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Organics removal and microbial interaction attributes of zeolite and ceramsite assisted bioretention system in copper-contaminated stormwater treatment.

J Environ Manage 2021 May 8;292:112654. Epub 2021 May 8.

College of Environment, Hohai University, 210098, PR China.

Bioretention has been increasingly used recently to treat heavy metals contaminated stormwater. However, less is known about how metal accumulation influences microbial performance and organics removal mechanisms in different layers of the bioretention system. Two lab-scale bioretention columns (i. Read More

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Effects of organic loading rate and hydraulic retention time on bioaugmentation performance to tackle ammonia inhibition in anaerobic digestion.

Bioresour Technol 2021 Apr 30;334:125246. Epub 2021 Apr 30.

Department of Hydraulics, Soil Science and Agricultural Engineering, School of Agriculture, Aristotle University of Thessaloniki, Thessaloniki GR-54124, Greece. Electronic address:

Three continuously stirred-tank reactors fed with manure operating under high ammonia levels (5.0 g NH-N L) and with increased organic loading rate (OLR), (2.09 R1, 3. Read More

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Healthcare utilization and cost outcomes for a multicenter first seizure and new onset epilepsy clinic.

Epilepsy Behav 2021 May 7;120:107972. Epub 2021 May 7.

Western University of Health Sciences College of Osteopathic Medicine of the Pacific, Northwest, 200 Mullins Dr, Lebanon, OR 97355, United States; Providence Brain and Spine Institute, 9135 SW Barnes Rd., Suite 363, Portland, OR 97225, United States.

Rationale: A First Seizure/New Onset Epilepsy (FS/NOE) protocol was implemented to ensure proper evaluation by an epileptologist and improve overall care for patients. We compared healthcare utilization and cost incurred by patients pre and post protocol implementation.

Methods: Clinical data were retrospectively collected from the EMR and cost data from the financial database. Read More

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eGFR Variability in Patients with Heart Failure and Chronic Kidney Disease.

J Card Fail 2021 May 7. Epub 2021 May 7.

Department of Medicine, Duke University School of Medicine, Durham, NC; Duke Clinical Research Institute, Durham, NC. Electronic address:

Background: Greater variability in estimated glomerular filtration rate (eGFR) is associated with higher mortality in patients with chronic kidney disease (CKD). Heart failure (HF) is common in CKD and may increase variability through changes in hemodynamic and volume regulation. We sought to determine if patients with versus without HF have higher kidney function variability in CKD, and to define the association with mortality. Read More

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Exosomal circ_0030167 derived from BM-MSCs inhibits the invasion, migration, proliferation and stemness of pancreatic cancer cells by sponging miR-338-5p and targeting the Wif1/Wnt8/β-catenin axis.

Cancer Lett 2021 May 7. Epub 2021 May 7.

Research Center of Clinical Medical and Department of General Surgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu province, 226001, PR China. Electronic address:

Pancreatic cancer (PC) is one of the most lethal malignant tumors and has the lowest survival rate due to early metastasis and drug resistance. Exosomes derived from bone marrow mesenchymal stem cells (BM-MSCs) have emerged as crucial regulators of the progression of various tumors. These vesicles contain abundant circRNAs that have important biological functions. Read More

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First experimental evaluation of multi-target multileaf collimator tracking during volumetric modulated arc therapy for locally advanced prostate cancer.

Radiother Oncol 2021 May 7. Epub 2021 May 7.

ACRF Image X Institute, University of Sydney School of Health Sciences, Sydney, Australia; Northern Sydney Cancer Centre, Royal North Shore Hospital, Sydney, Australia; School of Biomedical Engineering, University of Technology Sydney, NSW, Australia.

Purpose: Locally advanced and oligometastatic cancer patients require radiotherapy treatment to multiple independently moving targets. There is no existing commercial solution that can simultaneously track and treat multiple targets. This study experimentally implemented and evaluated a real-time multi-target tracking system for locally advanced prostate cancer. Read More

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Neurophysiological and autonomic responses of high and low level chess players during difficult and easy chess endgames - a quantitative EEG and HRV study.

