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Danning tablets alleviate high fat diet-induced obesity and fatty liver in mice via modulating SREBP pathway.

J Ethnopharmacol 2021 Jun 8:114320. Epub 2021 Jun 8.

The Ministry of Education (MOE) Key Laboratory for Standardization of Chinese Medicines, The State Administration of TCM (SATCM) Key Laboratory for New Resources and Quality Evaluation of Chinese Medicine, Shanghai Key Laboratory of Complex Prescriptions, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Shanghai R&D Center for Standardization of Traditional Chinese Medicines, Shanghai 201203, China. Electronic address:

Ethnopharmacological Relevance: The traditional Chinese formula Danningtablets exhibit wide clinical applications in liver and gallbladder diseases, and currently it is reported to be effective on fatty liver disease in clinical trials. However, the underlying mechanisms remain elusive.

Aim Of The Study: The purpose of the present study was to assess the effects and potential pharmacological mechanisms of Danning tablet against high fat diet (HFD)-induced obesity, fatty liver, and related metabolic disorders in mice. Read More

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Should nutritional therapy be modified to account for mitochondrial dysfunction in critical illness?

JPEN J Parenter Enteral Nutr 2021 Jun 11. Epub 2021 Jun 11.

William Harvey Research Institute, Queen Mary University of London, London.

Metabolic dysfunction, and its associated muscle atrophy, remains the most common complication of critical care. At the centre of this is mitochondrial dysfunction, secondary to hypoxia and systemic inflammation. This leads to a bioenergetic crisis, with decreased intramuscular adenosine tri-phosphate content and a reduction in the highly energy dependent process of protein synthesis. Read More

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General health of patients with diabetic macular edema-The LIPSIA study.

PLoS One 2021 11;16(6):e0252321. Epub 2021 Jun 11.

Department of Ophthalmology, University Hospital Leipzig, Leipzig, Germany.

Purpose: Cardiovascular risk factors such as hypertension or dyslipidemia can influence the incidence and progression of diabetic retinopathy (DR) and diabetic macular edema (DME). The aim of this study is to describe the comorbidities in patients with DME.

Methods: Prospective, monocentric observational study. Read More

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Tendon Transfers for the Treatment of Finger Flexion Weakness in a Patient With Inclusion Body Myositis: A Case Report.

JBJS Case Connect 2021 Jun 11;11(2). Epub 2021 Jun 11.

Department of Orthopaedics and Rehabilitation, Oregon Health & Science University, Portland, Oregon.

Case: We describe a 71-year-old patient with inclusion body myositis (IBM), characterized by progressive atrophy and weakness in his left upper extremity. This patient underwent extensor carpi radialis longus to flexor pollicis longus and brachioradialis to flexor digitorum profundus tendon transfers in the left upper extremity to reduce IBM-related functional deficits. He had noticeable improvements in finger flexion after the transfers, which have been sustained for 2 years after the procedure. Read More

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Renal Mass and Localized Renal Cancer: Evaluation, Management, and Follow-Up: AUA Guideline Part I.

J Urol 2021 Jun 11:101097JU0000000000001911. Epub 2021 Jun 11.

Fox Chase Cancer Center, Philadelphia, Pennsylvania.

Purpose: This AUA Guideline focuses on evaluation/counseling/management of adult patients with clinically-localized renal masses suspicious for cancer, including solid-enhancing tumors and Bosniak 3/4 complex-cystic lesions.

Materials/methods: The Renal Mass and Localized Renal Cancer guideline underwent an update literature review which resulted in the 2021 amendment. When sufficient evidence existed, the body of evidence was assigned a strength rating of A (high), B (moderate), or C (low) for support of Strong, Moderate, or Conditional Recommendations. Read More

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Influential factors of subacromial impingement syndrome after hook plate fixation for acromioclavicular joint dislocation: A retrospective study.

Medicine (Baltimore) 2021 Jun;100(23):e26333

Department of Orthopedic Trauma Surgery, Ningbo No.6 Hospital.

