274,703 results match your criteria redox state

Hypoxic acclimation improves cardiac redox homeostasis and protects heart against ischemia-reperfusion injury through upregulation of O-GlcNAcylation.

Redox Biol 2021 Apr 30;43:101994. Epub 2021 Apr 30.

Laboratory of Mitochondria and Metabolism, Department of Anesthesiology, National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, 610041, China; Laboratory of Anesthesia and Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, 610041, China. Electronic address:

Ischemia-reperfusion (I/R) injury is detrimental to cardiovascular system. Alteration in glucose metabolism has been recognized as an important adaptive response under hypoxic conditions. However, the biological benefits underlying this metabolic phenotype remain to be elucidated. Read More

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Energy management and mitochondrial dynamics in cerebral cortex during endotoxemia.

Arch Biochem Biophys 2021 May 5:108900. Epub 2021 May 5.

Universidad de Buenos Aires, CONICET, Instituto de Bioquímica y Medicina Molecular (IBIMOL), Facultad de Farmacia y Bioquímica, Junín 946, C1113AAD, CABA, Argentina; Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Departamento de Química Analítica y Fisicoquímica, Cátedra de Fisicoquímica, Junín 946, C1113AAD, CABA, Argentina. Electronic address:

Mitochondria play an essential role in inflammatory processes such as sepsis or endotoxemia, contributing to organ-cellular redox metabolism, emerging as the energy hub of the cell, and as an important center of action of second messengers. In this work, we aimed to elucidate the energy state, redox balance, and mitochondrial remodeling status in cerebral cortex in an experimental model of endotoxemia. Female Sprague-Dawley rats were subjected to a single dose of LPS (ip 8 mg kg body weight) for 6 h. Read More

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The role of metabolic reprogramming and de novo amino acid synthesis in collagen protein production by myofibroblasts: implications for organ fibrosis and cancer.

Amino Acids 2021 May 8. Epub 2021 May 8.

Department of Medicine, Section of Pulmonary and Critical Care Medicine, The University of Chicago, 5841 S. Maryland Avenue, MC6026, Chicago, IL, 60637, USA.

Fibrosis is a pathologic condition resulting from aberrant wound healing responses that lead to excessive accumulation of extracellular matrix components, distortion of organ architecture, and loss of organ function. Fibrotic disease can affect every organ system; moreover, fibrosis is an important microenvironmental component of many cancers, including pancreatic, cervical, and hepatocellular cancers. Fibrosis is also an independent risk factor for cancer. Read More

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A Safe and Sustainable Lithium-Ion-Oxygen Battery based on a Low-Cost Dual-Carbon Electrodes Architecture.

Adv Mater 2021 May 8:e2100827. Epub 2021 May 8.

Energy Technology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 1-1-1, Umezono, Tsukuba, 305-8568, Japan.

People anticipate high-energy-density battery technology with better security, stability, and sustainability. By tuning the advantage of specific capacity, the lithium-metal anode is replaced with a graphite intercalation compound and a conceptual prototype lithium-ion-oxygen battery based on a low-cost dual-carbon electrodes architecture is proposed. The lithium-ion involves a (de)intercalation process into the graphite anode and an O /Li O redox conversion on the carbon-nanotube cathode. Read More

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Redox sensor QSOX1 regulates plant immunity by targeting GSNOR to modulate ROS generation.

Mol Plant 2021 May 4. Epub 2021 May 4.

Division of Applied Life Sciences (BK21) and PMBBRC, Gyeongsang National University, Jinju 52828, Korea; College of Life Sciences, Qingdao Agricultural University, Qingdao 266109, P.R.China. Electronic address:

Reactive oxygen signaling regulates numerous biological processes, including stress responses in plants. Redox sensors transduce reactive oxygen signals into cellular responses. We present biochemical evidence that a plant quiescin sulfhydryl oxidase homolog (QSOX1) is a redox sensor that negatively regulates immunity against a bacterial pathogen. Read More

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Determination of Vanadium Isotope Compositions in Carbonates Using an Fe Coprecipitation Method and MC-ICP-MS.

