7,296 results match your criteria reduced hearing

Transcription Factor Reprogramming in the Inner Ear: Turning on Cell Fate Switches to Regenerate Sensory Hair Cells.

Front Cell Neurosci 2021 29;15:660748. Epub 2021 Mar 29.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, United States.

Non-mammalian vertebrates can restore their auditory and vestibular hair cells naturally by triggering the regeneration of adjacent supporting cells. The transcription factor ATOH1 is a key regulator of hair cell development and regeneration in the inner ear. Following the death of hair cells, supporting cells upregulate ATOH1 and give rise to new hair cells. Read More

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Speech Perception with Noise Vocoding and Background Noise: An EEG and Behavioral Study.

Yue Dong Yan Gai

J Assoc Res Otolaryngol 2021 Apr 13. Epub 2021 Apr 13.

Biomedical Engineering, Parks College of Engineering, Aviation and Technology, Saint Louis University, 3507 Lindell Blvd, St Louis, MO, 63103, USA.

This study explored the physiological response of the human brain to degraded speech syllables. The degradation was introduced using noise vocoding and/or background noise. The goal was to identify physiological features of auditory-evoked potentials (AEPs) that may explain speech intelligibility. Read More

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Ultrastructural maturation of the endbulb of Held active zones comparing wild-type and otoferlin-deficient mice.

iScience 2021 Apr 8;24(4):102282. Epub 2021 Mar 8.

Molecular Architecture of Synapses Group, Institute for Auditory Neuroscience, InnerEarLab and Center for Biostructural Imaging of Neurodegeneration, University Medical Center Göttingen, 37075 Göttingen, Germany.

Endbulbs of Held are located in the anteroventral cochlear nucleus and present the first central synapses of the auditory pathway. During development, endbulbs mature functionally to enable rapid and powerful synaptic transmission with high temporal precision. This process is accompanied by morphological changes of endbulb terminals. Read More

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Use of Medications for Treating Anxiety or Depression among Testicular Cancer Survivors: A Multi-Institutional Study.

Cancer Epidemiol Biomarkers Prev 2021 Apr 13. Epub 2021 Apr 13.

Indiana University – Purdue University Indianapolis

Background: This study examined sociodemographic factors, cisplatin-related adverse health outcomes (AHOs), and cumulative burden of morbidity (CBMPt) scores associated with medication use for anxiety and/or depression in testicular cancer survivors (TCS).

Methods: A total of 1,802 TCS who completed cisplatin-based chemotherapy {greater than or equal to}12 months previously completed questionnaires regarding sociodemographic features and cisplatin-related AHOs (hearing impairment, tinnitus, peripheral sensory neuropathy (PSN), kidney disease). A CBMPt score encompassed the number and severity of cisplatin-related AHOs. Read More

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Results of the Active Middle Ear Implantation in Patients With Mixed Hearing Loss After the Middle Ear Surgery: Prospective Multicenter Study (ROMEO Study).

Clin Exp Otorhinolaryngol 2021 Apr 9. Epub 2021 Apr 9.

Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea.

Objectives: To evaluate the user satisfaction, efficacy, and safety of round window (RW) vibroplasty using the Vibrant Soundbridge (VSB) in patients with persistent mixed hearing loss after mastoidectomy.

Methods: The study included twenty-seven patients (mean age, 58.7 years; age range, 28-76 years; 11 men and 16 women) with mixed hearing loss after mastoidectomy surgery from 15 tertiary referral centers in Korea. Read More

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Neuroplastin expression is essential for hearing and hair cell PMCA expression.

Brain Struct Funct 2021 Apr 12. Epub 2021 Apr 12.

Neurogenetics Laboratory, Leibniz Institute for Neurobiology, Brenneckestr. 6, 39118, Magdeburg, Germany.

Hearing deficits impact on the communication with the external world and severely compromise perception of the surrounding. Deafness can be caused by particular mutations in the neuroplastin (Nptn) gene, which encodes a transmembrane recognition molecule of the immunoglobulin (Ig) superfamily and plasma membrane Calcium ATPase (PMCA) accessory subunit. This study investigates whether the complete absence of neuroplastin or the loss of neuroplastin in the adult after normal development lead to hearing impairment in mice analyzed by behavioral, electrophysiological, and in vivo imaging measurements. Read More

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Deletion of BDNF in Pax2 Lineage-Derived Interneuron Precursors in the Hindbrain Hampers the Proportion of Excitation/Inhibition, Learning, and Behavior.