Physiol Behav 2021 May 7:113454. Epub 2021 May 7.

Faculty of Sport Science, University of Extremadura, Avda: Universidad S/N, 10003, Cáceres, Spain. Electronic address:

The aim of the present study was to analyze the heart rate variability (HRV) and the electroencephalographic (EEG) power spectrum in low and high performance chess players during easy and difficult chess endgames. A total of 28 chess players participated in this cross-sectional study. Participants were divided into two groups according to their ELO level (rating system used by the international chess federation): 1) high level chess players (more than 1600 of ELO score); and 2) low level chess players (ELO less than 1599 of ELO score). Read More

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Stability evaluation and formula optimization of cellulose-based scaffold for the air-liquid interface cultivation of Navicula incerta.

Environ Res 2021 May 7:111298. Epub 2021 May 7.

School of Chemical Engineering, Engineering Campus, Universiti Sains Malaysia, 14300, Nibong Tebal, Pulau Pinang, Malaysia. Electronic address:

Culture scaffolds allow microalgae cultivation with minimum water requirement using the air-liquid interface approach. However, the stability of cellulose-based scaffolds in microalgae cultivation remains questionable. In this study, the stability of regenerated cellulose culture scaffolds was enhanced by adjusting TiO loading and casting gap. Read More

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Mitigation of endemic GI-tract pathogen-mediated inflammation through development of multimodal treatment regimen and its impact on SIV acquisition in rhesus macaques.

PLoS Pathog 2021 May 10;17(5):e1009565. Epub 2021 May 10.

Infectious Disease Resource, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, United States of America.

Here, we assessed the efficacy of a short-course multimodal therapy (enrofloxacin, azithromycin, fenbendazole, and paromomycin) to eliminate common macaque endemic pathogens (EPs) and evaluated its impact on gastrointestinal (GI) microbiota, mucosal integrity, and local and systemic inflammation in sixteen clinically healthy macaques. Treatment combined with expanded practices resulted in successful maintenance of rhesus macaques (RM) free of common EPs, with no evidence of overt microbiota diversity loss or dysbiosis and instead resulted in a more defined luminal microbiota across study subjects. Creation of a GI pathogen free (GPF) status resulted in improved colonic mucosal barrier function (histologically, reduced colonic MPO+, and reduced pan-bacterial 16s rRNA in the MLN), reduced local and systemic innate and adaptive inflammation with reduction of colonic Mx1 and pSTAT1, decreased intermediate (CD14+CD16+) and non-classical monocytes (CD14-CD16+), reduced populations of peripheral dendritic cells, Ki-67+ and CD38+ CD4+ T cells, Ki-67+IgG+, and Ki-67+IgD+ B cells indicating lower levels of background inflammation in the distal descending colon, draining mesenteric lymph nodes, and systemically in peripheral blood, spleen, and axillary lymph nodes. Read More

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Long-term outcome of 177Lu-PSMA-617 radioligand therapy in heavily pre-treated metastatic castration-resistant prostate cancer patients.

PLoS One 2021 10;16(5):e0251375. Epub 2021 May 10.

Department of Nuclear Medicine, Thyroid Clinic, AIIMS, Ansari Nagar, New Delhi, India.

Objective: Investigators have extensively explored the short-term safety and efficacy data on 177Lu-PSMA-617 radioligand therapy (RLT) in mCRPC patients. However, scarce literature is reported on the long-term outcome of these patients. The current goal of this study is focused on the long-term outcome of mCRPC patients treated with 177Lu-PSMA-617 RLT. Read More

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An efficient post-processing adaptive filtering technique to rectifying the flickering effects.

PLoS One 2021 10;16(5):e0250959. Epub 2021 May 10.

Department of Computer Science and Engineering, Soonchunhyang University, Asan, Korea.

Compression at a very low bit rate(≤0.5bpp) causes degradation in video frames with standard decoding algorithms like H.261, H. Read More

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Chaperone-mediated autophagy controls the turnover of E3 ubiquitin ligase MARCHF5 and regulates mitochondrial dynamics.

