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P300/CBP-associated factor (PCAF)-mediated acetylation of Fascin at lysine 471 inhibits its actin-bundling activity and tumor metastasis in esophageal cancer.

Cancer Commun (Lond) 2021 Sep 23. Epub 2021 Sep 23.

The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area, Department of Biochemistry and Molecular Biology, Shantou University Medical College, Shantou, Guangdong, 515041, P. R. China.

Background: Fascin is crucial for cancer cell filopodium formation and tumor metastasis, and is functionally regulated by post-translational modifications. However, whether and how Fascin is regulated by acetylation remains unclear. This study explored the regulation of Fascin acetylation and its corresponding roles in filopodium formation and tumor metastasis. Read More

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September 2021

BSHI/BTS guidance on crossmatching before deceased donor kidney transplantation.

Int J Immunogenet 2021 Sep 23. Epub 2021 Sep 23.

Transplantation Laboratory, Manchester Royal Infirmary, Manchester, UK.

All UK H&I laboratories and transplant units operate under a single national kidney offering policy, but there have been variations in approach regarding when to undertake the pre-transplant crossmatch test. In order to minimize cold ischaemia times for deceased donor kidney transplantation we sought to find ways to be able to report a crossmatch result as early as possible in the donation process. A panel of experts in transplant surgery, nephrology, specialist nursing in organ donation and H&I (all relevant UK laboratories represented) assessed evidence and opinion concerning five factors that relate to the effectiveness of the crossmatch process, as follows: when the result should be ready for reporting; what level of donor HLA typing is needed; crossmatch sample type and availability; fairness and equity; risks and patient safety. Read More

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September 2021

Exposure to organochlorine pesticides as a predictor to breast cancer: A case-control study among Ethiopian women.

PLoS One 2021 23;16(9):e0257704. Epub 2021 Sep 23.

Department of Oncology Addis Ababa, College of Health Sciences, University, Addis Ababa, Ethiopia.

Breast cancer (BC) is becoming one of the most prevalent non-infectious disease in low and middle income countries. The steady rise of BC incidence may be related to the different risk factors. Among many, rampant presence of environmental pollutants might be one of the risk factors. Read More

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September 2021

Spatial anxiety and spatial ability: Mediators of gender differences in math anxiety.

J Exp Psychol Gen 2021 Sep 23. Epub 2021 Sep 23.

School of Psychology.

Females tend to be more anxious than males while engaging in mathematics, which has been linked to lower math performance and higher math avoidance. A possible repercussion of this gender difference is the underrepresentation of females in STEM fields (science, technology, engineering, and math), as math competencies are an essential part of succeeding in such fields. A related, but distinct, area of research suggests that males tend to outperform females in tasks that require spatial processing (i. Read More

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September 2021

Effects of different enantiomers of amlodipine on lipid profiles and vasomotor factors in atherosclerotic rabbits.

Open Life Sci 2021 6;16(1):899-908. Epub 2021 Sep 6.

Department of Cardiology, Affiliated Hospital of Hebei University, Baoding, Hebei, 071000, China.

This research aimed to describe the functions of vascular endothelial cells (VECs) in protecting target organs and the anti-atherosclerotic effects of different enantiomers of amlodipine on a rabbit model of atherosclerosis. Thirty male New Zealand white rabbits were randomly allocated to four groups (nA = 9, nB = 7, nC = 7, and nD = 7 rabbits): rabbits in group-A (control group) were fed a high-fat diet, group-B rabbits were fed a high-fat diet plus 2.5 mg/kg/day S-amlodipine, group-C rabbits were fed a high-fat diet plus 2. Read More

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September 2021

Combined BRM270 and endostatin inhibit relapse of NSCLC while suppressing lung cancer stem cell proliferation induced by endostatin.

Mol Ther Oncolytics 2021 Sep 1;22:565-573. Epub 2021 Jun 1.

Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China.

Endostatin (ES, ENDO) has been reported to suppress the growth of tumors while inducing the proliferation of lung cancer stem cells (LCSCs), causing a poor prognosis for lung cancer. In this study, we aimed to clarify whether BRM270 can inhibit the proliferation of cancer stem cells (CSCs). Endostatin + BRM270 showed anti-tumor effects by reducing tumor volume and increasing survival. Read More

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September 2021

Implementation of an Injury Prevention Program in NCAA Division I Athletics Reduces Injury-Related Health Care Costs.

