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The Burden of Reoperations and Timeline of Problems in 1,530 Cases of Mesh-Related Complications.

Urol Int 2021 Apr 22:1-8. Epub 2021 Apr 22.

Division of Pelvic Medicine and Reconstructive Surgery, University of California Los Angeles-UCLA, São Paulo, Brazil.

Background: Mesh-related complications resulting from pelvic organ prolapse (POP) reconstruction operations may be a devastating experience leading to multiple and complex interventions.

Objectives: The aim of the study was to describe the experience and time frame of management of mesh-related complications in women treated for POP or stress urinary incontinence in a tertiary center.

Methods: 1,530 cases of mesh-related complications were accessed regarding their clinical presentation, number of surgeries, and timeline of surgical treatments to treat multiple clinical complaints until the ultimate operation where all the meshes were removed in a single tertiary center. Read More

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Fast track clinic for early diagnosis of polymyalgia rheumatica: Impact on symptom duration and prednisolone initiation.

Joint Bone Spine 2021 Apr 19:105185. Epub 2021 Apr 19.

Department of Rheumatology, Diagnostic Centre, Silkeborg Regional Hospital, Denmark. Electronic address:

Objectives: To evaluate the efficacy of a fast track clinic (FTC) for patients suspected of polymyalgia rheumatica (PMR) regarding symptom duration, prednisolone initiation before rheumatological assessment, number of hospital contacts before diagnosis, and cancer diagnosis.

Methods: It is a retrospective cohort study with a one year follow-up period. Patients referred to the FTC (1 August 2016 to 25 June 2019) were compared to a historical cohort of PMR patients (1 August 2014 to 1 August 2016). Read More

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Assessment of main complications of regional anesthesia recorded in an acute pain unit in a tertiary care university hospital: a retrospective cohort.

Braz J Anesthesiol 2021 Apr 19. Epub 2021 Apr 19.

Hospital Universitário São João, Departamento de Anestesiologia, Porto, Portugal.

Background: Regional anesthesia has been increasingly used. Despite its low number of complications, they are associated with relevant morbidity. This study aims to evaluate the incidence of complications after neuraxial block and peripheral nerve block. Read More

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Expert consensus on endoscopic papillectomy using a Delphi process.

Gastrointest Endosc 2021 Apr 19. Epub 2021 Apr 19.

Department of Gastroenterology and Hepatology, Amsterdam University Medical Center, Amsterdam Gastroenterology Endocrinology & Metabolism, Amsterdam, the Netherlands. Electronic address:

Background And Aims: Consensus regarding an optimal algorithm for endoscopic treatment of papillary adenomas has not been established. We aimed to assess the existing degree of consensus among international experts and develop further concordance by means of a Delphi process.

Methods: A total of 52 international experts in the field of endoscopic papillectomy were invited to participate. Read More

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Conceptual and operational definition of the components of the nursing diagnosis hypothermia (00006) in the perioperative period.

Rev Bras Enferm 2021 16;74(2):e20190684. Epub 2021 Apr 16.

Universidade Estadual de Campinas. Campinas, São Paulo, Brazil.

Objective: to construct the conceptual and operational definitions of the defining and conceptual characteristics of the related factors of the nursing diagnosis (ND) hypothermia (00006) of NANDA-I, 2015-2017, in adult patients in the perioperative period.

Method: an integrative literature review in the Medical Literature Analysis and Retrieval System Online, Cochrane Library, The Cumulative Index to Nursing and Allied Health Literature and in Latin & American Literature in Health Sciences databases.

Results: 2,041 articles were found, 95 selected for reading in full and 24 used to construct such definitions. Read More

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Impact of the COVID-19 lockdown on screen media use in patients referred for ADHD to child and adolescent psychiatry: an introduction to problematic use of the internet in ADHD and results of a survey.

J Neural Transm (Vienna) 2021 Apr 22. Epub 2021 Apr 22.

Department of Child and Adolescent Psychiatry and Psychotherapy, Centre for Child and Adolescent Psychiatric Research, Neuropsychology, University Hospital of Psychiatry Zurich, University of Zurich, Eisengasse 16, 8008, Zurich, Switzerland.