Autophagy 2020 Dec 1:1-16. Epub 2020 Dec 1.

Department of Neurology, First Affiliated Hospital of GuangZhou Medical University, Guangzhou, Guangdong, China.

As a highly dynamic organelle, mitochondria undergo constant fission and fusion to change their morphology and function, coping with various stress conditions. Loss of the balance between fission and fusion leads to impaired mitochondria function, which plays a critical role in the pathogenesis of Parkinson disease (PD). Yet the mechanisms behind mitochondria dynamics regulation remain to be fully illustrated. Read More

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December 2020

Prolonged care delivery time and reduced rate of electrophysiological procedures during the lockdown period due to Covid-19 Outbreak.

Expert Rev Med Devices 2021 May 10. Epub 2021 May 10.

Cardiology and Electrophysiology Unit, S. Maria Nuova Hospital, Florence, Italy.

: The aim of this study is to demonstrate how Electrophysiology activity has been impacted by the pandemic Coronavirus disease 2019 (COVID-19).: In this multicenter retrospective study, we analyze all consecutive patients admitted for electrophysiological procedures during the Covid-19 lockdown in the Tuscany region of Italy, comparing them to patients hospitalised in the corresponding period of the previous year.: The impact of COVID-19 on cardiac arrhythmia management was impressive, with a reduction of more than 50% in all kinds of procedures. Read More

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Surfactant therapy via thin catheter in preterm infants with or at risk of respiratory distress syndrome.

Cochrane Database Syst Rev 2021 May 10;5:CD011672. Epub 2021 May 10.

Department of Paediatrics, Royal Hobart Hospital, Hobart, Australia.

Background: Non-invasive respiratory support is increasingly used for the management of respiratory dysfunction in preterm infants. This approach runs the risk of under-treating those with respiratory distress syndrome (RDS), for whom surfactant administration is of paramount importance. Several techniques of minimally invasive surfactant therapy have been described. Read More

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The rationale for selenium supplementation in patients with autoimmune thyroiditis, according to the current state of knowledge.

Endokrynol Pol 2021 ;72(2):153-162

Department of Endocrinology, Metabolism, and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland.

Selenium (Se) supplements are commonly prescribed to autoimmune thyroiditis (AIT) patients by European endocrinologists, despite the lack of official guidelines. The majority of Europe is depleted of natural Se sources, and the daily population intake does not comply with recommended values. Optimal individual plasma Se concentration is reached when the selenoproteins (selenoprotein P, glutathione peroxidase) are fully saturated. Read More

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January 2021

Povidone-iodine irrigation combined with Vancomycin powder lowers infection rates in pediatric deformity surgery.

Spine Deform 2021 May 10. Epub 2021 May 10.

Department of Orthopedics University of California, Davis, Sacramento, USA.

Background: Surgical site infection is a morbid, devastating complication after spinal procedures. Studies have investigated the effect of wound lavage with 3.5% Povidone-iodine solution or the use of intrawound Vancomycin powder. Read More

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Spider mite resistance to miticides in South Carolina strawberry and implications for improved integrated pest management.

Exp Appl Acarol 2021 May 10. Epub 2021 May 10.

USDA-ARS, Temperate Tree Fruit and Vegetable Research Unit, Wapato, WA, 98951, USA.

Tetranychus urticae Koch (Acari: Tetranychidae), twospotted spider mite, is a major secondary pest of strawberry and can cause significant yield loss. Tetranychus urticae is typically controlled using miticides, which has led to rapid resistance development. In South Carolina (USA), extension agents and growers have reported field failures of miticides (inadequate pest suppression), but resistance has not been quantitatively determined. Read More

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Autologous platelet-rich plasma repairs burn wound and reduces burn pain in rats.

J Burn Care Res 2021 May 10. Epub 2021 May 10.

Department of transfusion medicine, PLA Rocket Force Characteristic Medical Center, Beijing, China.

Objective: To investigate the effects of autologous platelet-rich plasma (PRP) on burn wound and burn pain in rats.