Front Mol Neurosci 2021 26;14:642679. Epub 2021 Mar 26.

Department of Otolaryngology, Head and Neck Surgery, Tübingen Hearing Research Centre, Molecular Physiology of Hearing, University of Tübingen, Tübingen, Germany.

Numerous studies indicate that deficits in the proper integration or migration of specific GABAergic precursor cells from the subpallium to the cortex can lead to severe cognitive dysfunctions and neurodevelopmental pathogenesis linked to intellectual disabilities. A different set of GABAergic precursors cells that express Pax2 migrate to hindbrain regions, targeting, for example auditory or somatosensory brainstem regions. We demonstrate that the absence of BDNF in Pax2-lineage descendants of KOs causes severe cognitive disabilities. Read More

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Epac1 signaling pathway mediates the damage and apoptosis of inner ear hair cells after noise exposure in a rat model.

Neuroscience 2021 Apr 7. Epub 2021 Apr 7.

Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of USTC, Hefei, 230001, China. Electronic address:

To investigate the role of the exchange protein directly activated by cAMP (Epac) signaling pathway in inner ear hair cell damage and apoptosis after noise exposure, we analyzed the expression level of Epac1 in a rat model of noise-induced hearing loss (NIHL), based on rat exposure to a 4-kHz and 106-dB sound pressure level (SPL) for 8 h. Loss of outer hair cells (OHCs), mitochondrial lesions, and hearing loss were examined after treatment with the Epac agonist, 8-CPT, or the Epac inhibitor, ESI-09. The effects of 8-CPT and ESI-09 on cell proliferation and apoptosis were examined by CCK-8 assays, holographic microscopy imaging, and Annexin-V FITC/PI staining in HEI-OC1 cells. Read More

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Speech Intensity Response to Altered Intensity Feedback in Individuals With Parkinson's Disease.

J Speech Lang Hear Res 2021 Apr 8:1-15. Epub 2021 Apr 8.

Department of Clinical Neurological Sciences, Western University, London, Ontario, Canada.

Purpose Hypophonia (low speech intensity) is the most common speech symptom experienced by individuals with Parkinson's disease (IWPD). Previous research suggests that, in IWPD, there may be abnormal integration of sensory information for motor production of speech intensity. In the current study, intensity of auditory feedback was systematically manipulated (altered in both positive and negative directions) during sensorimotor conditions that are known to modulate speech intensity in everyday contexts in order to better understand the role of auditory feedback for speech intensity regulation. Read More

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Neurophysiological improvements in speech-in-noise task after short-term choir training in older adults.

Aging (Albany NY) 2021 Apr 6;13. Epub 2021 Apr 6.

Brain and Creativity Institute, University of Southern California, Los Angeles, CA 90089, USA.

Perceiving speech in noise (SIN) is important for health and well-being and decreases with age. Musicians show improved speech-in-noise abilities and reduced age-related auditory decline, yet it is unclear whether short term music engagement has similar effects. In this randomized control trial we used a pre-post design to investigate whether a 12-week music intervention in adults aged 50-65 without prior music training and with subjective hearing loss improves well-being, speech-in-noise abilities, and auditory encoding and voluntary attention as indexed by auditory evoked potentials (AEPs) in a syllable-in-noise task, and later AEPs in an oddball task. Read More

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Satellite habilitation centres following cochlear implantation - Are they the way ahead in improving outcomes in developing countries?

Int J Pediatr Otorhinolaryngol 2021 Jan 27;144:110606. Epub 2021 Jan 27.

Madras ENT Research Foundation, Chennai, India.

Introduction: Cochlear implantation is a safe surgery for restoration of hearing in profoundly deaf children. Following cochlear implantation, children undergo rehabilitation (or 'habilitation' for those without previous hearing). The device is programmed after the surgery, so that the user can hear sounds through it and through rehabilitation training, the heard sounds are made to understand. Read More

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January 2021

Combination photobiomodulation/N-acetyl-L-cysteine treatment appears to mitigate hair cell loss associated with noise-induced hearing loss in rats.

Lasers Med Sci 2021 Apr 6. Epub 2021 Apr 6.

Beckman Laser Institute Korea, Dankook University, 119 Dandae-ro, Cheonan, 31116, Republic of Korea.

