7,043 results match your criteria reduced hba1c

Effectiveness of empowerment-based intervention on HbA1c and self-efficacy among cases with type 2 diabetes mellitus: A meta-analysis of randomized controlled trials.

Medicine (Baltimore) 2021 Sep;100(38):e27353

Department of Endocrinology, Tianjin Medical University Hospital for Metabolic Diseases, Tianjin, China.

Objective: The aim of this study was to determine the effect of empowerment-based interventions on glucose metabolism control and psychosocial self-efficacy in people with type 2 diabetes mellitus (T2DM).

Methods: The Cochrane Library, Embase, PubMed, and Web of Science electronic databases were searched up to 22 February 2021 for randomized controlled trials (RCTs) that evaluated the effectiveness of empowerment-based intervention versus conventional treatment in type 2 diabetes cases. At least two investigators independently screened the literature, extracted data and evaluated the methodological quality. Read More

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September 2021

Long-term wheel-running prevents reduction of grip strength in type 2 diabetic rats.

Physiol Rep 2021 Sep;9(18):e15046

Department of Physiology 1, Nara Medical University School of Medicine, Kashihara, Japan.

Diabetic skeletal muscles show reduced contractile force and increased fatigability. Hands are a target for several diabetes-induced complications. Therefore, reduced handgrip strength often occurs as a consequence of diabetes. Read More

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September 2021

Study of Neurocognitive Function in Type 2 Diabetes Mellitus Patients Using P300 Event-Related Potential.

Ann Neurosci 2020 Jul 6;27(3-4):98-103. Epub 2020 Nov 6.

 Department of Psychiatry, SRM Medical College, Kattangulathur, Chennai, India.

Background: Diabetes mellitus is the most prevailing metabolic disease. It causes structural and functional alterations in several organs, including the central nervous system. Altered glucose metabolism, atherosclerosis, and inflammation of blood vessels are seen in diabetes. Read More

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Effects of resistance training on insulin sensitivity in the elderly: A meta-analysis of randomized controlled trials.

J Exerc Sci Fit 2021 Oct 19;19(4):241-251. Epub 2021 Aug 19.

School of Sports Medicine and Rehabilitation, Beijing Sport University, 100084, China.

We performed a systematic review and meta-analysis of randomized controlled trials (RCTs) assessing the effect of resistance training in older adults on insulin sensitivity.

Methods: Cochrane, Embase, PubMed, Web of Science and EBSCO were searched from inception to April 2021. We integrated randomized controlled trials published in English, and participants were non-athletic and aged ≥60 years. Read More

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October 2021

Liraglutide reduces plasma PCSK9 in patients with type 2 diabetes not treated with statins.

Diabetes Metab 2021 Sep 19:101284. Epub 2021 Sep 19.

University of Burgundy, INSERM LNC UMR1231, Dijon, France; CHU Dijon, Department of Biochemistry, Dijon, France.

Aim: Dyslipidaemia in type 2 diabetes mellitus (T2DM), which increases cardiovascular risk, includes abnormal metabolism of low-density lipoproteins (LDL). Our group has recently shown that liraglutide increases LDL catabolism in patients with T2DM and that it reduces the expression of PCSK9 (a major inhibitor of LDL-receptor expression) in vitro and in mice. This prompted us to study the effect of liraglutide on plasma PCSK9 level in patients with T2DM. Read More

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September 2021

Understanding Metabolic Memory: The Prolonged Influence of Glycemia During the Diabetes Control and Complications Trial (DCCT) on Future Risks of Complications During the Study of the Epidemiology of Diabetes Interventions and Complications (EDIC).

Diabetes Care 2021 Sep 21. Epub 2021 Sep 21.

Biostatistics Center, The George Washington University, Rockville, MD

The Diabetes Control and Complications Trial (DCCT, 1983-1993) showed that intensive therapy (mean HbA 7.2%) compared with conventional therapy (mean HbA 9.0%) markedly reduced the risks of retinopathy, nephropathy, and neuropathy, and these reductions in complications were entirely attributable, statistically, to the difference in mean HbA levels. Read More

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September 2021

Factors Influencing Change in Serum Uric Acid after Administration of the Sodium-Glucose Cotransporter 2 Inhibitor Luseogliflozin in Patients With Type 2 Diabetes Mellitus.

J Clin Pharmacol 2021 Sep 21. Epub 2021 Sep 21.

Division of Regenerative Medicine and Therapeutics, Department of Genomic Medicine and Regenerative Medicine, Faculty of Medicine, Tottori University, Tottori, Japan.