Abstract: Subacromial impingement syndrome (SIS) after hook plate fixation for acromioclavicular joint (AC) dislocation was the most common complication. However, the researches on its' influential factors were rare. The purpose of this study was to identify the risk factors by analyzing the influencing factors of postoperative SIS and minimize the incidence of SIS in clinical surgery. Read More

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The therapeutic effects of glucagon-like peptide-1 receptor agonists and metformin on polycystic ovary syndrome: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 Jun;100(23):e26295

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.

Background: Obesity and insulin resistance (IR) are common in polycystic ovary syndrome (PCOS), which contribute to reproductive and metabolic abnormalities. Metformin increases insulin sensitivity, but it is associated with unsatisfied benefits of weight loss. Recent studies have reported that glucagon-like peptide 1 (GLP-1) receptor agonists improve IR and reduce weight in women with PCOS. Read More

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Dietary recommendations during the Covid-19 pandemic. Statement of the Committee of Human Nutrition Science of the Polish Academy of Sciences.

Rocz Panstw Zakl Hig 2021 ;72(2):209-220

Department of Dietetics, Warsaw University of Life Sciences, Warsaw, Poland.

During the COVID-19 pandemic, care for an adequate diet, well adapted to the body's needs and the current level of physical activity, becomes of particular importance. Many dietary compounds participate in the functioning of the immune system, while vitamins D, C, A (including beta-carotene), E, B6, B12, folic acid, zinc, copper, selenium, iron, amino acids, n-3 and n-6 polyunsaturated fatty acids and intestinal microbiota are crucial in various types of defence processes. There has been no evidence that consumed food and its compounds, including those with pro-/prebiotic properties, play a significant role in preventing SARS-CoV-2 infection or alleviating its course. Read More

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January 2021

Link between methyl nutrients and the DNA methylation process in the course of selected diseases in adults.

Rocz Panstw Zakl Hig 2021 ;72(2):123-136

Department of Dietetics, Wroclaw Medical University, Wroclaw, Poland.

DNA methylation is a reversible epigenetic modification that plays a crucial role in transcriptional gene silencing. Both excessive (hypermethylation) and reduced DNA methylation (hypomethylation) can contribute to the disturbance of the proper course of many important processes in the human body. The aim of the study was to discuss the relationship between methyl nutrients and the DNA methylation process in the course of selected diseases in adults. Read More

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January 2021

The role of vitamin D in selected autoimmune diseases.

Rocz Panstw Zakl Hig 2021 ;72(2):111-121

Wroclaw Medical University, Department of Dietetics, Wrocław, Poland.

The authors of recently published scientific papers are focusing increasingly often on the effect of vitamin D on immune processes. In the case of deficiencies of this vitamin, an imbalance in the immune system is observed, which is associated with the intensification of the inflammatory reaction in the body and the increased possibility of an autoimmune reaction. Therefore, due to the growing interest of scientists in the relationship between the effects of vitamin D and the development of autoimmune diseases, this paper considers the use of Vitamin D in autoimmune therapies. Read More

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January 2021

A novel cost-effective postural tracking algorithm by using marker-based video processing.

Int J Occup Saf Ergon 2021 Jun 11:1-31. Epub 2021 Jun 11.

Department of Industrial Engineering, Eastern Mediterranean University, Famagusta, North Cyprus, 99628, Turkey.

Recently, many postural analysis techniques are developed in order to reduce the risk of musculoskeletal problems. Methods such as Rapid Entire Body Assessment are capable of analyzing the most constant or awkward positions, but the selection of these postures are subjective. To make an objective postural analysis, devices such as Electro Magnetic Trackers can be used continuously during the job task, but utilizing such devices are costly. Read More

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Markerless Real-Time 3-Dimensional kV Tracking of Lung Tumors During Free Breathing Stereotactic Radiation Therapy.

Adv Radiat Oncol 2021 Jul-Aug;6(4):100705. Epub 2021 Apr 20.

Department of Radiation Oncology, Amsterdam UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, Amsterdam, the Netherlands.

