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Molecular mechanisms and signaling pathways of reactive astrocytes responding to traumatic brain injury.

Histol Histopathol 2021 Apr 13:18338. Epub 2021 Apr 13.

Department of Anatomy, Histology and Embryology, School of Basic Medical Sciences, Fudan University, Shanghai, China.

Traumatic brain injury (TBI) is one of the most common causes of death and disability worldwide. Astrocytes are the largest cell types in the central nervous system (CNS) with numerous functions both physiologically and pathologically. In response to TBI, astrocytes go through a series of alterations referred to as reactive astrogliosis. Read More

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Effectiveness and Safety of Thermal Ablation in the Treatment of Primary Hyperparathyroidism: A Multicenter Study.

J Clin Endocrinol Metab 2021 Apr 13. Epub 2021 Apr 13.

Department of Interventional Medicine, China-Japan Friendship Hospital, No. 2 Ying-hua-yuan East Street, Chao-yang district, Beijing, China.

Purpose: To evaluate the effectiveness and safety of thermal ablation for primary hyperparathyroidism (pHPT).

Materials And Methods: From January 2015 to March 2020, data pertaining to patients who received thermal ablation for pHPT at 4 centers were retrospectively analyzed. The median follow-up duration was 18. Read More

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Serum free testosterone level in coronary artery disease in candidates for coronary artery bypass graft surgery: A cross-sectional study.

Int J Reprod Biomed 2021 Mar 21;19(3):293-302. Epub 2021 Mar 21.

Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Background: Due to the controversy over the effect of serum testosterone levels on coronary artery diseases, this survey explores the serum levels of free testosterone, luteinizing hormone, and follicle-stimulating hormone in candidates for coronary artery bypass graft compared with an age-matched control group and evaluates the associated factors in these participants.

Objective: To determine the testosterone level in elective coronary artery bypass grafting participants.

Materials And Methods: In this cross-sectional study, all male patients aged 40 yr as candidates for elective coronary artery bypass grafting, who were referred to the Afshar Hospital, Yazd, Iran, from March 2018 to March 2019, were included. Read More

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[Clinical and phenomenological features of the formation of gender reassignment ideas in schizophrenia spectrum disorders].

Zh Nevrol Psikhiatr Im S S Korsakova 2021 ;121(3):18-23

Serbsky National Medical Research Center for Psychiatry and Narcology, Moscow, Russia.

Objective: To study the features of the formation of gender reassignment`s ideas in schizophrenia spectrum disorders and to differentiate diagnosis of these psychopathological formations with transsexualism.

Material And Methods: The study was carried out in the Department of Sexology and Therapy of Sexual Dysfunctions of the Moscow Research Institute of Psychiatry - a branch of the Serbsky National Medical Research Center for Psychiatry and Narcology in the period from October 2018 to May 2020. The study included 100 outpatients referred for gender reassignment. Read More

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Case Report: Abdominal Lymph Node Metastases of Parathyroid Carcinoma: Diagnostic Workup, Molecular Diagnosis, and Clinical Management.

Front Endocrinol (Lausanne) 2021 23;12:643328. Epub 2021 Mar 23.

Department of Internal Medicine I, Division of Endocrinology and Diabetes, University Hospital, University of Würzburg, Würzburg, Germany.

Parathyroid carcinoma (PC) is an orphan malignancy accounting for only ~1% of all cases with primary hyperparathyroidism. The localization of recurrent PC is of critical importance and can be exceedingly difficult to diagnose and sometimes futile when common sites of recurrence in the neck and chest cannot be confirmed. Here, we present the diagnostic workup, molecular analysis and multimodal therapy of a 46-year old woman with the extraordinary manifestation of abdominal lymph node metastases 12 years after primary diagnosis of PC. Read More

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[Immunoglobulin G4( IgG4)-related Fibrosing Mediastinitis Localized in the Retrosternal Area:Report of a Case].

