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Use of academic electronic medical records in nurse education: A scoping review.

Nurse Educ Today 2021 Apr 9;101:104889. Epub 2021 Apr 9.

School of Nursing and Midwifery, La Trobe University, Bundoora, Victoria 3086, Australia.

Background: Use of academic electronic medical records is internationally recognised as a means for preparing health professional students for the digital healthcare environment. Reported practice benefits include skills for electronic documentation, health informatics, point-of-care clinical decision support systems, as well as preparation for information technology-enabled clinical settings, while challenges include lack of access to simulation software, faculty-related barriers, limited finances and educational software costs. However, little is known about best practices related to its use within pre-licensure or entry-to-practice nursing curricula and impact on clinical practice outcomes. Read More

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Investigation on removal effects and condensation characteristics of condensable particulate matter: Field test and experimental study.

Sci Total Environ 2021 Apr 14;783:146985. Epub 2021 Apr 14.

Shandong Engineering Laboratory for Solid Waste Green Materials, National Engineering Laboratory for Reducing Emissions from Coal Combustion, Engineering Research Center of Environmental Thermal Technology of Ministry of Education, Shandong Key Laboratory of Energy Carbon Reduction and Resource Utilization, School of Energy and Power Engineering, Shandong University, Jinan 250014, China.

Condensable particulate matter (CPM) has become the main part of the total primary PM emitted from stationary sources and has aroused increasing concern. In this work, the removal effects of wet flue gas desulfurization (WFGD) on CPM components were studied. A new CPM-containing flue gas system was designed and used to investigate the condensation characteristics of 16 PAHs, sulfuric acid mist and SO conversion into CPM. Read More

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Risk assessment of occupational exposure to anesthesia Isoflurane in the hospital and veterinary settings.

Sci Total Environ 2021 Apr 5;783:146894. Epub 2021 Apr 5.

Environmental Health and Radiation Safety, Temple University, Philadelphia, PA, USA.

Despite the modern ventilation and waste anesthetic gas (WAG) scavenging systems, occupational exposure to common volatile anesthesia, isoflurane, can occur in the hospital and veterinary settings, but limited information exists on potential exposure and health risk of isoflurane. We assessed exposure dose rates and risks among clinicians and veterinary professionals from occupational exposure to isoflurane. Through a critical review of open literature (1965 to 2020), we summarized potential adverse effects and exposure scenarios of isoflurane among the professional groups, including anesthetists, nurses, operating room personnel, researchers, and/or veterinarians. Read More

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Bioleaching of vanadium by Acidithiobacillus ferrooxidans from vanadium-bearing resources: Performance and mechanisms.

J Hazard Mater 2021 Apr 8;416:125843. Epub 2021 Apr 8.

School of Energy and Environmental Engineering, University of Science and Technology Beijing, Beijing 100083, PR China.

Bioleaching is promising to meet the demand of strategic vanadium both economically and environmentally. Whereas the combination of bioleaching with traditional techniques is of great interest, little is known on bioleaching of vanadium from abundant vanadium-bearing resources utilized/produced in existing processes. This study investigated the bioleaching of vanadium from vanadium-titanium magnetite, steel slag, and clinker, which are common raw mineral and intermediates used in conventional vanadium extraction process. Read More

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Does Ostmann's fat pad size correlate with development of chronic otitis media in children?

Int J Pediatr Otorhinolaryngol 2021 Apr 14;145:110710. Epub 2021 Apr 14.

Department of Otorhinolaryngology - Head and Neck Surgery, Meir Medical Center, Kfar Saba, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address:

Objective: To compare Ostmann's fat pad (OFP) size between healthy ears and ears with chronic otitis media with cholesteatoma (COMwC) in children, to assess its role in the disease.

Methods: MRI scans of 29 children with unilateral COMwC with conductive hearing loss were used to measure OFP, represented by the maximal diameter of the high intensity area medial to the tensor veli palatini muscle (TVP): M1. A reference diameter was defined from the medial border of OFP reaching the medial border of the medial pterygoid muscle: M2. Read More

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Design, synthesis, biological evaluation, and computational studies of novel thiazolo-pyrazole hybrids as promising selective COX-2 inhibitors: Implementation of apoptotic genes expression for ulcerogenic liability assessment.

Bioorg Chem 2021 Mar 31;111:104883. Epub 2021 Mar 31.

Department of Organic and Medicinal Chemistry, Faculty of Pharmacy, University of Sadat City, Menoufiya 32897 Egypt.