Anal Chem 2021 May 7. Epub 2021 May 7.

CAS Key Laboratory of Mantel Materials and Environments, School of Earth and Space Science, University of Science and Technology of China, 96 Jinzhai Road, Hefei 230026, Anhui, People's Republic of China.

Vanadium isotope compositions (δ(V)) in marine carbonates are a potential proxy to trace global redox states of ancient oceans. Although high-precision δ(V) analyses are available for many geological materials, carbonate-hosted δ(V) data have not been reported yet due to extremely high matrix elements and low V contents (generally below 10 μg g). In this study, we developed an Fe coprecipitation method combined with an Fe column to preconcentrate V from the major matrix elements and subsequent four-step chromatographic procedures to further purify V in carbonates. Read More

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Enhancing the Photocatalytic Conversion of Pt(IV) Substrates by Flavoprotein Engineering.

J Phys Chem Lett 2021 May 7:4504-4508. Epub 2021 May 7.

Donostia International Physics Center, Paseo Manuel de Lardizabal 4, Donostia 20018, Spain.

Our recent work demonstrates that certain flavoproteins can catalyze the redox activation of Pt(IV) prodrug complexes under light irradiation. Herein, we used site-directed mutagenesis on the mini singlet oxygen generator (mSOG) to modulate the photocatalytic activity of this flavoprotein toward two model Pt(IV) substrates. Among the prepared mutants, Q103V mSOG displayed enhanced catalytic efficiency as a result of its longer triplet excited-state lifetime. Read More

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Identification and characterization of melon circular RNAs involved in powdery mildew responses through comparative transcriptome analysis.

PeerJ 2021 15;9:e11216. Epub 2021 Apr 15.

Shandong Key Laboratory of Greenhouse Vegetable Biology, Shandong Branch of National Improvement Center for Vegetable, Vegetable Science Observation and Experiment Station in Huang huai District of Ministry of Agriculture (Shandong), Institute of Vegetables and Flowers, Shandong Academy of Agricultural Sciences, Jinan, China.

Circular RNAs (circRNAs) are a class of newly discovered non-coding RNAs that are typically derived from a genome's exonic, intronic, and intergenic regions. Recent studies of circRNAs in animals and plants have shown that circRNAs are vital in response to various abiotic and biotic stresses. Powdery mildew disease (PM) is a serious fungal disease threatening the melon industry. Read More

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Novel strategy of natural antioxidant nutrition quality evaluation in food: Oxidation resistance mechanism and synergistic effects investigation.

Food Chem 2021 Apr 24;359:129768. Epub 2021 Apr 24.

Center for Advanced Analytical Science, School of Chemistry and Chemical Engineering c/o School of Civil Engineering, Guangzhou University, Guangzhou 510006, PR China; State Key Laboratory of Electroanalytical Chemistry, c/o Engineering Laboratory for Modern Analytical Techniques, CAS Center for Excellence in Nanoscience, Changchun Institute of Applied Chemistry, Changchun 130022, PR China; University of Chinese Academy of Sciences, Beijing 100039, PR China.

Effective evaluation methods for assessing the nutritional quality of foods that eliminate free radicals (i.e., foods that are classified as antioxidants) have long attracted the attention of scientists and the populace. Read More

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Pathological findings and husbandry management in captive Chrysaora spp. medusae affected by umbrellar ulcerative lesions.

J Invertebr Pathol 2021 May 3:107599. Epub 2021 May 3.

