136,034 results match your criteria reduction number

Interpretability of selected variables and performance comparison of variable selection methods in a polyethylene and polypropylene NIR classification task.

Vilma Sem

Spectrochim Acta A Mol Biomol Spectrosc 2021 Apr 20;258:119850. Epub 2021 Apr 20.

Faculty of Agriculture and Life Sciences, University of Maribor, Pivola 10, 2311 Hoce, Slovenia. Electronic address:

Near infrared (NIR) spectra are collected as a high amount of absorption values which usually greatly exceeds the sample size. Variable selection methods are employed in NIR spectroscopy to avoid "curse of dimensionality" related issues. In this paper, we examined the interpretability of selected variables, that is, how much selected wavelengths are related to the chemical structure of the materials studied, and if the relation is important for classification performance. Read More

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Arsenic exposure in drinking water reduces Lgr5 and secretory cell marker gene expression in mouse intestines.

Toxicol Appl Pharmacol 2021 May 3:115561. Epub 2021 May 3.

Environmental Toxicology Graduate Program, Clemson University, 132 Long Hall, Clemson, SC 29634, USA; Department of Biological Sciences, Clemson University, 132 Long Hall, Clemson, SC 29634, USA. Electronic address:

Arsenic is a global health concern that causes toxicity through ingestion of contaminated water and food. In vitro studies suggest that arsenic reduces stem and progenitor cell differentiation. Thus, this study determined if arsenic disrupted intestinal stem cell (ISC) differentiation, thereby altering the number, location, and/or function of intestinal epithelial cells. Read More

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The Impact of a Population-based Prevention Program on Cardiovascular Events: Findings from the Heart of New Ulm Project.

Am Heart J 2021 May 3. Epub 2021 May 3.

Minneapolis Heart Institute Foundation, 920 East 28th Street, Suite 100, Minneapolis, MN; Minneapolis Heart Institute, 920 East 28th Street, Suite 300, Minneapolis, MN.

Background: Cardiovascular disease (CVD) and its associated risk factors are the principal drivers of mortality and healthcare costs in the United States with rural residents experiencing higher CVD death rates than their urban counterparts.

Methods: The purpose of this study was to examine incidence of major CVD events over 9 years of implementation of the Heart of New Ulm (HONU) Project, a rural population-based CVD prevention initiative. HONU interventions were delivered at individual, organizational, and community levels addressing clinical risk factors, lifestyle behaviors and environmental changes. Read More

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Genetic diversity and the application of runs of homozygosity-based methods for inbreeding estimation in German White-headed Mutton sheep.

PLoS One 2021 6;16(5):e0250608. Epub 2021 May 6.

Department of Animal Breeding, University of Kassel, Witzenhausen, Germany.

The German White-headed Mutton (GWM) sheep is a monitoring population believed to have been improved through crosses with other breeds, e.g., Texel (TXL) and French Berrichone du Cher (BDC). Read More

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Surveillance to Track Progress Toward Polio Eradication - Worldwide, 2019-2020.

MMWR Morb Mortal Wkly Rep 2021 May 7;70(18):667-673. Epub 2021 May 7.

When the Global Polio Eradication Initiative (GPEI) was established in 1988, an estimated 350,000 poliomyelitis cases were reported worldwide. In 2020, 140 wild poliovirus (WPV) cases were confirmed, representing a 99.99% reduction since 1988. Read More

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When the World Throws You a Curve Ball: Lessons Learned in Breast Cancer Management.

Am Soc Clin Oncol Educ Book 2021 Mar;41:1-11

Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA.

In the care of patients with operable breast cancer, there has been a shift toward increasing use of neoadjuvant therapy. There are benefits to neoadjuvant therapy, such as monitoring for response, as well as an increased rate of breast conservation and reduction of potential morbidity associated with breast surgery, including axillary management. Among patients with highly proliferative tumors, such as HER2-positive or triple-negative breast cancer, those with residual disease are at higher risk of recurrence, which informs the recommended systemic therapy in the adjuvant setting. Read More

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HaploBlocker: Creation of Subgroup-Specific Haplotype Blocks and Libraries.

