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Functional Ankle Range of Motion but Not Peak Achilles Tendon Force Diminished With Heel-Rise and Jumping Tasks After Achilles Tendon Repair.

Am J Sports Med 2021 Jun 11:3635465211019436. Epub 2021 Jun 11.

Department of Physical Therapy, University of Delaware, Newark, Delaware, USA.

Background: Deficits in sporting performance after Achilles tendon repair may be due to changes in musculotendinous unit structure, including tendon elongation and muscle fascicle shortening.

Purpose/hypothesis: The purpose was to discern whether Achilles tendon rupture reduces triceps surae muscle force generation, alters functional ankle range of motion, or both during sports-related tasks. We hypothesized that individuals who have undergone Achilles tendon repair lack the functional ankle range of motion needed to complete sports-related tasks. Read More

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Accuracy of CGM Systems During Continuous and Interval Exercise in Adults with Type 1 Diabetes.

J Diabetes Sci Technol 2021 Jun 11:19322968211023522. Epub 2021 Jun 11.

Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University and Hospital of Verona, Verona, Italy.

Background: continuous glucose monitoring systems (CGMs) play an important role in the management of T1D, but their accuracy may reduce during rapid glucose excursions. The aim of study was to assess the accuracy of recent rt-CGMs available in Italy, in subjects with T1D during 2 sessions of physical activity: moderate continuous (CON) and interval exercise (IE).

Method: we recruited 22 patients with T1D, on CSII associated or integrated with a CGM, to which a second different sensor was applied. Read More

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Focal Loss Analysis of Nerve Fiber Layer Reflectance for Glaucoma Diagnosis.

Transl Vis Sci Technol 2021 May;10(6)

Casey Eye Institute, Oregon Health & Science University, Portland, OR, USA.

Purpose: To evaluate nerve fiber layer (NFL) reflectance for glaucoma diagnosis.

Methods: Participants were imaged with 4.5 × 4. Read More

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Ga-PSMA PET/CT: effect of external cooling on salivary gland uptake.

Radiol Bras 2021 May-Jun;54(3):171-176

Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, SP, Brazil.

Objective: To evaluate the effect that external cooling of the salivary glands (ECSG) has on the uptake of gallium-68-labeled prostate-specific membrane antigen (Ga-PSMA), as an indirect assessment of the capacity of ECSG to reduce the local dose in lutetium-177-PSMA-617 radioligand therapy.

Materials And Methods: Ten patients with prostate cancer were submitted to Ga-PSMA positron emission tomography/computed tomography with unilateral ECSG. The ECSG was started at 30 min before the injection of the radiotracer and maintained until the end of image acquisition (1 h after injection). Read More

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[The clinical effect of percutaneous curved kyphoplasty for osteoporosis vertebral compression fractures].

Zhonghua Wai Ke Za Zhi 2021 Jun;59(6):458-463

Department of Orthopaedics, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.

To evaluate the clinical effect of percutaneous curved kyphoplasty (PCK) for osteoporosis vertebral compression fractures (OVCF). This is a prospective study.Patients with OVCF who underwent PCK at the Department of Orthopedics,Beijing Chaoyang Hospital, Capital Medical University from June 2018 to June 2019 were included. Read More

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Paired inhibitory stimulation and gait training modulates supplemental motor area connectivity in freezing of gait.

Parkinsonism Relat Disord 2021 Jun 1;88:28-33. Epub 2021 Jun 1.

Department of Neurology, Medical University of South Carlina, Charleston, SC, USA. Electronic address:

Introduction: Freezing of gait (FOG) is a debilitating feature of Parkinson's disease (PD). Evidence suggests patients with FOG have increased cortical control of gait. The supplementary motor area (SMA) may be a key structure due to its connectivity with locomotor and cognitive networks. Read More

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Relationships between activated dendritic cells and dry eye symptoms and signs.

Ocul Surf 2021 Jun 5. Epub 2021 Jun 5.

