77,556 results match your criteria regional cancer

Food antigens exacerbate intestinal damage and inflammation following the disruption of the mucosal barrier.

Int Immunopharmacol 2021 May 10;96:107670. Epub 2021 May 10.

Biological Therapy Institute, Guangdong Provincial Key Laboratory of Regional Immunity and Diseases, Department of Immunology, Health Science Center, Shenzhen University, Shenzhen 518055, China. Electronic address:

Food antigens are closely related to progression of inflammatory bowel disease; however, details of how they induce intestinal immune responses and causes intestinal inflammation is not yet clear. The present study aimed to examine the effects of oral collagen on the intestinal mucosa, and elucidate the mechanism of food antigen-induced enteritis. Here, we provide evidence that Aspirin (a mucosal-damaging agent) and type II collagen (CII; a food antigen) acted synergistically to disrupt the intestinal mucosal barrier, and increase intestinal permeability, which resulted in a large amount of CII entered into the lamina propria, where it interacted with the intestinal immune system, promoted intestinal inflammation, and shaped innate and adaptive immune reactions into Th1-dominant. Read More

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Breast cancer patients treated with intrathecal therapy for leptomeningeal metastases in a large real-life database.

ESMO Open 2021 May 10;6(3):100150. Epub 2021 May 10.

Department of Medical Oncology, Institut Curie, Saint-Cloud and Paris, France. Electronic address:

Background: Leptomeningeal metastasis (LM) is a rare complication of metastatic breast cancer (MBC), with high morbidity/mortality rates. Our study aimed to describe the largest-to-date real-life population of MBC patients treated with intrathecal (IT) therapy and to evaluate prognostic models.

Methods: The Epidemiological Strategy and Medical Economics (ESME) MBC database (NCT03275311) includes all consecutive patients who have initiated treatment for MBC since 2008. Read More

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Extent of Paranasal Sinus Involvement and its Prognostic Value in Nasopharyngeal Carcinoma: Proposed Modification in the Current UICC/AJCC staging system.

Radiother Oncol 2021 May 10. Epub 2021 May 10.

Department of Medical Imaging, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine. Electronic address:

Purpose: This study aimed to evaluate the prognostic value of paranasal sinus involvement (PSI) in NPC and to explore its appropriate position in the current AJCC staging system.

Materials And Methods: Pretreatment MRI of 1317 patients with NPC treated with intensity-modulated radiotherapy (IMRT) between January 2010, and January 2013, were reviewed retrospectively. Survival was compared between patients with PSI-slight (sinus bone wall erosion only) and PSI-severe (tumor penetrated into sinus cavity). Read More

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An integrated multicomponent care model for men affected by prostate cancer: A feasibility study of TrueNTH Australia.

Psychooncology 2021 May 13. Epub 2021 May 13.

Queensland University of Technology, Cancer and Palliative Care Outcomes Centre, Kelvin Grove, QLD, Australia.

Objective: To evaluate the feasibility of implementing an integrated multicomponent survivorship care model for men affected by prostate cancer.

Methods: Using a single arm prospective cohort study design, men with prostate cancer were recruited from two regional public hospitals in Australia for a 6-month program that provided information and decision support, exercise and nutrition management, specialised clinical support, and practical support through localised and central care coordination. Carers of the men were also invited to the program. Read More

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Autoimmune Hemolytic Anemia in a 24-Year-Old Patient With COVID-19 Complicated by Secondary Cryptococcemia and Acute Necrotizing Encephalitis: A Case Report and Review of Literature.

J Med Cases 2020 Nov 23;11(11):362-365. Epub 2020 Sep 23.

Windsor Regional Hospital, Windsor, ON, Canada.

Since the initial reported outbreak of coronavirus disease 2019 (COVID-19), many unique case reports have been published in the medical literature. Here we report a complicated clinical course of a young patient with COVID-19 who presented initially with recurrent autoimmune hemolytic anemia (AIHA). He subsequently developed bilateral pulmonary emboli, and ultimately succumbed to encephalitis and cryptococcemia in the context of being treated with high dose immunosuppression for the AIHA. Read More

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November 2020

Trend Analysis of Cutaneous Squamous Cell Carcinoma of the External Lip From 1975 to 2016.