A novel series of thiazolo-pyrazole hybrids has been prepared and assessed for their in vitro COX-1/COX-2 inhibitory activity. Compound 6c exhibited the most selective COX-2 inhibition profile (SI of 264) not far of Celecoxib (294). In-vivo anti-inflammatory activity revealed that compound 6d exhibited the highest activity (97. Read More

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Evaluation of factors influencing the trace metals in Puducherry and Diu coasts of India through multivariate techniques.

Mar Pollut Bull 2021 Apr 14;167:112342. Epub 2021 Apr 14.

Ocean Science and Technology for Islands, National Institute of Ocean Technology, Ministry of Earth Sciences, Government of India, Chennai, India.

In recent years, urban and industrial development initiatives at Puducherry and Diu such as tourism, shipping, and fisheries have led to sediment contamination by trace metals, and contributed to this investigation that extended from 2016 to 2017. Strong factor loadings of Cd (0.94), Ni (0. Read More

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Performance of the rapid high-throughput automated electrochemiluminescence immunoassay targeting total antibodies to the SARS-CoV-2 spike protein receptor binding domain in comparison to the neutralization assay.

J Clin Virol 2021 Apr 10;139:104820. Epub 2021 Apr 10.

Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Zaloška 4, 1000 Ljubljana, Slovenia. Electronic address:

Background: Neutralization tests (NT) are the gold standard for detecting and quantifying anti-SARS-CoV-2 neutralizing antibodies (NAb), but their complexity restricts them to research settings or reference laboratories. Antibodies against S protein receptor binding domain (RBD) have been shown to confer a neutralizing activity against SARS-CoV-2. Assays quantitatively measuring anti-S1-RBD-SARS-CoV-2 antibodies could be of great value for NAb screening of potential donors for convalescent-phase plasma therapy, assessing natural or vaccine-induced immunity, stratifying individuals for vaccine receipt, and documenting vaccine response. Read More

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Potential medicinal value of celastrol and its synthesized analogues for central nervous system diseases.

Biomed Pharmacother 2021 Apr 14;139:111551. Epub 2021 Apr 14.

Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility, and State Key Laboratory of Research & Development of Characteristic Qin Medicine Resources (Cultivation), and Shaanxi Key Laboratory of Chinese Medicine Fundamentals and New Drugs Research, and Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Shaanxi University of Chinese Medicine, Xi'an 712046, Shaanxi Province, China. Electronic address:

The central nervous system (CNS) is a vital part of the human nervous system, and the incidence of CNS disease is increasing year by year, which has become a major public health problem and a prominent social problem. At present, the drugs most commonly used in the clinic are receptor regulators, and neurotransmitter inhibitors, but they are accompanied by serious side effects. Therefore, the identification of new drugs and treatment strategies for CNS disease has been a research hotspot in the medical field. Read More

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Quantification of vitamin D and 25-hydroxyvitamin D in food - The impact of eluent additives and labelled internal standards on matrix effects in LC-MS/MS analysis.

Food Chem 2021 Mar 13;357:129588. Epub 2021 Mar 13.

National Food Institute, Technical University of Denmark, Research Group for Bioactives - Analysis and Application, Kemitorvet, 2800 Kgs. Lyngby, Denmark. Electronic address:

Deuterated vitamin D standards are used commonly as internal standards in LC-MS/MS analysis of vitamin D and 25-hydroxyvitamin D in food. However, the use of various eluent additives, such as methylamine, formic acid and ammonium formate, also contributes to matrix effects and the performance of analysis by affecting accuracy and robustness. For the first time, continuous post-column infusion experiments of isotopically labelled vitamin D-[d] were performed to evaluate ion-suppression in a wide variety of food (salmon, cheese, pork fat, pork meat, and egg yolk). Read More

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A personalized 3D-printed plate for tibiotalocalcaneal arthrodesis: Design, fabrication, biomechanical evaluation and postoperative assessment.

Comput Biol Med 2021 Apr 3;133:104368. Epub 2021 Apr 3.

Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, 100191, Beijing, China; Key Laboratory of Human Motion Analysis and Rehabilitation Technology of the Ministry of Civil Affairs, Beijing Key Laboratory of Rehabilitation Technical Aids for Old-Age Disability, National Research Centre for Rehabilitation Technical Aids, 100176, Beijing, China; Rehabilitation Hospital, National Research Center for Rehabilitation Technical Aids, 100176, Beijing, China; School of Engineering Medicine, Beihang University, 100191, Beijing, China. Electronic address:

Personalized plates (P-Plates) could provide improved clinical outcomes in joint fusion by enabling perfect geometric matching between irregular bone and implants. However, there is no unified application framework for P-Plates for joint fusion. The objective of this study was to develop such a framework for P-Plates for tibiotalocalcaneal arthrodesis. Read More

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MOL-PCR and xMAP technology - a multiplex system for fast detection of food- and water-borne viruses.

