6,181 results match your criteria reducing susceptibility


Susceptibility of Boll Weevil (Coleoptera: Curculionidae) to Ethiprole, Differential Toxicity Against Selected Natural Enemies, and Diagnostic Concentrations for Resistance Monitoring.

J Econ Entomol 2021 Sep 22. Epub 2021 Sep 22.

Instituto Goiano de Agricultura, Rodovia 174 km 45, Zona Rural, Caixa postal 61, CEP 75915-000, Montividiu, GO, Brazil.

Synthetic insecticide application is one tactic for reducing boll weevil, Anthonomus grandis grandis Boheman (Coleoptera: Curculionidae), infestations during the cotton, Gossypium hirsutum L., reproductive stage. We assessed the susceptibility of the boll weevil and its natural enemies to ethiprole (mode of action 2B), a phenylpyrazole insecticide, and diagnostic concentrations of ethiprole indicative of boll weevil susceptibility. Read More

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September 2021

Physicochemical characterization of monazite sand and its associated bacterial species from the beaches of southeastern Brazil.

Environ Sci Pollut Res Int 2021 Sep 22. Epub 2021 Sep 22.

Universidade de São Paulo, São Paulo, SP, Brazil.

Beaches with monazitic sands show high natural radiation, and the knowledge of this radiation is fundamental to simulate the effects of natural terrestrial radiation on biological systems. Monazite-rich sand from a beach in the southeastern Brazil were collected and analyzed by X-ray fluorescence, X-ray diffraction, and magnetic susceptibility. The natural terrestrial radiation of the beach sand showed a positive correlation with the Th and Y elements, which are closely associated with Ce, Nd, Ca, and P, suggesting that this grouping is mainly associated with local natural radiation. Read More

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September 2021

Wedge-tailed Shearwater () nesting success in human-dominated coastal environments.

PeerJ 2021 30;9:e12096. Epub 2021 Aug 30.

Natural Resources and Environmental Management, University of Hawai'i at Mānoa, Honolulu, Hawai'i, United States of America.

Many seabird populations are declining globally, but successful conservation efforts have led to population expansion of some species into human-dominated landscapes. Thus, there is an increased potential for direct human and seabird interactions for certain species in human-occupied areas, with nest-site characteristics potentially affecting the susceptibility of nests to human disturbance. We assessed the effect of human activity and nest-site characteristics on Wedge-tailed Shearwater ( '') nesting success at two breeding colonies, one with human exposure and one without, located in Kailua, O'ahu, Hawai'i. Read More

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Relation of Pre-stroke Aspirin Use With Cerebral Infarct Volume and Functional Outcomes.

Ann Neurol 2021 Sep 18. Epub 2021 Sep 18.

Department of Neurology, Dongguk University Ilsan Hospital, Goyang, Korea.

Objective: We investigated a) the associations between pre-stroke aspirin use and thrombus burden, infarct volume, hemorrhagic transformation, early neurological deterioration (END), and functional outcome, and b) whether stroke subtypes modify these associations in first-ever ischemic stroke.

Methods: This multicenter MRI-based study included 5,700 consecutive patients with acute first-ever ischemic stroke, who did not undergo intravenous thrombolysis or endovascular thrombectomy, from May-2011 through February-2014. Propensity score-based augmented inverse probability weighting was performed to estimate adjusted effects of pre-stroke aspirin use. Read More

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September 2021

Genome-Wide Association Study of NAFLD Using Electronic Health Records.

Hepatol Commun 2021 Sep 17. Epub 2021 Sep 17.

Centre for Global Health Research, Usher Institute, University of Edinburgh, Edingburgh, Scotland.

Genome-wide association studies (GWAS) have identified several risk loci for nonalcoholic fatty liver disease (NAFLD). Previous studies have largely relied on small sample sizes and have assessed quantitative traits. We performed a case-control GWAS in the UK Biobank using recorded diagnosis of NAFLD based on diagnostic codes recommended in recent consensus guidelines. Read More

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September 2021

Similar Ferroportin Q248H polymorphism prevalence in patients with Plasmodium falciparum malaria and control subjects in the low-endemic setting of Botswana.

Clin Chim Acta 2021 Sep 14;523:77-80. Epub 2021 Sep 14.

School of Allied Health Professions, Faculty of Health Sciences, University of Botswana, Gaborone, Botswana. Electronic address:

Introduction: Recent evidence suggests that ferroportin (FPN) Q248H may confer a survival advantage against malaria by reducing erythrocytic intracellular iron in Africans. We investigated if FPN Q248H mutation, that is prevalent in Batswana, is a factor in limiting the susceptibility to Plasmodium falciparum malaria.

