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Application of Human Factors Methods to Ensure Appropriate Infant Identification and Abduction Prevention Within the Hospital Setting.

J Perinat Neonatal Nurs 2021 Jul-Sep 01;35(3):258-265

Department of Patient Safety, Regulatory, & Accreditation, Cincinnati Children's Hospital, Cincinnati, Ohio (Dr Webster); Center for Women & Infants, UofL Hospital, Louisville, Kentucky (Mss Stikes and Gardner); Labor & Delivery and Mother/Baby, Center for Women & Infants, UofL Hospital, Louisville, Kentucky (Ms Bunnell); and Department of Obstetrics, Gynecology and Women's Health, University of Louisville, Louisville, Kentucky (Dr Petruska).

Infant misidentification and abduction are recognized as "never" events for hospitals in the United States. As near misses are often unreported, root cause analysis of observed near misses may fail to uncover important contributors. We utilized failure mode and effects analysis to proactively identify and eliminate or reduce the risk of infant misidentification or abduction. Read More

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Breast cancer screening using synthesized two-dimensional mammography: A systematic review and meta-analysis.

Breast 2021 Jul 22;59:270-278. Epub 2021 Jul 22.

Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Centre, Beijing, China.

Purpose: We conducted a systematic review and meta-analysis to compare the screening performance of synthesized mammography (SM) plus digital breast tomosynthesis (DBT) with digital mammography (DM) plus DBT or DM alone.

Methods: Medline, Embase, Web of Science, and the Cochrane Library databases were searched from January 2010 to January 2021. Eligible population-based studies on breast cancer screening comparing SM/DBT with DM/DBT or DM in asymptomatic women were included. Read More

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FLAMSA-busulfan-melphalan as sequential conditioning regimen in HLA-matched or haploidentical hematopoietic stem cell transplantation for high-risk myeloid diseases.

Transplant Cell Ther 2021 Jul 27. Epub 2021 Jul 27.

Sorbonne Université, Service d'Hématologie Clinique, Hôpital Pitié-Salpêtrière, APHP, Paris, France.

Background: Given the poor prognosis of relapsed/refractory myeloid malignancies, the concept of sequential conditioning prior to allogeneic hematopoietic stem cell transplantation has been shown as an effective approach.

Objective: We sought to evaluate a sequential scheme combining fludarabine, amsacrine and cytarabine for cytoreduction, followed by a reduced-intensity conditioning with melphalan and busulfan (FLAMSA-BuMel), which was designed to be suitable for both HLA-matched and haploidentical grafts.

Study Design: In this monocentric retrospective study, 36 adult patients with high-risk myeloid malignancies were included, and transplanted from HLA-matched (n=19) or haploidentical (n=17) donors. Read More

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Intimal aortic atherosclerosis in cardiac surgery: surgical strategies to prevent embolic stroke.

Eur J Cardiothorac Surg 2021 Jul 30. Epub 2021 Jul 30.

Cardiothoracic Surgery, Erasmus Medical Center, Rotterdam, Netherlands.

Objectives: Although the incidence of perioperative stroke after cardiac surgery gradually decreased over the last decades, there is much variation between centres. This review aimed to create a concise overview of the evidence on possible surgical strategies to prevent embolic stroke in patients with intimal aortic atherosclerosis.

Methods: The PubMed and EMBASE databases were searched for studies on surgical management of aortic atherosclerosis and the association with perioperative stroke in cardiac surgery, including specific searches on the most common types of surgery. Read More

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Characteristics of aspiration pneumonia patients in acute care hospitals: A multicenter, retrospective survey in Northern Japan.

PLoS One 2021 30;16(7):e0254261. Epub 2021 Jul 30.

Department of Otolaryngology, Sendai City Hospital, Sendai, Japan.

Background: Pneumonia is a common cause of illness and death of the elderly in Japan. Its prevalence is escalating globally with the aging of population. To describe the latest trends in pneumonia hospitalizations, especially aspiration pneumonia (AP) cases, we assessed the clinical records of pneumonia patients admitted to core acute care hospitals in Miyagi prefecture, Japan. Read More

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Social determinants associated with Zika virus infection in pregnant women.

PLoS Negl Trop Dis 2021 Jul 30;15(7):e0009612. Epub 2021 Jul 30.

Instituto de Saúde Coletiva, Universidade Federal da Bahia, Salvador, Brazil.