Pathology group, PASAPTA, Facultad de Veterinaria, Universidad Cardenal Herrera-CEU, CEU Universities, Av. Seminario s/n, 46113 Moncada, Valencia, Spain. Electronic address:

During a 12 month period, a group of 14 medusa-stage jellies of the genus Chrysaora, including Pacific sea nettle (Chrysaora fuscescens, n=11) and Japanese sea nettle (Chrysaora pacifica, n=3), that were maintained in a public aquarium developed progressive ulcerative umbrellar lesions. In 6 cases (42.9%), ulceration was deep, transmural, and perforated through the mesoglea and subumbrella. Read More

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Synthesis and Structural Elucidation of Bisdibenzocorannulene at Redox States.

Angew Chem Int Ed Engl 2021 May 6. Epub 2021 May 6.

Hunan University, College of Chemistry and Chemical Engineering, State Key Laboratory of Chemo/Biosensing and Chemometrics,, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China, 410082, Changsha, CHINA.

π-Extended curved polycyclic hydrocarbons have attracted widespread attention in not only chemistry but also materials science. We now report an anti -folded bowl-shaped bisdibenzocorannulene ( BDBC ), featuring a new chair-cyclohexane-like hexagon as a bridge of two dibenzocorannulene moieties. The neutral compound showed a multiple redox active property, and would be converted to the corresponding redox states through chemical reduction or oxidation. Read More

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Fungal transformation of natural and synthetic cobalt-bearing manganese oxides and implications for cobalt biogeochemistry.

Environ Microbiol 2021 May 6. Epub 2021 May 6.

Geomicrobiology Group, School of Life Sciences, University of Dundee, Dundee, Scotland, DD1 5EH, UK.

Manganese oxide minerals can become enriched in a variety of metals through adsorption and redox processes, and this forms the basis for a close geochemical relationship between Mn oxide phases and Co. Since oxalate-producing fungi can effect geochemical transformation of Mn oxides, an understanding of the fate of Co during such processes could provide new insights on the geochemical behaviour of Co. In this work, the transformation of Mn oxides by Aspergillus niger was investigated using a Co-bearing manganiferous laterite, and a synthetic Co-doped birnessite. Read More

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Molecular evidence of the avocado defense response to infection: a deep transcriptome analysis using RNA-Seq.

PeerJ 2021 14;9:e11215. Epub 2021 Apr 14.

Catedrático CONACyT en la Red de Estudios Moleculares Avanzados, Instituto de Ecología A.C., Xalapa, Veracruz, México.

is a novel member of the Ambrosia Clade (AFC) that has been recognized as one of the symbionts of the invasive Kuroshio shot hole borer, an Asian ambrosia beetle. This complex is considered the causal agent of dieback, a disease that has severely threatened natural forests, landscape trees, and avocado orchards in the last 8 years. Despite the interest in this species, the molecular responses of both the host and during the infection process and disease establishment remain unknown. Read More

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Correlative operando microscopy of oxygen evolution electrocatalysts.

Nature 2021 May 5;593(7857):67-73. Epub 2021 May 5.

Department of Materials Science and Engineering, Stanford University, Stanford, CA, USA.

Transition metal (oxy)hydroxides are promising electrocatalysts for the oxygen evolution reaction. The properties of these materials evolve dynamically and heterogeneously with applied voltage through ion insertion redox reactions, converting materials that are inactive under open circuit conditions into active electrocatalysts during operation. The catalytic state is thus inherently far from equilibrium, which complicates its direct observation. Read More

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A lysine-cysteine redox switch with an NOS bridge regulates enzyme function.

Nature 2021 May 5. Epub 2021 May 5.

Department of Molecular Enzymology, Göttingen Center of Molecular Biosciences, Georg August University Göttingen, Göttingen, Germany.

Disulfide bonds between cysteine residues are important post-translational modifications in proteins that have critical roles for protein structure and stability, as redox-active catalytic groups in enzymes or allosteric redox switches that govern protein function. In addition to forming disulfide bridges, cysteine residues are susceptible to oxidation by reactive oxygen species, and are thus central not only to the scavenging of these but also to cellular signalling and communication in biological as well as pathological contexts. Oxidized cysteine species are highly reactive and may form covalent conjugates with, for example, tyrosines in the active sites of some redox enzymes. Read More

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Comparative transcriptomic analysis reveals an association of gibel carp fatty liver with ferroptosis pathway.

