648,137 results match your criteria reference standard

Doubling Recruitment of Pediatric Low-grade Glioma within Two Decades does not change Outcome - Report from the German LGG Studies.

Klin Padiatr 2021 May 10;233(3):107-122. Epub 2021 May 10.

Division of Childhood Cancer Epidemiology, Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Centre of the Johannes Gutenberg University Mainz, Mainz, Germany.

Background: Successive multicenter studies for pediatric low-grade glioma (LGG) in Germany were accompanied by a doubling of annual recruitment over 2 decades. We investigated whether this increase conveyed a change of epidemiologic characteristics or survival.

Methods And Results: Participating centers reported 4634 patients with the radiologic/histologic diagnosis of LGG (1996-2018), rising from 109 to 278/year. Read More

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Miniaturized scintillator dosimeter for small field radiation therapy.

Phys Med Biol 2021 May 10. Epub 2021 May 10.

Optics, Institut FEMTO - ST, Route de Gray, 25030 Besançon cedex, Besancon, FRANCE.

The concept of a miniaturized inorganic scintillator detector is demonstrated in the analysis of the small static photon fields used in external radiation therapy. Such a detector is constituted by a 0.25-millimeter diameter and 0. Read More

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DNA metabarcoding and morphological methods show complementary patterns in the metacommunity organization of lentic epiphytic diatoms.

Sci Total Environ 2021 Apr 30;786:147410. Epub 2021 Apr 30.

Ecology Unit, University of León, Campus de Vegazana S/N, 24071 León, Spain; Institute of Environment, Natural Resources and Biodiversity, La Serna, 58, 24007 León, Spain. Electronic address:

Diatoms are important organisms in freshwater ecosystems due to their position as primary producers and therefore, analyzing their assemblages provides relevant information on ecosystem functioning. Diatoms have historically been identified based on morphological traits, which is time-consuming and requires well-trained specialists. Nevertheless, DNA barcoding offers an alternative approach to overcome some limitations of the morphological method. Read More

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Pericoronary adipose tissue CT attenuation and volume: Diagnostic performance for hemodynamically significant stenosis in patients with suspected coronary artery disease.

Eur J Radiol 2021 Apr 28;140:109740. Epub 2021 Apr 28.

Department of Radiology, Xijing Hospital, Fourth Military Medical University, 127# West Changle Road, Xi'an 710032, Shaanxi Province, China. Electronic address:

Objectives: The aim of this study was to investigate the diagnostic abilities of both pericoronary adipose tissue (PCAT) CT attenuation and volume for the predication hemodynamic significance of coronary artery stenosis as evaluated by fractional flow reserve (FFR).

Methods: Patients with ≥ 30 % in at least 1 major epicardial coronary artery were retrospectively included. Furthermore, all eligible patients underwent coronary computed tomography angiography (CCTA) and invasive coronary angiography (ICA) as well as FFR within 1 month. Read More

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Application of lectin immobilized on polyHIPE monoliths for bioprocess monitoring of glycosylated proteins.

J Chromatogr B Analyt Technol Biomed Life Sci 2021 Apr 25;1174:122731. Epub 2021 Apr 25.

Faculty for Chemistry and Chemical Technology, University of Ljubljana, Večna pot 113, 1000 Ljubljana, Slovenia; COBIK, Tovarniška 26, 5270 Ajdovščina, Slovenia. Electronic address:

In-process monitoring of glycosylated protein concentration becomes very important with the introduction of perfusion bioprocesses. Affinity chromatography based on lectins allows selective monitoring when carbohydrates are accessible on the protein surface. In this work, we immobilized lectin on polyHIPE type of monoliths and implemented it for bioprocess monitoring. Read More

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The effect of microstructure on mechanical properties of corn cob.

Micron 2021 Apr 20;146:103070. Epub 2021 Apr 20.

Key Laboratory of Bionic Engineering, Ministry of Education, Jilin University, Changchun, 130025, China; College of Biological and Agricultural Engineering, Jilin University, Changchun, 130025, China.

As a natural biomass resource, corn cob has excellent mechanical properties and a special layered structure. To investigate the relationship between the mechanical properties and microstructure of corn cob, the ultra-deep field 3D microscope was used to characterize the macro geometric parameters, and the scanning electron microscopy (SEM) was observe the microstructure of the corn cob. The Fourier transform infrared spectrometer was used to analyze the fiber composition, revealing the contribution of fiber composition to the mechanical properties. Read More

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Sampling strategy for bacteriological diagnosis of intrathoracic tuberculosis.