This study aims to describe the sociodemographic determinants associated with exposure to Zika Virus (ZIKV) in pregnant women during the 2015-2016 epidemic in Salvador, Brazil.

Methods: We recruited women who gave birth between October 2015 and January 2016 to a cross-sectional study at a referral maternity hospital in Salvador, Brazil. We collected information on their demographic, socioeconomic, and clinical characteristics, and evaluated their ZIKV exposure using a plaque reduction neutralization test. Read More

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Septic Arthritis of the Shoulder After SARS-CoV-2 Pfizer Vaccination: A Case Report.

JBJS Case Connect 2021 Jul 30;11(3). Epub 2021 Jul 30.

Department of Orthopaedics, University of Miami, Miami, Florida.

Case: We report a case of a 68-year-old woman who developed left shoulder glenohumeral joint septic arthritis within 1 week of receiving the COVID-19 Pfizer-BioNTech vaccine.

Conclusion: Common vaccine complications include injection site pain, fever, chills, arthralgia, and hypersensitivity reactions. A less common and more serious complication of septic arthritis has been reported and requires invasive treatment of surgical irrigation and debridement, and culture-specific parenteral antibiotic therapy. Read More

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Survey on storage, application and incorporation practices for organic fertilizers in Germany.

J Environ Manage 2021 Jul 29;296:113380. Epub 2021 Jul 29.

Institute of Animal Science, University of Bonn, Bonn, Germany. Electronic address:

Organic fertilizers from animal production might contain undesirable components, such as veterinary medical product (VMP) residues, that are released into the environment during application. In addition to measures to reduce the use of VMPs through animal health measures, manure management could be an expedient strategy to prevent VMPs from entering the environment. The quantity applied is mainly determined by the nitrogen content. Read More

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Carbon monoxide releasing molecule A1 reduces myocardial damage after acute myocardial infarction in a porcine model.

J Cardiovasc Pharmacol 2021 May 20. Epub 2021 May 20.

Cardiology department, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.

Infarct size is a major determinant of outcomes after acute myocardial infarction (AMI). Carbon monoxide releasing molecules (CORMs), which deliver nano-molar concentrations of carbon monoxide to tissues, have been shown to reduce infarct size in rodents. We evaluated efficacy and safety of CORM-A1 to reduce infarct size in a clinically relevant porcine model of AMI. Read More

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30-Day Morbidity and Mortality of Bariatric Surgery During the COVID-19 Pandemic: a Multinational Cohort Study of 7704 Patients from 42 Countries.

Obes Surg 2021 Jul 30. Epub 2021 Jul 30.

Bariatric Unit, South Tyneside and Sunderland NHS Trust, Sunderland, UK.

Background: There are data on the safety of cancer surgery and the efficacy of preventive strategies on the prevention of postoperative symptomatic COVID-19 in these patients. But there is little such data for any elective surgery. The main objectives of this study were to examine the safety of bariatric surgery (BS) during the coronavirus disease 2019 (COVID-19) pandemic and to determine the efficacy of perioperative COVID-19 protective strategies on postoperative symptomatic COVID-19 rates. Read More

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Procalcitonin and C-Reactive Protein as an Early Predictor of Infection in Elective Gastrointestinal Cancer Surgery-a Prospective Observational Study.

J Gastrointest Cancer 2021 Jul 30. Epub 2021 Jul 30.

Department of Social and Preventive Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.

Background: Postoperative infections are a common entity following elective gastrointestinal surgery among which intra-abdominal infection is notorious and life threatening. Early detection could reduce postoperative morbidity and permit safe and early discharge. This study was aimed to establish the usefulness of procalcitonin (PCT) and C-reactive protein (CRP) on postoperative day 3 as reliable markers for early detection of intra-abdominal infection and other postoperative infections following elective gastrointestinal cancer surgery. Read More

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Pitavastatin stimulates retinal angiogenesis via HMG-CoA reductase-independent activation of RhoA-mediated pathways and focal adhesion.

Graefes Arch Clin Exp Ophthalmol 2021 Jul 30. Epub 2021 Jul 30.

Department of Biological Repositories, Zhongnan Hospital of Wuhan University, 169 Donghu Road, Wuhan, 430071, Hubei, China.

Background: Excessive angiogenesis of the retina is a key component of irreversible causes of blindness in many ocular diseases. Pitavastatin is a cholesterol-lowering drug used to reduce the risk of cardiovascular diseases. Various studies have shown the effects of pitavastatin on angiogenesis but the conclusions are contradictory. Read More

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Recursive Partitioning vs Computerized Adaptive Testing to Reduce the Burden of Health Assessments in Cleft Lip and/or Palate: Comparative Simulation Study.