Sensorineural hearing loss is an intractable disease. Acoustic overstimulation creates hearing loss; many patients exhibit social and emotional dysfunctions. In a model of noise-induced hearing loss (NIHL), low-level laser photobiomodulation (PBM) at a near-infrared wavelength significantly improved auditory brainstem response (ABR) thresholds. Read More

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Co-occurrence of Hyperacusis Accelerates With Tinnitus Burden Over Time and Requires Medical Care.

Front Neurol 2021 18;12:627522. Epub 2021 Mar 18.

Tübingen Hearing Research Centre, Department of Otolaryngology, Head and Neck Surgery, University of Tübingen, Tübingen, Germany.

Although tinnitus represents a major global burden, no causal therapy has yet been established. Ongoing controversies about the neuronal pathophysiology of tinnitus hamper efforts in developing advanced therapies. Hypothesizing that the unnoticed co-occurrence of hyperacusis and differences in the duration of tinnitus may possibly differentially influence the neural correlate of tinnitus, we analyzed 33 tinnitus patients without (T-group) and 20 tinnitus patients with hyperacusis (TH-group). Read More

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Placental features of fetal vascular malperfusion and infant neurodevelopmental outcomes at two years of age in severe fetal growth restriction.

Am J Obstet Gynecol 2021 Apr 1. Epub 2021 Apr 1.

Department of Obstetrics and Gynecology, IRCCS Foundation Policlinico San Matteo and University of Pavia, Pavia, Italy.

Background: Placental pathological lesions suggesting maternal (MVM) or fetal (FVM) vascular malperfusion are common among pregnancies complicated by fetal growth restriction (FGR). Data on the relationship between pathological placental lesions and subsequent infant neurodevelopmental outcomes are limited.

Objective: The aim of the study was to assess the relationship between placental pathological lesions and infant neurodevelopmental outcomes at two years of age in a cohort of pregnancies complicated by FGR. Read More

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Decreased miRNA-320e correlates with allergy in children with otitis media with effusion.

Auris Nasus Larynx 2021 Apr 1. Epub 2021 Apr 1.

Department of Pediatric Otolaryngology, Poznan University of Medical Sciences, Szpitalna 27/33 60-572 Poznań, Poland.

Objective: Otitis media with effusion (OME) is a common childhood disease and the main cause of conductive hearing loss in this age group. Many factors predispose to OME but allergy is still widely disputed. The answer may lay in the molecular mechanisms of ear exudate formation and the recent studies showed miRNAs might take part in it. Read More

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Working memory in adults who stutter using a visual N-back task.

J Fluency Disord 2021 Mar 26;70:105846. Epub 2021 Mar 26.

The University of Texas at Austin, Department of Speech, Language, and Hearing Sciences, USA.

Purpose: The purpose of this study was to investigate working memory in adults who do (AWS) and do not (AWNS) stutter using a visual N-back task. Processes involved in an N-back task include encoding, storing, rehearsing, inhibition, temporal ordering, and matching.

Methods: Fifteen AWS (11 males, 4 females; M = 23. Read More

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A Novel Truncating Mutation in HOMER2 Causes Nonsyndromic Progressive DFNA68 Hearing Loss in a Spanish Family.

Genes (Basel) 2021 Mar 12;12(3). Epub 2021 Mar 12.

Servicio de Genética, Hospital Universitario Ramón y Cajal, IRYCIS, Carretera de Colmenar km 9.100, 28034 Madrid, Spain.

Nonsyndromic hereditary hearing loss is a common sensory defect in humans that is clinically and genetically highly heterogeneous. So far, 122 genes have been associated with this disorder and 50 of them have been linked to autosomal dominant (DFNA) forms like DFNA68, a rare subtype of hearing impairment caused by disruption of a stereociliary scaffolding protein (HOMER2) that is essential for normal hearing in humans and mice. In this study, we report a novel HOMER2 variant (c. Read More

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Selective Serotonin Reuptake Inhibitor Citalopram Ameliorates Cognitive Decline and Protects Against Amyloid Beta-induced Mitochondrial Dynamics, Biogenesis, Autopahgy, Mitophagy and Synaptic Toxicities in a Mouse Model of Alzheimer's Disease.

Hum Mol Genet 2021 Mar 31. Epub 2021 Mar 31.

Internal Medicine Department, Texas Tech University Health Sciences Center, 3601 4th Street, Lubbock, TX 79430, USA.