Respir Med Res 2021 Apr 27;79:100825. Epub 2021 Apr 27.

Laboratoire de bactériologie-hygiène, centre national de référence des mycobactéries et de la résistance des mycobactéries aux antituberculeux, groupe hospitalier, Sorbonne Université, Site Pitié-Salpêtrière, AP-HP, Paris, France; Inserm U1135, Sorbonne université, centre d'immunologie et des maladies infectieuses (CIMI-Paris), Paris, France; Département de bactériologie, groupe hospitalier, Sorbonne université, site Saint-Antoine, AP-HP, Paris, France.

Background: Pulmonary tuberculosis (TB) is the most frequent site of TB and the one leading its spread worldwide. Multiple specimens are commonly collected for TB diagnosis including those requiring invasive procedures. This study aimed to review the sampling strategy for the microbiological diagnosis of pulmonary TB. Read More

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Dengue in pregnancy: Review article.

Eur J Obstet Gynecol Reprod Biol 2021 Apr 30;261:205-210. Epub 2021 Apr 30.

Sidra Medicine, Education City, Al Luqta Street, Doha, Qatar.

Dengue is the most common viral mosquito- borne disease. It is a major public health problem, especially in tropical and sub-tropical areas worldwide. According to the World Health Organization (WHO), approximately 40% of the world's population (over 2. Read More

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Histopathological features of systemic sclerosis-associated myopathy: A scoping review.

Autoimmun Rev 2021 May 7:102851. Epub 2021 May 7.

Division of Rheumatology, Centre hospitalier de l'Université de Montréal (CHUM), CHUM Research Center, Department of Medicine, Université de Montréal, Montréal, Québec, Canada. Electronic address:

Background: Scleromyositis (SM) is an emerging subset of myositis associated with features of systemic sclerosis (SSc) but it is currently not recognized as a distinct histopathological subset by the European NeuroMuscular Center (ENMC). Our aim was to review studies reporting muscle biopsies from SSc patients with myositis and to identify unique histopathological features of SM.

Methods: A scoping review was conducted and included all studies reporting histopathological findings in SSc patients with myositis searching the following databases: PubMed, MEDLINE, EMBASE, CINAHL and EBM-Reviews. Read More

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Longer Operative Time Associated with Prolonged Length of Stay, Non-Home Discharge and Transfusion Requirement after Anterior Cervical Discectomy and Fusion: an Analysis of 24,593 Cases.

Spine J 2021 May 7. Epub 2021 May 7.

Department of Orthopaedic Surgery, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH, USA; Center for Spine Health, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH, USA.

Background: Prolonged operative time of single-level ACDF has been associated with adverse postoperative outcomes. The current literature does not contain a comprehensive quantitative description of these associations PURPOSE: This study characterized the associations between single-level anterior cervical discectomy and fusion(ACDF) operative time and 1)30-day postoperative healthcare utilization, and 2)the incidence of local wound complications, need for transfusion and mechanical ventilation.

Design/setting: Retrospective database analysis PATIENT SAMPLE: The American College of Surgeons National Surgical Quality Improvement Program(ACS-NSQIP) database was queried for single-level ACDF cases(2012-2018) using current procedural terminology codes. Read More

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Sexual differences in bone porosity, osteocyte density, and extracellular matrix organization due to osteoblastic-specific Bmp2 deficiency in mice.

Bone 2021 May 7:116002. Epub 2021 May 7.

Department of Orthopaedic Surgery, Saint Louis University, St. Louis, MO, United States of America. Electronic address:

Clinical studies have come to conflicting conclusions regarding BMP2 deficiency's link to regulating bone mass and increasing fracture risk. This may be due to the signaling protein having sex- or age-dependent effects. Previous pre-clinical studies have supported a role, but have not adequately determined the physical mechanism causing altered bulk material properties. Read More

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Genome mutations of the Turkish strain Leishmania infantum_TR01.

Infect Genet Evol 2021 May 7:104907. Epub 2021 May 7.

Ankara University Faculty of Veterinary Medicine, Department of Parasitology, Ankara, Turkey.

