112,453 results match your criteria reduced mass

Low Skeletal Muscle Mass Is Associated With Perioperative Neurocognitive Disorder Due To Decreased Neurogenesis in Rats.

Anesth Analg 2021 Aug 4. Epub 2021 Aug 4.

From the Department of Anesthesia and Intensive Care Medicine, Akita University Graduate School of Medicine, Akita, Japan.

Background: Perioperative neurocognitive disorder (PND) is a postsurgical complication associated with neuroinflammation and impaired hippocampal neurogenesis, in which brain-derived neurotrophic factor (BDNF) plays a key role. Sarcopenia refers to age-related muscle loss that causes cognitive decline, muscle atrophy, and postoperative delirium. Rats with tail suspension (TS) were used to represent a low-activity model, which involves decreased hind limb function by TS. Read More

View Article and Full-Text PDF

Hepatoprotective effects of root extract in carbon tetrachloride-induced hepatotoxicity in Wistar albino rats through amelioration of oxidative stress.

Pharm Biol 2021 Dec;59(1):986-997

Chemistry of Medicinal Plants Department, Pharmaceutical and Drug Industries Research Division, National Research Centre, Giza, Egypt.

Context: The roots of Cav. (Asteraceae) have antioxidant and antimicrobial properties.

Objective: This study aimed to examine the hepatoprotective effects of roots ethanol extract (TLRE) using carbon tetrachloride (CCl)-induced hepatotoxicity in rats. Read More

View Article and Full-Text PDF
December 2021

[Low muscular mass and ketoacidosis].

Ned Tijdschr Geneeskd 2021 Apr 29;165. Epub 2021 Apr 29.

Universitair Medisch Centrum Utrecht, afd. Intensive Care, Utrecht.

Fasting ketoacidosis is especially an underdiagnosed problem in patients with neuro-muscular disease with severely depleted muscular mass. During periods of prolonged fasting, low levels of insulin and high levels of glucagon induce lipolysis in the peripheral fat tissue. This will result in elevated free fatty acids levels in de blood and increased ketogenesis in the liver. Read More

View Article and Full-Text PDF

Encapsulation of polyprodrugs enables an efficient and controlled release of dexamethasone.

Nanoscale Horiz 2021 Aug 4. Epub 2021 Aug 4.

Max Planck Institute for Polymer Research, Ackermannweg 10, Mainz 55128, Germany.

Water-soluble low molecular weight drugs, such as the synthetic glucocorticoid dexamethasone (DXM), can easily leak out of nanocarriers after encapsulation due to their hydrophilic nature and small size. This can lead to a reduced therapeutic efficacy and therefore to unwanted adverse effects on healthy tissue. Targeting DXM to inflammatory cells of the liver like Kupffer cells or macrophages is a promising approach to minimize typical side effects. Read More

View Article and Full-Text PDF

TRPM7 is a critical regulator of pancreatic endocrine development and high-fat diet-induced β-cell proliferation.

Development 2021 Aug 4. Epub 2021 Aug 4.

Department of Molecular Physiology and Biophysics, Vanderbilt University, 7425B MRB IV, 2213 Garland Ave., Nashville, TN 37232, USA.

The melastatin subfamily of the transient receptor potential channels (TRPM) are regulators of pancreatic β-cell function. TRPM7 is the most abundant islet TRPM channel; however, the role of TRPM7 in β-cell function has not been determined. Here, we utilized various spatiotemporal transgenic mouse models to investigate how TRPM7 knockout influences pancreatic endocrine development, proliferation, and function. Read More

View Article and Full-Text PDF

An adverse outcome pathway for lung surfactant function inhibition leading to decreased lung function.

Curr Res Toxicol 2021 27;2:225-236. Epub 2021 May 27.

National Research Centre for the Working Environment, Copenhagen, Denmark.