JAMA Otolaryngol Head Neck Surg 2021 May 13. Epub 2021 May 13.

Department of Otolaryngology-Head and Neck Surgery, Louisiana State University-Health Shreveport, Shreveport.

Importance: Cutaneous squamous cell carcinoma (cSCC) is the second most common nonmelanoma skin cancer and commonly affects the head and neck. Increasing regional reports of aggressive cases warrant an analysis of population-based trends of cSCC of the head and neck.

Objective: To assess demographic, clinical, and survival trends among patients with cSCC of the external lip. Read More

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The role of comprehensive analysis with circulating tumor DNA in advanced non-small cell lung cancer patients considered for osimertinib treatment.

Cancer Med 2021 May 12. Epub 2021 May 12.

Education and Research Center for Community Medicine, Faculty of Medicine, Saga University, Saga, Japan.

Background: EGFR mutations are good predictive markers of efficacy of EGFR tyrosine kinase inhibitors (EGFR-TKI), but whether comprehensive genomic analysis beyond EGFR itself with circulating tumor DNA (ctDNA) adds further predictive or prognostic value has not been clarified.

Methods: Patients with NSCLC who progressed after treatment with EGFR-TKI, and with EGFR T790 M detected by an approved companion diagnostic test (cobas ), were treated with osimertinib. Plasma samples were collected before and after treatment. Read More

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Autoimmune regulation of chronic pain.

Pain Rep 2021 9;6(1):e905. Epub 2021 Mar 9.

Laboratories of Neuroimmunology, Department of Symptom Research, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Chronic pain is an unpleasant and debilitating condition that is often poorly managed by existing therapeutics. Reciprocal interactions between the nervous system and the immune system have been recognized as playing an essential role in the initiation and maintenance of pain. In this review, we discuss how neuroimmune signaling can contribute to peripheral and central sensitization and promote chronic pain through various autoimmune mechanisms. Read More

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Barriers and facilitators to the adoption of artificial intelligence in radiation oncology: A New Zealand study.

Tech Innov Patient Support Radiat Oncol 2021 Jun 21;18:16-21. Epub 2021 Apr 21.

Waikato Hospital, Regional Cancer Centre Selwyn Street Level 1 Lomas Street Hamilton, Waikato 3240 New Zealand.

Introduction: Advances in computing capabilities and automated data collection have led to an increase in the use of Artificial Intelligence (AI) in radiation therapy. This has implications to workflow and workforce planning in radiation oncology departments. A survey was conducted in New Zealand to determine the likelihood of departments adopting AI into their practice. Read More

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The timing and design of stereotactic radiotherapy approaches as a part of neoadjuvant therapy in pancreatic cancer: Is it time for change?

Clin Transl Radiat Oncol 2021 May 19;28:124-128. Epub 2021 Apr 19.

Department of Radiation Oncology, University of Nebraska Medical Center, Omaha, NE, USA.

Stereotactic Radiotherapy (SRT) over 5-15 days can be interdigitated without delaying chemotherapy. Bridging chemotherapy may allow for extended intervals to surgery, potentially improving sterilization of surgical margins and overall survival. SRT for pancreatic adenocarcinoma should not be limited to the tumor, and should consider hypofractionated approaches to regional nodes. Read More

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Performance of 18F-DCFPyL PET/CT Imaging in Early Detection of Biochemically Recurrent Prostate Cancer: A Systematic Review and Meta-Analysis.

Front Oncol 2021 26;11:649171. Epub 2021 Apr 26.

Department of Urology, The First Affiliated Hospital of Soochow University, Suzhou, China.