BMC Genomics 2021 May 5;22(1):328. Epub 2021 May 5.

College of Fisheries, Huazhong Agricultural University, Wuhan, 430070, China.

Background: Fatty liver has become a main problem that causes huge economic losses in many aquaculture modes. It is a common physiological or pathological phenomenon in aquaculture, but the causes and occurring mechanism are remaining enigmatic.

Methods: Each three liver samples from the control group of allogynogenetic gibel carp with normal liver and the overfeeding group with fatty liver were collected randomly for the detailed comparison of histological structure, lipid accumulation, transcriptomic profile, latent pathway identification analysis (LPIA), marker gene expression, and hepatocyte mitochondria analyses. Read More

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PFAS and their substitutes in groundwater: Occurrence, transformation and remediation.

J Hazard Mater 2021 Jun 23;412:125159. Epub 2021 Jan 23.

Guangdong Provincial Key Laboratory of Soil and Groundwater Pollution Control, State Environmental Protection Key Laboratory of Integrated Surface Water-Groundwater Pollution Control, School of Environmental Science and Engineering, Southern University of Science and Technology, Shenzhen 518055, China. Electronic address:

Poly- and perfluoroalkyl substances (PFAS) are increasingly investigated due to their global occurrence and potential human health risk. The ban on PFOA and PFOS has led to the use of novel substitutes such as GenX, F-53B and OBS. This paper reviews the studies on the occurrence, transformation and remediation of major PFAS i. Read More

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Longitudinal Monitoring of Cell Metabolism in Biopharmaceutical Production using Label-free Fluorescence Lifetime Imaging Microscopy.

Biotechnol J 2021 May 5:e2000629. Epub 2021 May 5.

GSK Center for Optical Molecular Imaging, University of Illinois at Urbana-Champaign, Urbana, IL, USA.

Chinese hamster ovary (CHO) cells are routinely used in the biopharmaceutical industry for production of therapeutic monoclonal antibodies (mAbs). Although multiple offline and time-consuming measurements of spent media composition and cell viability assays are used to monitor the status of culture in biopharmaceutical manufacturing, the day-to-day changes in the cellular microenvironment need further in-depth characterization. In this study, two-photon fluorescence lifetime imaging microscopy (2P-FLIM) was used as a tool to directly probe into the health of CHO cells in a bioreactor, exploiting the autofluorescence of intracellular nicotinamide adenine dinucleotide phosphate (NAD(P)H), an enzymatic cofactor that determines the redox state of the cells. Read More

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Redox-sensitive transcriptional regulator SoxR directly controls antibiotic production, development and thiol-oxidative stress response in Streptomyces avermitilis.

Microb Biotechnol 2021 May 5. Epub 2021 May 5.

State Key Laboratory of Agrobiotechnology and College of Biological Sciences, China Agricultural University, Beijing, China.

The redox-sensitive transcriptional regulator SoxR is conserved in bacteria. Its role in mediating protective response to various oxidative stresses in Escherichia coli and related enteric bacteria has been well established. However, functions and regulatory mechanisms of SoxR in filamentous Streptomyces, which produce half of known antibiotics, are unclear. Read More

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Rhesus monkeys as a translational model for late-onset Alzheimer's disease.

Aging Cell 2021 May 5:e13374. Epub 2021 May 5.

Division of Geriatrics, Department of Medicine, SMPH, Madison, WI, USA.

Age is a major risk factor for late-onset Alzheimer's disease (AD) but seldom features in laboratory models of the disease. Furthermore, heterogeneity in size and density of AD plaques observed in individuals are not recapitulated in transgenic mouse models, presenting an incomplete picture. We show that the amyloid plaque microenvironment is not equivalent between rodent and primate species, and that differences in the impact of AD pathology on local metabolism and inflammation might explain established differences in neurodegeneration and functional decline. Read More

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Anchoring γ-MnO within β-NiCo(OH) as an Interfacial Electrode Material for Boosting Power Density in an Asymmetric Supercapacitor Device and for Oxygen Evolution Catalysis.