Kyobu Geka 2021 Apr;74(4):317-320

Department of Thoracic Surgery, Kanazawa Medical Center, Kanazawa, Japan.

An 84-year-old man was referred to our out-patient clinic with an elongated mass localized to the retrosternal area that was incidentally identified by computed tomography. On 18F-fluorodeoxyglucose-positron emission tomography, this lesion showed intense tracer uptake. Thus, a surgical biopsy under thoracoscopy was performed. Read More

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[Ectopic Adrenocorticotropic Hormone-Producing Pulmonary Carcinoid Presenting as Cushing's Syndrome after Intrapleural Hyperthermic Chemotherapy].

Kyobu Geka 2021 Mar;74(3):197-201

Department of Surgery, Okinawa National Hospital, Ginowan, Japan.

The patient was a woman in her 70's was referred to our hospital because of an abnormal shadow on chest roentgenogram at an annual medical checkup. Since preoperative examinations suggested lung cancer in the right middle lobe, thoracoscopic right middle lobectomy was planned. However, pleural dissemination was detected at surgery and we changed the treatment plan to the intrapleural hyperthermic chemotherapy. Read More

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Clinical and genetic characteristics of hypophosphatasia in Chinese children.

Orphanet J Rare Dis 2021 Apr 7;16(1):159. Epub 2021 Apr 7.

Department of Endocrinology, Genetics and Metabolism, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.

Background: Hypophosphatasia (HPP) is a rare inherited disorder, which is caused by loss-of-function mutations in the ALPL gene. HPP is a heterogeneous disease that has a wide spectrum of phenotypes. Few studies were carried out in the Chinese population with HPP, especially in children. Read More

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Long-term outcomes of prostate radiotherapy for newly-diagnosed metastatic prostate cancer.

Prostate Cancer Prostatic Dis 2021 Apr 5. Epub 2021 Apr 5.

Radiation Medicine Program, The Ottawa Hospital Cancer Centre, Ottawa, ON, Canada.

Background: In patients presenting with metastatic prostate cancer, the role of local therapy is evolving. Two recently reported large-scale randomized trials suggest that radiotherapy (RT) directed at the prostate improves overall survival (OS) in patients with low metastatic burden. We reviewed the experience of prostate RT in this setting at our center. Read More

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Vaginal bleeding in a misdiagnosed Mayer-Rokitansky-Küster-Hauser syndrome.

BMJ Case Rep 2021 Apr 5;14(4). Epub 2021 Apr 5.

Department of Pediatric Endocrine, Parc Tauli Foundation-UAB University Institute, Sabadell, Catalunya, Spain

The Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome, a spectrum of anomalies arising from incomplete development of the Müllerian ducts, is characterised by congenital aplasia of the uterus and upper part of the vagina, often in the absence of other phenotypical abnormalities. We report the case of a 13-year-old girl referred to our endocrinology unit after an incidental finding of uterine agenesis during laparoscopy to correct suspected ovarian torsion. Initial transabdominal ultrasonography found no uterus. Read More

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Subclinical Hypothyroidism Affects Postoperative Outcome of Patients Undergoing Total Knee Arthroplasty.

Orthop Surg 2021 Apr 4. Epub 2021 Apr 4.

Department of Orthopedic, China-Japan Friendship Hospital, China-Japan Friendship Hospital, Peking Union Medica College, Chinese Academy of Medical College, No.2 Yin Hua East Street, Beijing, 100029, China.

Objective: The aim of this study was to investigate whether subclinical hypothyroidism could increase the risk of postoperative complications in patients undergoing primary total knee arthroplasty (TKA).

Methods: A prospective case-control study of 796 patients undergoing primary TKA between January 2015 and January 2020 was performed. A total of 700 patients (87. Read More

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A Pediatric Parathyroid Carcinoma: An Unusual Clinical Presentation and Mini-review.

Int J Endocrinol Metab 2021 Jan 25;19(1):e110234. Epub 2021 Jan 25.