Methods: 264 archived dried blood spot samples (183 P. Read More

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September 2021

Assessment of Hearing Screening Combined With Limited and Expanded Genetic Screening for Newborns in Nantong, China.

JAMA Netw Open 2021 Sep 1;4(9):e2125544. Epub 2021 Sep 1.

Department of Epidemiology and Biostatistics, Nantong University School of Public Health, Nantong, China.

Importance: Early identification and intervention for newborns with hearing loss (HL) may lead to improved physiological and social-emotional outcomes. The current newborn hearing screening is generally beneficial but improvements can be made.

Objective: To assess feasibility and evaluate utility of a modified genetic and hearing screening program for newborn infants. Read More

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September 2021

Ability of known colorectal cancer susceptibility SNPs to predict colorectal cancer risk: A cohort study within the UK Biobank.

PLoS One 2021 15;16(9):e0251469. Epub 2021 Sep 15.

Centre for Epidemiology and Biostatistics, University of Melbourne, Parkville, Victoria, Australia.

Colorectal cancer risk stratification is crucial to improve screening and risk-reducing recommendations, and consequently do better than a one-size-fits-all screening regimen. Current screening guidelines in the UK, USA and Australia focus solely on family history and age for risk prediction, even though the vast majority of the population do not have any family history. We investigated adding a polygenic risk score based on 45 single-nucleotide polymorphisms to a family history model (combined model) to quantify how it improves the stratification and discriminatory performance of 10-year risk and full lifetime risk using a prospective population-based cohort within the UK Biobank. Read More

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September 2021

Tuning Magnetic Interactions Between Triphenylene Radicals by Variation of Crystal Packing in Structures with Alkali Metal Counterions.

Inorg Chem 2021 Sep 15. Epub 2021 Sep 15.

Department of Chemistry, University at Albany, State University of New York, Albany, New York 12222, United States.

The monoanion of triphenylene (CH, ) was generated in THF using several alkali metals (Na, K, Rb, and Cs) as reducing agents and crystallized with the corresponding cations in the presence of 18-crown-6 ether. The UV-vis spectroscopy points to the metal-dependent coordination environment of the triphenylene monoanion-radicals, , in solution. The X-ray diffraction characterization confirmed the formation of a solvent-separated ion pair (SSIP) with sodium ions, [{Na(18-crown-6)(THF)}()] (), and three contact-ion pair (CIP) complexes formed by larger alkali metal ions, [{K(18-crown-6)}()] (), [{Rb(18-crown-6)}()] (), and [{Cs(18-crown-6)}()] (). Read More

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September 2021

Exploring the Genomic Diversity and Antimicrobial Susceptibility of Bifidobacterium pseudocatenulatum in a Vietnamese Population.

Microbiol Spectr 2021 Sep 15:e0052621. Epub 2021 Sep 15.

The Wellcome Sanger Institute, Hinxton, Cambridge, United Kingdom.

Bifidobacterium pseudocatenulatum is a member of the human gut microbiota, and specific variants of have been associated with health benefits such as improving gut integrity and reducing inflammatory responses. Here, we aimed to assess the genomic diversity and predicted metabolic profiles of B. pseudocatenulatum cells found colonizing the gut of healthy Vietnamese adults and children. Read More

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September 2021

Deep proteome profiling of human mammary epithelia at lineage and age resolution.

iScience 2021 Sep 23;24(9):103026. Epub 2021 Aug 23.

Department of Population Sciences, Beckman Research Institute, Duarte, USA.

Age is the major risk factor in most carcinomas, yet little is known about how proteomes change with age in any human epithelium. We present comprehensive proteomes comprised of >9,000 total proteins and >15,000 phosphopeptides from normal primary human mammary epithelia at lineage resolution from ten women ranging in age from 19 to 68 years. Data were quality controlled and results were biologically validated with cell-based assays. Read More

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September 2021

MARCH8 Restricts Influenza A Virus Infectivity but Does Not Downregulate Viral Glycoprotein Expression at the Surface of Infected Cells.

mBio 2021 Sep 14:e0148421. Epub 2021 Sep 14.

Department of Microbiology and Immunology, The University of Melbournegrid.1008.9 at the Peter Doherty Institute for Infection and Immunity, Victoria, Australia.

