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Side-ffects 15 Years after Lymph Node Irradiation in Breast Cancer: Randomized EORTC Trial 22922/10925.

J Natl Cancer Inst 2021 Jul 28. Epub 2021 Jul 28.

Department of Radiation Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands.

Background: Uncertainty about the benefit/risk ratio of regional lymph node irradiation led to varying clinical protocols. We investigated long-term late side effects after internal mammary and medial supraclavicular (IM-MS) lymph node irradiation to improve shared decision-making.

Methods: The multicentre EORTC trial (ClinicalTrials. Read More

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Topological Alterations in White Matter Structural Networks in Blepharospasm.

Mov Disord 2021 Jul 28. Epub 2021 Jul 28.

Department of Neurology, Guangdong Provincial Key Laboratory for Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Background: Accumulating evidence indicates regional structural changes in the white matter (WM) of brains in patients with blepharospasm (BSP); however, whether large-scale WM structural networks undergo widespread reorganization in these patients remains unclear.

Objective: We investigated topology changes and global and local features of large-scale WM structural networks in BSP patients compared with hemifacial spasm (HFS) patients or healthy controls (HCs).

Methods: This cross-sectional study applied graph theoretical analysis to assess deterministic diffusion tensor tractography findings in 41 BSP patients, 41 HFS patients, and 41 HCs. Read More

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Rates and trends in stage-specific prostate cancer incidence by age and race/ethnicity, 2000-2017.

Prostate 2021 Jul 28. Epub 2021 Jul 28.

Department of Medical Oncology, The Fourth Affiliated Hospital of China Medical University, Shenyang, China.

Background: The 2008 and 2012 United States Preventive Services Task Force (USPSTF) recommendations against prostate-specific antigen (PSA) screening have led to changes in the incidence pattern of prostate cancer. We sought to examine rates and trends in stage-specific prostate cancer incidence by age and race/ethnicity using the most recent data obtained from Surveillance, Epidemiology, and End Results (SEER) program.

Methods: SEER*Stat version 8. Read More

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Breast and Prostate Cancer Risks for Male BRCA1 and BRCA2 Pathogenic Variant Carriers Using Polygenic Risk Scores.

J Natl Cancer Inst 2021 Jul 28. Epub 2021 Jul 28.

Department of Molecular Medicine, University La Sapienza, Rome, Italy.

Background: Recent population-based female breast cancer and prostate cancer polygenic risk scores (PRS) have been developed. We assessed the associations of these PRS with breast and prostate cancer risks for male BRCA1 and BRCA2 pathogenic variant carriers.

Methods: 483 BRCA1 and 1,318 BRCA2 European ancestry male carriers were available from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). Read More

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Impact of scaling up prenatal nutrition interventions on human capital outcomes in low- and middle-income countries: a modeling analysis.

Am J Clin Nutr 2021 Jul 28. Epub 2021 Jul 28.

Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Background: Prenatal nutrition interventions can lead to improved birth outcomes, which in turn are associated with better education and human capital outcomes later in life.

Objective: We estimated the impact of scaling up iron-folic acid (IFA), calcium, multiple micronutrient (MMS), and balanced energy protein (BEP) supplementation for pregnant women, on human capital outcomes in low- and middle-income countries (LMIC).

Methods: We used mathematical modeling with proportional reductions in adverse birth outcomes to estimate the potential gains in school years and lifetime income due to scaling up each prenatal nutrition intervention. Read More

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Temporal Trend of Mortality Due to Ischemic Heart Diseases in Northeastern Brazil (1996-2016): An Analysis According to Gender and Age Group.

Arq Bras Cardiol 2021 Jul;117(1):51-60

Universidade Federal de Alagoas, Maceió, AL - Brasil.

Background: Ischemic heart disease (IHD) is the leading cause of death among cardiovascular diseases (CVD).

Objective: To describe the sociodemographic profile and analyze the trend in the mortality rate due to IHD, according to sex and by age group, in the states of the Northeast region of Brazil, from 1996 to 2016.

Methods: Ecological study involving IHD mortality in the northeastern states. Read More

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A drug comorbidity index to predict mortality in men with castration resistant prostate cancer.

PLoS One 2021 28;16(7):e0255239. Epub 2021 Jul 28.

Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.

Background: The Charlson Comorbidity Index is a poor predictor of mortality in men with castration resistant prostate cancer (CRPC). To improve this prediction, we created a comorbidity index based on filled prescriptions intended to be used in registry-based studies.