Purpose: Today, almost 15 years have passed since the whole genome sequence (WGS) of a Leishmania parasite was completed for the first time. However, information on the genetics of these parasites remains to be elucidated. Genome-based studies may contribute to control strategies for leishmaniasis. Read More

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Paired SARS-CoV-2 spike protein mutations observed during ongoing SARS-CoV-2 viral transfer from humans to minks and Back to humans.

Infect Genet Evol 2021 May 7:104897. Epub 2021 May 7.

Flow Pharma, Inc., 4829 Galaxy Parkway, Suite K, Warrensville Heights, OH 44128, United States of America; Department of Anesthesiology and Perioperative Medicine, University Hospitals, Cleveland Medical Center, Case Western Reserve School of Medicine, 11100 Euclid Ave, Cleveland, OH 44106, United States of America; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, United States of America. Electronic address:

A mutation analysis of SARS-CoV-2 genomes collected around the world sorted by sequence, date, geographic location, and species has revealed a large number of variants from the initial reference sequence in Wuhan. This analysis also reveals that humans infected with SARS-CoV-2 have infected mink populations in the Netherlands, Denmark, United States, and Canada. In these animals, a small set of mutations in the spike protein receptor binding domain (RBD), often occurring in specific combinations, has transferred back into humans. Read More

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Transcriptome analysis reveals a complex response to the RGNNV/SJNNV reassortant Nervous Necrosis Virus strain in sea bream larvae.

Fish Shellfish Immunol 2021 May 7. Epub 2021 May 7.

Department of Comparative Biomedicine and Food Science, University of Padova, Viale Dell'Università, 16 35020, Legnaro, PD, Italy.

The gilthead sea bream (Sparus aurata) is a marine fish of great importance for Mediterranean aquaculture. This species has long been considered resistant to Nervous Necrosis Virus (NNV), an RNA virus that causes massive mortalities in several farmed fish animals. However, the recent appearance of RGNNV/SJNNV reassortant strains started to pose a serious threat to sea bream hatcheries, as it is able to infect larvae and juveniles of this species. Read More

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Diffusion kurtosis imaging for the assessment of renal fibrosis of chronic kidney disease: A preliminary study.

Magn Reson Imaging 2021 May 7. Epub 2021 May 7.

Department of Radiology, Zhongshan Hospital, Fudan University; Shanghai Institute of Medical Imaging, 180 Fenglin Road, Shanghai 200032, People's Republic of China; Department of Radiology, Xiamen Branch, Zhongshan Hospital, Fudan University, Xiamen, China. Electronic address:

Purpose: To investigate the potential of diffusion kurtosis imaging (DKI) for the assessment of renal fibrosis in chronic kidney disease (CKD), using histopathology as the reference standard.

Methods: Eighty-nine CKD patients and twenty healthy volunteers were recruited in this study. DKI was. Read More

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SARS-CoV-2 and other viruses in soil: an environmental outlook.

Environ Res 2021 May 7:111297. Epub 2021 May 7.

Department of Civil and Mechanical Engineering, University of Cassino and Southern Lazio, Via Di Biasio 43, 03043 Cassino, Italy. Electronic address:

In the present review, the authors shed light on the SARS-CoV-2 impact, persistence, and monitoring in the soil environment. With this purpose, several aspects have been deepened: i) viruses in soil ecosystems; ii) direct and indirect impact on the soil before and after the pandemic, and iii) methods for quantification of viruses and SARS-CoV-2 monitoring in soil. Viruses are present in soil (i. Read More

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Metagenomics: A viable tool for reconstructing herbivore diet.

Mol Ecol Resour 2021 May 10. Epub 2021 May 10.

Section for Evolutionary Genomics, Globe Institute, University of Copenhagen, Øster Farimagsgade 5, 1353, Copenhagen K, Denmark.

Metagenomics can generate data on the diet of herbivores, without the need for primer selection and PCR enrichment steps as is necessary in metabarcoding. Metagenomic approaches to diet analysis have remained relatively unexplored, requiring validation of bioinformatic steps. Currently, no metagenomic herbivore diet studies have utilised both chloroplast and nuclear markers as reference sequences for plant identification, which would increase the number of reads that could be taxonomically informative. Read More

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Role of TRPV4 Channel in Vasodilation and Neovascularization.

