length that contained a large single-copy region (LSC) of 83,847 bp, a small single-copy region (SSC) of 17,890 bp and two inverted repeat regions (IR) of 25,080 bp. Read More

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February 2020

The complete chloroplast genome sequence of Lour.

Mitochondrial DNA B Resour 2020 Feb 3;5(1):1042-1043. Epub 2020 Feb 3.

Key Laboratory for Research and Utilization of Characteristic Biological Resources in Southern Yunnan, College of Life Science and Technology, Honghe University, Mengzi, PR China.

Lour. (Zingiberaceae) is an important edible and medicinal crop. The complete chloroplast (cp) genome of was determined using Illumina sequencing platform. Read More

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February 2020

The complete chloroplast genome of .

Mitochondrial DNA B Resour 2020 Jan 24;5(1):848-849. Epub 2020 Jan 24.

Key Laboratory for Research and Utilization of Characteristic Biological Resources in Southern Yunnan, College of Life Science and Technology, Honghe University, Mengzi, Yunnan, PR China.

(Zingiberaceae) is an important edible and medicinal crop. The complete chloroplast (cp) genome of was determined using Illumina sequencing platform. The size of whole cp genome was 163,648 bp, containing a small single copy (SSC) region of 15,355 bp and a large single copy (LSC) region of 88,741 bp, which were separated by a pair of inverted repeat (IRs) regions (29,776 bp). Read More

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January 2020

Characterization of the complete chloroplast genome of (Gramineae).

Mitochondrial DNA B Resour 2019 Dec 27;5(1):358-359. Epub 2019 Dec 27.

Academy of Animal and Veterinary, Qinghai University, Xining, China.

The complete chloroplast genome from , an important perennial bunchgrass of the Gramineae, is determined in this study. The whole chloroplast genome sequence of has been characterized by Illumina pair-end sequencing. The circular genome is 134,177 bp long, containing a large single-copy region (LSC) of 79,367 bp and a small single-copy region (SSC) of 12,510 bp, which are separated by a pair of 21,150 bp inverted repeat regions (IRs). Read More

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December 2019

Abnormal Whole Brain Functional Connectivity Pattern Homogeneity and Couplings in Migraine Without Aura.

Front Hum Neurosci 2020 11;14:619839. Epub 2020 Dec 11.

Department of Radiology, West China Hospital of Sichuan University, Chengdu, China.

Previous studies have reported abnormal amplitude of low-frequency fluctuation and regional homogeneity in patients with migraine without aura using resting-state functional magnetic resonance imaging. However, how whole brain functional connectivity pattern homogeneity and its corresponding functional connectivity changes in patients with migraine without aura is unknown. In the current study, we employed a recently developed whole brain functional connectivity homogeneity (FcHo) method to identify the voxel-wise changes of functional connectivity patterns in 21 patients with migraine without aura and 21 gender and age matched healthy controls. Read More

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December 2020

A Service Coverage Analysis of Primary Congenital Glaucoma Care Across the United States.

Am J Ophthalmol 2021 04 16;224:112-119. Epub 2020 Dec 16.

Bascom Palmer Eye Institute, University of Miami Health System, Miami, Florida, USA.

Purpose: To assess the number of infants at risk of delayed primary congenital glaucoma (PCG) evaluation due to long travel times to specialists.

Design: Cross-sectional geospatial service coverage analysis.

Methods: All American Glaucoma Society (AGS) and American Association for Pediatric Ophthalmology and Strabismus (AAPOS) provider locations were geocoded using each organization's member directory. Read More

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An integrative atlas of chicken long non-coding genes and their annotations across 25 tissues.

Sci Rep 2020 11 24;10(1):20457. Epub 2020 Nov 24.

PEGASE UMR 1348, INRA, AGROCAMPUS OUEST, 35590, Saint-Gilles, France.

Long non-coding RNAs (LNC) regulate numerous biological processes. In contrast to human, the identification of LNC in farm species, like chicken, is still lacunar. We propose a catalogue of 52,075 chicken genes enriched in LNC ( http://www. Read More

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November 2020

Graph theory analysis reveals premature ejaculation is a brain disorder with altered structural connectivity and depressive symptom: A DTI-based connectome study.

Eur J Neurosci 2021 Mar 20;53(6):1905-1921. Epub 2020 Dec 20.