Although sodium-glucose cotransporter 2 (SGLT2) inhibitors lower serum uric acid, their long-term effect on uric acid metabolism is not well understood. We analyzed pooled data from studies wherein patients with type 2 diabetes mellitus (T2DM) received luseogliflozin-an SGLT2 inhibitor. Upon stratifying patients by baseline glycated hemoglobin (HbA1c) or serum uric acid, lower HbA1c or higher serum uric acid level was associated with a greater reduction in serum uric acid after treatment. Read More

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September 2021

Sotagliflozin for patients with type 2 diabetes: a systematic review and meta-analysis.

Diabetes Obes Metab 2021 Sep 20. Epub 2021 Sep 20.

Clinical Research and Evidence-Based Medicine Unit, Second Medical Department, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Aim: To assess the efficacy and safety of sotagliflozin in patients with type 2 diabetes mellitus.

Methods: We searched Medline, Embase, the Cochrane Library, and grey literature sources up to August 2021 for randomized controlled trials (RCTs) that compared sotagliflozin with placebo or other antidiabetic agents in patients with type 2 diabetes. Our primary outcome was change in HbA1c from baseline. Read More

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September 2021

Pdia4 regulates β-cell pathogenesis in diabetes: molecular mechanism and targeted therapy.

EMBO Mol Med 2021 Sep 20:e11668. Epub 2021 Sep 20.

Agricultural Biotechnology Research Center, Academia Sinica, Taipei, Taiwan.

Loss of β-cell number and function is a hallmark of diabetes. β-cell preservation is emerging as a promising strategy to treat and reverse diabetes. Here, we first found that Pdia4 was primarily expressed in β-cells. Read More

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September 2021

The Dual GIP and GLP-1 Receptor Agonist Tirzepatide Improves Cardiovascular Risk Biomarkers in Patients with Type 2 Diabetes: a Post-Hoc Analysis.

Diabetes Obes Metab 2021 Sep 20. Epub 2021 Sep 20.

Eli Lilly and Company, Indianapolis, Indiana, USA.

In a phase 2 trial of once-weekly tirzepatide (1, 5, 10, or 15 mg), dulaglutide (1.5 mg), or placebo, the dual GIP and GLP-1 receptor agonist tirzepatide dose-dependently reduced HbA1c and body weight in patients with type 2 diabetes. In this post-hoc analysis, inflammation, endothelial dysfunction, and cellular stress biomarkers were measured at baseline, 4, 12, and 26 weeks to evaluate additional effects of tirzepatide on cardiovascular risk factors. Read More

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September 2021

Bariatric Metabolic Surgery Reduced Liver Enzyme Levels in Patients with Non-Alcohol Fatty Liver Disease.

Kans J Med 2021 1;14:209-214. Epub 2021 Sep 1.

University of Kansas School of Medicine-Wichita, Wichita, KS.

Introduction: Approximately 93.3 million Americans are obese (BMI > 30 kg/m) and 51% have non-alcoholic fatty liver disease (NAFLD). Progression of NAFLD can lead to non-alcoholic steatohepatitis (NASH), which is the leading cause of liver transplant in the United States. Read More

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September 2021

Effect of Microalgae Arthrospira on Biomarkers of Glycemic Control and Glucose Metabolism: A Systematic Review and Meta-analysis.

Curr Probl Cardiol 2021 Jul 24:100942. Epub 2021 Jul 24.

Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address:

Diabetes mellitus and insulin resistance are associated with an increased risk of cardiovascular disease (CVD) incidence and a higher rate of CVD-related death. In this study, the effects of Arthrospira (Spirulina) a blue-green algae supplementation on biomarkers of glycemic control and glucose metabolism has been evaluated. PubMed, Scopus, and ISI Web of Science were searched systematically of English human subjects and PubMed for pre-clinical animal studies (rats and mice) from January 2008 until November 2020. Read More

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Contact activated kallikrein generation is reduced six months after gastric bypass.

Thromb Res 2021 Sep 14;207:50-54. Epub 2021 Sep 14.

Unit for Thrombosis Research, Department of Clinical Biochemistry, University Hospital of Southern Denmark, Esbjerg, Denmark; Department of Regional Health Research, University of Southern Denmark, Denmark.

Background: Prothrombotic and inflammatory variables decrease after obesity surgery. The contact activation system may be a common denominator of these changes.

Objective: To characterize the contact system before and 6 months after Roux-en-Y gastric bypass (RYGB) and to evaluate associations with changes (post-surgery minus pre-surgery) in metabolic variables. Read More

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September 2021

Temporal trend of small nerve fibre degeneration in people with and without type 2 diabetes mellitus.