The COVID-19 outbreak and lockdown have been associated with multiple consequences for mental health, including an excessive and potentially harmful increase in screen media use. The specific consequences for children, adolescents and young adults with ADHD are still unknown. In the first part of this study, a short review of problematic use of the internet (PUI) in ADHD is presented, showing that patients with ADHD are at risk for different aspects of PUI, such as excessive gaming or problematic social media use. Read More

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Recall, perceptions and determinants of receiving physical activity advice amongst cancer survivors: a mixed-methods survey.

Support Care Cancer 2021 Apr 22. Epub 2021 Apr 22.

Department of Sport, Health & Exercise Science, University of Hull, Cottingham Road, Hull, HU6 7RX, UK.

Purpose: This study explored cancer survivors' views and experiences of receiving physical activity advice post-diagnosis. We also determined the influence of sociodemographic characteristics on the recall of physical activity advice and whether receiving advice was associated with meeting physical activity guidelines.

Methods: An anonymised, mixed-methods, 27-item survey was distributed to cancer survivors via online cancer communities in the UK. Read More

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'Hot gall bladder service' by emergency general surgeons: Is this safe and feasible?

J Minim Access Surg 2021 Apr 16. Epub 2021 Apr 16.

Department of General Surgery, William Harvey Hospital, Ashford, Kent, UK.

Background: Despite NICE/AUGIS recommendations, the practice of early laparoscopic cholecystectomy (ELC) has been particularly poor in the UK offered only by 11%-20% surgeons as compared to 33%-67% internationally, possibly due to financial constraints, logistical difficulties and shortage of expertise, thus, reflecting the varied provision of emergency general surgical care. To assess whether emergency general surgeons (EGS) could provide a 'Hot Gall Bladder Service' (HGS) with an acceptable outcome.

Patients And Methods: This was a prospective HGS observational study that was protocol driven with strict inclusion/exclusion criteria and secure online data collection in a district general hospital between July 2018 and June 2019. Read More

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Medicolegal evaluation of the erectile function of patients referred from the Forensic Medicine Authority of the Ministry of Justice in Upper Egypt.

Int J Clin Pract 2021 Apr 22:e14252. Epub 2021 Apr 22.

Dermatology, Venereology and Andrology Department, Faculty of Medicine, Sohag University, Egypt.

In Upper Egypt, the Forensic Medicine Authority of the Ministry of Justice transfers patients with marital conflicts or accusation of rape a for proper sexual function evaluation, which helps in making its decisions according to the law. Therefore, our study aims to evaluate the pattern of 40 cases referred for sexual function evaluation, their clinical, laboratory, imaging characteristics and finally the decisions of these cases. The study included 40 patients who referred from the forensic medicine authority for erectile function evaluation. Read More

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Oral health-related quality of life of patients with oral chronic graft-versus-host disease.

Support Care Cancer 2021 Apr 21. Epub 2021 Apr 21.

Department of Oral Medicine, Academic Centre for Dentistry (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, Gustav Mahlerlaan 3004, 1081, LA, Amsterdam, The Netherlands.

Purpose: Symptoms of oral chronic graft-versus-host-disease (cGVHD) may significantly affect the oral health-related quality of life (OHRQoL). This study aimed to assess the OHRQoL in patients with oral cGVHD and to examine whether oral cGVHD symptoms, mucosal cGVHD, and salivary gland function correlated with OHRQoL.

Methods: Patients referred to the oral cGVHD outpatient clinic were included. Read More

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RFC1 AAGGG repeat expansion masquerading as Chronic Idiopathic Axonal Polyneuropathy.

J Neurol 2021 Apr 21. Epub 2021 Apr 21.

Department of Neurosciences, Biomedicine, and Movement Sciences, University of Verona, Policlinico G.B. Rossi, Piazzale L.A. Scuro 10, 37134, Verona, VR, Italy.

Background: A biallelic intronic AAGGG repeat expansion in the Replication Factor C subunit 1 (RFC1) gene has been recently associated with Cerebellar Ataxia, Neuropathy, Vestibular Areflexia Syndrome, a disorder often presenting as a slowly evolving sensory neuropathy at the onset. "Chronic Idiopathic Axonal Polyneuropathy" (CIAP) is a common indolent axonal neuropathy of adulthood which remains without an identifiable cause despite thorough investigations.

