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Association of hypertension with infection and inflammation in a setting of disadvantage in rural India.

J Hum Hypertens 2021 Sep 17. Epub 2021 Sep 17.

Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Melbourne, VIC, Australia.

We assessed the association of hypertension with markers of inflammation and infection in a rural and disadvantaged Indian population. In a case-control study, we age- and gender-matched 300 cases with hypertension to 300 controls without hypertension. Blood pressure was measured according to a strict protocol. Read More

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September 2021

Benefit of an Internet-Based Management System among Hemodialysis Patients at the Risk of Intradialytic Hypotension and Muscle Cramps: A Controlled before and after Study.

Blood Purif 2021 Sep 15:1-8. Epub 2021 Sep 15.

Department of Nephrology, Hebei Key Laboratory of Vascular Calcification in Kidney Disease, Hebei Clinical Research Center for Chronic Kidney Disease, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.

Background: The purpose of this study was to observe the impact of an internet-based management system on the incidence of intradialytic hypotension (IDH) and muscle cramps in hemodialysis patients.

Methods: The patients, who underwent maintenance hemodialysis in the center from January 2018 to June 2020, were recruited and divided into the pre-intervention group (before operation of the internet-based hemodialysis management system, from January 2018 to December 2018) and intervention group (after operation of the system, from June 2019 to June 2020). The clinical outcomes were compared between groups. Read More

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September 2021

Effects of Hydroxychloroquine on endOthelial function in eLDerly with sleep apnea (HOLD): study protocol for a randomized clinical trial.

Trials 2021 Sep 17;22(1):638. Epub 2021 Sep 17.

Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.

Background: Sleep apnea and coronary artery disease are prevalent and relevant diseases. The mechanism by which sleep apnea leads to coronary artery disease remains unclear. Intermittent hypoxia, caused by sleep apnea, leads to inflammation and consequent endothelial dysfunction. Read More

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September 2021

Heat stable carbetocin vs. oxytocin for the prevention of post-partum hemorrhage in emergency caesarean delivery: a randomized controlled trial.

J Perinat Med 2021 Sep 20. Epub 2021 Sep 20.

Department of Obstetrics and Gynaecology, Al Kindy College of Medicine, University of Baghdad, Elwiyah Maternity Teaching Hospital, Iraqi Board for Medical Specializations, Baghdad, Iraq.

Objectives: To evaluate the uterotonic effect of carbetocin compared with oxytocin in emergency cesarean delivery in Iraq.

Methods: A double-blinded randomized noninferiority single center trial. Three-hundred patients were systematically randomized to intravenous bolus injection of 10 IU oxytocin or 100 mcg carbetocin after delivery in a ratio of 2:1. Read More

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September 2021

Effects of Breaking Up Prolonged Sitting on Cardiovascular Parameters: A systematic Review.

Int J Sports Med 2021 Sep 17. Epub 2021 Sep 17.

Post-graduate Program in Rehabilitation Sciences, Universidade Nove de Julho, Sao Paulo, Brazil.

The aim of this systematic review was to analyze the acute and chronic effects of sitting breaks on cardiovascular parameters. PubMed and Web of Science databases were searched by two independent researchers for relevant studies published until February 2020. Acute or chronic studies reporting the effects of sitting breaks or reduction in sitting time on cardiovascular parameters were examined. Read More

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September 2021

Phytomelatonin: a potential phytotherapeutic intervention on COVID-19-exposed individuals.

Microbes Infect 2021 Sep 14:104886. Epub 2021 Sep 14.

School of Environment and Safety Engineering, Jiangsu University, 212013 P.R. China; Department of Zoology and Environmental Biology, University of Nigeria, Nsukka, 410001, Enugu State, Nigeria; Biofuels Institute, Jiangsu University, Zhenjiang, 212013 P.R. China; Organization of African Academic Doctors (OAAD), Off Kamiti Road, 25305000100, Nairobi, Kenya. Electronic address:

Phytomelatonin is a pleiotropic molecule that originated in higher plants with many diverse actions and is primarily an antioxidant. The recent identification and advancement of phytomelatonin unraveled the potential of this modulatory molecule being considered a new plant hormone, suggesting its relevance in treating respiratory infections, including COVID-19. Besides, this molecule is also involved in multiple hormonal, physiological, and biological processes at different levels of cell organization and has been marked for its ability to cross the blood-brain barrier and prominent antioxidant effects, reducing mitochondrial electron leakage, up-regulating antioxidant enzymes, acting as a free radical scavenger, and interfering with pro-inflammatory signaling pathways as seen in mood swings, body temperature, sleep, cancer, cardiac rhythms, and immunological regulation modulators. Read More

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September 2021

Similar Ferroportin Q248H polymorphism prevalence in patients with Plasmodium falciparum malaria and control subjects in the low-endemic setting of Botswana.