Orthop J Sports Med 2021 Sep 16;9(9):23259671211029898. Epub 2021 Sep 16.

Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Background: The estimated cost per year of injuries in collegiate athletics has been reported to be billions of dollars in the United States. Injury prevention programs are often assessed only by their ability to reduce injuries, and there is little evidence of any potential reduction in associated health care costs.

Purpose: To investigate changes in injury-related health care costs at a National Collegiate Athletic Association (NCAA) Division I university after the implementation of an injury prevention program. Read More

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September 2021

Son of a Lesser God: The Case of Cell Therapy for Refractory Angina.

Front Cardiovasc Med 2021 6;8:709795. Epub 2021 Sep 6.

Unità di Biologia Vascolare e Medicina Rigenerativa, Centro Cardiologico Monzino-Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Milan, Italy.

In the last decades, various non-pharmacological solutions have been tested on top of medical therapy for the treatment of patients affected by refractory angina (RA). Among these therapeutics, neuromodulation, external counter-pulsation and coronary sinus constriction have been recently introduced in the guidelines for the management of RA in United States and Europe. Notably and paradoxically, although a consistent body of evidence has proposed cell-based therapies (CT) as safe and salutary for RA outcome, CT has not been conversely incorporated into current international guidelines yet. Read More

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September 2021

COVID-19 case doubling time associated with non-pharmaceutical interventions and vaccination: A global experience.

J Glob Health 2021 4;11:05021. Epub 2021 Sep 4.

Research Center for Epidemic Prevention, National Yang Ming Chiao Tung University, Taipei, Taiwan.

Background: Evidence has revealed that nonpharmaceutical interventions (NPIs) were effective in attenuating the spread of COVID-19. However, policymakers have encountered difficulty in identifying the most effective policies under different circumstances. This study investigated the relative effectiveness of different NPIs and vaccination in prolonging COVID-19 case doubling time (DT). Read More

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September 2021

Qingre Yiqi Method along with Oral Hypoglycemic Drugs in Treating Adults with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis.

Evid Based Complement Alternat Med 2021 11;2021:4395228. Epub 2021 Sep 11.

Graduate School, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, China.

Objective: To evaluate the efficacy of the Qingre Yiqi method in the treatment of type 2 diabetes mellitus (T2DM) with meta-analysis.

Method: The randomized controlled trials (RCTs) of the Qingre Yiqi method in the treatment of T2DM in the PubMed, Medline, EMBase, Cochrane Library, Web of Science, Weipu Journal, China Knowledge Network (CNKI), and Wanfang database were conducted. Three reviewers independently conducted the screening, extracted the data, and assessed methodological quality. Read More

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September 2021

Intraoperative Spinal Cord Monitoring Does Not Decrease New Postoperative Neurological Deficits in Patients With Cervical Radiculopathy or Spondylotic Myelopathy Undergoing One or Two Level Anterior Cervical Discectomy And Fusion.

Iowa Orthop J 2021 ;41(1):95-102

Department of Orthopedics and Rehabilitation, University of Iowa Hospitals & Clinics, Iowa City, IA, USA.

Background: Intraoperative neurological monitoring (IONM) is commonly used in spine surgery. However, the utility of IONM in anterior cervical decompression and fusion (ACDF) remains a topic of debate. The purpose of the study was to investigate the utility and cost of IONM (both Somatosensory evoked potentials (SSEPs) and Motor Evoked Potentials (Tc-MEPs)) in reducing postoperative neurological deficits in myelopathic and non-myelopathic patients undergoing ACDF. Read More

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January 2021

Natural Nano-Drug Delivery System in Extract with Modified Berberine Hydrochloride Pharmacokinetics.

Int J Nanomedicine 2021 14;16:6297-6311. Epub 2021 Sep 14.

Department of Pharmacology, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People's Republic of China.

Purpose: This study aimed to evaluate the pharmaceutical and pharmacokinetic effects of the natural nanoparticles (Nnps) isolated from extract on berberine hydrochloride (BBR) and systematically explore the related mechanisms.

Methods: Firstly, Nnps were isolated from extract and then an Nnps-BBR complex was prepared. After qualitative and quantitative analysis in terms of size, Zeta potential, morphology, and composition of the Nnps and the Nnps-BBR complex, the effects of the Nnps on the crystallization of BBR were characterized. Read More

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September 2021

A Survey of Potentially Modifiable Patient-Level Factors Associated with Self-Report and Objectively Measured Adherence to Adjuvant Endocrine Therapies After Breast Cancer.