Methods: We screened 234 probands diagnosed with CIAP for a pathogenic biallelic RFC1 AAGGG repeat expansion. Read More

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The syndrome of transient epileptic amnesia: a combined series of 115 cases and literature review.

Brain Commun 2021 13;3(2):fcab038. Epub 2021 Mar 13.

Cognitive & Behavioural Neurology, University of Exeter Medical School, College House, St Luke's Campus, Exeter EX1 2LU, UK.

The term transient epileptic amnesia was coined in 1990 to describe a form of epilepsy causing predominantly amnestic seizures which could be confused with episodes of Transient Global Amnesia. Subsequent descriptions have highlighted its association with 'atypical' forms of memory disturbance including accelerated long-term forgetting, disproportionate autobiographical amnesia and topographical amnesia. However, this highly treatment-responsive condition remains under-recognized and undertreated. Read More

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Afr J Infect Dis 2020 31;14(2):48-52. Epub 2020 Jul 31.

Ophthalmologist, Orbital Oncology Division, Department of Ophthalmology, Faculty of Medicine, Universitas Airlangga/Dr. Soetomo General Academic Hospital, Surabaya, Indonesia.

Background: Orbital cellulitis in immunocompetent patients with pulmonary tuberculosis (TB) is rare or unheard of. If left untreated, patients might lose their sight and potentially their life. This case describes orbital cellulitis due to extended spectrum β-lactamases (ESBLs)-producing bacteria in a patient with pulmonary tuberculosis. Read More

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Limited Adherence to Growth Hormone Replacement in Patients with Traumatic Brain Injury.

J Rehabil Med Clin Commun 2018 16;3:1000008. Epub 2018 Nov 16.

Division of Endocrinology, Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Canada.

Background: Growth hormone deficiency is a recognized consequence of traumatic brain injury. The aim of this study was to determine adherence to human growth hormone therapy among patients with traumatic brain injury compared with patients with hypothalamic or pituitary disease.

Methods: A retrospective chart review of patients with traumatic brain injury referred for growth hormone stimulation testing since December 2013. Read More

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November 2018

Retrospective Review of Complications of Liver Hydatid Cyst Surgery with Emphasis on Outcomes of Omentoplasty.

Iran J Parasitol 2020 Oct-Dec;15(4):488-494

Advanced Diagnostic and Interventional Radiology (ADIR) Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Background: The outcome and complications of liver hydatid cyst surgeries with new and old techniques are not well determined. We intended to present the results of operations done for patients with hepatic hydatid cyst in an endemic area.

Methods: Data of 112 patients referred and operated for liver hydatid cyst, in Imam Khomeini Hospital complex, Tehran, Iran, from 2015 to 2018, were collected including demographic characteristics, operation parameters and complication related statistics. Read More

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Serum Levels of Il-12 and Il-23 in Breast Cancer Patients Infected with : A Case-Control Study.

Iran J Parasitol 2020 Oct-Dec;15(4):466-474

Department of Biology, College of Sciences, University of Baghdad, Baghdad, Iraq.

Background: The possible risk factor of infection and its possible correlation with Interleukin-12 (IL-12) and Interleukin-23 (IL-23) in breast cancer patients was investigated.

Methods: Overall, 190 female patients referred to the Oncology Teaching Hospital in the Medical City Hospital, Baghdad, Iraq were enrolled from 2017-2018. All serum samples were tested for immunoglobulins (IgG and IgM (antibodies and IL-12, IL-23 levels. Read More

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Promising Response to Lenalidomide-Combination Therapy in a Discordant Lymphoma Consisting of EBV-Positive Diffuse Large B-Cell Lymphoma and Angioimmunoblastic T-Cell Lymphoma: A Case Report.

Onco Targets Ther 2021 12;14:2489-2495. Epub 2021 Apr 12.

Department of Oncology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, 226001, People's Republic of China.

Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma (DLBCL) complicated with angioimmunoblastic T-cell lymphoma (AITL) is extremely rare and typically shows an aggressive clinical course and unsatisfactory prognosis. Here, we describe the case of a 77-year-old man who was referred to the hospital because of repeated fever, night sweats, and weight loss. He was finally diagnosed with a discordant lymphoma consisting of AITL and DLBCL, with significantly different maximum standardized uptake values on positron emission tomography/computed tomography. Read More

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Chest radiography patterns of COVID-19 pneumonia in Kumasi, Ghana.