Clin Chim Acta 2021 Sep 14. Epub 2021 Sep 14.

School of Allied Health Professions, Faculty of Health Sciences, University of Botswana, Gaborone, Botswana. Electronic address:

Introduction: Recent evidence suggests that ferroportin (FPN) Q248H may confer a survival advantage against malaria by reducing erythrocytic intracellular iron in Africans. We investigated if FPN Q248H mutation, that is prevalent in Batswana, is a factor in limiting the susceptibility to Plasmodium falciparum malaria.

Methods: 264 archived dried blood spot samples (183 P. Read More

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September 2021

Preventing Postpartum Hemorrhage After Cesarean Delivery: A Network Meta-Analysis of Available Pharmacologic Agents.

Am J Obstet Gynecol 2021 Sep 14. Epub 2021 Sep 14.

Department of Anesthesiology, Division of Obstetrical Anesthesiology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA. Electronic address:

Background: Postpartum hemorrhage causes a quarter of global maternal deaths. WHO recommends oxytocin as the first line agent to prevent hemorrhage at cesarean delivery. However, some randomized controlled trials suggest other uterotonics are superior. Read More

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September 2021

Effects of a low-carbohydrate ketogenic diet on reported pain, blood biomarkers and quality of life in patients with chronic pain: A pilot randomised clinical trial.

Pain Med 2021 Sep 17. Epub 2021 Sep 17.

The University of Sydney, Faculty of Medicine and Health, NSW Australia.

Background: A low-carbohydrate ketogenic diet has been reported to improve chronic pain by reducing inflammation, oxidative stress, and sensitivity within the nervous system. The main aim of this trial is to evaluate the effects of a ketogenic diet on reported pain, blood biomarkers and quality of life in patients with chronic pain.

Methods: Participants with chronic musculoskeletal pain were recruited for a 12-week diet intervention that commenced with a 3-week run-in diet removing ultra-processed foods, followed by randomisation to either a whole-food/well-formulated ketogenic diet (WFKD) or to continue with the minimally processed whole-food diet (WFD). Read More

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September 2021

Immunosurveillance and molecular detection of hepatitis B virus infection amongst vaccinated children in the West Gonja District in Savanna Region of Ghana.

PLoS One 2021 17;16(9):e0257103. Epub 2021 Sep 17.

Department of Clinical Microbiology, School of Medicine and Dentistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.

Hepatitis B vaccination is the most effective preventive measure in reducing the incidence of chronic hepatitis B virus (HBV) infection and its consequences such as cirrhosis, hepatocellular carcinoma, liver failure and death. Ghana introduced the universal HBV vaccination in the national Expanded Programme on Immunization in 2002. The current study sought to determine the sero-protection rate and the prevalence of HBV infection among fully vaccinated children in the West Gonja District in the Savanna Region of Ghana. Read More

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September 2021

Cost-effectiveness of a Digital Health Intervention for Acute Myocardial Infarction Recovery.

Med Care 2021 Sep 17. Epub 2021 Sep 17.

Johns Hopkins Bloomberg School of Public Health Johns Hopkins University School of Nursing Digital Health Innovation Laboratory, Ciccarone Center for the Prevention of Cardiovascular Disease, Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine Johns Hopkins University School of Medicine, Baltimore, MD Department of Pharmaceutical & Health Economics, School of Pharmacy, University of Southern California Leonard D. Schaeffer Center for Health Economics & Policy, University of Southern California, Los Angeles, CA Dimock Center Johns Hopkins University Whiting School of Engineering, Baltimore, MD Massachusetts General Hospital, Boston, MA Reading Hospital, West Reading, PA Harvard Medical School, Boston, MA Johns Hopkins University Krieger School of Arts and Sciences Johns Hopkins Health System, Baltimore, MD.

Background: Acute myocardial infarction (AMI) is a common cause of hospital admissions, readmissions, and mortality worldwide. Digital health interventions (DHIs) that promote self-management, adherence to guideline-directed therapy, and cardiovascular risk reduction may improve health outcomes in this population. The "Corrie" DHI consists of a smartphone application, smartwatch, and wireless blood pressure monitor to support medication tracking, education, vital signs monitoring, and care coordination. Read More

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September 2021

Trends in Differences Across Subgroups of Adults in Preventive Services Utilization.