Inhaled substances, such as consumer products, chemicals at the workplace, and nanoparticles, can affect the lung function in several ways. In this paper, we explore the adverse outcome pathway (AOP) that starts when inhaled substances that reach the alveoli inhibit the function of the lung surfactant, and leads to decreased lung function. Lung surfactant covers the inner surface of the alveoli, and regulates the surface tension at the air-liquid interface during breathing. Read More

View Article and Full-Text PDF

The use of human induced pluripotent stem cells to screen for developmental toxicity potential indicates reduced potential for non-combusted products, when compared to cigarettes.

Curr Res Toxicol 2020 Jun 15;1:161-173. Epub 2020 Nov 15.

Imperial Brands PLC, 121 Winterstoke Road, Bristol BS3 2LL, UK.

devTOX Predict (devTOX ) is a metabolomics biomarker-based assay that utilises human induced pluripotent stem (iPS) cells to screen for potential early stage embryonic developmental toxicity Developmental toxicity potential is assessed based on the assay endpoint of the alteration in the ratio of key unrelated biomarkers, ornithine and cystine (o/c). This work aimed to compare the developmental toxicity potential of tobacco-containing and tobacco-free non-combustible nicotine products to cigarette smoke. Smoke and aerosol from test articles were produced using a Vitrocell VC10 smoke/aerosol exposure system and bubbled into phosphate buffered saline (bPBS). Read More

View Article and Full-Text PDF

Acrylamide induces a thyroid allostasis-adaptive response in prepubertal exposed rats.

Curr Res Toxicol 2020 Jun 31;1:124-132. Epub 2020 Oct 31.

Laboratory of Reproductive Toxicology, Department of Medicine, State University of Central-West, Rua Simeao Camargo Varela de Sa, 03, 85040-080 Parana, Brazil.

Some endocrine-disrupting chemicals (EDCs) can affect the endocrine system through covalent interactions with specific sites, leading to deregulation of physiological homeostasis. The acrylamide (AA) present in some fried or baked foods is an example of an electrophile molecule that is able to form adducts with nucleophilic regions of nervous system proteins leading to neurological defects. A positive correlation between increased urinary AA metabolite concentration and reduced levels of thyroid hormones (TH) was described in adolescents and young adults. Read More

View Article and Full-Text PDF

Knockdown of circ_0001883 may inhibit epithelial-mesenchymal transition in laryngeal squamous cell carcinoma via the miR-125-5p/PI3K/AKT axis.

Exp Ther Med 2021 Sep 15;22(3):1007. Epub 2021 Jul 15.

Department of Radiation Oncology, Eye and ENT Hospital of Fudan University, Shanghai 200031, P.R. China.

Laryngeal squamous cell carcinoma (LSCC) is a malignant tumor with increasing incidence and poor prognosis. Circular RNAs (circRNAs) are known to modulate tumorigenesis and cancer development that may function through microRNAs (miRs). The aim of the present study was to investigate the functional roles of circ_0001883 in LSCC and the underlying molecular mechanism. Read More

View Article and Full-Text PDF
September 2021

RNF141 interacts with KRAS to promote colorectal cancer progression.

Oncogene 2021 Aug 3. Epub 2021 Aug 3.

Department of Gastroenterology, The Second Hospital of Hebei Medical University, Hebei Key Laboratory of Gastroenterology, Hebei Institute of Gastroenterology, Shijiazhuang, P. R. China.

RING finger proteins (RNFs) play a critical role in cancer initiation and progression. RNF141 is a member of RNFs family; however, its clinical significance, roles, and mechanism in colorectal cancer (CRC) remain poorly understood. Here, we examined the expression of RNF141 in 64 pairs of CRC and adjacent normal tissues by real-time PCR, Western blot, and immunohistochemical analysis. Read More

View Article and Full-Text PDF

Carotid sheath xanthoma: A rare manifestation of lipid disorders.

J Clin Lipidol 2021 May 21. Epub 2021 May 21.