J Med Internet Res 2021 Jul 30;23(7):e26412. Epub 2021 Jul 30.

Warwick Clinical Trials Unit, University of Warwick, Coventry, United Kingdom.

Background: Computerized adaptive testing (CAT) has been shown to deliver short, accurate, and personalized versions of the CLEFT-Q patient-reported outcome measure for children and young adults born with a cleft lip and/or palate. Decision trees may integrate clinician-reported data (eg, age, gender, cleft type, and planned treatments) to make these assessments even shorter and more accurate.

Objective: We aimed to create decision tree models incorporating clinician-reported data into adaptive CLEFT-Q assessments and compare their accuracy to traditional CAT models. Read More

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Social Media and mHealth Technology for Cancer Screening: Systematic Review and Meta-analysis.

J Med Internet Res 2021 Jul 30;23(7):e26759. Epub 2021 Jul 30.

Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada.

Background: Cancer is a leading cause of death, and although screening can reduce cancer morbidity and mortality, participation in screening remains suboptimal.

Objective: This systematic review and meta-analysis aims to evaluate the effectiveness of social media and mobile health (mHealth) interventions for cancer screening.

Methods: We searched for randomized controlled trials and quasi-experimental studies of social media and mHealth interventions promoting cancer screening (breast, cervical, colorectal, lung, and prostate cancers) in adults in MEDLINE, Embase, PsycINFO, Scopus, CINAHL, Cochrane Central Register of Controlled Trials, and Communication & Mass Media Complete from January 1, 2000, to July 17, 2020. Read More

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Pharmacological management of antifungal agents in pulmonary aspergillosis: an updated review.

Expert Rev Anti Infect Ther 2021 Jul 30. Epub 2021 Jul 30.

Pharmacy Department, Hospital del Mar, Parc de Salut Mar, Barcelona, Spain.

Introduction: may cause different types of lung infections: invasive, chronic pulmonary or allergic bronchopulmonary aspergillosis. Pharmacological management with antifungals poses as a challenge. Patients diagnosed with pulmonary aspergillosis are complex, as well as the problems associated with antifungal agents. Read More

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Childhood psychosocial stress is linked with impaired vascular endothelial function, lower SIRT1, and oxidative stress in young adulthood.

Am J Physiol Heart Circ Physiol 2021 Jul 30. Epub 2021 Jul 30.

Integrative Immunology Center, University of Oklahoma School of Community Medicine, Tulsa, OK, United States.

Adverse childhood experiences (ACEs) are psychosocial stressors that occur during sensitive developmental windows and are associated with increased lifetime cardiovascular disease (CVD) risk in a dose-dependent manner. Vascular endothelial dysfunction is a pathophysiological mechanism that promotes hypertension and CVD, and may be a mechanism by which ACEs contribute to lifetime CVD risk. We examined whether exposure to ACEs is associated with reduced vascular endothelial function (VEF) in otherwise healthy, young adult women (20. Read More

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Preimplantation genetic testing in assisted reproduction.

Minerva Obstet Gynecol 2021 Jul 30. Epub 2021 Jul 30.

Clínica EUGIN, Bogotá, Colombia.

In the last years technologies, have been developed that allow obtaining genetic information in less time and at lower cost, revolutionizing the genetic diagnosis in reproductive medicine, with availability of genetic tests from conception. High throughput sequencing analyzes have increased the ability to detect embryos with genetic diseases, which has contributed to the better selection of embryos for in vitro fertilization and, therefore, better reproductive outcomes. The preimplantation genetic testing (PGT) includes three sub-categories of PGT for aneuploidies (PGTA), PGT for single gene / monogenic disorders (PGT-M), and PGT for chromosome structural rearrangements (PGT-SR). Read More

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[Neurological complications in haematopoietic stem cell transplant patients].

Rev Neurol 2021 Sep;73(5):174-183

Hospital de la Santa Creu i Sant Pau , Barcelona, España.

Introduction: Neurological complications are some of the most important complications that can occur in a patient undergoing haematopoietic stem cell transplantation (HSCT), not only because of the high mortality rate, but also because of the sequelae that appear in survivors. The causes of such complications are manifold and very often coexist in the same patient: toxicity of the conditioning regimen, graft-versus-host disease and its treatment, infections and their treatment, platelets and coagulation disorders, liver failure or arterial hypertension with low platelet count.