Patient Prefer Adherence 2021 15;15:2039-2050. Epub 2021 Sep 15.

Department of Psychology, University of Calgary, Calgary, AB, Canada.

Purpose: Despite the efficacy of adjuvant endocrine therapy (AET) in reducing breast cancer recurrence and mortality, suboptimal AET adherence is common and hence an important clinical issue among breast cancer survivors. Delineating potentially modifiable patient-level factors associated with AET adherence may support the development of successful adherence-enhancing interventions.

Patients And Methods: The present study included 133 breast cancer survivors prescribed AET recruited from a cancer pharmacy. Read More

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September 2021

A pilot study shows the positive effects of continuous airway pressure for treating hypernasal speech in children with infantile-onset Pompe disease.

Sci Rep 2021 Sep 22;11(1):18826. Epub 2021 Sep 22.

Department of Medical Genetics, National Taiwan University Hospital, Taipei, Taiwan.

Children with infantile-onset Pompe disease (IOPD) demonstrate hypernasality. This study aimed to evaluate whether continuous positive airway pressure (CPAP) training may reduce hypernasality in children with IOPD. Five children with IOPD were enrolled in a single-subject experimental design of type A-B-A'. Read More

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September 2021

The level and trend of road traffic injuries attributable mortality rate in Iran, 1990-2015: a story of successful regulations and a roadmap to design future policies.

BMC Public Health 2021 Sep 22;21(1):1722. Epub 2021 Sep 22.

Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Background: Road-Traffic-Injuries (RTIs) are predicted to rise up to the fifth leading cause of worldwide death by 2030 and Iran has the third highest RTIs mortality among higher-middle income countries. Although the high mortality of RTI in Iran is a warning, it provides the opportunity to indirectly assess the implemented RTI-related regulations' effectiveness via high-resolution relevant statistics and, hence, Iran could serve as a guide for countries with similar context. In order to do so, we utilized this study to report the time and spatial trends of RTIs-related mortality in different age and sex groups and road user classes in Iran. Read More

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September 2021

Role of Fracture Liaison Service Program in Reducing Refracture Rate in the Elderly Osteoporotic Trauma Patients Presenting With Vertebral Compression Fracture: A Six-Year Study.

Am Surg 2021 Sep 22:31348211047512. Epub 2021 Sep 22.

Michigan Neurosurgical Institute, Grand Blanc, MI, USA.

Introduction: As the elderly population of the United States and the world increases, so does the incidence of osteoporotic fragility fractures from a fall or minor injury. This results in a large cost to the health care system. This cost is further increased as more than 50% of individuals will have refractures within the first year. Read More

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September 2021

Comparisons of efficacy and safety in insulin glargine and lixisenatide (iGlarLixi) plus glulisine combination therapy with multiple daily injection therapy in Japanese patients with type 2 diabetes.

J Diabetes Investig 2021 Sep 22. Epub 2021 Sep 22.

Department of Internal Medicine, Minami Osaka Hospital, Osaka, Japan.

Aims/introduction: Multiple daily injection therapy for early glycemic control in patients with type 2 diabetes mellitus is associated with hypoglycemia and weight gain. This study aimed to compare the efficacy (time in range of glucose level 70-180 mg/dL), safety (time below range level 1 of glucose <70 mg/dL), glycemic variability changes, therapeutic indices, body mass index, and titration periods between multiple daily injection and iGlarLixi combination (insulin glargine U100/lixisenatide [iGlarLixi] + insulin glulisine; injected once daily [evenings]) therapies using intermittent continuous glucose monitoring.

Materials And Methods: Forty hospitalized patients with type 2 diabetes were randomly assigned to the iGlarLixi + insulin glulisine group or the multiple daily injection group. Read More

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September 2021

Prevalence, determinants, and outcomes of SARS-COV-2 infection among cancer patients. A population-based study in northern Italy.

Cancer Med 2021 Sep 22. Epub 2021 Sep 22.

Friuli Venezia Giulia Regional Health Coordination Agency, Udine, Italy.

Background: It is well established that cancer patients infected with SARS-CoV-2 are at particularly elevated risk of adverse outcomes, but the comparison of SARS-CoV-2 infection risk between cancer patients and cancer-free individuals has been poorly investigated on a population-basis.