Department of Ultrasound, West China Hospital of Sichuan University, 37 Guoxue Lane, Wuhou District, Chengdu 610041, Sichuan Province, China. Electronic address:

Xanthomas are visibly deformed cholesterol deposits that are commonly associated with lipid disorders, such as familial hypercholesterolemia (FH) or rare sitosterolemia. We present the first report of two cases of carotid sheath xanthomas in patients with lipid disorders. Case 1 involved a 26-year-old woman presenting with two heterogeneous mutations on the ABCG5 gene-as noted on genetic testing-who was finally diagnosed with sitosterolemia. Read More

View Article and Full-Text PDF

Effect of bariatric surgery on in vitro fertilization in infertile men with obesity.

Surg Obes Relat Dis 2021 Jul 9. Epub 2021 Jul 9.

Department of Advanced Biomedical Sciences, University of Naples "Federico II", Naples, Italy. Electronic address:

Background: Obesity has previously been related to reduced female fertility, with prolonged waiting time to pregnancy among women with a body mass index (BMI) >35 kg/m but there are few studies investigating the relationship between high BMI, bariatric surgery, and male fertility.

Objectives: The primary objective of this article was to investigate the effect of bariatric surgery on in vitro fertilization (IVF) outcomes in a cohort of men with morbid obesity who underwent sleeve gastrectomy (SG).

Setting: University hospital, bariatric surgery unit. Read More

View Article and Full-Text PDF

The hepatoprotective effects of Pyrus biossieriana buhse leaf extract on tert-butyl hydroperoxide toxicity in HepG2 cell line.

BMC Res Notes 2021 Aug 3;14(1):298. Epub 2021 Aug 3.

Department of Clinical Biochemistry, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran.

Objective: In present study, the effects of the leaf extract of Pyrus biossieriana Buhse on tert-Butyl hydroperoxide (t-BHP) induced toxicity in the HepG2 cell line were investigated.

Results: HepG2 cells were exposed to different concentrations of both extract (1.5, 2. Read More

View Article and Full-Text PDF

Jute sticks biomass delignification through laccase-mediator system for enhanced saccharification and sustainable release of fermentable sugar.

Chemosphere 2021 Jul 27;286(Pt 2):131687. Epub 2021 Jul 27.

CSIR-Indian Institute of Petroleum, Mohkampur, Dehradun, 248005, Uttarakhand, India. Electronic address:

Jute sticks obtained after the extraction of jute fiber are an excellent biomass feedstock with a significant amount of carbohydrates that makes it an attractive resource for sustainable energy generation. However, the high lignin content in the jute stick hinders the cellulosic component of the cell wall from enzymatic hydrolysis.This work demonstrates the lignin degradation of jute stick biomass by Trametes maxima laccase in the presence of mediator Hydroxybenzotriazole and improvement in its subsequent saccharification. Read More

View Article and Full-Text PDF

Insulin sensitivity, cardiovascular function and bone health in women with early stage breast cancer before and after cancer treatment.

Intern Med J 2021 Aug 3. Epub 2021 Aug 3.

College of Medicine and Public Health, Flinders University, Adelaide, Australia.

Background: Cardiovascular disease is a leading cause of death in breast cancer survivors, but the underlying cause is not fully characterised.

Aims: To determine whether insulin sensitivity, cardiovascular risk markers and body composition were perturbed in women treated with chemotherapy for early stage breast cancer and whether perturbations occurred before or after cancer treatment.

Methods: Sixteen women with breast cancer and 17 control subjects were studied. Read More

View Article and Full-Text PDF

Differential Response in Ethanol Behaviors of Female Rats Given Various Weight Loss Surgeries.

Alcohol Alcohol 2021 Aug 3. Epub 2021 Aug 3.

The Pennsylvania State University, College of Medicine, Department of Neural and Behavioral Sciences, 700 HMC Crescent road, Hershey, PA 17033.