In the current study, we investigated the protective role of citalopram against cognitive decline, impaired mitochondrial dynamics, defective mitochondrial biogenesis, defective autophagy, mitophagy, and synaptic dysfunction in APP transgenic mouse model of Alzheimer's disease (ad). We treated 12-month-old wild-type (WT) and age-matched transgenic APP mice with citalopram for 2 months. Using Morris Water Maze and rotarod tests, quantitative RT-PCR, immunoblotting, biochemical methods and transmission electron microscopy methods, we assessed cognitive behavior, RNA and protein levels of mitochondrial dynamics, biogenesis, autophagy, mitophagy, synaptic, ad-related and neurogenesis genes in wild-type and APP mice treated and untreated with citalopram. Read More

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Universal newborn hearing screening in South Africa: a single-centre study.

BMJ Paediatr Open 2021 18;5(1):e000976. Epub 2021 Mar 18.

School of Clinical Medicine, University of KwaZulu-Natal, Durban, South Africa.

Hearing screening for newborn babies is an established protocol in many high-income countries. Implementing such screening has yielded significant socioeconomic advantages at both an individual and societal level. This has yet to permeate low/middle-income countries (LMIC). Read More

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Changes in Relative Fundamental Frequency Under Increased Cognitive Load in Individuals With Healthy Voices.

J Speech Lang Hear Res 2021 Apr 31;64(4):1189-1196. Epub 2021 Mar 31.

Department of Speech, Language and Hearing Sciences, Boston University, MA.

Purpose The purpose of this study was to determine the effect of cognitive load on relative fundamental frequency (RFF) in individuals with healthy voices. Method Twenty adults with healthy voices read sentences under different cognitive load conditions. Each sentence contained color terms printed in colored ink, creating an embedded Stroop task. Read More

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Aging Effects on Categorical Perception of Mandarin Lexical Tones in Noise.

J Speech Lang Hear Res 2021 Apr 31;64(4):1376-1389. Epub 2021 Mar 31.

Department of Speech, Language, and Hearing Sciences, The University of Texas at Austin.

Purpose The purpose of this study was to examine the aging effects on the categorical perception (CP) of Mandarin lexical Tones 1-4 and Tones 1-2 in noise. It also investigated whether listeners' categorical tone perception in noise correlated with their general tone identification of 20 natural vowel-plus-tone signals in noise. Method Twelve younger and 12 older listeners with normal hearing were recruited in both tone identification and discrimination tasks in a CP paradigm where fundamental frequency contours of target stimuli varied systematically from the flat tone (Tone 1) to the rising/falling tones (Tones 2/4). Read More

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Exposure to leisure noise and intermittent tinnitus among young adults in Bavaria: longitudinal data from a prospective cohort study.

Int J Audiol 2021 Mar 31:1-8. Epub 2021 Mar 31.

Department of Occupational and Environmental Medicine, Epidemiology, Bavarian Health and Food Safety Authority, Munich, Germany.

Objectives: To investigate the association between total leisure noise exposure and intermittent tinnitus among young adults.

Design: Data were obtained from the study, an ongoing prospective cohort study conducted in South Germany since 2009. Information about exposure to impulse and leisure noise, tinnitus occurrences, sociodemographic variables, and self-rated hearing ability were analysed at four time points over a period of seven and a half years. Read More

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Effects of speech-rhythm disruption on selective listening with a single background talker.

Atten Percept Psychophys 2021 Mar 29. Epub 2021 Mar 29.

Department of Speech, Language and Hearing Sciences, Indiana University, Bloomington, IN, USA.

Recent work by McAuley et al. (Attention, Perception, & Psychophysics, 82, 3222-3233, 2020) using the Coordinate Response Measure (CRM) paradigm with a multitalker background revealed that altering the natural rhythm of target speech amidst background speech worsens target recognition (a target-rhythm effect), while altering background speech rhythm improves target recognition (a background-rhythm effect). Here, we used a single-talker background to examine the role of specific properties of target and background sound patterns on selective listening without the complexity of multiple background stimuli. Read More

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[The effect of different diagnostic standards on the diagnosis of suspected occupational noise-induced deafness].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2021 Mar;39(3):207-210

Qingcheng Center for Disease Control and Prevention of Qingxin City, Qingxin 511500, China.

To explore the effect of different diagnostic criteria on occupational noise-induced deafness (Onid) , and to provide theoretical basis for the revision of ONID diagnostic criteria. From January 2016 to January 2018, the physical examination results of noise-exposed workers during occupational health examination in Qingyuan Occupational Disease Prevention and Treatment Hospital were retrospectively investigated in September 2019, with Gbz 49-2014《diagnosis of occupational noise deafness》as the study object, 471 workers suspected of Onid were weighted with different combinations of high frequency hearing threshold, and the better ear weight was calculated, compared with the diagnostic criteria of 2007 and 2014, the degree of hearing loss was evaluated. SPSS 22. Read More

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Brain Structural and Functional Reorganization in Tinnitus Patients Without Hearing Loss After Sound Therapy: A Preliminary Longitudinal Study.