Prostate-specific membrane antigen (PSMA)-targeted 2-(3-{1-carboxy-5-[(6-[18F] fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid (18F-DCFPyL) positron emission tomography/computed tomography (PET/CT) has shown advantages in primary staging, restaging, and metastasis detection of prostate cancer (PCa). However, little is known about the role of 18F-DCFPyL PET/CT in biochemically recurrent prostate cancer (BRPCa). Hence, we performed a systematic review and meta-analysis to evaluate 18F-DCFPyL PET/CT as first-line imaging modality in early detection of BRPCa. Read More

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A comprehensive retrospective cohort study of the journey of B-cell lymphoma in Taiwan.

Sci Rep 2021 May 12;11(1):10069. Epub 2021 May 12.

Global Epidemiology, Janssen Research & Development, 2 Science Park Drive, Singapore, 118222, Singapore.

Complete disease journey and risk factors for poor outcomes are needed to facilitate effectiveness evaluations of new therapies and clinical decision-making in B-cell Non-Hodgkin lymphoma (B-NHL), particularly in Asia where such data are lacking. This retrospective cohort study used electronic medical records from a regional medical centre in southern Taiwan to follow-up 441 patients newly diagnosed with common B-NHL subtypes: Diffuse Large B-cell Lymphoma (DLBCL), Follicular Lymphoma (FL), Chronic Lymphocytic Leukaemia/Small Lymphocytic Lymphoma (CLL/SLL), Marginal Zone Lymphoma (MZL), Mantle Cell Lymphoma (MCL), and Waldenström macroglobulinemia (WM), between 01-Jan-2008 and 31-Dec-2013, until 31-Dec-2017. Treatment pathways were modelled using a Markov approach. Read More

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Estimated National and State Level Incidence of Childhood and Adolescent Cancer in India.

Indian Pediatr 2021 May;58(5):417-423

Global Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, USA.

Background: Hitherto, incidence burden of childhood cancer in India has been derived from GLOBOCAN data. Recent analyses have challenged whether this accurately measures the true incidence of childhood cancer.

Objective: To use observed data rather than simulation to estimate the number of children (0-14 years), as well as number of children and adolescents (0-19 years), in India who develop cancer every year at the national and state/union territory (UT) level. Read More

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Right extraperitoneal approach for laparoscopic paracaval bulky lymph node dissection for endometrial cancer.

Int J Gynecol Cancer 2021 May 12. Epub 2021 May 12.

Gynecologic Oncology, N.N. Blokhin National Medical Research Center of Oncology оf the Ministry of Health of the Russian Federation, Moscow, Russian Federation.

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Children with medical complexity and paediatric palliative care: a retrospective cross-sectional survey of prevalence and needs.

Ital J Pediatr 2021 May 12;47(1):110. Epub 2021 May 12.

Bioethics Unit, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.

Background: Children with medical complexity (CMC) have been defined (Cohen et al., Pediatrics 127: 529-538, 2011.) as an emerging population potentially eligible for PPC. Read More

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Relationship between long non-coding RNA PCAT-1 expression and gefitinib resistance in non-small-cell lung cancer cells.

Respir Res 2021 May 12;22(1):146. Epub 2021 May 12.

Department of Thoracic Surgery, The Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Yunnan Cancer Center, No. 519 Kunzhou Road, Kunming, 650118, Yunnan, China.

Background: Gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, has been used as first-line treatment for advanced non-small-cell lung cancer (NSCLC). However, during treatment, cancer cells often develop resistance to gefitinib, the mechanisms of which are not fully understood. This study was designed to elucidate the expression and role of long non-coding RNA (lncRNA)-PCAT-1, a potential biomarker for drug resistance and a therapeutic target for NSCLC, in gefitinib resistance in NSCLC cells. Read More

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Social mobility and healthy behaviours from a gender perspective in the Spanish multicase-control study (MCC-Spain).

PLoS One 2021 12;16(5):e0251447. Epub 2021 May 12.

Cancer and Public Health Area, Foundation for the Promotion of the Research in Healthcare and Biomedicine (FISABIO-Salud Pública), Valencia, Valencian Community, Spain.