Diabet Med 2021 Sep 18:e14691. Epub 2021 Sep 18.

Department of Translational Medicine, Hand Surgery, Lund University, Malmö, Sweden.

Aims: We investigated the long-term temporal trend of intraepidermal nerve fibre density (IENFD) and the association between changes in IENFD and metabolic factors in individuals with and without type 2 diabetes.

Methods: A total of 66 participants were enrolled in this longitudinal population-based study, at baseline consisting of 35 individuals (median 61 years) without diabetes and 31 individuals with type 2 diabetes mellitus. Participants underwent clinical and electrophysiological examinations, as well as a skin biopsy both at baseline and at the follow-up visit (mean 8. Read More

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September 2021

Safety, feasibility and efficacy of metformin and sitagliptin in patients with a TIA or minor ischaemic stroke and impaired glucose tolerance.

BMJ Open 2021 Sep 16;11(9):e046113. Epub 2021 Sep 16.

Neurology, Isala Hospitals, Zwolle, The Netherlands.

Introduction: Impaired glucose tolerance (IGT) is highly prevalent after stroke and is associated with recurrent stroke and unfavourable outcome.

Objectives: We aimed to assess the feasibility, safety and effects on glucose metabolism of metformin or sitagliptin in patients with transient ischaemic attack (TIA) or minor ischaemic stroke and IGT.

Design: We performed a multicentre, randomised, controlled, open-label phase II trial with blinded outcome assessment. Read More

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September 2021

Higher ambient temperature is associated with worsening of HbA1c levels in a Saudi population.

Int J Clin Exp Pathol 2021 15;14(8):881-891. Epub 2021 Aug 15.

Faculty of Health and Life Sciences, De Montfort University Leicester, UK.

Background: Ambient temperature is predicted to rise in Saudi Arabia, and how this will impact the health of its population has not been investigated. Saudi Arabia is one of the top ten countries with the highest prevalence of diabetes. The current study investigates the correlation between ambient temperature and HbA1c levels in a group of Saudis in Riyadh. Read More

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Use of connected pen as a diagnostic tool to evaluate missed bolus dosing behavior in people with type 1 and type 2 diabetes.

Diabetes Technol Ther 2021 Sep 15. Epub 2021 Sep 15.

Behavioral Diabetes Institute, 5230 Carroll Canyon Road, Suite 208, San Diego, California, United States, 92121.

Objective: This study used connected pen to determine missed bolus dose (MBD) frequency during masked and unmasked continuous glucose monitoring (CGM) periods and examined its link with time-in-range (TIR), time-above-range (TAR), time-below-range (TBR), and key participant characteristics in people with diabetes.

Methods: This was a 12-week, single-arm, exploratory, 2-period study for people with type 1 diabetes (T1D) or type 2 diabetes (T2D). The primary objective was to estimate the average number of MBD during masked and real-time CGM use. Read More

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September 2021

Higher blood high density lipoprotein and apolipoprotein A1 levels are associated with reduced risk of developing amyotrophic lateral sclerosis.

J Neurol Neurosurg Psychiatry 2021 Sep 13. Epub 2021 Sep 13.

Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK

Background: Premorbid body mass index, physical activity, diabetes and cardiovascular disease have been associated with an altered risk of developing amyotrophic lateral sclerosis (ALS). There is evidence of shared genetic risk between ALS and lipid metabolism. A very large prospective longitudinal population cohort permits the study of a range of metabolic parameters and the risk of subsequent diagnosis of ALS. Read More

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September 2021

Ceramides and phospholipids are downregulated with liraglutide treatment: results from the LiraFlame randomized controlled trial.

BMJ Open Diabetes Res Care 2021 Sep;9(1)

Steno Diabetes Center Copenhagen, Gentofte, Denmark.

Introduction: Treatment with glucagon-like peptide-1 receptor agonists (GLP-1 RAs) can reduce risk of cardiovascular disease (CVD) in persons living with type 2 diabetes, however the mechanisms explaining this cardiovascular benefit are still debated. We investigated changes in the plasma lipidome following treatment with the GLP-1 RA liraglutide.

Research Design And Methods: In a double-blind placebo-controlled trial, we randomized 102 persons with type 2 diabetes to liraglutide or placebo for 26 weeks. Read More

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September 2021

Effect of inflammatory bowel disease treatments on patients with diabetes mellitus.