Salam Abdus

Med Care 2021 Sep 17. Epub 2021 Sep 17.

Agency for Healthcare Research and Quality, Department of Health and Human Services, Center for Financing, Access, and Cost Trends, Division of Research and Modeling, Rockville, MD.

Background: There were large differences across subgroups of adults in preventive services utilization before 2010. The Affordable Care Act had numerous provisions aimed at increasing utilization as well as at reducing disparities.

Objective: This study examines whether preventive services utilization changed over time, across subgroups of adults defined by race/ethnicity, insurance coverage, poverty status, Census region, and urbanicity. Read More

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September 2021

Effectiveness of a Gamification Strategy to Prevent Childhood Obesity in Schools: A Cluster Controlled Trial.

Obesity (Silver Spring) 2021 Sep 17. Epub 2021 Sep 17.

Health Service & Population Research Department, Institute of Psychiatry, Psychology Neuroscience, King's College, London, UK.

Objective: The aim of this study was to examine the effectiveness of a school-based gamification strategy to prevent childhood obesity.

Methods: Schools were randomized in Santiago, Chile, between March and May 2018 to control or to receive a nutrition and physical activity intervention using a gamification strategy (i.e. Read More

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September 2021

Combination of Activating Blood Circulation and Detoxifying Chinese Medicines Played an Anti-Inflammatory Role in Unstable Angina Patients after Percutaneous Coronary Intervention: A Multicenter, Open-Labeled, Randomized Controlled Trial.

Chin J Integr Med 2021 Sep 16. Epub 2021 Sep 16.

National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China.

Objective: To investigate the combined anti-inflammatory effect of activating blood circulation and detoxifying Chinese medicines in unstable angina (UA) patients.

Methods: This study was an open-labeled, randomized controlled trial conducted in 5 centers in Beijing. A total of 154 patients were randomized into two groups at a 1:1 ratio by random numbers. Read More

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September 2021

Vitamin C reduces vancomycin-related nephrotoxicity through the inhibition of oxidative stress, apoptosis, and inflammation in mice.

Ann Transl Med 2021 Aug;9(16):1319

Department of Pharmacy, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background: Vancomycin (VCM) is an antibiotic widely used to treat a range of serious bacterial infections; however, it is associated with nephrotoxicity. Vitamin C (VC) is a classical antioxidant that can alleviate various organ injuries and inflammatory responses by reducing inflammation and oxidative stress. This study aimed to examine the effect of VC on VCM-related nephrotoxicity in mice. Read More

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Novel nanoliposomes alleviate contrast-induced acute kidney injury in New Zealand rabbits by mediating inflammatory response.

Ann Transl Med 2021 Aug;9(15):1250

Department of Cardiology, Tianjin Chest Hospital, Tianjin, China.

Background: The purpose of the research was to investigate the preventive effect of nanoliposomes on contrast-induced nephropathy (CIN) in New Zealand rabbits and to provide a theoretical basis for clinically effective prevention and treatment of CIN and the development of new contrast agents.

Methods: A total of 48 New Zealand rabbits were divided into four groups randomly, there were 12 rabbits in eacj group: (I) control group; (II) contrast group; (III) hydration prevention group; and (IV) nanoliposome group. The changes of serum creatinine (SCr) and blood urea nitrogen (BUN) were messured before and after injection of iopromide. Read More

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Hepatoprotective effects of flavonoids from common buckwheat hulls in type 2 diabetic rats and HepG2 cells.

Food Sci Nutr 2021 Sep 7;9(9):4793-4802. Epub 2021 Jul 7.

College of Food Science and Engineering Jilin Agricultural University Changchun China.

Flavonoids from common buckwheat hulls (BHFs) show significant antioxidant and antidiabetic potential. However, their hepatoprotective property is yet to be defined. This study aims to examine the hepatoprotective effect of BHFs in type 2 diabetes mellitus (T2DM) rats and chronic high glucose-damaged HepG2 cells. Read More

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September 2021

Protective mechanism of Erigeron breviscapus injection on blood-brain barrier injury induced by cerebral ischemia in rats.

Sci Rep 2021 Sep 16;11(1):18451. Epub 2021 Sep 16.

College of Ethnomedicine, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, Sichuan, China.