Materials And Methods: In a population-based cohort of men with CPRC a drug comorbidity index (DCI-CRPC) was calculated based on prescriptions filled during a 365-day period before the date of CRPC diagnosis to predict mortality. Read More

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Challenges of Estimating Accurate Prevalence of Arm Weakness Early After Stroke.

Neurorehabil Neural Repair 2021 Jul 28:15459683211028240. Epub 2021 Jul 28.

Department of Physical Therapy, 574564University of British Columbia, Vancouver, BC, Canada.

. Recent studies have reported lower statistics of upper limb (UL) weakness (48-57%) compared to widely cited values collected over 2 decades ago (70-80%). . Read More

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Pneumococcal nasopharyngeal carriage and antimicrobial susceptibility profile in children under five in southern Ethiopia.

F1000Res 2020 16;9:1466. Epub 2020 Dec 16.

School of Medicine, Hawassa University, Hawassa, Sidama National Regional State, 1560, Ethiopia.

: causes high morbidity and mortality, particularly in children under five. Nasopharyngeal (NP) carriage predisposes individuals to pneumococcal infection and horizontal spread within the community. Overuse of antibiotics has been linked to increased risk of antimicrobial resistance to . Read More

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December 2020

Physical rehabilitation versus no physical rehabilitation after total hip and knee arthroplasties: Protocol for a pragmatic, randomized, controlled, superiority trial (The DRAW1 trial).

F1000Res 2021 25;10:146. Epub 2021 Feb 25.

Physical Medicine and Rehabilitation Research - Copenhagen (PMR-C), Copenhagen University Hospital - Amager and Hvidovre, Copenhagen, Denmark.

Following total hip- and knee arthroplasty (THA and TKA), post-discharge physical rehabilitation is common practice, but varies significantly regarding content, duration, intensity and mode of delivery. Recent systematic reviews have found home-based rehabilitation to be as good as outpatient rehabilitation in terms of pain and physical function. We therefore wonder if physical rehabilitation "works" at all when compared to no physical rehabilitation after THA and TKA - "no rehabilitation" defined as no prescribed therapeutic rehabilitation exercises. Read More

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February 2021

Virtual Herbarium ALTB: collection of vascular plants of the Altai Mountain Country.

Biodivers Data J 2021 13;9:e67616. Epub 2021 Jul 13.

Altai State University, Barnaul, Russia Altai State University Barnaul Russia.

Background: The herbarium of the South-Siberian Botanical Garden of Altai State University (ALTB) houses the largest collection of plants from the Altai Mountain Country (AMC), an area that extends across Russia, Kazakhstan, Mongolia and China. The collection of ALTB includes more than 450,00 specimens, making it the seventh largest in Russia and the fourth largest amongst Russian university herbaria. Altai State University (ASU), the home of ALTB, is one of the most important centres of academic education and research in Siberia and the Russian Far East. Read More

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Prevalence Rates of Congenital Coronary Anomalies and Coronary Variations in Adult Indian Population Using Dual-Source Computed Tomography Coronary Angiography: Analysis of Regional Distribution of Coronary Anomalies and the Need for Standardized Reporting Formats.

Indian J Radiol Imaging 2021 Jan 1;31(1):138-149. Epub 2021 Jun 1.

Department of Cardiovascular Radiology and Endovascular Interventions, All India Institute of Medical Sciences, New Delhi, India.

 Congenital coronary artery anomalies (CCAA) are predominantly discovered as incidental findings on computed tomography coronary angiography (CTCA) of adults. They are rare but significant, considering their importance during endovascular or surgical interventions. This study describes the prevalence of CCAA and coronary variants (CV) in adults as identified by CTCA. Read More

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January 2021

Sputum colour as a marker for bacteria in acute exacerbations of COPD: protocol for a systematic review and meta-analysis.

Syst Rev 2021 Jul 27;10(1):211. Epub 2021 Jul 27.

Division of Pulmonology, Department of Medicine, University of Cape Town, Cape Town, South Africa.

Background: Chronic obstructive pulmonary disease (COPD) is a major cause of years of life lost globally. Acute exacerbations of COPD (AECOPD) drive disease progression, reduce quality of life and are a source of mortality in COPD. Approximately 50% of AECOPD are due to bacterial infections. Read More

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Genome of the pincer wasp Gonatopus flavifemur reveals unique venom evolution and a dual adaptation to parasitism and predation.

BMC Biol 2021 Jul 27;19(1):145. Epub 2021 Jul 27.

