11,185 results match your criteria reducing depression

Comparing the Effectiveness of Education Versus Digital Cognitive Behavioral Therapy for Adults With Sickle Cell Disease: Protocol for the Cognitive Behavioral Therapy and Real-time Pain Management Intervention for Sickle Cell via Mobile Applications (CaRISMA) Study.

JMIR Res Protoc 2021 May 14;10(5):e29014. Epub 2021 May 14.

Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States.

Background: Patients with sickle cell disease (SCD) experience significant medical and psychological stressors that affect their mental health, well-being, and disease outcomes. Digital cognitive behavioral therapy (CBT) has been used in other patient populations and has demonstrated clinical benefits. Although evidence-based, nonpharmacological interventions for pain management are widely used in other populations, these treatments have not been well studied in SCD. Read More

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Mental Health Triggers and Protective Factors Among Arabic-Speaking Immigrants and Refugees in North America: A Scoping Review.

J Immigr Minor Health 2021 May 13. Epub 2021 May 13.

Department of Anthropology, Faculty of Social Sciences, McMaster University, CNH 527, Hamilton, ON, L8S 4L9, Canada.

Poor mental health (MH) is a substantial public health problem, affecting over 13% of the population worldwide. Arabic-speaking immigrants and refugees (ASIR) are at high risk of MH problems due to intercultural adjustment stress, racism and discrimination. This scoping review of 49 studies explored pre- and post-migration MH determinants among ASIR in North America. Read More

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Effects of resistance training on the mental health of patients with fibromyalgia: a systematic review.

Clin Rheumatol 2021 May 14. Epub 2021 May 14.

Health and Sports Science Center, CEFID / Santa Catarina State University - UDESC, Florianópolis, Santa Catarina, Brazil.

Fibromyalgia is a chronic disease characterized by generalized skeletal muscle pain and the presence of mental disorders is common among patients. As there is no cure, several treatment alternatives have been investigated, including the practice of resistance training. Thus, the aim of the current study is to analyze the effects of resistance training on the mental health of patients with fibromyalgia. Read More

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Reducing Risk for Adolescent Substance Misuse with Text-Delivered Counseling to Adolescents and Parents.

Subst Use Misuse 2021 May 13:1-11. Epub 2021 May 13.

Center for Behavioral Health Research, College of Social Work, University of Tennessee, Knoxville, Tennessee, USA.

Text-delivered prevention programs provide unique opportunities to deliver substance use prevention interventions to at-risk populations. A pilot randomized controlled trial was conducted to test the feasibility, acceptability, and preliminary efficacy of a 4-week, automated personalized text-messaging prevention program, designed to reduce risk factors and increase protective factors associated with adolescent substance use and misuse. Sixty-nine adolescents were recruited from a Federally Qualified Health Care clinic and randomized to a text-delivered intervention, or a wait-list control condition. Read More

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Post-ICU Care in the Outpatient Setting.

Am Fam Physician 2021 May;103(10):590-596

University of Iowa Carver College of Medicine, Iowa City, IA, USA.

More than 5 million patients in the United States are admitted to intensive care units (ICUs) annually, and an increasing percentage of patients treated in the ICU survive to hospital discharge. Because these patients require follow-up in the outpatient setting, family physicians should be prepared to provide ongoing care and screening for post-ICU complications. Risk factors for complications after ICU discharge include previous ICU admissions, preexisting mental illness, greater number of comorbidities, and prolonged mechanical ventilation or higher opioid exposure while in the ICU. Read More

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Early Adverse Stress and Depressive and Bipolar Disorders: A Systematic Review and Meta-Analysis of Treatment Interventions.

Front Psychiatry 2021 26;12:650706. Epub 2021 Apr 26.

Psicomedica, Clinical and Research Group, Santiago, Chile.

A significant proportion of adults with depressive or bipolar disorders exposed to early adverse stressors do not adequately respond to standard treatments. This review aimed at synthesizing the evidence on the effectiveness of treatment interventions for depressive or bipolar disorders in adult individuals (aged 18 years or more) exposed to adverse stress early in life. Systematic review and meta-analysis including experimental and quasi-experimental published studies indexed in CINAHL, EMBASE, PubMed, and Web of Science databases and/or in reference lists. Read More

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Brief interventions for older adults (BIO) delivered by non-specialist community health workers to reduce at-risk drinking in primary care: a study protocol for a randomised controlled trial.

BMJ Open 2021 May 11;11(5):e043918. Epub 2021 May 11.

Department of Psychobiology, Escola Paulista de Medicina, Universidade Federal de São Paulo, Sao Paulo, Brazil

Introduction: Evidence suggests that brief interventions are effective in reducing alcohol consumption among older adults. However, the effectiveness of these interventions when delivered by community health workers (non-specialists) in a primary healthcare setting is unknown. To our knowledge, this will be the first randomised trial to examine this. Read More

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Exercise for Patients with Gastrointestinal Cancer Undergoing Chemotherapy and at High Risk for Depression: A Randomized Clinical Trial.