Membrane-associated RING-CH8 (MARCH8) impairs the cell surface expression of envelope glycoproteins from different viruses, reducing their incorporation into virions. Using stable cell lines with inducible MARCH8 expression, we show that MARCH8 did not alter susceptibility to influenza A virus (IAV) infection, but virions released from infected cells were markedly less infectious. Knockdown of endogenous MARCH8 confirmed its effect on IAV infectivity. Read More

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September 2021

Women's Understanding of Windows of Susceptibility and the Role of the Environment in Breast Cancer Risk.

J Cancer Educ 2021 Sep 10. Epub 2021 Sep 10.

Michigan State University, East Lansing, MI, USA.

Emerging evidence suggests women who are exposed to harmful environmental exposures, especially during certain critical periods across the lifespan, may increase their breast cancer risk. Such windows of susceptibility (WoS) occur throughout a woman's lifetime, during which she is especially vulnerable to the effects of harmful environmental exposures. This interaction makes the reduction of harmful environmental toxicants during those time periods a priority for community health promotion. Read More

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September 2021

BactoSpin: Novel Technology for Rapid Bacteria Detection and Antibiotic Susceptibility Testing.

Sensors (Basel) 2021 Sep 2;21(17). Epub 2021 Sep 2.

Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 7610001, Israel.

Inappropriate use of antibiotics is one of the leading causes of the increasing numbers of resistant bacteria strains, resulting in 700,000 deaths worldwide each year. Reducing unnecessary use of antibiotics and choosing the most effective antibiotics instead of broad-spectrum drugs will slow the arms race between germs and humans. Urinary tract infections (UTIs) are among the most common bacterial infections. Read More

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September 2021

Cost-effectiveness Analysis of Genotype-Specific Surveillance and Preventive Strategies for Gynecologic Cancers Among Women With Lynch Syndrome.

JAMA Netw Open 2021 Sep 1;4(9):e2123616. Epub 2021 Sep 1.

Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.

Importance: With the expansion of multigene testing for cancer susceptibility, Lynch syndrome (LS) has become more readily identified among women. The condition is caused by germline pathogenic variants in DNA mismatch repair genes (ie, MLH1, MSH2, MSH6, and PMS2) and is associated with high but variable risks of endometrial and ovarian cancers based on genotype. However, current guidelines on preventive strategies are not specific to genotypes. Read More

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September 2021

Susceptibility of Glutathione--S-Transferase Polymorphism to CVD Development in Type 2 Diabetes Mellitus - A Review.

Endocr Metab Immune Disord Drug Targets 2021 Sep 7. Epub 2021 Sep 7.

Natural Medicine and Molecular Physiology Lab, Faculty of Allied Health Sciences, Chettinad Academy of Research and Education, Kelambakkam-603103, Chengalpattu Dt., TN. India.

Background: Metabolic disorder affects normal homeostasis and can lead to the development of diseases. Diabetes mellitus is the most common metabolic disorder, and a cluster of metabolic conditions can lead to cardiovascular disease (CVD) development. Diabetes mellitus and CVD are closely related, with oxidative stress, playing a major role in the pathophysiology. Read More

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September 2021

Analysis of the Role of N-Linked Glycosylation in Cell Surface Expression, Function, and Binding Properties of SARS-CoV-2 Receptor ACE2.

Microbiol Spectr 2021 Sep 8:e0119921. Epub 2021 Sep 8.

Department of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.

Human angiotensin I-converting enzyme 2 (hACE2) is a type I transmembrane glycoprotein that serves as the major cell entry receptor for SARS-CoV and SARS-CoV-2. The viral spike (S) protein is required for the attachment to ACE2 and subsequent virus-host cell membrane fusion. Previous work has demonstrated the presence of N-linked glycans in ACE2. Read More

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September 2021

Probiotic Properties of Isolated From Tibetan Yaks, China.

Front Microbiol 2021 17;12:649207. Epub 2021 Aug 17.

College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.

Yaks () live primarily in high-altitude hypoxic conditions and have a unique intestinal micro-ecosystem, remarkable adaptability, and strong climatic resistance. Accumulating evidence revealed the importance of probiotics in host metabolism, gut microbiota, growth performance, and health. The goal of this study was to screen out probiotics with excellent probiotic potential for clinical application. Read More

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The synergistic role of TNFA - 308G/A and IL10 - 1082A/G polymorphisms in ankylosing spondylitis.

Rheumatol Int 2021 Sep 4. Epub 2021 Sep 4.

Department of Molecular Biology, Immunology and Medical Genetics, Medical Faculty, Trakia University, Stara Zagora, Bulgaria.