This study investigates the protective effect of Erigeron breviscapus injection, a classic traditional Chinese medicine most typically used by Chinese minority to treat stroke, on cerebral ischemia-reperfusion injury and the related signaling pathways. Use network pharmacology methods to study the relationship between E. breviscapus (Vant. Read More

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September 2021

Outcomes of human umbilical cord blood-derived mesenchymal stem cells in enhancing tendon-graft healing in anterior cruciate ligament reconstruction: an exploratory study.

Knee Surg Relat Res 2021 Sep 16;33(1):32. Epub 2021 Sep 16.

Department of Orthopaedic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, 06351, Korea.

Background: The study investigated whether allogeneic human umbilical cord blood-derived MSCs (hUCB-MSCs) could be safely used without treatment-related adverse events, reducing tunnel enlargement, and improve clinical results in human anterior cruciate ligament (ACL) reconstruction.

Methods: Thirty patients were enrolled consecutively. They were divided into three groups by randomization. Read More

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September 2021

Mesenchymal stromal cell aging impairs the self-organizing capacity of lung alveolar epithelial stem cells.

Elife 2021 09 16;10. Epub 2021 Sep 16.

John W. Deming Department of Medicine, Tulane University School of Medicine, New Orleans, United States.

Multicellular organisms maintain structure and function of tissues/organs through emergent, self-organizing behavior. In this report, we demonstrate a critical role for lung mesenchymal stromal cell (L-MSC) aging in determining the capacity to form three-dimensional organoids or 'alveolospheres' with type 2 alveolar epithelial cells (AEC2s). In contrast to L-MSCs from aged mice, young L-MSCs support the efficient formation of alveolospheres when co-cultured with young or aged AEC2s. Read More

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September 2021

[Treatment of a patient with acute thoracoabdominal aortic dissection complicated by haemothorax].

Angiol Sosud Khir 2021 ;27(3):140-145

Research Laboratory of Vascular and Hybrid Surgery of the Research Department of Vascular and Interventional Surgery, National Almazov Medical Research Centre, RF Ministry of Public Health, Saint Petersburg, Russia.

Total left-sided haemothorax is a rare and severe complication of acute DeBakey type III aortic dissection. The primary aim of treatment is immediate arrest of haemorrhage and stabilization of the haemodynamic status of the patient. Endovascular isolation of the ruptured thoracic portion of the aorta using a stent graft (TEVAR) has recently become the 'gold standard' in treatment of acute, rupture-complicated aortic dissections of this localization. Read More

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September 2021

Triterpenoid acids from medicinal mushroom Inonotus obliquus (Chaga) alleviate hyperuricemia and inflammation in hyperuricemic mice: Possible inhibitory effects on xanthine oxidase activity.

J Food Biochem 2021 Sep 15:e13932. Epub 2021 Sep 15.

Department of Pharmacy, Wuhan City Central Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

The purpose of this study was to explore the hypouricemic effect in hyperuricemia mice of triterpenoid acids from Inonotus obliquus (TAIO), and decipher of the underlying xanthine oxidase inhibitory mechanism. Measurement of xanthine oxidase (XO) inhibitory activity was assayed. Organ indexes and serum biochemical indicators were measured in potassium oxonate-induced hyperuricemia mice. Read More

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September 2021

Dietary patterns and cardiometabolic risks in diverse less-developed ethnic minority regions: results from the China Multi-Ethnic Cohort (CMEC) Study.

Lancet Reg Health West Pac 2021 Oct 20;15:100252. Epub 2021 Aug 20.

West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.

Background In Western developed countries, food-based dietary patterns have been associated with the risk of cardiometabolic diseases, but little is known about such associations in less developed ethnic minority regions (LEMRs), where the cardiometabolic disease burden is growing rapidly and food patterns differ substantially. Methods Between May 2018 and September 2019, we recruited 99556 participants aged 30-79 years from the China Multi-Ethnic Cohort (CMEC) Study. We measured habitual dietary intake with validated food frequency questionnaire (FFQ) and then calculated dietary pattern scores for two of the most studied a priori dietary patterns, i. Read More

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October 2021

Pathological Significance and Prognostic Roles of Indirect Bilirubin/Albumin Ratio in Hepatic Encephalopathy.

Front Med (Lausanne) 2021 30;8:706407. Epub 2021 Aug 30.

Guangzhou Municipal and Guangdong Provincial Key Lab of Protein Modification and Degradation Lab, State Key Lab of Respiratory Disease, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, China.