Purpose: Accurate verification of tumor position during irradiation could reduce the probability of target miss. We investigated whether a commercial gantry-mounted 2-dimensional (2D) kilo-voltage (kV) imaging system could be used for real-time 3D tumor tracking during volumetric modulated arc therapy (VMAT) lung stereotactic body radiation therapy (SBRT). Markerless tumor tracking on kV fluoroscopic images was validated using a life-like moving thorax phantom and subsequently performed on kV images continuously acquired before and during free-breathing VMAT lung SBRT. Read More

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No evidence for stochastic resonance effects on standing balance when applying noisy galvanic vestibular stimulation in young healthy adults.

Sci Rep 2021 Jun 10;11(1):12327. Epub 2021 Jun 10.

German Center for Vertigo and Balance Disorders (DSGZ), Ludwig-Maximilians-University, Munich, Germany.

Noisy galvanic vestibular stimulation (nGVS) at imperceptible levels has been shown to reduce body sway. This reduction was commonly attributed to the mechanism of stochastic resonance (SR). However, it has never been explicitly tested whether nGVS-induced effects on body sway consistently follow a SR-like bell-shaped performance curve with maximal reductions in a particular range of noise intensities. Read More

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[Application of extracorporeal membrane oxygenation regional treatment pattern in patients with severe cardiopulmonary diseases].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 May;33(5):596-599

Department of Public Service Development, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou 450003, Henan, China.

Objective: To assess the application of extracorporeal membrane oxygenation (ECMO) regional treatment pattern in patients with severe cardiopulmonary diseases.

Methods: A retrospective analysis was conducted. Patients with severe cardiopulmonary disease who were transferred to Henan Provincial People's Hospital after ECMO treatment in cooperative hospitals were selected. Read More

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This is the day your life must surely change : Prioritising behavioural change in musculoskeletal practice.

Physiotherapy 2021 May 21;112:158-162. Epub 2021 May 21.

School of Health Sciences, University of Brighton, Eastbourne BN20 7UR, East Sussex, United Kingdom; Western Sussex Hospitals NHS Trust, Lyndhurst Rd, Worthing, West Sussex BN11 2DH, United Kingdom.

Behavioural change is the modification or transformation of behaviour. Health behaviour has been defined as, 'any activity undertaken for the purpose of preventing or detecting disease or for improving health and wellbeing' (Bennell et al., 2019 [1]). Read More

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Accelerating Transdermal Delivery of Insulin by Ginsenoside Nanoparticles with Unique Permeability.

Int J Pharm 2021 Jun 7:120784. Epub 2021 Jun 7.

Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, College of Chemistry, Fuzhou University, Fuzhou 350116, China. Electronic address:

Diabetes is a metabolic disease caused by insufficient insulin secretion, action or resistance, in which insulin plays an irreplaceable role in the its treatment. However, traditional administration of insulin requires continuous subcutaneous injections, which is accompanied by inevitable pain, local tissue necrosis and hypoglycemia. Herein, a green and safe nanoformulation with unique permeability composed of insulin and ginsenosides is developed for transdermal delivery to reduce above-mentioned side effects. Read More

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Metronomic capecitabine as adjuvant therapy in locoregionally advanced nasopharyngeal carcinoma: a multicentre, open-label, parallel-group, randomised, controlled, phase 3 trial.

Lancet 2021 Jun 4. Epub 2021 Jun 4.

Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, China.

Background: Patients with locoregionally advanced nasopharyngeal carcinoma have a high risk of disease relapse, despite a high proportion of patients attaining complete clinical remission after receiving standard-of-care treatment (ie, definitive concurrent chemoradiotherapy with or without induction chemotherapy). Additional adjuvant therapies are needed to further reduce the risk of recurrence and death. However, the benefit of adjuvant chemotherapy for nasopharyngeal carcinoma remains controversial, highlighting the need for more effective adjuvant treatment options. Read More

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Influence of the different hormonal status changes during their life on fat mass localisation in women: a narrative review.

Arch Physiol Biochem 2021 Jun 10:1-6. Epub 2021 Jun 10.

Université Clermont Auvergne, CRNH, AME2P, Clermont-Ferrand, France.