Endocrinology and Metabolism Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

Introduction: Primary hyperparathyroidism (PHPT) is a rare condition in the pediatric population. Parathyroid carcinoma (PC) is a very uncommon cause of PHPT, accounting for < 1% of pediatric PHPT cases. It is challenging to distinguish between parathyroid adenoma (PA), the most common cause of PHPT, and PC. Read More

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January 2021

Integrating geriatric screening in the clinical setting: Recommendations for older adult oncology patients.

J Geriatr Oncol 2021 Apr 1. Epub 2021 Apr 1.

Senior Adult Oncology Moffitt Medical Group, H. Lee Moffitt Cancer Center, Tampa, FL, United States.

Purpose: The optimal time to assess older adults during cancer treatment regimen has not been established. This research study evaluated different points in time to reassess the geriatric oncology patient undergoing treatment.

Methods: This study included 250 patients who were new to the Senior Adult Oncology Clinic. Read More

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Is it safe to start steroids at home for a COPD exacerbation after virtual assessment in the COVID-19 era?

Cleve Clin J Med 2021 04 1;88(4):213-215. Epub 2021 Apr 1.

Chairman, Education Institute; Staff, Department of Critical Care Medicine, Respiratory Institute, Cleveland Clinic, Cleveland, OH; Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH.

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The role of the microbiome in ovarian cancer: mechanistic insights into oncobiosis and to bacterial metabolite signaling.

Mol Med 2021 04 1;27(1):33. Epub 2021 Apr 1.

Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, Debrecen, 4032, Hungary.

Ovarian cancer is characterized by dysbiosis, referred to as oncobiosis in neoplastic diseases. In ovarian cancer, oncobiosis was identified in numerous compartments, including the tumor tissue itself, the upper and lower female genital tract, serum, peritoneum, and the intestines. Colonization was linked to Gram-negative bacteria with high inflammatory potential. Read More

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The ménage à trois of autophagy, lipid droplets and liver disease.

Autophagy 2021 Apr 2:1-24. Epub 2021 Apr 2.

Department of Cell Biology, University of Groningen, University Medical Center Groningen, AV Groningen, The Netherlands.

Autophagic pathways cross with lipid homeostasis and thus provide energy and essential building blocks that are indispensable for liver functions. Energy deficiencies are compensated by breaking down lipid droplets (LDs), intracellular organelles that store neutral lipids, in part by a selective type of autophagy, referred to as lipophagy. The process of lipophagy does not appear to be properly regulated in fatty liver diseases (FLDs), an important risk factor for the development of hepatocellular carcinomas (HCC). Read More

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Matrix composition modulates vitamin D3's effects on 3D collagen fiber organization by MCF10A cells.

Tissue Eng Part A 2021 Apr 1. Epub 2021 Apr 1.

Tufts University School of Medicine, 12261, Boston, Massachusetts, United States;

Vitamin D3 (vitD3) has been implicated in various cellular functions affecting multiple tissue types. Epidemiological and laboratory studies suggest that vitD3 may be effective as a preventive or therapeutic option for breast cancer. However, randomized clinical trials have yet to confirm these suggestions. Read More

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Endocrinological features of a patient with 14q microdeletion and Dubowitz phenotype.

Mol Genet Genomic Med 2021 Mar 31:e1644. Epub 2021 Mar 31.

Dipartimento Pediatrico Universitario Ospedaliero, IRCCS "Bambino Gesù" Children's Hospital, Rome, Italy.

Background: Dubowitz syndrome (DS) is a complex and rare condition characterized by postnatal growth retardation, microcephaly, short stature, mild developmental delay, facial dysmorphism, skin eruption and bone marrow failure. Though approximately 200 cases have been described so far, no specific genetic analysis, laboratory tests or radiological exams are available to confirm the diagnosis which is still based on clinical and facial features. Although short stature is a major feature of the syndrome, no endocrine alterations have been reported so far and scant data are available about the efficacy and safety of GH treatment in these patients. Read More

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Macro-TSH: A Diagnostic Challenge.