Objective: Genetic polymorphisms of the cytokine genes could alter their protein expression, thus creating a genetic basis of dysregulated cytokine production and function, which render them as excellent candidates predisposing to autoimmune diseases. We investigated single nucleotide polymorphisms (SNPs) at TNFA - 308G/A and IL10 - 1082A/G locus to identify their involvement, separately or in combination, in determining susceptibility to ankylosing spondylitis (AS), as well as their functional connections with relevant serum cytokines and associations with disease characteristics.

Methods: Eighty-one AS patients and 215 healthy controls were genotyped by polymerase chain reaction-based method; 76 patients and sex-matched controls were also subjected to analysis of serum TNF-α and IL-10 levels by enzyme-linked immunosorbent assay. Read More

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September 2021

Neutrophil infiltration in co-housed littermates plays a key role in nasal transmission of Streptococcus pneumoniae in an infant mouse model.

Folia Microbiol (Praha) 2021 Sep 4. Epub 2021 Sep 4.

Department of Otorhinolaryngology-Head and Neck Surgery, Wakayama Medical University, 811-1 Kimiidera, Wakayama-shi, Wakayama, 640-8501, Japan.

Transmission plays an important role in establishing pneumococcal colonization. It comprises three key events: shedding to transmit, entering into a susceptible new host, and adhering to the mucosal surface. Shedding of pneumococci from the respiratory tract of a colonized host is a pivotal step in transmission. Read More

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September 2021

Modelling direct and herd protection effects of vaccination against the SARS-CoV-2 Delta variant in Australia.

Med J Aust 2021 Sep 3. Epub 2021 Sep 3.

Australian National University, Biological Data Sciences Institute, ANU College of Science, Australian Capital Territory, Canberra, Australia.

Objectives: To analyse the direct and indirect effects of vaccination by vaccine type, age-strategy, and coverage on Australia's Coronavirus Disease 2019 epidemic.

Design: Our model incorporates age-specific mixing, infectiousness, susceptibility and severity to assess the final size of the epidemic under different public health intervention scenarios in Australia.

Main Outcome Measures: The model predicts the final infected population, cumulative hospitalizations, deaths and years of life lost following an epidemic wave, taking into account vaccination and additional mitigation measures. Read More

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September 2021

Relaxing restrictions at the pace of vaccination increases freedom and guards against further COVID-19 waves.

PLoS Comput Biol 2021 09 2;17(9):e1009288. Epub 2021 Sep 2.

Max Planck Institute for Dynamics and Self-Organization, Göttingen, Germany.

Mass vaccination offers a promising exit strategy for the COVID-19 pandemic. However, as vaccination progresses, demands to lift restrictions increase, despite most of the population remaining susceptible. Using our age-stratified SEIRD-ICU compartmental model and curated epidemiological and vaccination data, we quantified the rate (relative to vaccination progress) at which countries can lift non-pharmaceutical interventions without overwhelming their healthcare systems. Read More

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September 2021

The Effects of Exercise on Lipid Biomarkers.

Methods Mol Biol 2022 ;2343:93-117

Department of Cardiovascular Diseases, John Ochsner Heart and Vascular Institute, Ochsner Clinical School, The University of Queensland School of Medicine, New Orleans, LA, USA.

The World Health Organization has declared obesity to be a global epidemic that increases cardiovascular disease (CVD) mortality risk factors, such as hypertension, diabetes, dyslipidemia, and atherosclerosis. The increasing ratio of time spent in sedentary activities to that spent performing physically demanding tasks increases the trends to obesity and susceptibility to these risk factors. Dyslipidemia is the foundation of atherosclerotic buildup and lipoproteins serve as cofactors to the inflammatory processes that destabilize plaques. Read More

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January 2022

Adiponectin gene polymorphisms associated with diabetes mellitus: A descriptive review.

Heliyon 2021 Aug 20;7(8):e07851. Epub 2021 Aug 20.

Department of Biotechnology and Genetic Engineering, Noakhali Science and Technology University, Noakhali, 3814, Bangladesh.

Diabetes is currently a growing concern of the age. Prevention and treatment of diabetes is a global health priority. Adiponectin is an adipocyte derived protein hormone that enhances insulin sensitivity and ameliorates diabetes by enhancing fatty acid oxidation and glucose uptake in skeletal muscle and reducing glucose production in the liver. Read More

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Effects of human-induced land degradation on water and carbon fluxes in two different Brazilian dryland soil covers.

Sci Total Environ 2021 Oct 17;792:148458. Epub 2021 Jun 17.

