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How I Handle Retreatment of LUTS Following a Failed MIST.

Curr Urol Rep 2021 Jun 11;22(8):40. Epub 2021 Jun 11.

Department of Urology, Weill Cornell Medical College of Cornell University, 425 East 61st street, 12th floor, New York, NY, 10065, USA.

Purpose Of Review: The goal of this paper is to review retreatment management after failed minimally invasive treatment (MIST) of various technologies.

Recent Findings: A failed MIST can be defined by the return, persistence, or worsening of LUTS, as documented by symptom scores. Persistence, development, or recurrence of comorbidities such as recurrent urinary tract infection (UTI), retention, stones, hematuria, and incontinence can also signal a failed MIST. Read More

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KCNT1-related epilepsies and epileptic encephalopathies: phenotypic and mutational spectrum.

Brain 2021 Jun 11. Epub 2021 Jun 11.

Pediatric Neurology Department, Lyon University Hospital, 69500 Bron, France.

Variants in KCNT1, encoding a sodium-gated potassium channel (subfamily T member 1), have been associated with a spectrum of epilepsies and neurodevelopmental disorders. These range from familial autosomal dominant or sporadic sleep-related hypermotor epilepsy ((AD)SHE) to epilepsy of infancy with migrating focal seizures (EIMFS) and include developmental and epileptic encephalopathies (DEE). This study aims to provide a comprehensive overview of the phenotypic and genotypic spectrum of KCNT1 mutation-related epileptic disorders in 248 individuals, including 66 unpreviously published and 182 published cases, the largest cohort reported so far. Read More

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Free-floating thrombus of the aorta: 3 case reports.

Surg Case Rep 2021 Jun 10;7(1):141. Epub 2021 Jun 10.

Department of Cardiovascular Surgery, Hiratsuka City Hospital, 1-19-1 Minamihara, Hiratsuka City, Kanagawa, 254-0065, Japan.

Background: Idiopathic free-floating thrombus (FFT) of the aorta is a rare occurrence, but it can lead to catastrophic consequences. The initial symptoms are typically cerebral or peripheral embolisms. Surgical thrombectomy and thrombolysis are two primary treatments for FFT. Read More

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Atrial fibrillation detection from raw photoplethysmography waveforms: A deep learning application.

Heart Rhythm O2 2020 Apr 27;1(1):3-9. Epub 2020 Apr 27.

Division of Cardiology, Department of Medicine, University of California, San Francisco, San Francisco, California.

Background: Atrial fibrillation (AF), a common cause of stroke, often is asymptomatic. Smartphones and smartwatches can detect AF using heart rate patterns inferred using photoplethysmography (PPG); however, enhanced accuracy is required to reduce false positives in screening populations.

Objective: The purpose of this study was to test the hypothesis that a deep learning algorithm given raw, smartwatch-derived PPG waveforms would discriminate AF from normal sinus rhythm better than algorithms using heart rate alone. Read More

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Imaging Assessment of the Postoperative Spine: An Updated Pictorial Review of Selected Complications.

Biomed Res Int 2021 18;2021:9940001. Epub 2021 May 18.

Directorate of Research, Hospital General de Mexico "Dr. Eduardo Liceaga", Mexico City, Mexico.

Imaging of the postoperative spine requires the identification of several critical points by the radiologist to be written in the medical report: condition of the underlying cortical and cancellous bone, intervertebral disc, and musculoskeletal tissues; location and integrity of surgical implants; evaluation of the success of decompression procedures; delineation of fusion status; and identification of complications. This article presents a pictorial narrative review of the most common findings observed in and postoperative spines. Complications in the spine were grouped in (hematomas, pseudomeningocele, and postoperative spine infection) and findings (arachnoiditis, radiculitis, recurrent disc herniation, spinal stenosis, and textiloma). Read More

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Cardiac Tamponade Unmasking Recurrent Ovarian Cancer.

Cureus 2021 Jun 5;13(6):e15464. Epub 2021 Jun 5.