Miami Veterans Administration Medical Center, Miami, FL, USA; Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA. Electronic address:

Purpose: To examine whether "activated" dendritic cells (aDCs) could serve as a biomarker of systemic immune disorders in individuals with dry eye (DE) symptoms. Secondarily, to examine the impact of a topical anti-inflammatory agent on aDC number.

Methods: Retrospective analysis was conducted to identify individuals with DE symptoms who had in-vivo confocal microscopy (IVCM) imaging between October 2018 and July 2020 at the Miami Veterans Hospital. Read More

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Association Between Attending Physicians' Rates of Referral to Palliative Care and Location of Death in Hospitalized Adults With Serious Illness: A Population-based Cohort Study.

Med Care 2021 Jul;59(7):604-611

Department of Medicine, University of Toronto.

Background: Patients who receive palliative care are less likely to die in hospital.

Objective: To measure the association between physician rates of referral to palliative care and location of death in hospitalized adults with serious illness.

Research Design: Population-based decedent cohort study using linked health administrative data in Ontario, Canada. Read More

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Reduced nontarget embolization and increased targeted delivery with a reflux-control microcatheter in a swine model.

Diagn Interv Imaging 2021 Jun 4. Epub 2021 Jun 4.

R&I, Guerbet, 95943 Roissy CdG Cedex, France.

Purpose: To evaluate the potential differences in non-target embolization and vessel microsphere filling of a reflux-control microcatheter (RCM) compared to a standard end-hole microcatheter (SEHM) in a swine model.

Materials And Methods: Radiopaque microspheres were injected with both RCM and SEHM (2.4-Fr and 2. Read More

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Synthesizing PET/MR (T1-weighted) images from non-attenuation-corrected PET images.

Phys Med Biol 2021 Jun 7. Epub 2021 Jun 7.

Paul C. Lauterbur Research Centre for Biomedical Imaging, Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences, 1068 Xueyuan Avenue, Shenzhen University Town, Shenzhen, P.R.China, Shenzhen, 518055, CHINA.

Positron emission tomography (PET) imaging can be used for early detection, diagnosis and postoperative patient monitoring of many diseases. Traditional PET imaging requires not only additional computed tomography (CT) imaging or magnetic resonance imaging (MR) to provide anatomical information but also attenuation correction (AC) map calculation based on CT images or MR images for accurate quantitative estimation. During a patient's treatment, PET/CT or PET/MR scans are inevitably repeated many times, leading to additional doses of ionizing radiation (CT scans) and additional economic and time costs (MR scans). Read More

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Reducing the metabolic energy of walking and running using an unpowered hip exoskeleton.

J Neuroeng Rehabil 2021 Jun 6;18(1):95. Epub 2021 Jun 6.

Department of Rehabilitation Medicine, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, 430074, Hubei, China.

Background: Walking and running are the most common means of locomotion in human daily life. People have made advances in developing separate exoskeletons to reduce the metabolic rate of walking or running. However, the combined requirements of overcoming the fundamental biomechanical differences between the two gaits and minimizing the metabolic penalty of the exoskeleton mass make it challenging to develop an exoskeleton that can reduce the metabolic energy during both gaits. Read More

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The Effects of a 7000-Step Goal and Weekly Group Walking Program for Overweight and Obese Elderly People in Sarawak, Malaysia: A Quasi-experimental Study.

J Prev Med Public Health 2021 May 29;54(3):199-207. Epub 2021 Apr 29.

Department of Community Medicine and Public Health, Faculty of Medicine and Health Sciences, University Malaysia Sarawak, Kota Samarahan, Malaysia.

Objectives: Physical inactivity is the fourth leading global risk factor for mortality, followed by obesity. The combination of these risk factors is associated with non-communicable diseases, impaired physical function, and declining mental function. The World Health Organization recommends physical activity to reduce the mortality rate. Read More

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Evidence for strictly monocular processing in visual motion opponency and Glass pattern perception.

Vision Res 2021 May 31;186:103-111. Epub 2021 May 31.