Department of Civil and Environmental Engineering, Federal University of Paraíba, Paraíba, João Pessoa 58051-900, Brazil.

The Brazilian semiarid region presents a physical water scarcity and high seasonal and interannual irregularities of precipitation, known as a region with periodic droughts. This region is mainly covered by the Caatinga biome, recognized as a Seasonally Dry Tropical Forest (SDTF). Soil water availability directly impacts the ecosystem's functioning, characterized by low fertility and sparse vegetation cover during the dry season, making it a fragile ecosystem vulnerable to climatic variations. Read More

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October 2021

A genetic screen for Drosophila social isolation mutants and analysis of sex pistol.

Authors:
Mark Eddison

Sci Rep 2021 Aug 30;11(1):17395. Epub 2021 Aug 30.

Howard Hughes Medical Institute, Janelia Research Campus, 19700 Helix Drive, Ashburn, VA, 20147, USA.

Prolonged periods of forced social isolation is detrimental to well-being, yet we know little about which genes regulate susceptibility to its effects. In the fruit fly, Drosophila melanogaster, social isolation induces stark changes in behavior including increased aggression, locomotor activity, and resistance to ethanol sedation. To identify genes regulating sensitivity to isolation, I screened a collection of sixteen hundred P-element insertion lines for mutants with abnormal levels of all three isolation-induced behaviors. Read More

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Estimating the impact of indoor relative humidity on SARS-CoV-2 airborne transmission risk using a new modification of the Wells-Riley model.

Build Environ 2021 Nov 23;205:108278. Epub 2021 Aug 23.

Department of Civil Engineering, Technical University of Denmark, Copenhagen, Denmark.

A novel modified version of the Wells-Riley model was used to estimate the impact of relative humidity (RH) on the removal of respiratory droplets containing the SARS-CoV-2 virus by deposition through gravitational settling and its inactivation by biological decay; the effect of RH on susceptibility to SARS-CoV-2 was not considered. These effects were compared with the removal achieved by increased ventilation rate with outdoor air. Modeling was performed assuming that the infected person talked continuously for 60 and 120 min. Read More

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November 2021

Collagenase Activity of Bromelain Immobilized at Gold Nanoparticle Interfaces for Therapeutic Applications.

Pharmaceutics 2021 Jul 27;13(8). Epub 2021 Jul 27.

Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, Santo André CEP 09210-580, SP, Brazil.

Bromelain (Bro) is a multiprotein complex extracted from the pineapple plant Ananas comosus, composed of at least eight cysteine proteases. Bro has a wide range of applications in medicine and industry, where the stability of its active proteases is always a major concern. The present study describes the improvement of stability and gain of specific activity in the enzymatic content of Bro immobilized on gold nanoparticles (GNPs). Read More

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Identification and Fine-Mapping of Quantitative Trait Loci Controlling Plant Height in Central European Winter Triticale (× Wittmack).

Plants (Basel) 2021 Aug 2;10(8). Epub 2021 Aug 2.

Institute of Plant Breeding, Seed Science and Population Genetics, University of Hohenheim, 70599 Stuttgart, Germany.

The quantitatively inherited trait plant height is routinely evaluated in triticale breeding programs as it substantially influences lodging and disease susceptibility, is a main contributor to biomass yield, and is required to improve hybrid seed production by fine-tuning plant height in the female and male parental pools in hybrid breeding programs. In this study, we evaluated a panel of 846 diverse Central European triticale genotypes to dissect the genetic architecture underlying plant height by genome-wide association mapping. This revealed three medium- to large-effect QTL on chromosomes 5A, 4B, and 5R. Read More

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Endometriosis Susceptibility to Dapsone-Hydroxylamine-Induced Alterations Can Be Prevented by Licorice Intake: In Vivo and In Vitro Study.

Int J Mol Sci 2021 Aug 6;22(16). Epub 2021 Aug 6.

Department of Molecular Medicine-Biological Chemistry, University of Padova, 35131 Padova, Italy.

Endometriosis, an estrogen-dependent chronic gynecological disease, is characterized by a systemic inflammation that affects circulating red blood cells (RBC), by reducing anti-oxidant defenses. The aim of this study was to investigate the potential beneficial effects of licorice intake to protect RBCs from dapsone hydroxylamine (DDS-NHOH), a harmful metabolite of dapsone, commonly used in the treatment of many diseases. A control group (CG, = 12) and a patient group (PG, = 18) were treated with licorice extract (25 mg/day), for a week. Read More

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