World J Diabetes 2021 Aug;12(8):1248-1254

Department of Gastroenterology, South Warwickshire Foundation Trust, Warwick CV34 5BW, United Kingdom.

As medical care progresses and the number of patients with chronic conditions increases there is the inevitable challenge of managing patients with multiple co-morbidities. Inflammatory bowel disease (IBD) is an umbrella term for are inflammatory conditions affecting the gastrointestinal tract, the two most common forms being Ulcerative Colitis and Crohn's disease. These diseases, usually diagnosed in young adults, exhibit a relapsing and remitting course and usually require long-term treatment. Read More

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Type 2 Diabetes Mellitus and Latent Tuberculosis Infection Moderately Influence Innate Lymphoid Cell Immune Responses in Uganda.

Front Immunol 2021 27;12:716819. Epub 2021 Aug 27.

Immunomodulation and Vaccines Programme, Medical Research Council/Uganda Virus Research Institute (MRC/UVRI) and London School of Hygiene and Tropical Medicine (LSHTM) Uganda Research Unit, Entebbe, Uganda.

Background: Type 2 diabetes mellitus (T2DM) is a major risk factor for the acquisition of latent tuberculosis (TB) infection (LTBI) and development of active tuberculosis (ATB), although the immunological basis for this susceptibility remains poorly characterised. Innate lymphoid cells (ILCs) immune responses to TB infection in T2DM comorbidity is anticipated to be reduced. We compared ILC responses (frequency and cytokine production) among adult patients with LTBI and T2DM to patients (13) with LTBI only (14), T2DM only (10) and healthy controls (11). Read More

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Deuterium-depleted water stimulates GLUT4 translocation in the presence of insulin, which leads to decreased blood glucose concentration.

Mol Cell Biochem 2021 Sep 12. Epub 2021 Sep 12.

HYD LLC for Cancer Research and Drug Development, Villányi út 97, 1118, Budapest, Hungary.

Deuterium (D) is a stable isotope of hydrogen (H) with a mass number of 2. It is present in natural waters in the form of HDO, at a concentration of 16.8 mmol/L, equivalent to 150 ppm. Read More

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September 2021

Incidence of diabetic retinopathy in newly diagnosed subjects with type 2 diabetes mellitus over 5 years: Contribution of Β-cell function.

J Diabetes Complications 2021 Aug 30:108028. Epub 2021 Aug 30.

Diabetes Research Group, Swansea University, Singleton Park, Swansea SA2 8PP, UK.

Aims: Identifying and modulating risk factors is essential to prevent visual impairment due to diabetic retinopathy (DR). This study examines incident DR with metabolic and hormonal factors in newly-diagnosed, treatment naïve, individuals with Type2 Diabetes Mellitus (T2DM), over a 5 year period from diagnosis.

Methods: 233 T2DM subjects underwent serial DR screening using digital photography and standardised Meal Tolerance Tests at diagnosis and after 1, 2 and 5 years. Read More

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Metabolic improvement after gastric bypass correlates with changes in IGF-regulatory proteins stanniocalcin-2 and IGFBP-4.

Metabolism 2021 Sep 7;124:154886. Epub 2021 Sep 7.

Endocrine Research Unit, Department of Endocrinology, Odense University Hospital & Department of Clinical Research, Faculty of Health, University of Southern Denmark, Odense, Denmark; Medical Research Laboratory, Department of Clinical Medicine, Health, Aarhus University, Aarhus, Denmark. Electronic address:

Background: Pregnancy-associated plasma protein-A (PAPP-A) is an enzyme that increases IGF-activity through cleavage of IGF-binding proteins (IGFBPs), primarily IGFBP-4, whereby bound IGF-I becomes released as a free molecule. The enzymatic activity of PAPP-A is irreversibly suppressed by the glycoprotein stanniocalcin-2 (STC2). Pre-clinical and clinical studies suggest that the STC2 - PAPP-A - IGFBP-4 axis is important in controlling local IGF-action. Read More

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September 2021

Assessment of insulin resistance in patients with primary hyperparathyroidism before and after Parathyroidectomy.

Endocrinol Diabetes Metab 2021 Aug 5:e00294. Epub 2021 Aug 5.

Faculty of Medicine, Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Background: Primary hyperparathyroidism (PHPT) can lead to renal and skeletal disorders, as well as insulin resistance and impaired glucose metabolism. The current study aimed to assess the effects of parathyroidectomy on insulin resistance in patients with PHPT.