Methods: Rats were treated with high-temperature copper rod to induce skin burn. During treatment, the wound area of rats was recorded on days 0, 3, 7, 10, 14 and healing rates were calculated. Read More

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Association of a Marker of N-Acetylglucosamine With Progressive Multiple Sclerosis and Neurodegeneration.

JAMA Neurol 2021 May 10. Epub 2021 May 10.

Department of Neurology, University of California, Irvine, Irvine.

Importance: N-glycan branching modulates cell surface receptor availability, and its deficiency in mice promotes inflammatory demyelination, reduced myelination, and neurodegeneration. N-acetylglucosamine (GlcNAc) is a rate-limiting substrate for N-glycan branching, but, to our knowledge, endogenous serum levels in patients with multiple sclerosis (MS) are unknown.

Objective: To investigate a marker of endogenous serum GlcNAc levels in patients with MS. Read More

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Effects of Implementing a Higher Threshold for Recommending Thyroid Biopsies on Malignancy Rates.

Perm J 2021 May;25

Hawaii Permanente Medical Group, Honolulu, HI.

Introduction: We implemented a new thyroid nodule classification system in which a biopsy was recommended for thyroid lesions ≥ 1 cm with at least 2 or more suspicious features.

Methods: Three consecutive years of thyroid biopsies using the new classification system were reviewed for patient demographics, biopsy recommendation based on nodule size and imaging characteristics, and pathology results. The primary outcome was malignancy rates for thyroid biopsies. Read More

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Reuse of pacemakers and implantable cardioverter-defibrillators: systematic review, meta-analysis and quality assessment of the body of evidence.

Expert Rev Med Devices 2021 May 9. Epub 2021 May 9.

University of São Paulo - USP. Nursing School. Av. Dr. Enéas Carvalho de Aguiar, 419 - Cerqueira César, CEP 05403-000, São Paulo, SP, Brazil.

: Pacemakers (PMs) and implantable cardioverter-defibrillators (ICDs) have reduced mortality and improved the quality of life of cardiac patients. However, the high cost of these devices prevents their large-scale incorporation, particularly in low-income countries, where reusing explanted PMs/ICDs has become an alternative.: A systematic review and meta-analysis were conducted of studies that compare infection rates, device-related deaths, malfunction and premature battery depletion in patients with reused PM and ICD implants and those with new devices. Read More

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Analysis of frequency and severity of relapses in multiple sclerosis patients treated with cladribine tablets or placebo: The CLARITY and CLARITY Extension studies.

Mult Scler 2021 May 10:13524585211010294. Epub 2021 May 10.

Merck KGaA, Darmstadt, Germany.

Background: In the CLARITY (CLAdRIbine Tablets treating multiple sclerosis orallY) study of patients with relapsing-remitting multiple sclerosis, treatment with cladribine tablets 3.5 mg/kg (CladT) significantly reduced the annualised relapse rate (ARR) versus placebo; this effect was sustained in CLARITY Extension, without further treatment.

Objective: To assess the frequency and severity of relapses in patients treated with CladT versus placebo in CLARITY over 2 years and evaluate the durability of effect in patients who received no further treatment for 2 years in CLARITY Extension. Read More

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Higher circular RNA_0015278 correlates with absence of extrathyroidal invasion, lower pathological tumor stages, and prolonged disease-free survival in papillary thyroid carcinoma patients.

J Clin Lab Anal 2021 May 9:e23819. Epub 2021 May 9.

Department of Emergency, Affiliated Hospital of Chengde Medical College, Chengde, China.

Background: Circular RNA_0015278 (circ_0015278) inhibits the progression of several cancers and is greatly reduced in papillary thyroid carcinoma (PTC) tissues compared with benign thyroid lesions by microarray profiling. This study aimed to further investigate the correlation of circ_0015278 with tumor characteristics and prognosis in PTC patients.

Methods: Totally, 206 PTC patients who underwent tumor resection were retrospectively enrolled; subsequently, circ_0015278 expression in their tumor and adjacent tissues was detected by reverse transcriptional-quantitative polymerase chain reaction. Read More

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Identification of a novel MICU1 nonsense variant causes myopathy with extrapyramidal signs in an Iranian consanguineous family.