There is evidence for the influence of socioeconomic status (SES) on healthy behaviours but the effect of social mobility (SM) is not yet well known. This study aims to analyse the influence of origin and destination SES (O-SES and D-SES) and SM on healthy behaviours and co-occurrence, from an integrated gender and age perspective. Data were obtained from the controls of MCC-Spain between 2008-2013 (3,606 participants). Read More

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Decreasing trends in thyroid cancer incidence in South Korea: What happened in South Korea?

Cancer Med 2021 May 12. Epub 2021 May 12.

Division of Cancer Registration and Surveillance, National Cancer Control Institute, National Cancer Center, Goyang, South Korea.

Background: South Korea has the highest incidence of thyroid cancer in the world. Our study examined the trends in thyroid cancer incidence by the histologic type, cancer stage, and age group and explored possible factors that affected thyroid cancer trends.

Methods: We conducted a descriptive epidemiological study using the national cancer registry data and cause of death data from 1999 to 2016 in South Korea. Read More

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Toxicological and anti-tumor effects of a linden extract ( Scop.) in a HPV16-transgenic mouse model.

Food Funct 2021 May;12(9):4005-4014

Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), Inov4Agro, University of Trás-os-Montes and Alto Douro (UTAD), Vila Real, Portugal.

Tilia platyphyllos Scop. is a popular broad-leaved tree, native to Central and Southern Europe. Hydroethanolic extracts rich in phenolic compounds obtained from T. Read More

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[Genomic Medicine Sweden - a national initiative for the broad introduction of precision medicine in Swedish healthcare].

Lakartidningen 2021 May 11;118. Epub 2021 May 11.

professor, överläkare, Karolinska institutet och Karolinska universitetssjukhuset.

The Genomic Medicine Sweden (GMS) initiative aims to strengthen precision medicine across the country. This will be accomplished through the implementation of large-scale sequencing techniques in Swedish healthcare. With a patient-centered view, initial efforts will focus on rare diseases, cancer, pharmacogenomics, and infectious diseases, and subsequently extend to complex diseases. Read More

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Anal squamous cell carcinoma: a retrospective case series.

Ir J Med Sci 2021 May 11. Epub 2021 May 11.

Department of Radiation Oncology, St Luke's Radiation Oncology Network, Dublin, Ireland.

Background: Anal cancer is a relatively rare cancer with 660 cases diagnosed in 2000-2015 in Ireland (1). The current standard treatment is radical chemoradiotherapy (CRT). The aim of our study was to review the treatment and outcomes of patients with localised anal squamous cell carcinoma (SCC), who received radical treatment in our radiation oncology network between 2008 and 2014 inclusive. Read More

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Time-Varying mHAP-III Is the Most Accurate Predictor of Survival in Patients with Hepatocellular Carcinoma Undergoing Transarterial Chemoembolization.

Liver Cancer 2021 Apr 17;10(2):126-136. Epub 2021 Mar 17.

Internal Medicine and Hepatology Unit, Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.

Introduction: The prognosis of patients undergoing transarterial chemoembolization (TACE) is extremely variable, and a confounding factor is that TACE is often repeated several times. We retrospectively evaluated the accuracy of different prognostic scores and staging systems in estimating overall survival (OS) in patients with hepatocellular carcinoma (HCC).

Methods: An analysis considering prognostic models as time-varying variables was performed, calculating OS from the time of TACE to the time of the subsequent treatment. Read More

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Contemporary analysis of epididymal tumors using a national database.

Cent European J Urol 2021 19;74(1):39-43. Epub 2021 Feb 19.

Division of Urology, Department of Surgery, Saint Louis University, St. Louis, MO, United States.

Introduction: Epididymal tumors are rare malignancies with sparse research available to guide recommendations. We sought to characterize malignant epididymal tumors in the United States using population level data.

Material And Methods: The Surveillance, Epidemiology, and End-Results database was queried for patients diagnosed with malignant epididymal tumors between 1975-2016. Read More

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February 2021

Prognosis of duodenal gangliocytic paraganglioma with lymph node metastasis: is follow-up >5 years required?

J Surg Case Rep 2021 May 4;2021(5):rjab159. Epub 2021 May 4.