Genetics 2019 Aug;212(4):1045-1061

Department of Animal Sciences, Animal Breeding and Genetics Group, University of Goettingen, 37075, Germany.

The concept of haplotype blocks has been shown to be useful in genetics. Fields of application range from the detection of regions under positive selection to statistical methods that make use of dimension reduction.. Read More

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Analysis of Efficacy and Safety of Pediatric Ahmed Glaucoma Valve (FP8) in Advanced Age Populations.

J Glaucoma 2021 Feb;30(2):164-169

Ophthalmology, University of Calgary, Calgary, AB, Canada.

Precis: The FP8 glaucoma valve was demonstrated to be reasonably safe with reliable results in an advanced age patient population.

Purpose: As life expectancy increases, a growing number of patients with glaucoma are of an advanced age. There are little to no data looking at glaucoma surgical treatment options in patients over the age of 85. Read More

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February 2021

Influence of Stress, Gender, and Minority Status on Cardiovascular Disease Risk in the Hispanic/Latino Community: Protocol for a Longitudinal Observational Cohort Study.

JMIR Res Protoc 2021 May 6;10(5):e28997. Epub 2021 May 6.

Department of Social Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, United States.

Background: Hispanic/Latino sexual and gender minorities (SGM) are the fastest growing ethnic group of SGM in the United States. Cardiovascular disease (CVD) is a leading cause of morbidity and mortality among Hispanics/Latinos. SGM inequities in CVD risk have been identified as early as young adulthood, and minority stress has been identified as a potential mediator. Read More

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A cluster-randomized controlled trial of a combination HIV risk reduction and microfinance intervention for female sex workers who use drugs in Kazakhstan.

J Int AIDS Soc 2021 May;24(5):e25682

Global Health Research Center of Central Asia, Columbia University School of Social Work, New York, NY, USA.

Introduction: Female sex workers (FSW) who use drugs are a key population at risk of HIV in Kazakhstan, and face multiple structural barriers to HIV prevention. More research is needed on the role of structural interventions such as microfinance (MF) in reducing HIV risk. This paper describes the results of a cluster-randomized controlled trial to test the efficacy of a combination HIVRR + MF intervention in reducing biologically confirmed STIs and HIV risk behaviours. Read More

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Dental amalgam restorations in nationally representative sample of US population aged ≥15 years: NHANES 2011-2016.

J Public Health Dent 2021 May 5. Epub 2021 May 5.

ADA Science and Research Institute, Chicago, USA.

Objectives: Estimate the proportion of amalgam restorations among the US population.

Methods: Data from ≥15 year old clinically examined dentate participants in three 2-year survey cycles (NHANES 2011-2016) were analyzed. The 2015-2016 data include restorative material type, allowing for the first time a US estimate of amalgam-restored teeth. Read More

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Mutant Evolution in Spatially Structured and Fragmented Expanding Populations.

Genetics 2020 Sep;216(1):191-203

Department of Mathematics, University of California Irvine, California 92697.

Mutant evolution in spatially structured systems is important for a range of biological systems, but aspects of it still require further elucidation. Adding to previous work, we provide a simple derivation of growth laws that characterize the number of mutants of different relative fitness in expanding populations in spatial models of different dimensionalities. These laws are universal and independent of "microscopic" modeling details. Read More

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September 2020

Organoselenium ligands for heterogeneous and nanocatalytic systems: development and applications.

Dalton Trans 2021 May 6. Epub 2021 May 6.

Department of Chemistry, School of Physical Sciences, Doon University, Dehradun, Uttarakhand 248012, India.

Organoselenium ligands have attracted great attention among researchers during the past two decades. Various homogeneous, heterogeneous and nanocatalytic systems have been designed using such ligands. Although reports on selenium ligated homogeneous catalysts are quite high in number, significant work has also been done on the development of heterogeneous and nanocatalytic systems using organoselenium ligands. Read More

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Vaccinations and Vaccinators' Tracking System in Island Settlements: CHAD 2017-2018.