Methods: A population-based study was thus conducted in Friuli Venezia Giulia region, northeastern Italy, to estimate prevalence and determinants of SARS-CoV-2 infection among cancer patients, as compared to cancer-free individuals, and to evaluate adverse outcomes of SARS-CoV-2 infection. The study included 263,042 individuals tested for SARS-CoV-2 in February-December 2020 with cancer history retrieved through the regional cancer registry. Read More

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September 2021

Revision Rhinoplasty after Open Rhinoplasty: Lessons from 252 Cases and Analysis of Risk Factors.

Plast Reconstr Surg 2021 Oct;148(4):747-757

From the Department of Plastic, Reconstructive, and Aesthetic Surgery, Gazi University Hospital.

Background: In this study, patients who required aesthetic revision surgery after open rhinoplasty were retrospectively screened for risk factors.

Methods: Two hundred fifty-two patients who underwent revision were included in the study. Nasal deformities before the revision were determined for each patient and evaluated in terms of their statistical relationship with preoperative nasal morphology and surgical techniques used. Read More

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October 2021

Predicting and Understanding Non-Covalent Interactions Using Novel Forms of Symmetry-Adapted Perturbation Theory.

Acc Chem Res 2021 Sep 22. Epub 2021 Sep 22.

Department of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio 43210, United States.

ConspectusAlthough sometimes derided as "weak" interactions, non-covalent forces play a critical role in ligand binding and crystal packing and in determining the conformational landscape of flexible molecules. Symmetry-adapted perturbation theory (SAPT) provides a framework for accurate calculation of intermolecular interactions and furnishes a natural decomposition of the interaction energy into physically meaningful components: semiclassical electrostatics (rigorously obtained from monomer charge densities), Pauli or steric repulsion, induction (including both polarization and charge transfer), and dispersion. This decomposition helps to foster deeper understanding of non-covalent interactions and can be used to construct transferable, physics-based force fields. Read More

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September 2021

Quantitative Electrophysiological Evaluation of the Analgesic Efficacy of Two Lappaconitine Derivatives: A Window into Antinociceptive Drug Mechanisms.

Neurosci Bull 2021 Sep 22. Epub 2021 Sep 22.

College of Life Science, Northwest Normal University, Lanzhou, 730070, China.

Quantitative evaluation of analgesic efficacy improves understanding of the antinociceptive mechanisms of new analgesics and provides important guidance for their development. Lappaconitine (LA), a potent analgesic drug extracted from the root of natural Aconitum species, has been clinically used for years because of its effective analgesic and non-addictive properties. However, being limited to ethological experiments, previous studies have mainly investigated the analgesic effect of LA at the behavioral level, and the associated antinociceptive mechanisms are still unclear. Read More

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September 2021

Surgeon volume and the risk of deep surgical site infection following open reduction and internal fixation of closed tibial plateau fracture.

Int Orthop 2021 Sep 22. Epub 2021 Sep 22.

Department of Orthopaedic Surgery, the 3Rd Hospital of Hebei Medical University, Shijiazhuang, 050051, Hebei, People's Republic of China.

Background: Emerging evidences supported that the surgeon case volume significantly affected post-operative complications or outcomes following a range of elective or non-elective orthopaedic surgery; no data has been available for surgically treated tibial plateau fractures. We aimed to investigate the relationship between surgeon volume and the risk of deep surgical site infection (DSSI) following open reduction and internal fixation (ORIF) of closed tibial plateau fracture.

Methods: This was a further analysis of the prospectively collected data. Read More

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September 2021

A Web-Based Integrated Management Program for Improving Medication Adherence and Quality of Life, and Reducing Readmission in Patients With Atrial Fibrillation: Randomized Controlled Trial.

J Med Internet Res 2021 Sep 22;23(9):e30107. Epub 2021 Sep 22.

Department of Mathematics, Tamkang University, Taipei, Taiwan.

Background: Atrial fibrillation (AF) is related to a variety of chronic diseases and life-threatening complications. It is estimated that by 2050, there will be 72 million patients with AF in Asia, of which 2.9 million will have AF-associated stroke. Read More

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September 2021

[Causal relationship between physical exercise and risk of ischemic stroke recurrence based on the potential outcome theory].