Department of Anesthesiology, Robert Packer Hospital, Sayre, PA, USA.

Gangliocytic paragangliomas (GP) are rare tumors encountered exclusively in the second portion of the duodenum. Duodenal gangliocytic paraganglioma (DGP) belongs to a subclass of neuroendocrine neoplasms, characterized with unique histologic features of carcinoid tumor, paraganglioma and ganglioneuromas. According to the recent World Health Organization classification of gastrointestinal neuroendocrine tumors (NETs), there is a debate to classify them either as low-grade NETs or as an independent entity. Read More

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IDH2 mutations in patients with normal karyotype AML predict favorable responses to daunorubicin, cytarabine and cladribine regimen.

Sci Rep 2021 May 11;11(1):10017. Epub 2021 May 11.

Department of Cancer Prevention, School of Public Health, Silesian Medical University, Katowice, Poland.

Mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2) genes occur in about 20% patients with acute myeloid leukemia (AML), leading to DNA hypermethylation and epigenetic deregulation. We assessed the prognostic significance of IDH1/2 mutations (IDH1/2) in 398 AML patients with normal karyotype (NK-AML), treated with daunorubicine + cytarabine (DA), DA + cladribine (DAC), or DA + fludarabine. IDH2 mutation was an independent favorable prognostic factor for 4-year overall survival (OS) in total NK-AML population (p = 0. Read More

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[Upper Gastric Poorly Differentiated Adenocarcinoma with a Giant Ulcer That Regressed Due to the Malignant Cycle-A Case Report].

Gan To Kagaku Ryoho 2021 Apr;48(4):549-551

Dept. of Surgery, Chiba Tokushukai Hospital.

This case is that of an 84‒year‒old woman in whom upper gastrointestinal endoscopy revealed a giant ulcerative lesion with irregular margins on the upper curvature of the stomach. Abdominal contrast computed tomography(CT)showed marked thickening of the stomach wall in contact with the pancreatic body and enlargement of the regional lymph nodes, suggesting a tumor metastasis to the lymph nodes. At the patient's request, she was followed‒up without surgery, and 8 months later, upper gastrointestinal endoscopy revealed that the ulcerative lesion was scarred and covered with a non‒ tumor mucosa. Read More

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Correction to: A meaning-centered spiritual care training program for hospice palliative care teams in South Korea: development and preliminary evaluation.

BMC Palliat Care 2021 May 11;20(1):65. Epub 2021 May 11.

Department of Hematology and Oncology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Republic of Korea.

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Trends of cervical cancer at global, regional, and national level: data from the Global Burden of Disease study 2019.

BMC Public Health 2021 May 12;21(1):894. Epub 2021 May 12.

Huiqiao Medical Center, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.

Background: Cervical cancer is an important global health problem. In this study we aimed to analyze trends in cervical cancer at the global, regional, and national levels from 1990 to 2019, to inform health service decision-making.

Methods: Data on cervical cancer was extracted from the Global Burden of Disease study, 2019. Read More

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Cervical cancer in the Newly Independent States of the former Soviet Union: Incidence will remain high without action.

Cancer Epidemiol 2021 May 8;73:101944. Epub 2021 May 8.

Cancer Surveillance Branch, International Agency for Research on Cancer, Lyon, France.

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Determinants of Survival in Skull Base Osteosarcoma: A National Cancer Database Study.

World Neurosurg 2021 May 8. Epub 2021 May 8.

Department of Otolaryngology - Head and Neck Surgery, University of California, Irvine, Orange, CA, USA;; Department of Neurological Surgery, University of California, Irvine, Orange, CA, USA;. Electronic address:

Objective: Osteosarcomas of the skull base are rare and aggressive tumors that are most commonly treated with primary surgical resection and adjuvant chemoradiation. Using the National Cancer Database (NCDB), we analyzed demographic and clinical prognosticators for overall survival (OS).

Methods: The NCDB was queried for cases of histologically confirmed skull base osteosarcoma treated between 2004 and 2015, excluding patients receiving palliation or having less than 1 month of follow-up. Read More

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