Ghana Med J 2020 Dec;54(4):264-268

Obstetrics and Gynaecology Directorate - Komfo Anokye Teaching Hospital, Kumasi, Ghana.

Objectives: To document the pattern of chest radiographic findings in coronavirus disease 2019 (COVID-19) patients with moderate to severe disease.

Design: Retrospective cross-sectional study.

Setting: The study site was Komfo Anokye Teaching Hospital (KATH) located at Bantama in Kumasi, the capital town of the Ashanti Region. Read More

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December 2020

Chest CT features of patients under investigation for Covid-19 pneumonia in a Ghanaian tertiary hospital: a descriptive study.

Ghana Med J 2020 Dec;54(4):253-263

Korle Bu Teaching Hospital, Accra. Ghana.

Background: Coronavirus disease 2019 (COVID-19) has since December 2019 become a problem of global concern. Due to the virus' novelty and high infectivity, early diagnosis is key to curtailing spread. The knowledge and identification of chest Computerized Tomography (CT) features in Patients Under Investigation (PUI) for the disease would help in its management and containment. Read More

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December 2020

Novel tier 2 service model for complex NHS endodontics.

Br Dent J 2021 Apr 21. Epub 2021 Apr 21.

Dental Director and Consultant in Restorative Dentistry, Swansea Bay University Health Board, Morriston Hospital, Swansea, SA6 6NL, UK.

Aim The use of tier 2 practitioners has been suggested as an intermediate tier in the NHS workforce completing cases of moderate difficulty previously referred to secondary care. Provision of such services varies depending on speciality and local commissioning priorities. This service evaluation investigated reasons for and outcomes of endodontic referrals to an NHS tier 2 service in Powys, Wales. Read More

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Conventional landmark palpation versus preprocedural ultrasound for neuraxial procedures in nonobstetric patients: A systematic review with meta-analysis and trial sequential analysis of randomised controlled trials.

Eur J Anaesthesiol 2021 Apr 20. Epub 2021 Apr 20.

From the Department of Anaesthesia, Guy's and St Thomas' NHS Foundation Trust, London, UK (DO, GN, BY, ND) and King's College London (DO, ND).

Background: Central neuraxial modalities can occasionally be challenging to perform, particularly if the underlying anatomy is altered or obscured.

Objectives: To compare the efficacy, efficiency and the safety of preprocedural ultrasound to landmark palpation in the nonobstetric adult population.

Design: Systematic review of randomised controlled trials with meta-analysis and trial sequential analysis. Read More

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Idiopathic granulomatous mastitis: challenges of treatment in iranian women.

BMC Surg 2021 Apr 21;21(1):206. Epub 2021 Apr 21.

Department of Surgery, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

Background And Objective: As a chronic inflammatory disease of an unknown origin, the treatment of granulomatous mastitis has always been controversial. According to some researchers, surgical treatment and certain medications, especially steroids, are more effective in treating the disease. This study aimed at evaluating the results of treatment in a group of patients with granulomatous mastitis. Read More

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Effect of analgesia with pethidine during labour on false positivity of newborn hearing screening test.

J Matern Fetal Neonatal Med 2021 Apr 21:1-6. Epub 2021 Apr 21.

Department of Obstetrics and Gynecology, Kanuni Sultan Suleyman Research and Training Hospital, Istanbul Health Sciences University, Istanbul, Turkey.

Objectives: Newborn hearing screening may fail due to some perinatal and neonatal factors. False positivity of newborn hearing screening increases costs, familial concerns and anxiety. The objective of this study was to determine the effects of pethidine administered in the mother for labor analgesia on the false positivity rates of the newborn hearing screening test. Read More

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Challenges for asthma units in response to COVID-19: a qualitative group dynamics analysis.

J Asthma 2021 Apr 21:1-13. Epub 2021 Apr 21.

Centro de Investigación Biomédica en Red (CIBER) Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain.