Langmuir 2021 May 5. Epub 2021 May 5.

Department of Chemistry, Bharathiar University, Coimbatore 641 046, India.

The great challenge is to improve the high-competence electrochemical supercapacitor (ES) and oxygen evolution reaction (OER) electrocatalyst with earth-abundant transition metals rather than using limited noble metals. Herein, we developed a facile strategy to introduce two different phases such as α-MnO or γ-MnO on porous hexagonal bimetallic β-NiCo(OH)-layered double hydroxide (LDH) nanosheets for an enhanced bifunctionality and to ease out interfacial redox reaction kinetics. Due to the rational intend of LDH morphology and well-retained starlike γ-MnO nanostructures, the bifunctional LDHs exhibit commendable activities toward ESs and in the OER study. Read More

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Usnic Acid Treatment Changes the Composition of Mycobacterium tuberculosis Cell Envelope and Alters Bacterial Redox Status.

mSystems 2021 May 4;6(3). Epub 2021 May 4.

Bulgarian Academy of Sciences, The Stephan Angeloff Institute of Microbiology, Laboratory of Metabolomics, Plovdiv, Bulgaria.

developed efficient adaptation mechanisms in response to different environmental conditions. This resulted in the ability to survive in human macrophages and in resistance to numerous antibiotics. To get insight into bacterial responses to potent antimycobacterial natural compounds, we tested how usnic acid, a lichen-derived secondary metabolite, would influence mycobacteria at transcriptomic and metabolomic levels. Read More

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The Effect of Using Micro-Clustered Water as a Polymer Medium.

Int J Mol Sci 2021 Apr 29;22(9). Epub 2021 Apr 29.

Department of Functional Food Products Development, The Faculty of Biotechnology and Food Science, Wroclaw University of Environmental and Life Sciences, Chelmonskiego 37/41, 51-630 Wroclaw, Poland.

The aim of the study was to investigate the changes within the physicochemical properties of gelatin, carrageenan, and sodium alginate hydrosols prepared on the basis of micro-clustered (MC) water. The rheological parameters, contact angle and antioxidant activity of hydrosols were investigated. Moreover, the pH, oxidation-reduction potential (ORP) and electrical conductivity (EC) were measured. Read More

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Validation of a Gas Chromatography-Mass Spectrometry Method for the Measurement of the Redox State Metabolic Ratios Lactate/Pyruvate and β-Hydroxybutyrate/Acetoacetate in Biological Samples.

Int J Mol Sci 2021 Apr 30;22(9). Epub 2021 Apr 30.

Service of Biochemistry and Molecular Genetics, Hospital Clinic Universitari, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Carrer de Villarroel 170, 08036 Barcelona, Spain.

The metabolic ratios lactate/pyruvate and β-hydroxybutyrate/acetoacetate are considered valuable tools to evaluate the in vivo redox cellular state by estimating the free NAD+/NADH in cytoplasm and mitochondria, respectively. The aim of the current study was to validate a gas-chromatography mass spectrometry method for simultaneous determination of the four metabolites in plasma and liver tissue. The procedure included an o-phenylenediamine microwave-assisted derivatization, followed by liquid-liquid extraction with ethyl acetate and silylation with bis(trimethylsilyl)trifluoroacetamide:trimethylchlorosilane 99:1. Read More

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Nanosized non-proteinaceous complexes III and IV mimicking electron transfer of mitochondrial respiratory chain.

J Colloid Interface Sci 2021 Apr 17;599:198-206. Epub 2021 Apr 17.