Eur Thyroid J 2021 Mar 21;10(1):93-97. Epub 2020 Aug 21.

Department of Endocrinology, Odense University Hospital, Odense, Denmark.

Introduction: Analytical problems should be considered in case of a discrepancy between the results of biochemical tests and the clinical findings. Macro-hormones often artefactually elevate biochemical tests.

Case Presentation: A young male was referred with persistently elevated TSH (148 mIU/L) measured by a sandwich electrochemiluminescence immunoassay, ECLIA (Cobas; Roche, Basel, Switzerland). Read More

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Physical, Mental and Sexual Health Among Transgender Women. A comparative Study Among Operated Transgender and Cisgender Women in a National Tertiary Referral Network.

J Sex Med 2021 Mar 23. Epub 2021 Mar 23.

Urology Clinic, Department of Medical, Surgical and Health Science, University of Trieste, Trieste, Italy.

Background: Few studies have investigated how physical, mental and sexual function are associated with each other in operated transgender women (oTW).

Aim: To provide information on the physical, mental and sexual health of oTW in comparison with a group of cisgender women (cisW).

Methods: An age-matched control study was carried out, recruiting 125 oTW in 7 national referral centers and 80 volunteer women. Read More

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Benefits of a Multidisciplinary Women's Sexual Health Clinic in the Management of Sexual and Menopausal Symptoms After Pelvic Radiotherapy.

Am J Clin Oncol 2021 Apr;44(4):143-149

Departments of Therapeutic Radiology.

Objective: The objective of this study was to examine patterns of care and outcomes of female cancer patients treated for sexual and menopausal symptoms following pelvic radiotherapy (PRT) at our institution's multidisciplinary Sexuality, Intimacy, and Menopause (SIMS) Program.

Materials And Methods: We performed a retrospective review of 69 female patients who received PRT for gynecologic or gastrointestinal malignancies and were referred for SIMS Program intervention. Indications for referral and treatment patterns were summarized. Read More

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Reporter gene assays for screening and identification of novel molting hormone- and juvenile hormone-like chemicals.

J Pestic Sci 2021 Feb;46(1):29-42

Department of Biological Science, Graduate School of Science, Osaka Prefecture University, 1-1 Gakuen-cho, Naka-ku, Sakai city, Osaka 599-8531, Japan.

A reporter gene assay (RGA) is used to investigate the activity of synthetic chemicals mimicking the molting hormones (MHs) and juvenile hormones (JHs) of insects, so-called insect growth regulators (IGRs). The MH receptor, a heterodimer of the ecdysone receptor (EcR) and ultraspiracle (USP), and the JH receptor Methoprene-tolerant (Met) are ligand-dependent transcription factors. Ligand-bound EcR-USP and Met bind to specific -acting DNA elements, referred to as the ecdysone-responsive element (EcRE) and the JH-responsive element (JHRE), respectively, in order to transactivate target genes. Read More

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February 2021

Treatment-related fertility impairment in long-term female childhood, adolescent and young adult cancer survivors: investigating dose-effect relationships in a European case-control study (PanCareLIFE).

Hum Reprod 2021 Mar 21. Epub 2021 Mar 21.

Department of Paediatrics, Emma Children's Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

Study Question: Which chemotherapeutic agents and body site-specific radiation fields are dose-dependently associated with an increased risk of fertility impairment in long-term female childhood, adolescent and young adulthood (CAYA) cancer survivors?

Summary Answer: Busulfan, lower abdominal radiotherapy (RT) and total body irradiation (TBI) seem to be associated with fertility impairment at any dose, whereas gonadotoxicity of melphalan and procarbazine is suggested at medium/high (>140 mg/m2) or high dose (>5600 mg/m2) therapy, respectively.