J Immunol Sci 2021 Apr;Spec Issue(2):1116

WHO Regional Office for African (WHO AFRO), Brazzaville, Congo.

Introduction: Chad is a country within the Lake Chad sub region, currently at risk for poliovirus infection. The Lake Chad Task Team on polio eradication in this sub region made significant efforts to reduce the risk of polio transmission in Chad by tacking immunization teams in the Island Settlement using a Geographic Information System (GIS) technology. This article demonstrates the application of GIS technology to track vaccination teams to monitor immunization coverage in the Island settlements, reduce the number of missed settlements, to provide evidence for vaccination implementation and accountability and improve team performance. Read More

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A manifesto for reproducible science.

Nat Hum Behav 2017 Jan;1:0021

Meta-Research Innovation Center at Stanford (METRICS), Stanford University, Stanford 94304, California, USA.

Improving the reliability and efficiency of scientific research will increase the credibility of the published scientific literature and accelerate discovery. Here we argue for the adoption of measures to optimize key elements of the scientific process: methods, reporting and dissemination, reproducibility, evaluation and incentives. There is some evidence from both simulations and empirical studies supporting the likely effectiveness of these measures, but their broad adoption by researchers, institutions, funders and journals will require iterative evaluation and improvement. Read More

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January 2017

A visual analytic approach for the identification of ICU patient subpopulations using ICD diagnostic codes.

PeerJ Comput Sci 2021 6;7:e430. Epub 2021 Apr 6.

Department of Electrical Engineering (ESAT) STADIUS Center for Dynamical Systems, Signal Processing and Data Analytics, KU Leuven, Leuven, Belgium.

A large number of clinical concepts are categorized under standardized formats that ease the manipulation, understanding, analysis, and exchange of information. One of the most extended codifications is the International Classification of Diseases (ICD) used for characterizing diagnoses and clinical procedures. With formatted ICD concepts, a patient profile can be described through a set of standardized and sorted attributes according to the relevance or chronology of events. Read More

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Molecular evidence of the avocado defense response to infection: a deep transcriptome analysis using RNA-Seq.

PeerJ 2021 14;9:e11215. Epub 2021 Apr 14.

Catedrático CONACyT en la Red de Estudios Moleculares Avanzados, Instituto de Ecología A.C., Xalapa, Veracruz, México.

is a novel member of the Ambrosia Clade (AFC) that has been recognized as one of the symbionts of the invasive Kuroshio shot hole borer, an Asian ambrosia beetle. This complex is considered the causal agent of dieback, a disease that has severely threatened natural forests, landscape trees, and avocado orchards in the last 8 years. Despite the interest in this species, the molecular responses of both the host and during the infection process and disease establishment remain unknown. Read More

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Tenogenic effects of silymarin following experimental Achilles tendon transection in rats.

Vet Res Forum 2021 15;12(1):69-75. Epub 2021 Mar 15.

Department of Pathobiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.

Tendon healing is prolonged due to the small number of cells, poor circulation, and low metabolism. The optimal tendon healing and its complete functional recovery have always been a challenge for researchers. Silymarin possesses anti-inflammatory, anti-oxidant, analgesic, and regenerative properties. Read More

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Lymphocyte Non-Specific Function Detection Facilitating the Stratification of Infection.

Front Immunol 2021 19;12:641378. Epub 2021 Apr 19.

Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Background: Inadequate tuberculosis (TB) diagnostics, especially for discrimination between active TB (ATB) and latent TB infection (LTBI), are major hurdle in the reduction of the disease burden. The present study aims to investigate the role of lymphocyte non-specific function detection for TB diagnosis in clinical practice.

Methods: A total of 208 participants including 49 ATB patients, 64 LTBI individuals, and 95 healthy controls were recruited at Tongji hospital from January 2019 to October 2020. Read More

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Early Exposure to High-Sucrose Diet Leads to Deteriorated Ovarian Health.

