Microbes Infect 2006 Apr 9;8(4):957-64. Epub 2006 Feb 9.
Laboratório de Imunobiologia, Departamento Biologia Celular e Genética, Instituto de Biologia, Universidade do Estado do Rio de Janeiro, Rua S. Francisco Xavier, 524, PHLC, Maracanã, CEP 20559-900 Rio de Janeiro, Brazil.
Two strains of mice selected according to extreme phenotypes of susceptibility and resistance to oral tolerance (TS and TR mice, respectively) were infected with 1 x 10(7) Leishmania amazonensis promastigotes and studied comparatively. TS mice developed a minor pathology while permitting parasite growth with the presence of increased IL-4, IL-10 and IFN-gamma, and lower NO and IL-2 levels and delayed-type hypersensitivity (DTH). In contrast, in TR mice, footpad swelling was increased but parasite growth was reduced. Read More