Aims: Currently, the only effective treatment for morbid obesity and its comorbidities is weight loss surgery (WLS). Growing evidence suggests that different types of WLS, such as Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG), have differential effects on alcohol consumption in humans and rats. Thus, we aimed to directly compare the effects of these two surgical procedures, for the first time in female rats, and to determine whether presence or absence of the ghrelin-producing stomach tissue has critical influence on postoperative alcohol intake. Read More

View Article and Full-Text PDF

Metformin improves glycemic variability in adults with type 1 diabetes mellitus: an open-label randomized control trial.

Endocr Connect 2021 Aug 1. Epub 2021 Aug 1.

F Yuan, Shenzhen, China.

Introduction: Metformin has been demonstrated to enhance cardioprotective benefits in type 1 diabetes (T1DM). Although glycemic variability (GV) is associated with increased risk of CVD in diabetes, there is a scarcity of research evaluating the effect of metformin on GV in T1DM.

Objectives: In the present study, the effects of adjuvant metformin therapy on GV and metabolic control in T1DM were explored. Read More

View Article and Full-Text PDF

Simulation of Cluster Dynamics of Proton-Bound Water Clusters in a High Kinetic Energy Ion-Mobility Spectrometer.

J Am Soc Mass Spectrom 2021 Aug 3. Epub 2021 Aug 3.

Department of Physical and Theoretical Chemistry, University of Wuppertal, Gauss Straße 20, 42119 Wuppertal, Germany.

Ions are separated in ion mobility spectrometry (IMS) by their characteristic motion through a gas-filled drift tube with a static electric field present. Chemical dynamics, such as clustering and declustering of chemically reactive systems, and physical parameters, as, for example, the electric field strength or background gas temperature, impact on the observed ion mobility. In high kinetic energy IMS (HiKE-IMS), the reduced electric field strength is up to 120 Td in both the reaction region and drift region of the instrument. Read More

View Article and Full-Text PDF

Transcriptomic links to muscle mass loss and declines in cumulative muscle protein synthesis during short-term disuse in healthy younger humans.

FASEB J 2021 Sep;35(9):e21830

MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research and National Institute of Health Research, Nottingham Biomedical Research Centre, Royal Derby Hospital Centre, School of Medicine, University of Nottingham, Derby, UK.

Muscle disuse leads to a rapid decline in muscle mass, with reduced muscle protein synthesis (MPS) considered the primary physiological mechanism. Here, we employed a systems biology approach to uncover molecular networks and key molecular candidates that quantitatively link to the degree of muscle atrophy and/or extent of decline in MPS during short-term disuse in humans. After consuming a bolus dose of deuterium oxide (D O; 3 mL. Read More

View Article and Full-Text PDF
September 2021

Post-ablation left atrial function impacts long-term recurrence of atrial fibrillation after ablation.

Heart Vessels 2021 Aug 3. Epub 2021 Aug 3.

Cardiovascular Center, Sakurabashi Watanabe Hospital, Osaka, Japan.

Left atrial (LA) function can help predict various cardiovascular events. Catheter ablation for atrial fibrillation (AF) modifies baseline LA function through the maintenance of sinus rhythm and myocardial injury. We investigated the impact of post-ablation LA function on recurrence of AF after ablation and identified the predictors of reduced post-ablation LA function. Read More

View Article and Full-Text PDF

Maternal choline supplementation in a rat model of periconceptional alcohol exposure: Impacts on the fetus and placenta.

Alcohol Clin Exp Res 2021 Aug 2. Epub 2021 Aug 2.

School of Biomedical Sciences, The University of Queensland, St Lucia, QLD, Australia.

Background: Maternal choline supplementation in rats can ameliorate specific neurological and behavioral abnormalities caused by alcohol exposure during pregnancy. We aimed to test whether choline supplementation could ameliorate fetal growth restriction and molecular changes in the placenta associated with periconceptional ethanol exposure in the rat.