Hepatic encephalopathy (HE) is a neurological disease caused by severe liver disease. Early identification of the risk factor is beneficial to the prevention and treatment of HE. Free bilirubin has always been considered to be the culprit of neonatal kernicterus, but there is no research to explore its role in HE. Read More

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Differences in faecal microbiome composition between adult patients with UCD and PKU and healthy control subjects.

Mol Genet Metab Rep 2021 Dec 8;29:100794. Epub 2021 Sep 8.

Department of Dietetics and Nutritional science and Department of Endocrinology and Metabolism, Amsterdam University Medical Centers, Amsterdam, the Netherlands.

Urea cycle disorders (UCDs) are a group of rare inherited metabolic diseases causing hyperammonemic encephalopathy. Despite intensive dietary and pharmacological therapy, outcome is poor in a subset of UCD patients. Reducing ammonia production by changing faecal microbiome in UCD is an attractive treatment approach. Read More

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December 2021

Overview of Sodium-Glucose Co-transporter 2 (SGLT2) Inhibitors for the Treatment of Non-diabetic Heart Failure Patients.

Cureus 2021 Aug 12;13(8):e17118. Epub 2021 Aug 12.

Medical Biology and Genetics, Bukovinian State Medical University, Chernivtsi, UKR.

Heart failure (HF) is a clinical syndrome that results from any structural or functional impairment of ventricular filling or ejection of blood, and results in low life quality and expectancy, creating a significant burden on the healthcare system. The pharmacological HF management has remained unchanged for a decade, however, several randomized clinical trials have demonstrated the potential clinical benefits of sodium-glucose cotransporter-2 inhibitors, an antidiabetic agent, by reducing the rate of hospitalizations for HF, cardiovascular death, and all-cause death. The cardioprotective effects are characterized by reduction of inflammatory, metabolic and ionic dyshomeostasis despite the diabetic status. Read More

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Tai Chi as a Therapy of Traditional Chinese Medicine on Reducing Blood Pressure: A Systematic Review of Randomized Controlled Trials.

Evid Based Complement Alternat Med 2021 4;2021:4094325. Epub 2021 Sep 4.

Guang'anmen Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, China.

Objective: This study systematically evaluated the effects of Tai Chi exercise on blood pressure, body mass index (BMI), and quality of life (QOL) in patients with hypertension. A meta-analysis was performed to provide a reliable reference for clinical practice.

Methods: We searched for randomized controlled trials (RCTs) in five English databases and two Chinese databases, with the earliest data dated December 5, 2020. Read More

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September 2021

A Retrospective Study of Malaria Trend in Libokemkem District Over the Last Five Years: North West Ethiopia.

Infect Drug Resist 2021 9;14:3683-3691. Epub 2021 Sep 9.

Department of Medical Laboratory, Debre Tabor University, Debre Tabor Town, Ethiopia.

Background: Malaria is a vector-borne disease caused by public health important species. Despite the fact that Ethiopia has implemented several malaria prevention and control techniques aimed at reducing its morbidity and death, it continues as major cause of morbidity and mortality in Ethiopia. Transmission dynamics are really critical for guiding the selection of the appropriate intervention in a given area. Read More

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September 2021

Comparison of interventions and outcomes of enhanced recovery after surgery: a systematic review and meta-analysis of 2456 adolescent idiopathic scoliosis cases.

Eur Spine J 2021 Sep 15. Epub 2021 Sep 15.

Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.

Purpose: The objective of this meta-analysis and systematic review is to compare the methodology and evaluate the efficacy of Enhanced recovery after Spine Surgery (ERAS) for adolescent idiopathic scoliosis (AIS) and to compare the outcomes with traditional discharge (TD) pathways.

Methods: Using major databases, a systematic search was performed. Studies comparing the implementation of ERAS or ERAS-like and TD pathways in patients with AIS were identified. Read More

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September 2021

[Effectiveness and safety of tranexamic acid combined with intraoperative controlled hypotension on reducing perioperative blood loss in primary total hip arthroplasty].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2021 Sep;35(9):1133-1140

Department of Orthopedics, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China.

Objective: To evaluate the effectiveness and safety of tranexamic acid (TXA) combined with intraoperative controlled hypotension (ICH) for reducing perioperative blood loss in primary total hip arthroplasty (THA).

Methods: The clinical data of 832 patients with initial THA due to osteonecrosis of femoral head between January 2017 and July 2020 were retrospectively analyzed. All patients received TXA treatment, and 439 patients (hypotension group) received ICH treatment with an intraoperative mean arterial pressure (MAP) below 80 mm Hg (1 mm Hg=0. Read More

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September 2021