Gynecologic Oncology, State University of New York (SUNY) Downstate Medical Center, Brooklyn, USA.

Pericardial disease is a common manifestation of malignancy. Gynecologic malignancies such as ovarian cancer rarely present with cardiac involvement. Cardiac tamponade may be the initial presentation of malignancy in as many as half of pericardial disease cases. Read More

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Importance of Skeletal Staging in Chondrosarcoma of Bone: Results of Survey on Current Practices Among Musculoskeletal Oncologists.

Indian J Orthop 2021 May 6;55(Suppl 1):234-240. Epub 2020 May 6.

Department of Surgical Oncology, Tata Memorial Hospital, HBNI, Mumbai, 400012 India.

Purpose: There are no clear guidelines for staging of conventional chondrosarcoma. We conducted an online survey to determine the current practices for skeletal staging for conventional chondrosarcoma among practicing oncologists and to assess any discrepancy in practices and with the published literature.

Methodology: A simple ten-question online survey (e-mails and WhatsApp) was conducted among practicing oncologists over a period of 3 weeks using online portal (surveymonkey. Read More

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Nemiralisib in Patients with an Acute Exacerbation of COPD: Placebo-Controlled, Dose-Ranging Study.

Int J Chron Obstruct Pulmon Dis 2021 3;16:1637-1646. Epub 2021 Jun 3.

Refractory Respiratory Inflammation Discovery Performance Unit, GlaxoSmithKline, Stevenage, UK.

Background: Management of acute exacerbations of chronic obstructive pulmonary disease (COPD) is sometimes inadequate leading to either prolonged duration and/or an increased risk of recurrent exacerbations in the period following the initial event.

Objective: To evaluate the safety and efficacy of inhaled nemiralisib, a phosphoinositide 3-kinase δ inhibitor, in patients experiencing an acute exacerbation of COPD.

Patients And Methods: In this double-blind, placebo-controlled study, COPD patients (40-80 years, ≥10 pack-year smoking history, current moderate/severe acute exacerbation of COPD requiring standard-of-care treatment) were randomized to placebo or nemiralisib 12. Read More

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Further Delineation of the Clinical and Pathologic Features of HIKESHI-Related Hypomyelinating Leukodystrophy.

Pediatr Neurol 2021 May 14;121:11-19. Epub 2021 May 14.

Division of Neurology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

Background: A recurrent homozygous missense variant, c.160G>C;p.(Val54Leu) in HIKESHI, was found to cause a hypomyelinating leukodystrophy with high frequency in the Ashkenazi Jewish population. Read More

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Real-world safety and effectiveness of nivolumab for recurrent or metastatic head and neck cancer in Japan: a post-marketing surveillance.

Int J Clin Oncol 2021 Jun 10. Epub 2021 Jun 10.

Department of Head and Neck Surgery, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.

Background: On the basis of phase III CheckMate 141 results, nivolumab was approved for recurrent or metastatic head and neck cancer after undergoing platinum-containing chemotherapy in Japan. This post-marketing surveillance aimed to evaluate the safety and effectiveness of nivolumab for head and neck cancer in the real-world setting.

Methods: All patients with head and neck cancer who planned to receive nivolumab were centrally registered. Read More

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Long-term silicone oil tamponade in eyes with complicated retinal detachment.

Eur J Ophthalmol 2021 Jun 10:11206721211019551. Epub 2021 Jun 10.

Department of Ophthalmology, Sheba Medical Centre, Ramat Gan, Israel.

Purpose: To report the visual and anatomic outcomes of eyes with exceedingly long-term silicone oil tamponade.

Methods: A retrospective chart review of 43 eyes of 41 patients with silicone oil tamponade for 5 years or more. Rates of retinal reattachment, visual acuity, and complications are presented. Read More

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Evaluation of the combined glucose-insulin and intravenous glucose tolerance tests for insulin dysregulation diagnosis in donkeys.

Equine Vet J 2021 Jun 10. Epub 2021 Jun 10.