Aims: The aim of the present study is to provide a clinical description and to describe the risk factors for complications involving the central nervous system that may occur during the course of HSCT, in order to assist in the early detection of these disorders that may have a negative influence on the morbidity and mortality of these patients. Read More

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September 2021

Genomic epidemiology and transmission dynamics of SARS-CoV-2 in congregate healthcare facilities in Santa Clara County, California.

Clin Infect Dis 2021 Jul 30. Epub 2021 Jul 30.

County of Santa Clara, Public Health Department, San Jose, California, USA.

Background: Outbreaks of SARS-CoV-2 in long term care facilities (LTCFs) cause significant morbidity and mortality. Mapping viral transmission within and between by combining genomic sequencing with epidemiologic investigations enables targeting infection control interventions.

Methods: We conducted weekly surveillance of residents and staff in LTCFs in Santa Clara County, CA with at least one confirmed COVID-19 case between March and July 2020. Read More

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Perceptions of heat-health impacts and the effects of knowledge and preventive actions by outdoor workers in Hanoi, Vietnam.

Sci Total Environ 2021 Jun 10;794:148260. Epub 2021 Jun 10.

Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Human Potential Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Global Asia Institute, National University of Singapore, Singapore; The N.1 Institute for Health, National University of Singapore, Singapore; The Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR), Singapore.

Extreme heat is an increasing climate threat, most pronounced in urban areas where poor populations are at particular risk. We analyzed heat impacts and vulnerabilities of 1027 outdoor workers who participated in a KAP survey in Hanoi, Vietnam in 2018, and the influence of their mitigation actions, their knowledge of heat-risks, and access to early warnings. We grouped respondents by their main income (vendors, builders, shippers, others, multiple jobs, and non-working) and analyzed their reported heat-health impacts, taking into consideration socioeconomics, knowledge of heat impacts and preventive measures, actions taken, access to air-conditioning, drinking amounts and use of weather forecasts. Read More

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The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial.

Biomed Pharmacother 2021 Jul 10;141:111915. Epub 2021 Jul 10.

Department of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address:

Background: Based on a comprehensive search, we realized that the findings of the available literature are contradictory, and also limited data are available on Middle Eastern populations in terms of probiotic supplementation during the pregnancy. Therefore, the current double-blind, randomized, placebo-controlled clinical trial was carried out to investigate the effects of probiotic supplementation during pregnancy on the risk of gestational diabetes mellitus and also other maternal and neonatal outcomes.

Materials And Methods: The pregnant women were randomized to either received probiotic supplement (n = 271) or placebo (n = 271) from the first half of the second trimester (14 weeks of pregnancy) up to 24 weeks when pregnant women routinely evaluated regarding the GDM. Read More

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Impulsivity and Medical Care Utilization in Veterans Treated for Substance Use Disorder.

Subst Use Misuse 2021 Jul 30:1-11. Epub 2021 Jul 30.

VA Palo Alto Health Care System, Palo Alto, California, USA.

Background: Impulsivity has been defined by acting rashly during positive mood states (positive urgency; PU) or negative mood states (negative urgency; NU) and by excessive de-valuation of deferred rewards. These behaviors reflect a "live in the now" mentality that is not only characteristic of many individuals with severe substance use disorder (SUD) but also impedes medical treatment compliance and could result in repeated hospitalizations or other poor health outcomes. We sought preliminary evidence that impulsivity may relate to adverse health outcomes in the veteran population. Read More

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Socio-Demographic and Coping Correlates and Predictors of Depressive Symptoms Among Low-Income and Ethnic Minority Mothers At-Risk.

Clin Nurs Res 2021 Jul 30:10547738211029685. Epub 2021 Jul 30.

Rutgers the State University of New Jersey School of Nursing-Camden, USA.

This study identified coping and sociodemographic correlates and predictors of depressive symptoms in mothers at risk for clinical depression. A descriptive, cross-sectional design was employed. A convenience sample of 88 low-income or ethnic-minority mothers aged 21 to 45 completed a depression scale, demographic data sheet, and responded to an open-ended question. Read More

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Probl Sotsialnoi Gig Zdravookhranenniiai Istor Med 2021 Jun;29(Special Issue):619-624

Moscow Regional Dental Clinic, 129110, Moscow, Russia.