J Mol Diagn 2021 Apr 14. Epub 2021 Apr 14.

Department of Animal Origin Food and Gastronomic Sciences, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences, Palackeho tr. 1946/1, CZ61242 Brno, Czech Republic.

Viruses are common causes of food- and water-borne diseases worldwide. Conventional identification of these agents is based on cultivation, antigen detection, electron microscopy or real-time polymerase chain reaction. Since recent technological advancements in detection methods are focused on fast and robust analysis, a rapid multiplexing technology, which can detect a broad spectrum of pathogenic viruses connected to food or water contamination, was utilized. Read More

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Efficacy of the Xpert Mycobacterium tuberculosis/rifampicin assay for diagnosing sputum-smear negative or sputum scarce pulmonary tuberculosis in bronchoalveolar lavage fluid.

Int J Infect Dis 2021 Apr 14. Epub 2021 Apr 14.

Department of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China; Shanghai Clinical Research Center for Infectious Disease (Tuberculosis), Shanghai, China. Electronic address:

Objective: The diagnostic performance of the Xpert Mycobacterium tuberculosis/Rifampin (MTB/RIF) assay in bronchoalveolar lavage fluid (BALF) is limited.

Methods: We retrospectively reviewed the clinical data from 671 sputum-smear negative or sputum scarce adult patients with suspected PTB who had an Xpert MTB/RIF assay performed on BALF. The diagnostic performance of the Xpert MTB/RIF assay, smear microscopy (SM), and MTB cultures was evaluated using MTB cultures or final clinical diagnoses as the reference standards. Read More

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Association of Plasmodium falciparum kelch13 R561H genotypes with delayed parasite clearance in Rwanda: an open-label, single-arm, multicentre, therapeutic efficacy study.

Lancet Infect Dis 2021 Apr 14. Epub 2021 Apr 14.

Malaria Branch, US Centers for Disease Control and Prevention, Atlanta, GA, United States; US President's Malaria Initiative, US Centers for Disease Control and Prevention, Kigali, Rwanda. Electronic address:

Background: Partial artemisinin resistance is suspected if delayed parasite clearance (ie, persistence of parasitaemia on day 3 after treatment initiation) is observed. Validated markers of artemisinin partial resistance in southeast Asia, Plasmodium falciparum kelch13 (Pfkelch13) R561H and P574L, have been reported in Rwanda but no association with parasite clearance has been observed. We aimed to establish the efficacy of artemether-lumefantrine and genetic characterisation of Pfkelch13 alleles and their association with treatment outcomes. Read More

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Simultaneous quantification of commonly used counter ions in peptides and active pharmaceutical ingredients by mixed mode chromatography and evaporative light scattering detection.

J Pharm Sci 2021 Apr 14. Epub 2021 Apr 14.

ETH Zurich, Institute of Pharmaceutical Sciences, Vladimir-Prelog-Weg1-5/10, CH-8093 Zurich, Switzerland. Electronic address:

In academia and industry, the analysis of counter ions in small molecules and synthetic peptides represents a great challenge. Due to the frequent use of salt forms and the application of a wider range of counter ions in pharmaceutically used substances, simple and generic methods for quantification are required. Especially, the analysis of trifluoracetic acid (TFA) in synthetic peptides is of high interest. Read More

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Inpatient measurements of urine metanephrines are indistinguishable from pheochromocytoma: retrospective cohort study.

Am J Med 2021 Apr 14. Epub 2021 Apr 14.

Cumming School of Medicine, Department of Medicine, University of Calgary; Department of Community Health Sciences, University of Calgary.

Background: Pheochromocytoma is a rare cause of acute cardiovascular disease however, any severe illness may have high catecholamines, simulating pheochromocytoma. We determined the spectrum of urine metanephrines from inpatient and outpatient collections without pheochromocytoma compared to confirmed pheochromocytoma patients.

Methods: Retrospective analysis using centralized laboratory data serving all outpatients and hospitals in southern Alberta. Read More

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In vitro Antifungal susceptibility patterns of Trichophyton benhamiae complex isolates from diverse origin.

Mycoses 2021 Apr 17. Epub 2021 Apr 17.

Infectious and Tropical Diseases Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Background: Species from the Trichophyton benhamiae complex are mostly zoophilic dermatophytes which cause inflammatory dermatophytosis in animals and humans worldwide.