To develop a set of recommendations for the management of severe asthma during COVID-19 pandemic. Eleven pneumologists and allergologists who were staff members of officially accredited asthma units in Catalonia (Spain) participated in a cross-section study based on three 2-hour virtual workshops (first: brainstorming, second: identification of impacts and challenges summarized in 10 topics, third: establishment of final recommendations by consensus).: Impacts and challenges identified were improvement of referral protocols between different levels of care; assessment of the minimum number of function tests to be performed and promote the performance of spirometry in primary care; implementation of videoconferencing, mobile apps, telephone calls, or integral virtual platforms for the follow-up of patients, and definition of the model of care (face-to-face, telematics, mixed) according to the patient's individual needs; self-administration of biologics for domiciliary treatment; and empowerment of the role of nursing and hospital pharmacy in particular for follow-up and self-administration of biologics. Read More

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Economic Burden of Colorectal Cancer: A Case of Fars, Iran.

Cancer Control 2021 Jan-Dec;28:10732748211009952

Health Human Resources Research Center, School of Management and Medical Information Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.

Among cancers, colorectal cancer is the third most common cancer in the world and the fourth leading cause of cancer deaths worldwide. Some studies have shown that the incidence of colorectal cancer is increasing in Iran and in Fars province. The present study aimed to determine the economic burden of colorectal cancer in patients referred to the referral centers affiliated to Iran, Shiraz University of Medical Sciences in 2019 from the patients' perspective. Read More

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Targeting Trained Innate Immunity With Nanobiologics to Treat Cardiovascular Disease.

Arterioscler Thromb Vasc Biol 2021 Apr 22:ATVBAHA120315448. Epub 2021 Apr 22.

Biomedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York (A.J.P.T., M.M.T.v.L., G.P., E.E.S.B., C.P.-M., R.D., Z.A.F., W.J.M.M.).

The innate immune system plays a key role in atherosclerosis progression and the pathogenesis of cardiovascular disease. Trained immunity, an epigenetically regulated hyperresponsive state of myeloid cells, is a driving force underlying chronic inflammation in atherosclerosis. Therapeutically targeting innate trained immunity therefore may mature into a compelling new paradigm for the effective treatment of cardiovascular patients, which would require effective engagement of myeloid cells. Read More

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Surgical and percutaneous management of aboriginal Australians with rheumatic heart disease: Timeliness and concordance between practice and guidelines.

Int J Cardiol 2021 Apr 18. Epub 2021 Apr 18.

Aboriginal Health Equity Theme, South Australian Health and Medical Research Institute, Adelaide, Australia; Adelaide Medical School, The University of Adelaide, Adelaide, Australia.

Background: Rheumatic heart disease (RHD) affects over 40 million people globally who are predominantly young and from impoverished communities. The barriers to valvular intervention are complex and contribute to the high morbidity and mortality associated with RHD. The rates of guideline indicated intervention in patients with significant RHD have not yet been reported. Read More

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The incidence and relevance of Non-Fatty components in trunk and extremity lipomatous soft tissue masses.

Br J Radiol 2021 Apr 21:20201403. Epub 2021 Apr 21.

Department of Radiology, Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, Middlesex HA7 4LP, UK.

Objectives: To determine the incidence and diagnostic relevance of non-fatty 'solid appearing' components within lipomatous tumours of the trunk and extremity.

Methods And Materials: Retrospective review of patients referred to a specialist musculoskeletal oncology service over a 12 month period with a lipomatous trunk or extremity soft tissue tumour. The presence and morphology (solitary/multifocal; homogeneous/heterogeneous; well-defined/poorly-defined) of non-fatty components was recorded based on MRI, and compared with the final histological diagnosis. Read More

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Changes in corneal thickness after vitrectomy-Implications for glaucoma practice.

PLoS One 2021 21;16(4):e0249945. Epub 2021 Apr 21.

Glaucoma Services, LV Prasad Eye Institute, Bhubaneswar, India.

Purpose: To evaluate changes in central corneal thickness (CCT) following vitrectomy.

Methods: All consecutive old and new patients referred to glaucoma services for possible secondary glaucoma after vitrectomy and who had undergone corneal pachymetry between July 2013 to June 2020, were included. The eye that developed elevated intraocular pressure (IOP) and was diagnosed clinically as glaucoma after vitrectomy, was labelled as the "affected" eye. Read More

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