Department of Radiology, Nanjing Brain Hospital, Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Recent research has shown that premature ejaculation (PE) is associated with negative psychological effects (e.g., depression) and the decline of control over ejaculation is accompanied by structural and functional abnormalities in specific brain areas and connections. Read More

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The Polycomb group protein Ring1 regulates dorsoventral patterning of the mouse telencephalon.

Nat Commun 2020 11 11;11(1):5709. Epub 2020 Nov 11.

Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.

Dorsal-ventral patterning of the mammalian telencephalon is fundamental to the formation of distinct functional regions including the neocortex and ganglionic eminence. While Bone morphogenetic protein (BMP), Wnt, and Sonic hedgehog (Shh) signaling are known to determine regional identity along the dorsoventral axis, how the region-specific expression of these morphogens is established remains unclear. Here we show that the Polycomb group (PcG) protein Ring1 contributes to the ventralization of the mouse telencephalon. Read More

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November 2020

The bed nucleus of the stria terminalis and functionally linked neurocircuitry modulate emotion processing and HPA axis dysfunction in posttraumatic stress disorder.

Neuroimage Clin 2020 24;28:102442. Epub 2020 Sep 24.

Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Background: The bed nucleus of the stria terminalis (BNST) plays an important role in rodent posttraumatic stress disorder (PTSD), but evidence to support its relevance to human PTSD is limited. We sought to understand the role of the BNST in human PTSD via fMRI, behavioral, and physiological measurements.

Methods: 29 patients with PTSD (childhood sexual abuse) and 23 healthy controls (HC) underwent BOLD imaging with an emotional word paradigm. Read More

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September 2020

PRC1 catalytic unit RING1B regulates early neural differentiation of human pluripotent stem cells.

Exp Cell Res 2020 11 21;396(1):112294. Epub 2020 Sep 21.

Symbiosis Centre for Stem Cell Research (SCSCR), Symbiosis International University (SIU), Lavale, Pune, 15, India. Electronic address:

Background: Polycomb group (PcG) proteins are histone modifiers which control gene expression by assembling into large repressive complexes termed - Polycomb repressive complex (PRC); RING1B, core catalytic subunit of PRC1 that performs H2AK119 monoubiquitination leading to gene repression. The role of PRC1 complex during early neural specification in humans is unclear; we have tried to uncover the role of PRC1 in neuronal differentiation using human pluripotent stem cells as an in vitro model.

Results: We differentiated both human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs) towards neural progenitor stage evident from the expression of NESTIN, TUJ1, NCAD, and PAX6. Read More

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November 2020

CBF-1 Promotes the Establishment and Maintenance of HIV Latency by Recruiting Polycomb Repressive Complexes, PRC1 and PRC2, at HIV LTR.

Viruses 2020 09 18;12(9). Epub 2020 Sep 18.

Center for Translational Medicine, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19107, USA.

The C-promoter binding factor-1 (CBF-1) is a potent and specific inhibitor of the human immunodeficiency virus (HIV)-1 LTR promoter. Here, we demonstrate that the knockdown of endogenous CBF-1 in latently infected primary CD4+ T cells, using specific small hairpin RNAs (shRNA), resulted in the reactivation of latent HIV proviruses. Chromatin immunoprecipitation (ChIP) assays using latently infected primary T cells and Jurkat T-cell lines demonstrated that CBF-1 induces the establishment and maintenance of HIV latency by recruiting polycomb group (PcG/PRC) corepressor complexes or polycomb repressive complexes 1 and 2 (PRC1 and PRC2). Read More

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September 2020

Defining the Boundaries of Polycomb Domains in .

Genetics 2020 11 18;216(3):689-700. Epub 2020 Sep 18.

Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892

Polycomb group (PcG) proteins are an important group of transcriptional repressors that act by modifying chromatin. PcG target genes are covered by the repressive chromatin mark H3K27me3. Polycomb repressive complex 2 (PRC2) is a multiprotein complex that is responsible for generating H3K27me3. Read More

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November 2020

Network analysis of targets showing the potential oncogenic role of in colorectal cancer.

Cancer Cell Int 2020 7;20:439. Epub 2020 Sep 7.

Department of Biochemistry and Molecular Biology, Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo University School of Medicine, Ningbo, 315211 Zhejiang China.