J Altern Complement Med 2021 May 12. Epub 2021 May 12.

Department of Oncology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.

This study evaluated the effects of a Chinese traditional exercise-monkey frolic in Wuqinxi on depression and quality of life in patients with gastrointestinal cancer undergoing chemotherapy and at high risk for depression. In this prospective, randomized-controlled clinical trial, 80 patients with gastrointestinal cancer undergoing chemotherapy and at high risk for depression were randomized to an intervention group or a control group. Participants in the intervention group participated in exercise five sessions each week and also received conventional treatment for 4 weeks; whereas participants in the control group received conventional treatment only. Read More

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Characterize, Optimize, and Harmonize: Caring for Older Adults With Hematologic Malignancies.

Am Soc Clin Oncol Educ Book 2021 Mar;41:1-9

Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA.

With the aging of the population, the number of older adults with hematologic malignancies is growing, and treatment paradigms for these patients are rapidly evolving. Use of allogeneic stem cell transplant has been expanding to include septuagenarians but remains a potentially morbid procedure, creating an opportunity for a geriatric-focused evaluation to improve assessment of the individual's risk in undergoing the procedure. Although age alone should not be the sole determinant for transplant eligibility, geriatric assessment often identifies vulnerabilities that are not captured in assessing performance status and comorbidities alone. Read More

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The Association Between Second-hand Smoke Exposure and Psychiatric Distress Among Naturally Pregnant Women and Pregnant Women After Assisted Reproductive Technology Treatment: a Birth Cohort Study.

Reprod Sci 2021 May 12. Epub 2021 May 12.

Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.

Second-hand smoke (SHS) has been shown to be associated with psychiatric distress in pregnant women spontaneously conceived (SC), but this has never been investigated in pregnant women with assisted reproductive technology (ART) treatment. This study aimed to investigate and compare the associations of SHS with psychiatric distress among SC and ART pregnant women. Participants (1467 SC and 857 ART women) were from the sub-study of Chinese National Birth Cohort (CNBC) in Anhui Province. Read More

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Therapist-Guided Internet-Delivered Cognitive Behavioral Therapy vs Internet-Delivered Supportive Therapy for Children and Adolescents With Social Anxiety Disorder: A Randomized Clinical Trial.

JAMA Psychiatry 2021 May 12. Epub 2021 May 12.

Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet and Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.

Importance: Social anxiety disorder (SAD) is a prevalent childhood-onset disorder associated with lifelong adversity and high costs for the individual and society at large. Cognitive behavioral therapy (CBT) is an established evidence-based treatment for SAD, but its availability is limited.

Objective: To assess the efficacy and cost-effectiveness of therapist-guided internet-delivered cognitive behavioral therapy (ICBT) for SAD in youths vs an active comparator, internet-delivered supportive therapy (ISUPPORT). Read More

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Associations between beta-blocker use and psychological distress in bereaved adults with cardiovascular conditions.

Stress Health 2021 May 11. Epub 2021 May 11.

Center for Research on End-of-Life Care, Weill Cornell Medicine, New York, NY, US.

The death of a close other is a major life stressor that disrupts mental and physical health. Beta-blocker medications are indicated treatments for cardiovascular conditions that may also mitigate psychological distress in the context of stressors by reducing adrenergic activity. We sought to examine observational links between beta-blocker medication use and psychological distress during bereavement. Read More

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Effect of a Digital Intervention on Depressive Symptoms in Patients With Comorbid Hypertension or Diabetes in Brazil and Peru: Two Randomized Clinical Trials.

JAMA 2021 05;325(18):1852-1862

CRONICAS Center of Excellence in Chronic Diseases, Universidad Peruana Cayetano Heredia, Lima, Peru.

Importance: Depression is a leading contributor to disease burden globally. Digital mental health interventions can address the treatment gap in low- and middle-income countries, but the effectiveness in these countries is unknown.

Objective: To investigate the effectiveness of a digital intervention in reducing depressive symptoms among people with diabetes and/or hypertension. Read More

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Secreted C-type lectin regulation of neuromuscular junction synaptic vesicle dynamics modulates coordinated movement.

J Cell Sci 2021 May 11;134(9). Epub 2021 May 11.

Department of Biological Sciences, Vanderbilt University and Medical Center, Nashville, TN 37235, USA.

The synaptic cleft manifests enriched glycosylation, with structured glycans coordinating signaling between presynaptic and postsynaptic cells. Glycosylated signaling ligands orchestrating communication are tightly regulated by secreted glycan-binding lectins. Using the Drosophila neuromuscular junction (NMJ) as a model glutamatergic synapse, we identify a new Ca2+-binding (C-type) lectin, Lectin-galC1 (LGC1), which modulates presynaptic function and neurotransmission strength. Read More

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Narrative reconstruction therapy for prolonged grief disorder - a pilot study.