Department of Psychology, University of California Los Angeles, Los Angeles, CA 90095, USA.

When presented with locally paired dots moving in opposite directions, motion selective neurons in the middle temporal cortex (MT) reduce firing while neurons in V1 are unaffected. This physiological effect is known as motion opponency. The current study used psychophysics to investigate the neural circuit underlying motion opponency. Read More

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Contrast-enhanced CT to noncontrast CT transformation via adjacency content transfer-based deep subtraction residual neural network.

Phys Med Biol 2021 Jun 2. Epub 2021 Jun 2.

Shenzhen Institutes of Advanced Technology, shenzhen, CHINA.

To reduce overall patient radiation exposure in some clinical scenarios (i.e., cancer patients need frequent follow-ups), noncontrast CT is skipped in some institutions. Read More

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Perceived stress and its predictors, stressors and coping strategies among undergraduate pharmacy students in northern Nigeria.

Curr Pharm Teach Learn 2021 Jul 6;13(7):804-811. Epub 2021 Apr 6.

Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmaceutical Sciences, University of Ilorin, Kwara State, Nigeria.

Introduction: Pharmacy education may be associated with stress due to the nature of its curriculum and expectations of high-quality services from students on graduation. This study evaluated perceived stress and its predictors, stressors, and coping strategies among undergraduate pharmacy students in northern Nigeria.

Methods: This was a prospective longitudinal study conducted at three randomly selected pharmacy schools in northern Nigeria. Read More

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Ga-Labeling: Laying the Foundation for an Anti-Radiolytic Formulation for NOTA-sdAb PET Tracers.

Pharmaceuticals (Basel) 2021 May 10;14(5). Epub 2021 May 10.

Department of Medical Imaging (MIMA), Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090 Brussels, Belgium.

During the preparation of [Ga]Ga-NOTA-sdAb at high activity, degradation of the tracers was observed, impacting the radiochemical purity (RCP). Increasing starting activities in radiolabelings is often paired with increased degradation of the tracer due to the formation of free radical species, a process known as radiolysis. Radical scavengers and antioxidants can act as radioprotectant due to their fast interaction with formed radicals and can therefore reduce the degree of radiolysis. Read More

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Optimizing Chronic Pain Treatment with Enhanced Neuroplastic Responsiveness: A Pilot Randomized Controlled Trial.

Nutrients 2021 May 5;13(5). Epub 2021 May 5.

Pain Research and Intervention Center of Excellence, University of Florida, Gainesville, FL 32611, USA.

Chronic pain affects mental and physical health and alters brain structure and function. Interventions that reduce chronic pain are also associated with changes in the brain. A number of non-invasive strategies can promote improved learning and memory and increase neuroplasticity in older adults. Read More

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Enhanced energy recovery using a cascaded reverse electrodialysis stack for salinity gradient power generation.

Water Res 2021 May 17;200:117255. Epub 2021 May 17.

Marine Energy Convergence and Integration Research Team, Jeju Global Research Center, Korea Institute of Energy Research, 200 Haemajihaean-ro, Gujwa-eup, Jeju 63357, Korea.

Despite significant advances in the field applications of reserve electrodialysis (RED) to produce salinity gradient power, net energy production remains an issue owing to limitations such as high energy requirement for high flow rates of feed solutions, and severe fouling and pressure build up when thin spacers are used. Therefore, to maximize the performance and efficiency of energy harvesting in the RED, a cascaded RED stack, with multiple stages between the anode and cathode electrodes, was investigated. In cascaded stacks, 100-cell paired stacks were divided into several stages, so the feed water flowed into the first stage, and the effluent from the first stage was then reused in the next stages. Read More

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Patient reported physical and mental health changes associated with a comprehensive cardiovascular risk reduction program for women with breast cancer receiving potentially cardiotoxic chemotherapy.

Cardiooncology 2021 May 31;7(1):22. Epub 2021 May 31.