Objectives: This study was purposed to 1) to identify 169 reference and clinical dermatophyte strains from the T. benhamiae complex species by molecular method and adhering to the newest taxonomy in the complex 2) to evaluate the in vitro antifungal susceptibility profile of these strains against eight common and new antifungal agents that may be used for the treatment of dermatophytosis. Read More

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Autochthonous and imported tegumentary leishmaniasis in Catalonia (Spain): aetiological evolution in the last four decades and usefulness of different typing approaches based on biochemical, molecular and proteomic markers.

Transbound Emerg Dis 2021 Apr 17. Epub 2021 Apr 17.

Secció de Parasitologia, Departament de Biologia, Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona, Sanitat i Medi Ambient, Barcelona, Spain.

Leishmaniasis is a transmissible disease caused by Leishmania protozoa. Spain is endemic for both visceral and cutaneous leishmaniasis, the autochthonous aetiological agent being Leishmania infantum. Around the world, the L. Read More

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Estimating the Reference Interval from a Fixed Effects Meta-Analysis.

Res Synth Methods 2021 Apr 17. Epub 2021 Apr 17.

1Division of Biostatistics, University of Minnesota, Minneapolis, Minnesota, USA.

A reference interval provides a basis for physicians to determine whether a measurement is typical of a healthy individual. It can be interpreted as a prediction interval for a new individual from the overall population. However, a reference interval based on a single study may not be representative of the broader population. Read More

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Improving memory effect correction to achieve high precision analysis of δ O, δ O δ H, O-excess and d-excess in water using cavity ring-down laser spectroscopy.

Rapid Commun Mass Spectrom 2021 Apr 17:e9108. Epub 2021 Apr 17.

CEREGE, Aix Marseille Univ, CNRS, IRD, INRA, Coll France, Aix-en-Provence, France.

Rationale: The precision obtained in routine isotope analysis of water (δ O, δ O, δ H, O-excess and d-excess values) by Cavity Ring-Down Spectroscopy is usually below the instrument specifications provided by the manufacturer. This study aimed at reducing this discrepancy, with particular attention paid to mitigating the memory effect (ME).

Methods: We used a Picarro L2140i analyzer coupled with a high-precision A0211 vaporizer and an A0325 autosampler. Read More

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Diagnostic performance of adult-based ATA and ACR-TIRADS ultrasound risk stratification systems in pediatric thyroid nodules: a systematic review and meta-analysis.

Eur Radiol 2021 Apr 17. Epub 2021 Apr 17.

Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, 86 Asanbyeongwon-Gil, Songpa-Gu, Seoul, 05505, Republic of Korea.

Objectives: To evaluate the diagnostic performance of adult-based "American College of Radiology- Thyroid Imaging Reporting And Data System" (ACR-TIRADS) and "American Thyroid Association" (ATA) in the pediatric population.

Methods: MEDLINE/PubMed, EMBASE, Cochrane Library, and Web of Science databases were searched for articles investigating the diagnostic performance of each stratification system (ACR-TIRADS or ATA) and evaluated them according to three aspects: (a) the risk of malignancy in each category; (b) diagnostic performance using the classic indicators (sensitivity, specificity); and (c) diagnostic performance regarding fine needle aspiration/biopsy recommendation. In addition to pathologic diagnosis, we allowed imaging follow-up as the reference standard for benign nodules. Read More

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Feasibility and prognostic role of machine learning-based FFR in patients with stent implantation.

Eur Radiol 2021 Apr 17. Epub 2021 Apr 17.

Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing, 210002, Jiangsu, China.

Objectives: To investigate the feasibility and prognostic implications of coronary CT angiography (CCTA) derived fractional flow reserve (FFR) in patients who have undergone stents implantation.

Methods: Firstly, the feasibility of FFR in stented vessels was validated. The diagnostic performance of FFR in identifying hemodynamically in-stent restenosis (ISR) in 33 patients with invasive FFR ≤ 0. Read More

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The triangular fibrocartilage complex on high-resolution 3 T MRI in healthy adolescents: the thin line between asymptomatic findings and pathology.

Skeletal Radiol 2021 Apr 17. Epub 2021 Apr 17.

Department of Radiology and Nuclear Medicine, Amsterdam Movement Sciences, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands.

Objective: The objective of the study is to provide a reference for morphology, homogeneity, and signal intensity of triangular fibrocartilage complex (TFCC) and TFCC-related MRI features in adolescents.

Materials And Methods: Prospectively collected data on asymptomatic participants aged 12-18 years, between June 2015 and November 2017, were retrospectively analyzed. A radiograph was performed in all participants to determine skeletal age and ulnar variance. Read More

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Rare deleterious de novo missense variants in RNF2/RING2 are associated with a neurodevelopmental disorder with unique clinical features.