Eur J Psychotraumatol 2021 Mar 30;12(1):1896126. Epub 2021 Mar 30.

Department of Psychology, Bar-Ilan University, Ramat Gan, Israel.

: Prolonged grief disorder (PGD) is a chronic and disabling condition that affects approximately 10% of non-traumatically bereaved people. Narrative reconstruction (NR), originally designed for the treatment of posttraumatic stress disorder (PTSD), is a time-limited integrative therapy consisting of exposure to the loss memory, detailed written reconstruction of the loss memory narrative, and an elaboration of the personal significance of that memory for the bereaved. : This pilot study examined the efficacy of NR therapy in reducing symptoms in bereaved people diagnosed with PGD. Read More

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L. as a Nutritional Strategy for Cardioprotection.

Front Physiol 2021 22;12:661778. Epub 2021 Apr 22.

Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.

This review aimed to provide a summary on the traditional uses, phytochemistry, and pharmacological activities in the cardiovascular system and cardiotoxicity of (MO), with the special emphasis on the protective mechanisms in different cardiovascular pathologies. MO is a perennial aromatic herb commonly known as lemon balm, honey balm, or bee balm, which belongs to family. Active components are mainly located in the leaves or essential oil and include volatile compounds, terpenoid (monoterpenes, sesquiterpenes, triterpenes), and polyphenolic compounds [rosmarinic acid (RA), caffeic acid, protocatechuic acid, quercitrin, rhamnocitrin, luteolin]. Read More

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Deciphering the role of physical activity in stress management during a global pandemic in older adult populations: a systematic review protocol.

Syst Rev 2021 05 7;10(1):140. Epub 2021 May 7.

Department of Gerontology, Simon Fraser University, Vancouver, V6B 5K3, Canada.

Background: The world has changed dramatically since the beginning of 2020 due to COVID-19. As a result of the pandemic, many older adults are now experiencing an increased and unprecedented amount of psychological stress. Physical activity has been found to be an evidence-based means of combating stress among older adults to promote their quality of life. Read More

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People with epilepsy still feel stigmatized.

Acta Neurol Scand 2021 May 7. Epub 2021 May 7.

National Centre for Epilepsy, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway.

Objectives: Those affected with epilepsy have long been subject to stigmatization. This may have manifold negative effects, for example social isolation, low self-esteem, reduced quality of life and worsening of seizures. In Norway educational programs have been arranged at the National Centre for Epilepsy, aiming at reducing stigma and shame associated with epilepsy, and thereby increase the quality of life for those affected and their families. Read More

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The role and mechanism of hyperoside against myocardial infarction in mice by regulating autophagy via NLRP1 inflammation pathway.

J Ethnopharmacol 2021 May 4;276:114187. Epub 2021 May 4.

Department of Pharmacology, School of Basic Medical Sciences, Anhui Medical University, No.81 Meishan Road, Hefei, 230032, People's Republic of China. Electronic address:

Ethnopharmacological Relevance: The genus Hypericum are widely distributed in China. Hypericum perforatum L. (genus Hypericum, family Hypericaceae) has a long history as a traditional Chinese medicine, which was traditionally used for the treatment of emotional distress, cardiothoracic depression, and acute mastitis. Read More

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Perceived stress, stressors, and coping strategies among nursing students in the Middle East and North Africa: an overview of systematic reviews.

Syst Rev 2021 May 5;10(1):136. Epub 2021 May 5.

Institute for Population Health, Weill Cornell Medicine-Qatar, Ar-Rayyan, Qatar.

Background: In nursing students, high stress levels can lead to burnout, anxiety, and depression. Our objective is to characterize the epidemiology of perceived stress, stressors, and coping strategies among nursing students in the Middle East and North Africa region.

Methods: We conducted an overview of systematic reviews. Read More

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Multidisciplinary program based on early management of psychological factors reduces disability of patients with subacute low back pain. Results of a randomised controlled study with one year follow-up.

Eur J Phys Rehabil Med 2021 May 5. Epub 2021 May 5.

Physical Medicine and Rehabilitation Unit, Scientific Institute of Lissone, Clinical and Scientific Institutes Maugeri, Institute of Care and Research, Lissone, Monza Brianza, Italy.

Background: Multidisciplinary rehabilitation induces disability improvement, pain reduction and favours return-to-work in patients with subacute low back pain (LBP). Current research advises additional high-quality trials.

Aim: To test the effect of a multidisciplinary rehabilitative programme incorporating cognitivebehavioural interventions compared to general physiotherapy alone to treat subacute LBP, and to appraise its long-term extent. Read More

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Differential paraventricular nucleus activation and behavioral responses to social isolation in prairie voles following environmental enrichment with and without physical exercise.