Methods: Sprague-Dawley dams were given either 12. Read More

View Article and Full-Text PDF

Experimental study of carbon dioxide absorption by [email protected]/NMP nanofluid.

Environ Sci Pollut Res Int 2021 Aug 3. Epub 2021 Aug 3.

School of Chemical and Petroleum Engineering, Shiraz University, Shiraz, Iran.

In this study, for the first time, the nanoparticle (NP) of [email protected] (CHNO) was synthesized to improve the FeO properties in absorbing carbon dioxide (CO) using the base fluid of hydrous N-methyl-2-pyrrolidone (NMP) solution (50 wt%), as a physically powerful CO absorbent. To do this, several nano-NMP solutions, in different weight percentages of NPs, were first prepared. Then, in a batch setup, the nano-NMP solutions were directly exposed to CO gaseous (at the pressures of 20, 30, and 40 bar) to clarify the effects of the mass percentage of NPs and initial pressure on CO absorption. Read More

View Article and Full-Text PDF

Reduced protein kinase C delta association with a higher molecular weight complex in mitochondria of Barth Syndrome lymphoblasts.

bioRxiv 2021 Jul 21. Epub 2021 Jul 21.

The protein kinase C delta (PKCδ) signalosome exists as a high molecular weight complex in mitochondria and controls mitochondrial oxidative phosphorylation. Barth Syndrome (BTHS) is a rare X-linked genetic disease in which mitochondrial oxidative phosphorylation is impaired due to a mutation in the gene TAFAZZIN which results in reduction in the phospholipid cardiolipin and an accumulation of monolysocardiolipin. Here we examined if PKCδ association with a higher molecular weight complex was altered in mitochondria of BTHS lymphoblasts. Read More

View Article and Full-Text PDF

Maternal body mass index, offspring body mass index, and blood pressure at 18 years: a causal mediation analysis.

Int J Obes (Lond) 2021 Aug 2. Epub 2021 Aug 2.

Children's Hospital Research Institute of Manitoba, Winnipeg, MB, Canada.

Objective: Understanding the natural history of hypertension is key to identifying prevention strategies. Previous work suggests that in utero exposures and offspring anthropometrics may play a role. This study examined the relationship between maternal pre-pregnancy body mass index (BMI) and the mediating role of childhood and adolescent BMI on offspring blood pressure at 18 years. Read More

View Article and Full-Text PDF

Differences in Muscle Activity and Kinetics Between the Goblet Squat and Landmine Squat in Men and Women.

J Strength Cond Res 2021 Aug 2. Epub 2021 Aug 2.

Department of Health, Nutrition, and Exercise Sciences, North Dakota State University, Fargo, North Dakota.

Abstract: Collins, KS, Klawitter, LA, Waldera, RW, Mahoney, SJ, and Christensen, BK. Differences in muscle activity and kinetics between the goblet squat and landmine squat in men and women. J Strength Cond Res XX(X): 000-000, 2021-Squat exercise variations are widely used and extensively researched. Read More

View Article and Full-Text PDF

Baseline pro-inflammatory gene expression in whole blood is related to adverse long-term outcomes after transcatheter aortic valve replacement: a case control study.

BMC Cardiovasc Disord 2021 Aug 2;21(1):368. Epub 2021 Aug 2.

Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA.

Background: Age-associated inflammation and immune system dysfunction have been implicated as mechanisms that increase risk for adverse long-term procedural outcomes in older adults. The purpose of this study was to investigate relationships between baseline inflammatory and innate antiviral gene expression and outcomes after transcatheter aortic valve replacement (TAVR) in older adults with severe aortic stenosis.