State Key Laboratory of Rice Biology and Ministry of Agricultural and Rural Affairs Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Zhejiang University, Hangzhou, China.

Background: Hymenoptera comprise extremely diverse insect species with extensive variation in their life histories. The Dryinidae, a family of solitary wasps of Hymenoptera, have evolved innovations that allow them to hunt using venom and a pair of chelae developed from the fore legs that can grasp prey. Dryinidae larvae are also parasitoids of Auchenorrhyncha, a group including common pests such as planthoppers and leafhoppers. Read More

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Trends in Use of Cardioprotective Medication in Peripheral Artery Disease: A Nationwide Study.

J Am Heart Assoc 2021 Jul 28:e020333. Epub 2021 Jul 28.

Department of Cardiology Bispebjerg-Frederiksberg University Hospital Copenhagen Denmark.

Background Guideline-based cardioprotective medical therapy is intended to reduce the burden of adverse cardiovascular and limb outcomes in patients with peripheral artery disease (PAD). However, contemporary data describing trends in use of medication remains limited. The present study, therefore, aims to investigate changes in use of cardioprotective medication in PAD. Read More

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HCV Positive Allograft Use in Heart Transplant is Associated With Increased Access to Overdose Donors and Reduced Waitlist Mortality Without Compromising Outcomes.

J Card Fail 2021 Jul 24. Epub 2021 Jul 24.

Division of Cardiovascular Surgery, Department of Surgery, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104. Electronic address:

Background: Despite ongoing donor shortages in heart transplant, donor candidates arising from drug overdose (OD) are increasingly prevalent. These donors carry a high preponderance of now curable Hepatitis C virus (HCV). This study investigates temporal trends and regional variability in HCV+ allograft use in heart transplant, assessing the relation of HCV+ graft use on OD donor usage as well as waitlist and post-transplant outcomes. Read More

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Overexpression of circRNA circFAT1 in Endometrial Cancer Cells Increases Their Stemness by Upregulating miR-21 Through Methylation.

Cancer Biother Radiopharm 2021 Jul 27. Epub 2021 Jul 27.

Department of Obstetrics and Gynecology, Regional Specialized Disease Center of Northern Zhejiang, Jiaxing Maternal and Child Health Hospital Affiliated to Jiaxing University, Jiaxing, P.R. China.

Circular (Circ)RNA circFAT1 play tumor-suppressive or oncogenic roles in different cancers. Microarray analysis observed altered expression of circFAT1 in endometrial cancer (EC) and its inverse correlation with miR-21. Expression of circFAT1 and miR-21 in EC and paired nontumor tissues collected from 62 EC patients was analyzed by quantitative reverse transcription PCR (RT-qPCR). Read More

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Nutritional Status Influences Oxidative Stress and Insulin Resistance in Preschool Children.

Metab Syndr Relat Disord 2021 Jul 27. Epub 2021 Jul 27.

Servicio de Medicina Física y Rehabilitación, Hospital General de Zona No. 197, Texcoco, Mexico.

Child malnutrition represents a major public health problem with physiological, psychological, and social short- and long-term implications. To compare the influence of nutritional status on oxidative stress (OS) markers in children aged 3-6 years. Children were categorized into four groups: underweight, normal weight, overweight, and obesity. Read More

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A new bottom-up method for the standard analysis and comparison of workforce capacity in mental healthcare planning: Demonstration study in the Australian Capital Territory.

PLoS One 2021 27;16(7):e0255350. Epub 2021 Jul 27.

Centre for Mental Health Research, Australian National University, Canberra, Australian Capital Territory, Australia.

The aims of this study are to evaluate and describe mental health workforce and capacity, and to describe the relationship between workforce capacity and patterns of care in local areas. We conducted a comparative demonstration study of the applicability of an internationally validated standardised service classification instrument-the Description and Evaluation of Services and Directories-DESDE-LTC) using the emerging mental health ecosystems research (MHESR) approach. Using DESDE-LTC as the framework, and drawing from international occupation classifications, the workforce was classified according to characteristics including the type of care provided and professional background. Read More

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Evaluation of the relationship between pentraxin 3 (PTX3) rs2305619 (281A/G) and rs1840680 (1449A/G) polymorphisms and the clinical course of COVID-19.

J Med Virol 2021 Jul 27. Epub 2021 Jul 27.

Department of Pulmonary Diseases, Ataturk University School of Medicine, 25240, Yakutiye, Erzurum, Turkey.