Background: is a member of the Kruppel-like factor, subfamily of zinc finger proteins that are involved in cancers. functions as a transcription factor and regulates the diverse protein-coding genes (PCGs) in colorectal cancer (CRC). However, the long non-coding RNAs (lncRNAs) regulated by in CRC are currently unknown. Read More

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September 2020

Non-classical behavior of the default mode network regions during an information processing task.

Brain Struct Funct 2020 Nov 16;225(8):2553-2562. Epub 2020 Sep 16.

InBrain, Department of Physics, FFCLRP, University of São Paulo, Ribeirão Preto, Brazil.

The default mode network (DMN) efficient deactivation and suppressed functional connectivity (FC) during goal-directed tasks, which require attentional resources, have been considered essential to healthy brain cognition. However, recent studies have shown that DMN regions do not always show the expected behavior. Then, we aimed to investigate the functional activation and connectivity of DMN nodes in young, healthy controls during a goal-directed task. Read More

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November 2020

Influence of Alternative Restoration Technique with Different Composite Resins for Flared Root Reinforcement.

J Adhes Dent 2020 ;22(4):353-363

Purpose: To evaluate the influence of type and viscosity of composite resins used for root reinforcement in the adhesion of glass-fiber posts to flared root canals.

Materials And Methods: The crowns of 78 uniradicular permanent teeth were removed and the teeth were endodontically treated. After one week, the roots were prepared for root reinforcement and randomly divided into 6 groups (n = 13): positive control group ([PCG] the root canals were not enlarged), negative control group ([NCG] root canals were enlarged, no reinforcement), and in the remaining 4 groups, root canals were enlarged to receive root reinforcement according to a combination of the factors composite resin type (bulk-fill or conventional) and viscosity (flowable or regular). Read More

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Identifying a supramodal language network in human brain with individual fingerprint.

Neuroimage 2020 10 2;220:117131. Epub 2020 Jul 2.

State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University & IDG/McGovern Institute for Brain Research, Beijing, 100875, China. Electronic address:

Where is human language processed in the brain independent of its form? We addressed this issue by analyzing the cortical responses to spoken, written and signed sentences at the level of individual subjects. By applying a novel fingerprinting method based on the distributed pattern of brain activity, we identified a left-lateralized network composed by the superior temporal gyrus/sulcus (STG/STS), inferior frontal gyrus (IFG), precentral gyrus/sulcus (PCG/PCS), and supplementary motor area (SMA). In these regions, the local distributed activity pattern induced by any of the three language modalities can predict the activity pattern induced by the other two modalities, and such cross-modal prediction is individual-specific. Read More

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October 2020

Identification of distinct loci for de novo DNA methylation by DNMT3A and DNMT3B during mammalian development.

Nat Commun 2020 06 24;11(1):3199. Epub 2020 Jun 24.

Division of Stem Cell Pathology, Center for Experimental Medicine and Systems Biology, Institute of Medical Science, University of Tokyo, Tokyo, 108-8639, Japan.

De novo establishment of DNA methylation is accomplished by DNMT3A and DNMT3B. Here, we analyze de novo DNA methylation in mouse embryonic fibroblasts (2i-MEFs) derived from DNA-hypomethylated 2i/L ES cells with genetic ablation of Dnmt3a or Dnmt3b. We identify 355 and 333 uniquely unmethylated genes in Dnmt3a and Dnmt3b knockout (KO) 2i-MEFs, respectively. Read More

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The domesticated transposase ALP2 mediates formation of a novel Polycomb protein complex by direct interaction with MSI1, a core subunit of Polycomb Repressive Complex 2 (PRC2).

PLoS Genet 2020 05 28;16(5):e1008681. Epub 2020 May 28.

Institute of Molecular Plant Science, School of Biological Sciences, University of Edinburgh, Daniel Rutherford Building, Max Born Crescent, Edinburgh, United Kingdom.

A large fraction of plant genomes is composed of transposable elements (TE), which provide a potential source of novel genes through "domestication"-the process whereby the proteins encoded by TE diverge in sequence, lose their ability to catalyse transposition and instead acquire novel functions for their hosts. In Arabidopsis, ANTAGONIST OF LIKE HETEROCHROMATIN PROTEIN 1 (ALP1) arose by domestication of the nuclease component of Harbinger class TE and acquired a new function as a component of POLYCOMB REPRESSIVE COMPLEX 2 (PRC2), a histone H3K27me3 methyltransferase involved in regulation of host genes and in some cases TE. It was not clear how ALP1 associated with PRC2, nor what the functional consequence was. Read More

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