Front Endocrinol (Lausanne) 2021 19;12:656831. Epub 2021 Apr 19.

Laboratory of Experimental Physiology, Department of Physiological Sciences, Biological and Health Sciences Centre, Federal University of Maranhão, São Luís, Brazil.

Background: The metabolic syndrome (MetS) is correlated with disorders of the reproductive system, such as the polycystic ovary syndrome (PCOS). While consumption of a diet rich in carbohydrates is linked to the development of MetS, it is still unclear if this diet leads to ovarian dysfunction and PCOS.

Objectives: We investigated the influence of a high-sucrose diet (HSD) on the ovarian milieu of Wistar rats and studied the correlation between high consumption of sugary drinks and the prevalence of PCOS in women. Read More

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Selection of nitrogen responsive root architectural traits in spinach using machine learning and genetic correlations.

Sci Rep 2021 May 5;11(1):9536. Epub 2021 May 5.

Texas A&M AgriLife Research and Extension Center, Uvalde, TX, 78801, USA.

The efficient acquisition and transport of nutrients by plants largely depend on the root architecture. Due to the absence of complex microbial network interactions and soil heterogeneity in a restricted soilless medium, the architecture of roots is a function of genetics defined by the soilless matrix and exogenously supplied nutrients such as nitrogen (N). The knowledge of root trait combinations that offer the optimal nitrogen use efficiency (NUE) is far from being conclusive. Read More

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Metabolic Properties of Lowdensity Lipoprotein (LDL) Triglycerides in Patients with Type 2 Diabetes, Comparison with Small Dense LDL-Cholesterol.

J Atheroscler Thromb 2021 Apr 29. Epub 2021 Apr 29.

R&D Department, Denka Co., Ltd.

Aims: Abnormal compositional changes in low-density lipoprotein (LDL) particles, such as triglyceride (TG) enrichment and size reduction, are common in patients with diabetes. Several cohort studies have demonstrated that LDL-TG and sdLDL-cholesterol (C) are sensitive biomarkers for predicting atherosclerotic cardiovascular diseases beyond LDL-C. Although sdLDL has been extensively studied, little is known about the properties of LDL-TG. Read More

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Reduction of Inhospital Mortality of Patient Admissions to Cardiac Intensive Care Units During the COVID-19 Pandemic in Hunan, China.

Int Heart J 2021 May 1. Epub 2021 May 1.

Department of Cardiology, Cardiac Intensive Care Units, The Second Xiangya Hospital of Central South University.

This study aims to evaluate the impact of the coronavirus disease 2019 (COVID-19) pandemic on patient admissions to Hunan's cardiac intensive care units (CCUs).We conducted a retrospective, single-center study. Data were collected from patients who were confirmed to have critical cardiovascular disease and admitted to the CCU of the Second Xiangya Hospital of Central South University, Hunan, from January 23 to April 23, 2020. Read More

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Asthma exacerbation prevalence during the COVID-19 lockdown in a moderate-severe asthma cohort.

BMJ Open Respir Res 2021 05;8(1)

Pediatrics, Franciscus Gasthuis and Vlietland, Rotterdam, The Netherlands.

Introduction: Following the recent COVID-19 lockdown, a reduction in emergency healthcare visits was reported. Infectious diseases were less often diagnosed, while it was not clear if this was due to a decrease in prevalence or a decrease in emergency healthcare visits due to fear of COVID-19.

Methods: This study comprises a follow-up from a recently finished randomised controlled trial, to gain insight into the prevalence of asthma exacerbation and fear of COVID-19 in patients with moderate-severe asthma and controls in the Netherlands. Read More

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Closed incision negative pressure wound therapy versus standard dressings in obese women undergoing caesarean section: multicentre parallel group randomised controlled trial.

BMJ 2021 05 5;373:n893. Epub 2021 May 5.

National Health and Medical Research Council Centre of Research Excellence in Wiser Wound Care, Menzies Health Institute, Griffith University, Gold Coast, Qld, Australia.