Context: Independently of the total body fat mass, upper body fat mass deposition is strongly associated with cardiometabolic comorbidities. The mechanisms underlying fat mass localisation are not fully understood, but evidences indicate sex-specific fat mass distribution. Currently, data on women are scarce and the link between hormonal status changes during their life and fat mass distribution is overlooked. Read More

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Increased body fat content in horses alters metabolic and physiological exercise response, decreases performance, and increases locomotion asymmetry.

Physiol Rep 2021 Jun;9(11):e14824

Department of Equine Science, Hólar University, Sauðárkrókur, Iceland.

This study examined the effect of altered body weight (BW) and body fat content on exercise performance and recovery. Nine horses were divided into two groups, and changes in BW and fat content were induced by feeding a high (HA) or restricted (RA) energy allowance for 36 days in a cross-over design. In the last week of each treatment, BW and body condition score (BCS) were recorded, body fat percentage was estimated using ultrasound, and a standardized incremental treadmill exercise test (SET) and competition-like field test were performed (scored by judges blinded to treatments). Read More

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Risk factors for cooking-related burn injuries in children, WHO Global Burn Registry.

Bull World Health Organ 2021 Jun 1;99(6):439-445. Epub 2021 Apr 1.

Department of Surgery, University of Maryland School of Medicine, 22 S Greene St, Baltimore, MD 21230, United States of America (USA).

Objective: To assess the characteristics of cooking-related burn injuries in children reported to the World Health Organization Global Burn Registry.

Methods: On 1 February 2021, we downloaded data from the Global Burn Registry on demographic and clinical characteristics of patients younger than 19 years. We performed multivariate regressions to identify risk factors predictive of mortality and total body surface area affected by burns. Read More

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Spatiotemporal imaging and pharmacokinetics of fluorescent compounds in zebrafish eleuthero-embryos after different routes of administration.

Sci Rep 2021 Jun 9;11(1):12229. Epub 2021 Jun 9.

Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, University of Leuven, Leuven, Belgium.

Zebrafish (Danio rerio) is increasingly used to assess the pharmacological activity and toxicity of compounds. The spatiotemporal distribution of seven fluorescent alkyne compounds was examined during 48 h after immersion (10 µM) or microinjection (2 mg/kg) in the pericardial cavity (PC), intraperitoneally (IP) and yolk sac (IY) of 3 dpf zebrafish eleuthero-embryos. By modelling the fluorescence of whole-body contours present in fluorescence images, the main pharmacokinetic (PK) parameter values of the compounds were determined. Read More

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Genomic insights into body size evolution in Carnivora support Peto's paradox.

BMC Genomics 2021 Jun 9;22(1):429. Epub 2021 Jun 9.

Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences, Nanjing Normal University, 210023, Nanjing, China.

Background: The range of body sizes in Carnivora is unparalleled in any other mammalian order-the heaviest species is 130,000 times heavier than the lightest and the longest species is 50 times longer than the shortest. However, the molecular mechanisms underlying these huge differences in body size have not been explored.

Results: Herein, we performed a comparative genomics analysis of 20 carnivores to explore the evolutionary basis of the order's great variations in body size. Read More

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Therapy of uveal melanoma A Review.

Cesk Slov Oftalmol 2020 ;1(Ahead of print):1-13

The aim of intraocular melanoma therapy is to achieve local tumor control, reduce the risk of metastasis development, preserve the eyeball and possibly the visual function of the eye. The choice of therapeutic approach requires a comprehensive view and individual approach to each patient with uveal melanoma. Factors considered include local finding (location, tumor size and shape, tumor activity, central visual acuity, intraocular complications), age and the patients overall physical and psychological condition, as well as the patients wishes. Read More

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Associations between hedonic hunger and BMI during a two-year behavioural weight loss trial.

PLoS One 2021 9;16(6):e0252110. Epub 2021 Jun 9.

MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.

Objective: Prospective studies on relationships between hedonic hunger and BMI (Body Mass Index) during weight management are lacking. This study examined if hedonic hunger reduced during a behavioural weight management programme, and if hedonic hunger predicted future BMI.