Soc Neurosci 2021 May 5. Epub 2021 May 5.

Department of Psychology, Northern Illinois University, DeKalb, IL, 60115.

Social stressors produce neurobiological and emotional consequences in social species. Environmental interventions, such as environmental enrichment and exercise, may modulate physiological and behavioral stress responses. The present study investigated the benefits of environmental enrichment and exercise against social stress in the socially monogamous prairie vole. Read More

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Advances in Nano-Enabled Platforms for the Treatment of Depression.

Polymers (Basel) 2021 Apr 29;13(9). Epub 2021 Apr 29.

Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, University of Witwatersrand, 7 York Road, Parktown, Johannesburg 2193, South Africa.

Nanotechnology has aided in the advancement of drug delivery for the treatment of several neurological disorders including depression. Depression is a relatively common mental disorder which is characterized by a severe imbalance of neurotransmitters. Several current therapeutic regimens against depression display drawbacks which include low bioavailability, delayed therapeutic outcome, undesirable side effects and drug toxicity due to high doses. Read More

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Gender-specific effects of adverse childhood experiences on incidence of activities of daily life disability in middle-age and elderly Chinese population.

Child Abuse Negl 2021 May 1;117:105079. Epub 2021 May 1.

State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, China; Key Laboratory of Health Technology Assessment of Fujian Province, School of Public Health, Xiamen University, Xiamen, China. Electronic address:

Background: Adverse Childhood Experiences (ACEs) may have long-lasting effects on late life health, probably through life-course mediators. However, whether such effects still exist when these mediators have been appropriately controlled is unclear.

Objectives: To estimate the controlled direct effect of ACEs on Activities of Daily Life (ADL) disability in middle-aged people and examine the gender-difference of this effect. Read More

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Hydrogen sulfide alleviates the anxiety-like and depressive-like behaviors of type 1 diabetic mice via inhibiting inflammation and ferroptosis.

Life Sci 2021 May 1:119551. Epub 2021 May 1.

School of Medicine and State Key Laboratory of Medicinal Chemical Biology, Nankai University, 94 Weijin Road, Tianjin 300071, China. Electronic address:

Studies reported that sodium hydrosulfide (NaHS) can remit the depressive-like and anxiety-like behaviors induced by type 1 diabetes mellitus (T1DM). However, the mechanism is still unclear. In this study, we aimed to investigate the mechanism of NaHS on T1DM. Read More

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Exercise Reduces Pain and Deleterious Histological Effects in Fibromyalgia-like Model.

Neuroscience 2021 May 1;465:46-59. Epub 2021 May 1.

Laboratory of Autoimmunity and Immunopharmacology (LAIF), Department of Health Sciences, Campus Araranguá, Universidade Federal de Santa Catarina, 88906-072 Araranguá, Brazil; Post-Graduate Program of Neuroscience, Center of Biological Science, Campus Florianópolis, Universidade Federal de Santa Catarina, 88040-900 Florianópolis, Brazil. Electronic address:

Fibromyalgia (FM) is characterized by chronic pain and associated comorbidities such as fatigue, anxiety, depression, and sleep disorders. There is a large amount of evidence regarding the benefits of physical exercise in controlling chronic pain. However, there is no consensus on which exercise modality is most suitable and the real benefits of this intervention to treat FM symptoms. Read More

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The role of organizational supports in mitigating mental ill health in firefighters: A cohort study in Alberta, Canada.

Am J Ind Med 2021 May 4. Epub 2021 May 4.

Division of Preventive Medicine, University of Alberta, Edmonton, Alberta, Canada.

Introduction: Little is known about the effectiveness of ongoing mental health support in reducing the mental health impacts of a traumatic deployment.

Methods: A cohort of firefighters was established among those deployed to a devastating wildfire in Alberta, Canada in May 2016. Firefighters completed three questionnaires: at recruitment giving details of exposures, a first follow-up reporting mental health supports before, during, and after the fire and a second follow-up, at least 30 months after the fire, with screening questionnaires for anxiety, depression, and posttraumatic stress disorder (PTSD). Read More

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Cognitive Behavioral Therapy for Prodromal Stage of Psychosis-Outcomes for Transition, Functioning, Distress, and Quality of Life: A Systematic Review and Meta-analysis.

Schizophr Bull 2021 May 4. Epub 2021 May 4.

Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Objective: This study aimed to provide insight into the efficacy of cognitive-behavioral therapy for psychosis (CBTp) in patients with "clinical high risk of psychosis (CHR-P)".

Methods: Major scientific databases were searched up to April 17, 2020. Randomized controlled trials in CHR-P individuals, comparing CBTp with needs-based interventions (NBI, including treatment as usual or nonspecific control treatment) were included, following PRISMA guidelines. Read More

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