Cardio-Oncology Program, Moffitt Cancer Center, University of South Florida College of Medicine, Tampa, USA.

Objective: Women with breast cancer (BCA) and cardiovascular disease (CVD) risk factors are at increased risk of developing cardiovascular complications when exposed to potentially cardiotoxic cancer therapy. The benefit of aggressive CVD risk factor modification to reduce adverse treatment-related psychologic and biologic effects is not well established.

Methods: Using a single group pre-test, post-test design, 33 women with BCA receiving anthracycline and/or trastuzumab therapy participated in a 6-month comprehensive CVD risk reduction program involving formal cardio-oncology evaluation along with regular motivational counseling for improved nutrition and physical activity. Read More

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Slice encoding for the reduction of outflow signal artifacts in cine balanced SSFP imaging.

Magn Reson Med 2021 May 31. Epub 2021 May 31.

Department of Radiological Sciences, University of California Los Angeles, Los Angeles, California, USA.

Purpose: Standard balanced SSFP (bSSFP) cine MRI often suffers from blood outflow artifacts. We propose a method that spatially encodes these outflowing spins to reduce their effects in the intended slice.

Methods: Bloch simulations were performed to characterize through-plane flow and to investigate how the use of phase encoding along the slice select's direction ("slice encoding") could alleviate its issues. Read More

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High Trait Attention Promotes Resilience and Reduces Binge Drinking Among College Students With a Family History of Alcohol Use Disorder.

Front Psychiatry 2021 13;12:672863. Epub 2021 May 13.

Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.

Binge patterns of alcohol use among post-high school emerging adults are associated with both immediate negative consequences and increased risk of long-term drinking problems, particularly among individuals with a family history (FH) of alcohol use disorder (AUD). Therefore, the developmental time period of emerging adulthood, paired with the high-risk environment of college campuses, represents an important target for interventions. Attentional ability has recently emerged as a mediator of resilience to stress-related psychopathology and offers a potential neurocognitive target for interventions. Read More

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High through-plane resolution CT imaging with self-supervised deep learning.

Phys Med Biol 2021 May 28. Epub 2021 May 28.

Department of Radiology and Sciences Imaging Department of Radiology Oncology, Emory University, Atlanta, Georgia, UNITED STATES.

CT images for radiotherapy planning are usually acquired in thick slice to reduce imaging dose, especially for pediatric patients, and to lessen the need for contouring and treatment planning on more slices. However, low through-plane resolution may degrade the accuracy of dose calculations. In this paper, a self-supervised deep learning workflow is proposed to synthesize high through-plane resolution CT images by learning from their high in-plane resolution features. Read More

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Impact of intragastric balloon on blood pressure reduction: A retrospective study in Eastern North Carolina.

World J Gastrointest Endosc 2021 May;13(5):115-124

Division of Gastroenterology, East Carolina University, Greenville, NC 27834, United States.

Background: Obesity has evolved into a global pandemic. The prevalence of obesity and hypertension in eastern North Carolina are comparable, if not higher, than the national prevalence. In the United States, an estimated 34% of adults have hypertension, the most modifiable risk factor for heart disease and stroke. Read More

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Current Approaches to Desensitization in Solid Organ Transplantation.

Front Immunol 2021 11;12:686271. Epub 2021 May 11.

William J. von Liebig Transplant Center, Mayo Clinic, Rochester, MN, United States.

Major advancements in the development of HLA antibody detection techniques and our understanding of the outcomes of solid organ transplant in the context of HLA antibody have occurred since the relevance of sensitization was first recognized nearly 50 years ago. Additionally, kidney paired donation programs (KPD) have become widespread, deceased donor allocation policies have changed, and several new therapeutic options have become available with promise to reduce HLA antibody. In this overview we aim to provide thoughtful guidance about when desensitization in kidney transplantation should be considered taking into account the outcomes of HLA incompatible transplantation. Read More

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Visual Analytics Dashboard Promises to Improve Hypertension Guideline Implementation.