São Carlos Institute of Chemistry, University of São Paulo, São Carlos 13560-970, Brazil. Electronic address:

Synthetic biology pursues the understanding of biological processes and their possible mimicry with artificial bioinspired materials. A number of materials have already been used to mimic the active site of simple redox proteins, including nanosized iron oxides due to their redox properties. However, the mimicry of membrane redox protein complexes is still a challenge. Read More

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Root-secreted peptide OsPEP1 regulates primary root elongation in rice.

Plant J 2021 May 4. Epub 2021 May 4.

State Key Laboratory of Plant Physiology and Biochemistry, College of Life Sciences, Zhejiang University, Hangzhou, 310058, China.

Hormone-like signaling peptides play essential roles in plant growth and development; however, few peptides regulating root development have been identified in rice (Oryza sativa). Here, we combined liquid chromatography-tandem mass spectrometry (LC-MS/MS) with whole-genome in silico screening for root-secreted peptides in rice. We identified the 5-amino-acid PEPTIDE 1 (PEP1) encoded by OsPEP1 (LOC_Os11g09560). Read More

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In-depth review: is hepcidin a marker for the heart and the kidney?

Mol Cell Biochem 2021 May 4. Epub 2021 May 4.

Department of Nephrology, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey.

Iron is an essential trace element involved in oxidation-reduction reactions, oxygen transport and storage, and energy metabolism. Iron in excess can be toxic for cells, since iron produces reactive oxygen species and is important for survival of pathogenic microbes. There is a fine-tuning in the regulation of serum iron levels, determined by intestinal absorption, macrophage iron recycling, and mobilization of hepatocyte stores versus iron utilization, primarily by erythroid cells in the bone marrow. Read More

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On the redox property of AgAu clusters: One-way conversion from anionic [AuAgL] to charge neutral [AuAgL].

J Chem Phys 2021 Apr;154(16):164308

State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.

The redox property of metal nanoclusters plays a pivotal role and is of particular interest in catalysis and other applications, such as aerobic oxidation, hydrogenation, and singlet oxygen generation, over intact nanoclusters. In this study, we report a one-way conversion process of the anionic [AgAuL] nanocluster into a charge neutral nanocluster of [AgAuL] via oxidation in a solution phase using HO as the oxidant. Three-electron loss of [AgAuL] occurred during the oxidation process, which was confirmed by electron paramagnetic resonance and electrospray ionization mass spectrometry methods. Read More

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Enhanced reactivity of zero-valent aluminum/O by using Fe-bearing clays in 4-chlorophenol oxidation.

Sci Total Environ 2021 Jun 6;773:145661. Epub 2021 Feb 6.

State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing 210023, PR China. Electronic address:

Zero-valent aluminum (ZVAl) is a promising reductant because of its relatively low redox potential, which can efficiently activate molecular oxygen to generate reactive oxygen species. However, its long-term performance is limited by the intrinsic dense oxide layer and the passivation effect of the accumulative Al-(hydr)oxide on its surface during the reaction. In this study, four clay minerals with different compositions were mixed with ZVAl by ball milling to obtain four composites of ZVAl and clay (ZVAl-Clay), which were used to degrade a high concentration of 4-chlorophenol (4-CP) under ambient conditions. Read More

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One-pot synthesis of AuPd@FeO nanoagent with the activable Fe species for enhanced Chemodynamic-photothermal synergetic therapy.

Biomaterials 2021 Apr 27;274:120821. Epub 2021 Apr 27.

State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, PR China; School of Applied Chemical Engineering, University of Science and Technology of China, Road Baohe District, Hefei, Anhui, 230026, PR China. Electronic address:

Facile fabrication of Fe-based nanotheranostic agents with the enhanced Chemodynamic therapy (CDT) effect and multiple functions is important for oncotherapy. In this report, noble-metal@FeO core-shell nanoparticles (Au@FeO NPs, AuRu@FeO NPs, AuPt@FeO NPs and AuPd@FeO NPs) are one-pot constructed by a simply redox self-assembly strategy. As a typical example, AuPd@FeO NPs are applied for oncotherapy. Read More

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