It is known that the oral cavity is an epidemiological hazard due to the high level of viral and bacterial contamination. Despite the narrow specialization and distant connection with the problem of viral pneumonia, dentists, nevertheless, are at risk of contracting the new coronavirus infection COVID-19. To reduce the epidemiological activity the provision of routine dental care was suspended in the vast majority of regions of the Russian Federation including the Moscow region, from the end of March 2020 to June 20, 2020. Read More

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Omega-3 fatty acids are associated with blood-brain barrier integrity in a healthy aging population.

Brain Behav 2021 Jul 29. Epub 2021 Jul 29.

Department of Psychology, School of Behavioral Health, Loma Linda University, Loma Linda, California, USA.

In aging populations, omega-3 polyunsaturated fatty acids (PUFAs) have been associated with better cognitive function, slower rates of cognitive decline, and lower risk of developing dementia. Animal studies have shown that diets rich in omega-3 PUFAs reduce blood-brain barrier (BBB) disruption associated with aging, but this has yet to be observed in humans. Forty-five healthy subjects (mean age, 76 years) were recruited and underwent cognitive assessment (verbal learning and memory, language, processing speed, executive function, and motor control) and measurement of PUFAs. Read More

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Workplace bullying, occupational burnout, work-life imbalance, and perceived medical errors among nurses in Oman: A cluster analysis.

J Nurs Manag 2021 Jul 29. Epub 2021 Jul 29.

Faculty of Health Sciences, Department of Health Management and Policy, American University of Beirut, Beirut, Lebanon.

Aims: To explore whether different profiles exist in a cohort of nurses regarding demographic and occupational outcomes.

Background: Nurses will facing many occupational problems, including workplace bullying, work-life imbalance, burnout, and medical errors.

Methods: A cross-sectional study included 232 nurses working in a hospital in Oman. Read More

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Does work-family conflict play a role in the relationship between work-related hazards and musculoskeletal pain?

Am J Ind Med 2021 Jul 29. Epub 2021 Jul 29.

Department of Public Health and Primary Care, Ghent University, Ghent, Belgium.

Background: Previous research identified an association between work-family conflict and musculoskeletal pain. This study explores how conflict arising from participating in both the work and nonwork domains might influence the relationships between musculoskeletal pain experienced by workers and particular work-related hazards.

Methods: A cross-sectional survey of data was collected from 401 workers in Belgium across seven organizations in the service and production sector. Read More

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Coping and Adaptation in Response to Environmental and Climatic Stressors in Caribbean Coastal Communities.

Environ Manage 2021 Jul 29. Epub 2021 Jul 29.

Department of Environment and Geography, University of York, Wentworth Way, York, YO10 5NG, UK.

Cumulative and synergistic impacts from environmental pressures, particularly in low-lying tropical coastal regions, present challenges for the governance of ecosystems, which provide natural resource-based livelihoods for communities. Here, we seek to understand the relationship between responses to the impacts of El Niño and La Niña events and the vulnerability of mangrove-dependent communities in the Caribbean region of Colombia. Using two case study sites, we show how communities are impacted by, and undertake reactive short-term responses to, El Niño and La Niña events, and how such responses can affect their adaptive capacity to progressive environmental deterioration. Read More

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Ultrasound fusion biopsy.

Radiologe 2021 Jul 29. Epub 2021 Jul 29.

Department of Radiology, Interdisciplinary Ultrasound Center, Campus Charité Mitte, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117, Berlin, Germany.

Background: Ultrasound (US)-guided biopsy is widely used for the diagnostic confirmation of focal lesions. For sampling of prostate tissue, magnetic resonance imaging (MRI)/US fusion-guided biopsy has already been implemented in routine clinical practice and has shown a superior detection rate of significant prostate cancer in risk assessment compared with standard systematic biopsy. Newer three-dimensional software tools with volumetric mapping of the prostate and biopsy core channels provide a better overview of systematic biopsy and thus contribute to more accurate treatment planning. Read More

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Electrochemical bromofunctionalization of alkenes in a flow reactor.

Org Biomol Chem 2021 Jul 30. Epub 2021 Jul 30.

Cardiff University, School of Chemistry, Park Place, Main Building, Cardiff CF10 3AT, Cymru/Wales, UK.

The bromination of organic molecules has been extensively studied to date, yet there is still a demand for safe and sustainable methodologies. Hazardous reagents, selectivity, low atom economy and waste production are the most persisting problems of brominating reagents. The electrochemical oxidation of bromide to bromine is a viable strategy to reduce waste by avoiding chemical oxidants. Read More

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