Materials And Methods: The present study was conducted on 65 patients with PHPT and indications for parathyroidectomy who were referred to the endocrinology clinics of Mashhad University of Medical Sciences. Read More

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Benchmarking care outcomes for young adults with type 1 diabetes in Australia after transition to adult care.

Endocrinol Diabetes Metab 2021 Sep 9:e00295. Epub 2021 Sep 9.

Sydney Medical School, University of Sydney, Sydney, NSW, Australia.

Aim: To determine advantages conferred by a youth-specific transition clinic model for young adults with type 1 diabetes (T1D) at Westmead Hospital (WH) as compared with Australian registry data.

Methods: Prospectively collected data included age, diabetes duration, visit frequency, post code, BMI, mode of insulin delivery, continuous glucose monitoring, HbA1c, albumin creatinine ratio, BP, retinopathy and diabetic ketoacidosis (DKA) for all WH T1D clinic attendees aged 16-25 between January 2017 and June 2018 (n = 269). Results were compared with data collected during the same time period from 2 separate Australian data registries, one longitudinal (Australasian Diabetes Data Network, ADDN) and one a spot survey (the Australian National Diabetes Audit, ANDA). Read More

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September 2021

Comparison of the Efficacy, Tolerability and Side Effect Profile of Vildagliptin-Metformin with Metformin-GlibenclamideMamong Nigerian.

West Afr J Med 2021 08;38(8):756-761

Department of Medicine, Bayero University / Aminu Kano Teaching Hospital, Kano, Kano State, Nigeria. E-mail:

Background: The use of fixed dose combination oral antidiabetic drugs (OADs) in the therapeutic management of type 2 diabetes mellitus (DM) patients is becoming popular among clinicians. Reduced pill burden with fixed combination OADs is generally perceived to improve adherence and efficacy. The aim of this study was to compare the efficacy, tolerability and side effects (SEs) profile of vildagliptin-metformin (VM) combination with metformin-glibenclamide (MG) combination in type 2 DM patients at the Aminu Kano Teaching Hospital (AKTH). Read More

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Evaluation of the Low Carb Program Digital Intervention for the Self-Management of Type 2 Diabetes and Prediabetes in an NHS England General Practice: Single-Arm Prospective Study.

JMIR Diabetes 2021 Sep 9;6(3):e25751. Epub 2021 Sep 9.

Norwood Surgery, Southport, United Kingdom.

Background: Type 2 diabetes mellitus has serious health consequences, including blindness, amputation, and stroke. Researchers and clinicians are increasingly in agreement that type 2 diabetes may be effectively treated with a carbohydrate-reduced diet. Digital apps are increasingly used as an adjunct to traditional health care provisions to support remote self-management of long-term health conditions. Read More

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September 2021

Real-world experience with pasireotide-LAR in resistant acromegaly: a single center 1-year observation.

Pituitary 2021 Sep 8. Epub 2021 Sep 8.

Department of Endocrinology, The Centre of Postgraduate Medical Education, Warsaw, Poland.

Context: Pasireotide-LAR, a second-generation somatostatin receptor ligand (SRL), is recommended for patients with acromegaly as second-line treatment. Its efficacy and safety were assessed in clinical trials; however, the real-world evidence is still scarce.

Objective: The aim of this study was to evaluate the impact of 1-year treatment with pasireotide-LAR on disease control and glucose metabolism in acromegaly patients resistant to first-generation SRLs. Read More

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September 2021

Agriophyllum Oligosaccharides Ameliorate Diabetic Insulin Resistance Through INS-R/IRS/Glut4-Mediated Insulin Pathway in db/db Mice and MIN6 Cells.

Front Pharmacol 2021 23;12:656220. Epub 2021 Aug 23.

Key Laboratory for Traditional Chinese Korean Medicine of Jilin Province, College of Pharmacy, Yanbian University, Yanji, China.

We have previously reported that Agriophyllum oligosaccharides (AOS) significantly enhance glycemic control by increasing the activation of insulin receptor (INS-R), insulin receptor substrate-2 (IRS-2), phosphatidylinositol 3 kinase (PI3K), protein kinase B (AKT), peroxisome proliferator-activated receptor (PPAR)-γ, and glucose transporter 4 (Glut4) proteins in hepatic tissues. However, the effect of glucose control by AOS on the regulation of pancreatic tissues in db/db mice and MIN6 cells remains to be determined. An oral dose of AOS (380 or 750 mg/kg) was administered to type-2 diabetic db/db mice for 8 weeks to determine whether AOS regulates glucose by the INS-R/IRS/Glut4-mediated insulin pathway. Read More

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