Mol Cell Pediatr 2021 May 9;8(1). Epub 2021 May 9.

Department of Medical Genetics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.

Background: Ca as a universal second messenger regulates basic biological functions including cell cycle, cell proliferation, cell differentiation, and cell death. Lack of the protein mitochondrial calcium uptake1 (MICU1), which has been regarded as a gatekeeper of Ca ions, leads to the abnormal mitochondrial Ca handling, excessive production of reactive oxygen species (ROS), and increased cell death. Mutations in MICU1 gene causes a very rare neuromuscular disease, myopathy with extrapyramidal signs (MPXPS), due to primary alterations in mitochondrial calcium signaling which demonstrates the key role of mitochondrial Ca uptake. Read More

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Comparisons of urea or ammonium on growth and fermentative metabolism of Saccharomyces cerevisiae in ethanol fermentation.

World J Microbiol Biotechnol 2021 May 10;37(6):98. Epub 2021 May 10.

Linghua Group Limited, Jining, 272073, China.

This work was mainly about the understanding of how urea and ammonium affect growth, glucose consumption and ethanol production of S. cerevisiae, in particular regarding the basic physiology of cell. The basic physiology of cell included intracellular pH, ATP, NADH and enzyme activity. Read More

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Partial response to Chinese patent medicine Kangliu pill for adult glioblastoma: A case report and review of the literature.

World J Clin Cases 2021 Apr;9(12):2845-2853

Department of Pharmacy, Xuanwu Hospital of Capital Medical University, Beijing 100053, China.

Background: Glioblastoma is the most common type of brain tumor and is invariably fatal, with a mean survival time of 8-15 mo for recently diagnosed tumors, and a 5-year survival rate of only 7.2%. The standard treatment for newly diagnosed glioblastoma includes surgery followed by concurrent chemoradiotherapy and further adjuvant temozolomide. Read More

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Application of a rapid exchange extension catheter technique in type B2/C nonocclusive coronary intervention a transradial approach.

World J Clin Cases 2021 Apr;9(12):2751-2762

Department of Cardiology, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei Province, China.

Background: In transradial intervention procedures, poor back-up support and noncoaxial alignment of the guide catheter (GC) may result in failure of the balloon or stent to reach the targeted lesion. Methods to provide extra back-up support using the original GC and wire can improve procedural success with reduced complications. A rapid exchange guide extension catheter provides convenient and efficient back-up support while preserving the initial GC and inserted wire. Read More

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Real-World Methotrexate Dose on Clinical Effectiveness and Structural Damage of Certolizumab Pegol With Rheumatoid Arthritis.

Front Med (Lausanne) 2021 21;8:643459. Epub 2021 Apr 21.

Department of Hematology and Rheumatology, Kindai University Faculty of Medicine, Osaka-Sayama, Japan.

Rheumatoid arthritis (RA) treatments have markedly advanced with the introduction of biological agents, e. g., tumor necrosis factor (TNF) inhibitors. Read More

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Morphine Suppresses Liver Cancer Cell Tumor Properties and .

Front Oncol 2021 22;11:666446. Epub 2021 Apr 22.

Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Morphine is an analgesic widely adopted to relieve cancer pain. A number of discrepancies, however, are presented by the published literature, with reports suggesting that opioids may either promote or inhibit the spread of cancer. It is of great significance to determine whether morphine may increase the risk of metastasis while utilized in liver cancer surgical treatment. Read More

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Closed Incisional Negative Pressure Therapy Significantly Reduces Early Wound Dehiscence after Reduction Mammaplasty.

Plast Reconstr Surg Glob Open 2021 Mar 22;9(3):e3496. Epub 2021 Mar 22.

Department of Surgery, William Beaumont Army Medical Center, El Paso, Tex.

Background: Closed incisional negative pressure therapy (ciNPT) has been shown to improve surgical outcomes. Functional reduction mammaplasty has a wound dehiscence rate of 25% and higher in most series, requiring extra care and delayed secondary healing. We aimed to determine if shifting from standard care dressings to ciNPT reduced early dehiscence after breast reduction. Read More

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