Background: Macrophage activation syndrome (MAS) is one of the main causes of morbidity and mortality in patients with COVID-19. This study aimed to investigate the relationship between the pentraxin 3 (PTX3) gene polymorphisms rs2305619 (281A/G) and rs1840680 (1449A/G) and the development of MAS in COVID-19 patients.

Materials And Methods: The study included a total of 94 patients aged 18-45 who diagnosed as having COVID-19 between June and December 2020. Read More

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Healthier Minds in Fitter Bodies: A Systematic Review and Meta-Analysis of the Association between Physical Fitness and Mental Health in Youth.

Sports Med 2021 Jul 27. Epub 2021 Jul 27.

PROFITH 'PROmoting FITness and Health Through Physical Activity' Research Group, Sport and Health University Research Institute (iMUDS), Department of Physical Education and Sports, Faculty of Sport Sciences, University of Granada, Granada, Spain.

Background: Physical fitness is an important marker of current and future health status, yet the association between physical fitness and indicators of mental health in youth has not been systematically reviewed and meta-analyzed.

Objective: The aim of this work was to systematically review and meta-analyze the association between physical fitness components (i.e. Read More

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Hyperpolarized Xe MRI and Spectroscopy of Gas-Exchange Abnormalities in Nonspecific Interstitial Pneumonia.

Radiology 2021 Jul 27:204149. Epub 2021 Jul 27.

From the Department of Radiology (D.G.M., J.K., B.D., J.G.M.), Center for In Vivo Microscopy (D.G.M., B.D.), Department of Biomedical Engineering (E.A.B., Z.W., B.D.), Department of Medicine (L.M., C.B., H.P.M., R.T.), and Department of Medical Physics (B.D.), Duke University, DUMC Box 3302, Durham, NC 27710.

Background Recent studies demonstrate that antifibrotic drugs previously reserved for idiopathic pulmonary fibrosis (IPF) may slow progression in other interstitial lung diseases (ILDs), creating an urgent need for tools that can sensitively assess disease activity, progression, and therapy response across ILDs. Hyperpolarized xenon 129 (Xe) MRI and spectroscopy have provided noninvasive measurements of regional gas-exchange abnormalities in IPF. Purpose To assess gas exchange function using Xe MRI in a group of study participants with nonspecific interstitial pneumonia (NSIP) compared with healthy control participants. Read More

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Cerebellar and Brainstem Displacement Measured with DENSE MRI in Chiari Malformation Following Posterior Fossa Decompression Surgery.

Radiology 2021 Jul 27:203036. Epub 2021 Jul 27.

From the Conquer Chiari Research Center, Departments of Biomedical Engineering (M.S.E., B.S.T.N., F.L.) and Psychology (P.A.A.), University of Akron, 264 Wolf Ledges Pkwy, #211B, Akron, OH 44325; Laboratory of FMRI Technology (LOFT), USC Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, Calif (S.H.P.); Mercer University School of Medicine, Savannah, Ga (J.W.B.); Departments of Neurosurgery (D.L.B.), Radiology (J.N.O.), and Imaging Sciences and Biomedical Engineering (J.N.O.), Emory University, Atlanta, Ga; and Department of Mechanical and Industrial Engineering, Department of Bioengineering, Northeastern University, Boston, Mass (R.A.).

Background Posterior fossa decompression (PFD) surgery is a treatment for Chiari malformation type I (CMI). The goals of surgery are to reduce cerebellar tonsillar crowding and restore posterior cerebral spinal fluid flow, but regional tissue biomechanics may also change. MRI-based displacement encoding with stimulated echoes (DENSE) can be used to assess neural tissue displacement. Read More

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Equitable migrant-friendly perinatal healthcare access and quality in public maternity units in Portugal.

Eur J Public Health 2021 Jul 27. Epub 2021 Jul 27.

EPIUnit-Instituto de Saúde Pública da Universidade do Porto (ISPUP), Porto, Portugal.

Background: Migrant women are at higher risk to face access barriers to perinatal care services and to experience worse pregnancy outcomes compared to native. Assessing the perception of migrant women and health providers discloses a multifaceted view on migrant-friendly care, a multidimensional concept in itself. This study aims to compare self-perceived assessments of migrant women and directors of obstetrics and gynaecology (GYN/OBS) departments on equitable migrant-friendly perinatal healthcare quality and access during the intrapartum and postpartum period at public maternities in Portugal. Read More

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Duration on ART, Alcohol Use and HIV Stage May Predict Risky Sexual Behavior in a Resource-Limited Environment: A Cross-Sectional Study.