Methods: Participants were 594 community-dwelling, UK-based adults(396 female; age 56. Read More

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Effect of hydroxyethyl cellulose soluble hemostatic gauze on hemostasis in facial contouring surgery.

Medicine (Baltimore) 2021 May;100(19):e25847

16th Department, Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Shijingshan District, Beijing, China.

Background: In facial contour surgery, due to the narrow field of vision in the oral approach and the abundant blood supply to the maxillofacial area, hemostasis is not easy. The purpose of this study was to evaluate the hemostatic effect of soluble hemostatic gauze.

Methods: We organized a prospective randomized study of 282 patients receiving facial contouring surgery (4 types of procedures in total) during 2016. Read More

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Plasma thiol and disulphide levels and their relationship with left ventricular systolic functions: A propensity score matching analysis.

Turk Kardiyol Dern Ars 2021 Jun;49(4):266-274

Department of Cardiology, Ankara Yıldırım Beyazıt University School of Medicine, Ankara, Turkey.

Objective: Left ventricular (LV) systolic function measured through LV ejection fraction (LVEF) has prognostic implications in patients with cardiac and non-cardiac conditions. The balance of thiol and disulphide levels reflects oxidative status in the body. In this study, we aimed to investigate the relationship between plasma thiol and disulphide levels, and LVEF calculated by transthoracic echocardiography (TTE). Read More

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The Association between Elevated Carotid Intima-Media Thickness (CIMT) and Serum Uric Acid Levels (SUA) among Patients with Essential Hypertension in Primary Care Setting in Sungai Buloh, Malaysia.

Int J Clin Pract 2021 Jun 9:e14445. Epub 2021 Jun 9.

Sungai Buloh Health Clinic, Ministry of Health, Sungai Buloh, Selangor, Malaysia.

Aims: Our study aimed to investigate the association between elevated carotid-intima media thickness (CIMT) and serum uric acid (SUA) levels in hypertensive patients attending primary care clinics in Sungai Buloh, Malaysia.

Methods: We conducted a cross-sectional study on 140 hypertensive patients attending out-patient follow-up in two primary care clinics in Sungai Buloh, Malaysia, using a convenient sampling method. Serum uric acid levels were measured and divided into 4-quartile. Read More

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Comparison of constipation and nutritional status with disease-related parameters in COPD patients.

Int J Clin Pract 2021 Jun 9:e14451. Epub 2021 Jun 9.

Department of Pulmonary Medicine, Medicana International Istanbul Hospital, Istanbul, Turkey.

Aim: The aim of the study is to determine the effects of constipation symptoms and nutritional status on disease-related parameters, such as disease duration, spirometry test and quality of life, of COPD patients.

Methods: The research was performed with 48 COPD patients attending the center from January 2019 to August 2019. Assessment of constipation symptoms were done by Constipation Severity Instrument (CSI), while for quality of life assessment St George Respiratory Questionnaire (SGRQ) was used. Read More

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Growth hormone treatment for adults with Prader-Willi syndrome: a meta-analysis.

J Clin Endocrinol Metab 2021 Jun 9. Epub 2021 Jun 9.

Internal Medicine, division of Endocrinology, Erasmus MC, University Medical Centre Rotterdam, The Netherlands.

Context: Features of Prader-Willi syndrome (PWS) overlap with features of growth hormone (GH) deficiency, like small hands and feet, short stature, increased body fat and low muscle mass and strength. In children with PWS, GH treatment (GHt) improves physical health and cognition. GHt has become standard of care in PWS children, but in adults this is not yet the case. Read More

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Preliminary safety study of the Automated Wearable Artificial Kidney (AWAK) in Peritoneal Dialysis patients.

Perit Dial Int 2021 Jun 9:8968608211019232. Epub 2021 Jun 9.

Department of Renal Medicine, Singapore General Hospital, Singapore.

Background: Regeneration of peritoneal dialysis (PD) fluid using sorbent technology can provide flexibility and improve quality of life. This study examined the safety and efficacy of the automated wearable artificial kidney (AWAK) device in PD patients.

Methods: This pilot study included prevalent PD patients from a single center in Singapore between 2016 and 2018. Read More

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