What Is Known Already: Several treatment-related fertility deficits, as assessed by both self-reported outcomes and hormonal markers are known to occur following treatment of CAYA cancer. However, knowledge regarding precise dose-related estimates of these treatment-related risks are scarce. Read More

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Evaluation of an electronic consultation service for transgender care.

BMC Fam Pract 2021 Mar 20;22(1):55. Epub 2021 Mar 20.

C.T. Lamont Primary Health Care Research Centre, Bruyère Research Institute, Ottawa, ON, Canada.

Background: Access to transgender care in Canada is poor. Although primary care providers are ideally positioned to initiate care, many feel uncomfortable providing transgender care. This study aimed to explore the impact of an electronic consultation (eConsult) service between primary care providers and transgender care specialists on access to care and to explore the content of clinical questions that were asked. Read More

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Laparoscopic resection of a non-communicating uterine rudimentary horn using intra-operative indigocarmine injection: A case report.

Int J Surg Case Rep 2021 Mar 12;81:105743. Epub 2021 Mar 12.

Department of Pediatric Surgery, Seirei General Hospital, Hamamatsu, Japan. Electronic address:

Introduction And Importance: An unicornuate uterus with a non-communicating rudimentary horn (UUNCRH) is a very rare uterine malformation which is difficult to diagnose and to decide the surgical plan. We aim to describe the case of pediatric UUNCRH patient and our operative technique of laparoscopic intra-uterus indigo carmine injection (LIUICI) to confirm that the rudimentary horn (RH) is non-communicating before the resection and review the relevant literature to ascertain the most appropriate treatment option in these patients.

Case Presentation: A 11-year-old girl who developed progressive severe abdominal pain and dysmenorrhea was referred to our hospital. Read More

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Stress Hormones as Predictors of Response to Cognitive Behavior Therapy in Panic Disorder.

Neuropsychobiology 2021 Mar 18:1-10. Epub 2021 Mar 18.

First Department of Psychiatry, School of Medicine, Eginition Hospital, National and Kapodistrian University of Athens, Athens, Greece.

Objective: Data regarding the potential association between the outcome of psychotherapy of panic disorder (PD) and biological parameters are few. In 21 (16 females) consecutively referred, medication-free, acutely ill PD outpatients, without comorbidities, except agoraphobia, we systematically explored for potential neuroendocrine and clinical correlates of response to a brief cognitive behavior therapy (CBT).

Methods: Cortisol and adrenocorticotropic hormone (ACTH) basal plasma levels were measured. Read More

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Cold-induced dishabituation in rodents exposed to recurrent hypoglycaemia.

Diabetologia 2021 Mar 17. Epub 2021 Mar 17.

Division of Systems Medicine, School of Medicine, University of Dundee, Dundee, UK.

Aims/hypothesis: Recurrent hypoglycaemia in people with diabetes leads to progressive suppression of counterregulatory hormonal responses to subsequent hypoglycaemia. Recently it has been proposed that the mechanism underpinning this is a form of adaptive memory referred to as habituation. To test this hypothesis, we use two different durations of cold exposure to examine whether rodents exposed to recurrent hypoglycaemia exhibit two characteristic features of habituation, namely stimulus generalisation and dishabituation. Read More

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Familial Dysalbuminemic Hyperthyroxinemia as a Cause for Discordant Thyroid Function Tests.

J Endocr Soc 2021 Apr 1;5(4):bvab012. Epub 2021 Feb 1.

Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, Australia.

Introduction: Discordant thyroid function tests are routinely encountered in clinical practice. Differential diagnoses include acute thyroxine (T4) ingestion, laboratory interference from heterophilic antibodies, thyroid hormone resistance, thyroid-stimulating hormone (TSH)-secreting pituitary adenomas, and T4 protein binding abnormalities. The impact of abnormal binding proteins may be less recognized since widespread use of free T4 (FT4) assays compared to older total T4 assays. Read More

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