Am J Hypertens 2021 May 27. Epub 2021 May 27.

Department of Internal Medicine, Henry Ford Hospital and Wayne State University, Detroit, MI, United States.

Background: Primary care management of hypertension under new guidelines incorporates assessment of cardiovascular disease risk and commonly requires review of electronic health record (EHR) data. Visual analytics can streamline the review of complex data and may lessen the burden clinicians face using the EHR. This study sought to assess the utility of a visual analytics dashboard in addition to EHR in managing hypertension in a primary care setting. Read More

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RNA Backbone Torsion and Pseudotorsion Angle Prediction Using Dilated Convolutional Neural Networks.

J Chem Inf Model 2021 May 26. Epub 2021 May 26.

Institute for Glycomics and School of Information and Communication Technology, Griffith University, Southport, Queensland 4222, Australia.

RNA three-dimensional structure prediction has been relied on using a predicted or experimentally determined secondary structure as a restraint to reduce the conformational sampling space. However, the secondary-structure restraints are limited to paired bases, and the conformational space of the ribose-phosphate backbone is still too large to be sampled efficiently. Here, we employed the dilated convolutional neural network to predict backbone torsion and pseudotorsion angles using a single RNA sequence as input. Read More

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The Effect of Peers Support on Fear of Hypoglycemia in Iranian Patients with Type 1 Diabetes: A Clinical Trial Study.

Iran J Nurs Midwifery Res 2021 Mar-Apr;26(2):162-167. Epub 2021 Mar 5.

MSc in Critical Care Nursing, Research Committee, Qazvin University of Medical Sciences, Qazvin, Iran.

Background: Fear of hypoglycemia is a medical emergency which leads to disrupt individuals' normal lives. Peers support is a hopeful approach to improve diabetes self-care behaviors. This study was conducted to assess the effect of peers support on the fear of hypoglycemia in patients with type 1 diabetes. Read More

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The effect of one bout submaximal endurance exercise on the innate and adaptive immune responses of hypertensive patients.

J Sports Med Phys Fitness 2021 May 24. Epub 2021 May 24.

Department of Physical Education, Omidiyeh Branch, Islamic Azad University, Omidiyeh, Iran.

Background: Changes in some of the immune system factors are associated with a risk of cardiovascular disease. Therefore, the purpose of this study was to investigate the effect of one bout submaximal endurance exercise (OBSEE) on the innate and adaptive responses of hypertensive patients.

Methods: From among 70 men with hypertension, 20 men (Mean ± SD, age: 60. Read More

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Endothelial Cell Viability after DMEK Graft Preparation.

Curr Eye Res 2021 May 24:1-10. Epub 2021 May 24.

Netherlands Institute for Innovative Ocular Surgery, Rotterdam, The Netherlands.

: To evaluate the effect of graft preparation and organ-culture storage on endothelial cell density (ECD) and viability of Descemet membrane endothelial keratoplasty (DMEK) grafts.: DMEK grafts (n = 27) were prepared at Amnitrans EyeBank Rotterdam from 27 corneas (15 donors) that were eligible for transplantation but could not be allocated due to the Covid-19-related cancellation of elective surgeries. Cell viability (by Calcein-AM staining) and ECD of five grafts originally scheduled for transplantation were evaluated on the originally planned surgery day, whereas 22 grafts from paired donor corneas were evaluated either directly post-preparation or after 3-7 days of storage. Read More

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Highly Crosslinked Polyethylene Can Reduce Wear Rate in THA for High-Demand Patients: A Matched-Paired Controlled Study.

J Arthroplasty 2021 May 3. Epub 2021 May 3.

Department of Orthopedics and Traumatology, Institute for Locomotion, Aix-Marseille University, St. Marguerite Hospital, Marseille, France.

Background: The average age of patients benefiting from total hip arthroplasty (THA) has been declining. In addition to pain relief, patients seek to return to physical activity. However, the latter may increase polyethylene wear and therefore the potential risk of early aseptic loosening. Read More

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