Objective: To determine the effectiveness of closed incision negative pressure wound therapy (NPWT) compared with standard dressings in preventing surgical site infection (SSI) in obese women undergoing caesarean section.

Design: Multicentre, pragmatic, randomised, controlled, parallel group, superiority trial.

Setting: Four Australian tertiary hospitals between October 2015 and November 2019. Read More

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Perceived stress, stressors, and coping strategies among nursing students in the Middle East and North Africa: an overview of systematic reviews.

Syst Rev 2021 May 5;10(1):136. Epub 2021 May 5.

Institute for Population Health, Weill Cornell Medicine-Qatar, Ar-Rayyan, Qatar.

Background: In nursing students, high stress levels can lead to burnout, anxiety, and depression. Our objective is to characterize the epidemiology of perceived stress, stressors, and coping strategies among nursing students in the Middle East and North Africa region.

Methods: We conducted an overview of systematic reviews. Read More

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Neonatal screening for congenital hypothyroidism in an Italian Centre: a 5-years real-life retrospective study.

Ital J Pediatr 2021 May 5;47(1):108. Epub 2021 May 5.

Department of Health Promotion Sciences, Maternal and Infantile Care, Internal Medicine and Medical Specialities PROMISE, "G. D'Alessandro", University of Palermo, Via del Vespro 133, 90127, Palermo, Italy.

Introduction: Congenital hypothyroidism is an endocrine disease with a significant incidence in the general population (1:2000-1:3000 newborns in Italy) and a different geographical distribution, partially explained by endemic iodine deficiency, genetic traits and autoimmune thyroid diseases.

Objectives: Aims of this study are: to evaluate the incidence of positive neonatal blood spot screening for CH in western Sicily, identified by the screening centre of the Children Hospital "G. Di Cristina", ARNAS, Palermo; to evaluate the impact of a lower TSH cutoff in the neonatal blood spot screening for CH. Read More

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Transient hypoglycemia as a rare cause of recurring transient loss of consciousness: a case report.

J Med Case Rep 2021 May 6;15(1):261. Epub 2021 May 6.

Department of Internal Medicine II, University Medical Center Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany.

Background: Syncopes and transient loss of consciousness affect a large number of patients. Determining the underlying mechanism of a syncope is key to effectively treating and preventing future events. However, given the broad differential diagnosis of transient loss of consciousness, it can be challenging to determine the exact etiology. Read More

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Intraoperative 3D imaging in intraarticular tibial plateau fractures - Does it help to improve the patients' outcomes?

J Orthop Surg Res 2021 May 5;16(1):295. Epub 2021 May 5.

Affiliation: Department of Orthopedics, Trauma and Plastic Surgery, University Hospital Leipzig, Liebigstraße 20, 04103, Leipzig, Germany.

Background: In tibial plateau fractures (TPF) the restoration of an anatomical joint surface as well as an exact subchondral screw position for postoperative stability is crucial for the outcome. The aim of this study was to determine whether the additional use of an intraoperative 3D imaging intensifier (3D) might help to improve the outcome of complex TPF.

Methods: We performed a retrospective case-control study of a level 1 trauma center. Read More

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Cyclin D2 Overexpression Enhances the Efficacy of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Myocardial Repair in a Swine Model of Myocardial Infarction.

Circulation 2021 May 6. Epub 2021 May 6.

Department of Biomedical Engineering, School of Medicine and School of Engineering, the University of Alabama at Birmingham, Birmingham, AL.

Human-induced pluripotent stem cells (hiPSCs) with normal or upregulated levels of CCND2 expression were differentiated into cardiomyocytes (CCND2CMs or CCND2CMs, respectively) and injected into infarcted pig hearts. Acute myocardial infarction (AMI) was induced via a 60-minute occlusion of the left-anterior descending coronary artery. Immediately after reperfusion, CCND2CMs or CCND2CMs (3×10 cells each), or an equivalent volume of the delivery vehicle was injected around the infarct border zone area. Read More

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