Front Neurosci 2021 11;15:573858. Epub 2021 Mar 11.

Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Sound therapy is one of the most common first-line treatments for idiopathic tinnitus. We aimed to investigate the brain structural and functional alterations between patients with idiopathic tinnitus without hearing loss (HL) and healthy controls (HCs) and between patients before and after sound therapy (narrow band noise). Structural and resting-state functional images were acquired from 13 tinnitus patients without HL and 18 HCs before and after 6 months of narrow band sound therapy (only patients received the treatment). Read More

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Emerging and distinct video head impulse test responses in elderly with vestibular symptoms.

Braz J Otorhinolaryngol 2021 Mar 20. Epub 2021 Mar 20.

College of Medicine, University of Sharjah, Sharjah, United Arab Emirates; Advanced Hearing and Balance Center, Dubai, United Arab Emirates.

Introduction: Dizziness has been reported to be the most common symptom in elderly population. Video head impulse test, VHIT, allows clinicians to assess the vestibular function in elderly individuals, during their initial stages of vestibular symptoms. Inferences from VHIT responses were traditionally low vestibulo-ocular reflex gain or a normal vestibulo-ocular reflex gain. Read More

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Long-term outcomes of patients with mucopolysaccharidosis VI treated with galsulfase enzyme replacement therapy since infancy.

Mol Genet Metab 2021 Mar 14. Epub 2021 Mar 14.

UCSF Benioff Children's Hospital Oakland, Oakland, CA, USA. Electronic address:

Objective: Long-term outcomes of patients with mucopolysaccharidosis (MPS) VI treated with galsulfase enzyme replacement therapy (ERT) since infancy were evaluated.

Methods: The study was a multicenter, prospective evaluation using data from infants with MPS VI generated during a phase 4 study (ASB-008; Clinicaltrials.govNCT00299000) and clinical data collected ≥5 years after completion of the study. Read More

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Fasting and fasting-mimicking treatment activate SIRT1/LXRα and alleviate diabetes-induced systemic and microvascular dysfunction.

Diabetologia 2021 Mar 26. Epub 2021 Mar 26.

Department of Physiology, Michigan State University, East Lansing, MI, USA.

Aims/hypothesis: Homo sapiens evolved under conditions of intermittent food availability and prolonged fasting between meals. Periods of fasting are important for recovery from meal-induced oxidative and metabolic stress, and tissue repair. Constant high energy-density food availability in present-day society contributes to the pathogenesis of chronic diseases, including diabetes and its complications, with intermittent fasting (IF) and energy restriction shown to improve metabolic health. Read More

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Sound detection by the American lobster ().

J Exp Biol 2021 Mar 25;224(Pt 6). Epub 2021 Mar 25.

Massachusetts Institute of Technology-Woods Hole Oceanographic Institution Joint Program in Oceanography/Applied Ocean Science and Engineering, Cambridge, MA 02543, USA.

Although many crustaceans produce sounds, their hearing abilities and mechanisms are poorly understood, leaving uncertainties regarding whether or how these animals use sound for acoustic communication. Marine invertebrates lack gas-filled organs required for sound pressure detection, but some of them are known to be sensitive to particle motion. Here, we examined whether the American lobster () could detect sound and subsequently sought to discern the auditory mechanisms. Read More

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Monitoring changes in human activity during the COVID-19 shutdown in Las Vegas using infrasound microbarometers.

J Acoust Soc Am 2021 03;149(3):1796

Geophysical Detection Programs, Sandia National Laboratories, 1515 Eubank Southeast, MS 0404, Albuquerque, New Mexico 87123, USA.

While studies of urban acoustics are typically restricted to the audio range, anthropogenic activity also generates infrasound (<20 Hz, roughly at the lower end of the range of human hearing). Shutdowns related to the COVID-19 pandemic unintentionally created ideal conditions for the study of urban infrasound and low frequency audio (20-500 Hz), as closures reduced human-generated ambient noise, while natural signals remained relatively unaffected. An array of infrasound sensors deployed in Las Vegas, NV, provides data for a case study in monitoring human activity during the pandemic through urban acoustics. Read More

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