Methods: We performed a retrospective case-control study comparing pre-procedural pro-inflammatory and Type 1 interferon (IFN) gene expression in 48 controls with favorable outcomes (alive 1 year after TAVR with improved quality of life [QoL]) versus 48 individuals with unfavorable outcomes (dead by 1 year or alive at 1 year but with reduced QoL). Read More

View Article and Full-Text PDF

Controllable organosilane monolayer density of surface bonding using silatranes for thiol functionalization of silica particles for liquid chromatography and validation of microanalytical method for elemental composition determination.

J Chromatogr A 2021 Jul 22;1653:462418. Epub 2021 Jul 22.

Institute of Pharmaceutical Sciences, Pharmaceutical (Bio-)Analyses, University of Tübingen, Auf der Morgenstelle 8, Tübingen 72076, Germany. Electronic address:

The present work systematically investigates a new strategy for the functionalization of silica gel using alkyl silatrane chemistry instead of alkylsilanes for synthesis of chromatographic stationary phases. In this work, silica was chemically modified for further functionalization by a thiol-ene click reaction. Thus, 3-mercaptopropylsilatrane (MPS) was used which is capable to form self-assembled monolayers (SAM) on top of silanol surfaces in a controlled manner as previously shown for silicon wafers. Read More

View Article and Full-Text PDF

Biventricular dysfunction and lung congestion in athletes on anabolic androgenic steroids: a speckle tracking and stress lung echocardiography analysis.

Eur J Prev Cardiol 2021 Aug 2. Epub 2021 Aug 2.

Institute of Clinical Physiology, CNR, Pisa, Via G. Moruzzi, Pisa 56121, Italy.

Aims: The real effects of the chronic consumption of anabolic-androgenic steroids (AASs) on cardiovascular structures are subjects of intense debate. The aim of the study was to detect by speckle tracking echocardiography (STE) right ventricular (RV) and left ventricular (LV) dysfunction at rest and during exercise stress echocardiography (ESE) in athletes abusing AAS.

Methods And Results: One hundred and fifteen top-level competitive bodybuilders were selected (70 males), including 65 athletes misusing AAS for at least 5 years (users), 50 anabolic-free bodybuilders (non-users), compared to 50 age- and sex-matched healthy sedentary controls. Read More

View Article and Full-Text PDF

Impaired Lower Extremity Biomechanics, Hip External Rotation Muscle Weakness, and Proximal Femoral Morphology Predict Impaired Single-Leg Squat Performance in People With FAI Syndrome.

Am J Sports Med 2021 Aug 2:3635465211029032. Epub 2021 Aug 2.

Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, Illinois, USA.

Background: Impairments in squat depth have been reported in patients with femoroacetabular impingement syndrome (FAIS). However, little is known about single-leg squat (SLS) performance in these patients, despite this task being commonly used in the rehabilitation and training settings.

Purpose/hypothesis: The aims of this study were (1) to investigate whether patients with FAIS demonstrate differences in SLS performance compared with healthy controls and (2) to determine whether dynamic range of motion (ROM), muscle strength, hip morphologic measures, hip pain, and hip-specific function predict SLS performance in patients with FAIS. Read More

View Article and Full-Text PDF

How to improve clotting factors depletion in double-filtration plasmapheresis.

J Clin Apher 2021 Aug 2. Epub 2021 Aug 2.

Nephrology, Hemodialysis, Apheresis and Kidney Transplantation Department, Grenoble University Hospital, Grenoble, France.

Background: Double-filtration plasmapheresis (DFPP), a selective therapeutic apheresis, can deplete pathogenic antibodies/substances, but also important coagulation factors.

Aim: To determine if the use of a separator filter with different characteristics (CascadefloEC-50 W) as compared to the reference filter (PlasmafloOP-08 W) is as efficient in terms of immunoglobulin loss, but can reduce coagulation factor losses and have similar tolerability.

Patients/methods: This is a single-center prospective study including 14 patients divided into two groups (7 each): that is, group1 = CascadefloEC-50 W and group2 = PlasmafloOP-08 W. Read More

View Article and Full-Text PDF