Hum Mol Genet 2021 Apr 16. Epub 2021 Apr 16.

Department of Molecular and Human Genetics, Baylor College of Medicine (BCM), Houston, TX, USA.

The Polycomb group (PcG) gene RNF2 (RING2) encodes a catalytic subunit of the Polycomb Repressive Complex 1 (PRC1), an evolutionarily conserved machinery that post-translationally modifies chromatin to maintain epigenetic transcriptional repressive states of target genes including Hox genes. Here, we describe two individuals, each with rare de novo missense variants in RNF2. Their phenotypes include intrauterine growth retardation, severe intellectual disabilities, behavioral problems, seizures, feeding difficulties and dysmorphic features. Read More

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A rare missense variant in the ATP2C2 gene is associated with language impairment and related measures.

Hum Mol Genet 2021 Apr 16. Epub 2021 Apr 16.

School of Medicine, University of St Andrews, St Andrews, UK.

At least 5% of children present unexpected difficulties in expressing and understanding spoken language. This condition is highly heritable and often co-occurs with other neurodevelopmental disorders such as dyslexia and ADHD. Through an exome sequencing analysis, we identified a rare missense variant (chr16:84405221, GRCh38. Read More

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The utilize of complex arrangement approach for spectroscopic examination of a some cephalosporins with Eosin Y in their pure forms, pharmaceutical dosage forms and human plasma.

Luminescence 2021 Apr 16. Epub 2021 Apr 16.

Analytical Chemistry Department, Faculty of Pharmacy, Minia University, Minia, Egypt.

Approved, basic and taken a toll successful spectroscopic strategies (spectrophotometric and spectrofluorimetric) were created for the measure of seven cephalosporins to be specific; cefpiramide (I), cefuroxime (II), cefoxitin (III), ceftazidime (IV), cefpirome (V), ceftabiprole (VI) and ceftriaxone (VII). The most guideline of these strategies is twofold complex arrangement through the response of the drugs amino bunch with Eosin Y (EY). The examined drugs were decided spectrophotometrically at 542-550 nm in acetic acid derivation buffer. Read More

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Z-scores of fetal bladder distention for the antenatal differential diagnosis of posterior urethral valves and urethral atresia.

Ultrasound Obstet Gynecol 2021 Apr 16. Epub 2021 Apr 16.

Department of Obstetrics and Prenatal Diagnosis, University Medical Center Groningen, University of Groningen and Amsterdam UMC, location VU, Amsterdam, The Netherlands.

Objective: to construct reference values for fetal urinary bladder distension in pregnancy and use Z-scores as a diagnostic tool to differentiate posterior urethral valves (PUV) from urethral atresia (UA).

Methods: A prospective cross-sectional study was carried out on singleton healthy pregnancies in order to construct nomograms of fetal urinary bladder distension between 15 and 35 weeks' gestation. Z-scores were calculated and validated in a retrospective cohort of fetuses with megacystis. Read More

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Prosthetically-Driven Full-Mouth Implant-Supported Prostheses Using Guided Surgical Implant Planning With Composite Resin Markers: A Case Report.

J Prosthodont 2021 Apr 17. Epub 2021 Apr 17.

Department of Implant Surgery, Faculty of Health Sciences, Alfonso X El Sabio University, Madrid, Spain.

This report describes a prosthetically-driven implant planning method, guided by the alignment procedures between the cone beam computed tomography, intraoral digital scans, and digitized maxillary and mandibular interim complete dentures using intraoral composite resin markers as a common reference. The markers were attached to the keratinized oral mucosa of the edentulous ridges using cyanoacrylate and kept in place during the digitizing procedures. The technique provides a simpler and more economical alternative to conventional prosthetically-driven static implant planning methods. Read More

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Students as Leaders in Supporting Campus Wellbeing: Peer-to-Peer Health Promotion in Higher Education.

Health Promot J Austr 2021 Apr 16. Epub 2021 Apr 16.

Student Experience Office, Western Sydney University, Australia.

Issue Addressed: This study aimed to analyse the relationship between peer-delivered health promotion programs and student wellbeing, and to expand the limited body of research examining peer-to-peer mental health promotion as experienced by student leaders.

Methods: The study was cross-sectional and focused on the experience of participants of a Sydney-based University Mental Health Day event, including student leaders, student participants, university staff and industry partners. It adopted a mixed-method approach to data collection, including a quantitative and a qualitative phase. Read More

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