Miao Chen Xiucun Li

Microcirculation 2021 May 10:e12703. Epub 2021 May 10.

Department of Hand and Foot Surgery, The Second Hospital, Cheeloo College of Medicine, Shandong University, No.247, Beiyuan Street, Jinan, Shandong Province, 250031, China.

The transient receptor potential vallinoid type 4 (TRPV4) channel, a Ca -permeable nonselective cation channel, is widely distributed in the circulatory system, particularly in vascular endothelial cells (ECs) and smooth muscle cells (SMCs). The TRPV4 channel is activated by various endogenous and exogenous stimuli, including shear stress, low intravascular pressure, and arachidonic acid. TRPV4 has a role in mediating vascular tone and arterial blood pressure. Read More

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Excessive daytime sleepiness, morning tiredness and major adverse cardiovascular events in patients with chronic coronary syndrome.

J Intern Med 2021 May 10. Epub 2021 May 10.

From the, Uppsala Clinical Research Centre, Uppsala University, Uppsala, Sweden.

Background: Sleep-related breathing disorders (SRBDs), particularly obstructive sleep apnoea, are associated with increased cardiovascular (CV) risk. However, it is not known whether individual questions used for SRBD screening are associated with major adverse CV events (MACE) and death specifically in patients with chronic coronary syndrome (CCS).

Methods: Symptoms associated with SRBD were assessed by a baseline questionnaire in 15,640 patients with CCS on optimal secondary preventive therapy in the STABILITY trial. Read More

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Fit-for-purpose quantitative liquid biopsy based droplet digital PCR assay development for detection of programmed cell death ligand-1 (PD-L1) RNA expression in PAXgene blood samples.

PLoS One 2021 10;16(5):e0250849. Epub 2021 May 10.

Global Clinical Biomarkers & Companion Diagnostics, Translational Medicine, Global Development, EMD Serono Research and Development Institute, Inc. a division of Merck KGaA, Billerica, MA, United States of America.

Development of a clinically applicable liquid biopsy-based test for PD-L1 mRNA expression would be beneficial in providing complementary evidence to current immunohistochemistry assays. Hence, we report the development of a fit-for-purpose assay for detection of blood PD-L1 mRNA expression using droplet digital polymerase chain reaction (ddPCR). TaqMan® assays were selected based on coverage of the PD-L1 gene and were tested for linearity and efficiency using real-time quantitative PCR. Read More

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Proactive Consultation-Liaison Psychiatry: American Psychiatric Association Resource Document.

J Acad Consult Liaison Psychiatry 2021 Mar-Apr;62(2):169-185. Epub 2021 Jan 29.

Department of Psychiatry, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON.

In 2019, the American Psychiatric Association Council on Consultation-Liaison (C-L) Psychiatry convened a work group to develop a resource document on proactive C-L psychiatry. A draft of this document was reviewed by the Council in July 2020, and a revised version was approved by this Council in September 2020. The accepted version was subsequently reviewed by the American Psychiatric Association Council on Health Care Systems and Financing in November 2020. Read More

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January 2021

Practical Changes in Reference Services: A Case Study.

Med Ref Serv Q 2021 Apr-Jun;40(2):151-167

University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.

Between 2018 and 2019, the librarians at the Strauss Health Sciences Library improved the efficiency and reach of their reference service by implementing four small-scale changes. These changes included revising the method of collecting statistics, creating FAQs, utilizing an appointment scheduler, and launching proactive chat. This case study will provide the background and research to support these changes, details on how the changes were implemented using Springshare tools, as well as the results and implications. Read More

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Reference Revamp: A 1-2 Model for Training and Tiered Services.

Med Ref Serv Q 2021 Apr-Jun;40(2):188-204

Center for Health Sciences, Los Angeles, California, USA.

The UCLA Science Libraries improved upon our single service points by creating a team-based, tiered research assistance model to foster student employee skill development. This model was further developed to expand training for public services staff, enabling librarians and student research assistants to move beyond desk-based services. This multi-phased approach involved restructured training and the development of collaborative, tiered services. Read More

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The microbiome of deep-sea fish reveals new microbial species and a sparsity of antibiotic resistance genes.