Nan Fang Yi Ke Da Xue Xue Bao 2021 Aug;41(8):1191-1197

Department of Epidemiology and Health Statistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China.

Objective: To explore the causal relationship between physical exercise and ischemic stroke recurrence using a multiple imputation approach based on the potential outcomes framework.

Methods: We collected data from 636 patients who were diagnosed with first-ever ischemic stroke between July, 2010 and December, 2018 at West China Hospital, Sichuan University.All the patients had motor ability and were followed up at least for 1 year. Read More

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Tetrahedral Framework Nucleic Acid Delivered RNA Therapeutics Significantly Attenuate Pancreatic Cancer Progression via Inhibition of CTR1-Dependent Copper Absorption.

ACS Appl Mater Interfaces 2021 Sep 22. Epub 2021 Sep 22.

Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.

Copper is vital for various life processes, whereas severely toxic at excess level. Intracellular copper homeostasis is strictly controlled by a set of transporters and chaperones encoded by the copper homeostasis genes. Increasing evidence has shown that copper is usually overloaded in multiple malignancies, including pancreatic cancer, which has an extremely poor prognosis. Read More

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September 2021

[Project to Reduce Cases of Drug-Resistant Strain Colonization in the Intensive Care Unit Using a Chlorhexidine Gluconate Bath].

Hu Li Za Zhi 2021 Oct;68(5):74-82

PhD, RN, Head Nurse, Department of Nursing, National Taiwan University Hospital, Taiwan, ROC.

Background: Drug-resistant strains of bacteria are associated with severe consequences such as bacteremia, shock, and death, and increase hospital stay durations and medical health expenses. Therefore, reducing the spread of drug-resistant strains is a priority concern.

Purpose: This project was developed to reduce the number of colonization cases of drug-resistant strains and subsequently increase the quality of care provided in our intensive care unit. Read More

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October 2021

Prevalence and Associated Factors of Problematic Smartphone Use During the COVID-19 Pandemic: A Bangladeshi Study.

Risk Manag Healthc Policy 2021 13;14:3797-3805. Epub 2021 Sep 13.

CHINTA Research Bangladesh, Dhaka, Bangladesh.

Background: Problematic smartphone use (PSU) has been increasing hastily in recent decades, and it has become inseparable during the COVID-19 pandemic, especially among the students who are at risk of problematic smartphone use. Therefore, the present study aimed to investigate the prevalence and associated factors of PSU during the COVID-19 pandemic among the Bangladeshi students.

Methods: A total of 601 Bangladeshi students were recruited through an online-based cross-sectional survey that was conducted between October 7 and November 2, 2020. Read More

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September 2021

The Association Between Medical Liability Insurance Coverage and Medical Disturbances in Tertiary Psychiatric Hospitals in China: A National Survey.

Risk Manag Healthc Policy 2021 13;14:3767-3774. Epub 2021 Sep 13.

Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA.

Background: Medical disturbances (MD), a severe type of medical disputes, are common in Chinese hospitals. Medical liability insurances were introduced to establish a new system of conflict resolution and risk management. However, data are scarce on the effects of medical liability insurance coverage and MD in psychiatric hospitals. Read More

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September 2021

Impact of Timing of Tocilizumab Use in Hospitalized Patients With SARS-CoV-2 Infection.

Respir Care 2021 Sep 21. Epub 2021 Sep 21.

Department of Pulmonary Critical Care and Sleep Medicine, Lenox Hill Hospital - Northwell Health System, New York, New York.

Background: SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) continues to be a global challenge due to the lack of definitive treatment strategies. We sought to determine the efficacy of early administration of anti-interleukin 6 therapy in reducing hospital mortality and progression to mechanical ventilation.

Methods: This was a retrospective chart review of 11,512 patients infected with SARS-CoV-2 who were admitted to a New York health system from March to May 2020. Read More

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September 2021

Apremilast downregulates interleukin-17 production and induces splenic regulatory B cells and regulatory T cells in imiquimod-induced psoriasiform dermatitis.

J Dermatol Sci 2021 Aug 4. Epub 2021 Aug 4.

Department of Dermatology, Teikyo University School of Medicine, Tokyo, Japan.

Background: Apremilast, a selective inhibitor of the enzyme phosphodiesterase 4, is efficacious for psoriasis. However, detailed in vivo effects of apremilast on psoriasis remain to be elucidated.

Objective: To examine the in vivo effects of apremilast on psoriasis. Read More

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