Curr HIV Res 2021 Jul 25. Epub 2021 Jul 25.

Department of Epidemiology, College of Public Health, University of Nebraska Medical Center, Omaha, Nebraska, United States.

Background: The intention of antiretroviral therapy (ART) and regular clinic visits is to engender safe sex attitudes among HIV-infected individuals. However, this may not be the case due to the perceived therapeutic benefits of ART and may result in exposure to drug-resistant HIV strains.

Objective: We aimed to determine the prevalence and predict the factors associated with risky sexual behaviors among ART users in a resource-limited environment. Read More

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Molecular characterization of Malaysian fowl adenovirus (FAdV) serotype 8b species E and pathogenicity of the virus in specific-pathogen-free chicken.

J Vet Sci 2021 Jul;22(4):e42

Laboratory of Vaccine and Immunotherapeutics, Institute of Bioscience, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia.

Background: Inclusion body hepatitis (IBH) is an economically important viral disease primarily affecting broiler and breeder chickens. All 12 serotypes of fowl adenovirus (FAdV) can cause IBH.

Objectives: To characterize FAdV isolates based on phylogenetic analysis, and to study the pathogenicity of FAdV-8b in specific-pathogen-free (SPF) chickens following virus inoculation via oral and intramuscular (IM) routes. Read More

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The Prevalence of Depression, Anxiety and Associated Factors among the General Public during COVID-19 Pandemic: a Cross-sectional Study in Korea.

J Korean Med Sci 2021 Jul 26;36(29):e214. Epub 2021 Jul 26.

Department of Psychiatry, Dong-A University Hospital, Busan, Korea.

Background: Since its first case confirmed on January 20, 2020, Korea has been through three waves of the COVID-19 pandemic. Fears of the fourth wave persist as new cases continue to emerge. In such unpredictable times, the mental well-being of people is of crucial importance. Read More

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Cannabinoids, their cellular receptors, and effects on the invasive phenotype of carcinoma and metastasis.

Cancer Rep (Hoboken) 2021 Jul 26:e1475. Epub 2021 Jul 26.

School of Pharmacy, University of Waterloo, Waterloo, Ontario, Canada.

Background: The morbidity and mortality of cancer are significantly impacted by the invasive and metastatic potential of particular subgroups of malignant cells within a tumor. The particular pre-metastatic properties of cancerous cells are thus a critical target for novel therapeutics in the oncology field. Cannabinoid molecules have been investigated in recent years in the context of invasion and metastasis of various malignancies, with varying effects reported in the literature. Read More

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General health condition of patients hospitalized after an incident of in-hospital or out-of hospital sudden cardiac arrest with return of spontaneous circulation.

Clin Cardiol 2021 Jul 27. Epub 2021 Jul 27.

Department of Histology, Cytophysiology, and Embryology, Faculty of Medicine in Zabrze, The University of Technology in Katowice, Katowice, Poland.

Background: Sudden cardiac arrest (SCA) is one of the main reasons for admission to the intensive care unit (ICU), which influences discharge in a good neurological state.

Hypothesis: To analyze patients who had recovery of spontaneous circulation (ROSC) during hospitalization in the ICU using the Glasgow Outcome Scale (GOS).

Methods: The study group comprised 78 patients after SCA (35 after out-of-hospital cardiac arrest [OHCA] and 43 after in-hospital cardiac arrest [IHCA]) with ROSC who were admitted to the ICU of Regional Hospital No. Read More

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High-parameter cytometry unmasks microglial cell spatio-temporal response kinetics in severe neuroinflammatory disease.

J Neuroinflammation 2021 Jul 26;18(1):166. Epub 2021 Jul 26.

Discipline of Pathology, Faculty of Medicine and Health, School of Medical Sciences, The University of Sydney, Sydney, Australia.

Background: Differentiating infiltrating myeloid cells from resident microglia in neuroinflammatory disease is challenging, because bone marrow-derived inflammatory monocytes infiltrating the inflamed brain adopt a 'microglia-like' phenotype. This precludes the accurate identification of either cell type without genetic manipulation, which is important to understand their temporal contribution to disease and inform effective intervention in its pathogenesis. During West Nile virus (WNV) encephalitis, widespread neuronal infection drives substantial CNS infiltration of inflammatory monocytes, causing severe immunopathology and/or death, but the role of microglia in this remains unclear. Read More

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