Gut Microbes 2021 Jan-Dec;13(1):1-13

Teagasc Food Research Centre, Fermoy, Ireland.

Adaptation to life in the deep-sea can be dramatic, with fish displaying behaviors and appearances unlike those seen in any other aquatic habitat. However, the extent of which adaptations may have developed at a microbial scale is not as clear. Shotgun metagenomic sequencing of the intestinal microbiome of 32 species of deep-sea fish from across the Atlantic Ocean revealed that many of the associated microbes differ extensively from those previously identified in reference databases. Read More

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Effect of spatial distribution of boron and oxygen concentration on DNA damage induced from boron neutron capture therapy using Monte Carlo simulations.

Int J Radiat Biol 2021 May 10:1-36. Epub 2021 May 10.

Department of Radiation Physics, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

This paper aims to investigate how the spatial distribution of boron in cells and oxygen concentration affect the DNA damage induced by charged particles in boron neutron capture therapy (BNCT) by Monte Carlo simulations, and further to evaluate the relative biological effectiveness (RBE) of DNA double-strand breaks (DSBs) induction in BNCT. The DNA damage induced by all charged particles in BNCT was evaluated by combining Geant4 and Monte Carlo Damage Simulation software (MCDS 3.10A). Read More

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Biomarkers as a Prognostic Factor in COPD Exacerbation: A Cohort Study.

COPD 2021 May 10:1-14. Epub 2021 May 10.

Internal Medicine Department, Medical School, University of Antioquia, Medellín, Colombia.

The acute exacerbations of COPD (AECOPD) are one of the main causes of hospitalization and morbimortality in the adult population. There are not many tools available to predict the clinical course of these patients during exacerbations. Our goal was to estimate the clinical utility of C Reactive Protein (CRP), Mean Platelet Volume (MPV), eosinophil count and neutrophil/lymphocyte ratio (NLR) as in-hospital prognostic factors in patients with AECOPD. Read More

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Cognitive impairment profile in adolescent early-onset psychosis using the MATRICS Battery: Age and sex effects.

Neuropsychology 2021 Mar;35(3):300-309

NORMENT Center of Excellence, Institute of Clinical Medicine, University of Oslo.

To examine cognitive performance, stratified by age and sex, in adolescents with early-onset psychosis (EOP), relative to the healthy adolescent standardized scores for the MATRICS Consensus Cognitive Battery (MCCB). Seventy-one EOP patients (12-18 years) were included in the study. Raw scores of nine MCCB tests were converted into age- and sex-corrected scores comprising six domains and global cognition (cognitive composite score). Read More

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Electron-Injection-Engineering Induced Phase Transition toward Stabilized 1T-MoS with Extraordinary Sodium Storage Performance.

ACS Nano 2021 May 10. Epub 2021 May 10.

School of Chemical Engineering & Advanced Materials, The University of Adelaide, Adelaide 5005, SA, Australia.

Phase transition engineering, with the ability to alter the electronic structure and physicochemical properties of materials, has been widely used to achieve the thermodynamically unstable metallic phase MoS (1T-MoS), although the complex operating conditions and low yield of previous strategies make the large-scale fabrication of 1T-MoS a big challenge. Herein, we report a facile electron injection strategy for phase transition engineering and fabricate a composite of conductive TiO chemically bonded to 1T-MoS nanoflowers (TiO-1T-MoS NFs) on a large scale. The underlying mechanism analysis reveals that electron-injection-engineering triggers a reorganization of the Mo 4d orbitals and results in a 100% phase transition of MoS from 2H to 1T. Read More

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The physiology of fish in acidic waters rich in dissolved organic carbon, with specific reference to the Amazon basin: Ionoregulation, acid-base regulation, ammonia excretion, and metal toxicity.

J Exp Zool A Ecol Integr Physiol 2021 May 10. Epub 2021 May 10.

Department of Zoology, University of British Columbia, Vancouver, British Columbia, Canada.

Although blackwaters, named for their rich content of dissolved organic carbon (DOC), are often very poor in ions and very acidic, they support great fish biodiversity. Indeed, about 8% of all freshwater fish species live in the blackwaters of the Rio Negro watershed in the Amazon basin. We review how native fish survive these harsh conditions that would kill most freshwater fish, with a particular focus on the role of DOC, a water quality parameter that has been relatively understudied. Read More

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