Department of Animal Medicine and Surgery, University of Cordoba, Campus Rabanales, Road Madrid-Cadiz km 396, 14104, Cordoba, Spain.

Background: Insulin dysregulation (ID) and donkey metabolic syndrome (DMS) are common in this species. Contrary to horses, diagnostic guidelines compiling insulin cut-offs values and dynamic testing interpretations have not been reported for this species.

Objectives: To evaluate resting serum insulin concentrations, the combined glucose-insulin test (CGIT) and the glucose intravenous tolerance test (IVGTT) for the diagnosis of DMS with ID suspicion. Read More

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Genetic Variation in Two Populations From Ecuador Highlands-Extensive Copy-Number Variation, Distinctive Distribution of Functional Polymorphisms, and a Novel, Locally Common, Chimeric (CD16B/A) Gene.

Front Immunol 2021 24;12:615645. Epub 2021 May 24.

Immunogenetics & Histocompatibility Lab, Instituto de Investigación Sanitaria Puerta de Hierro-Segovia de Arana, Majadahonda, Spain.

Fcγ receptors (FcγR), cell-surface glycoproteins that bind antigen-IgG complexes, control both humoral and cellular immune responses. The locus on chromosome 1q23.3 comprises five homologous genes encoding low-affinity FcγRII and FcγRIII, and displays functionally relevant polymorphism that impacts on human health. Read More

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A Complex-Valued Oscillatory Neural Network for Storage and Retrieval of Multidimensional Aperiodic Signals.

Front Comput Neurosci 2021 24;15:551111. Epub 2021 May 24.

Laboratory for Computational Neuroscience, Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai, India.

Recurrent neural networks with associative memory properties are typically based on fixed-point dynamics, which is fundamentally distinct from the oscillatory dynamics of the brain. There have been proposals for oscillatory associative memories, but here too, in the majority of cases, only binary patterns are stored as oscillatory states in the network. Oscillatory neural network models typically operate at a single/common frequency. Read More

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Recurrent and Reversible, Bitemporal Field Defect from Presumed Chiasmitis in a Patient with Systemic Lupus Erythematosus.

Neuroophthalmology 2021 16;45(2):117-119. Epub 2020 Jul 16.

Division of Ophthalmology, University of São Paulo Medical School, São Paulo, Brazil.

Systemic lupus erythematosus (SLE) is a chronic, recurrent and remitting autoimmune disease affecting mostly women and presenting between late adolescence and the fourth decade of life. Ocular manifestations may occur in one-third of patients with SLE, with keratoconjunctivitis sicca as the most common and optic nerve and retina abnormalities as the most severe. Neuro-ophthalmological manifestations occur in approximately 1% of patients with SLE, usually in the form of optic neuropathy. Read More

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Protein kinase C δ as a neuronal mechanism for headache in a chronic intermittent nitroglycerin model of migraine in mice.

Pain 2021 May 31. Epub 2021 May 31.

Department of Pharmaceutical Sciences and Center for Biomolecular Science, University of Illinois, Chicago, IL 60612 Division of Pharmacology and Toxicology, College of Pharmacy, University of Texas, Austin, Texas, USA Department of Neurology & Rehabilitation, University of Illinois, Chicago, IL 60612 Department of Bioengineering, University of Illinois, Chicago, IL 60607.

Abstract: Migraine is one of the most common neurological disorders characterized by recurrent attacks of typically throbbing and unilateral headaches, affecting up to 20 % of the population worldwide. Despite the high prevalence and severity of this primary headache disorder, it remains to be a challenge to fully understand and treat migraine headaches. By characterizing and validating a mouse migraine model, this study aimed to investigate the functional contribution of PKC isoforms in migraine. Read More

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A randomized controlled trial of dihydroartemisinin-piperaquine, artesunate-mefloquine and extended artemether-lumefantrine treatments for malaria in pregnancy on the Thailand-Myanmar border.

BMC Med 2021 Jun 10;19(1):132. Epub 2021 Jun 10.

Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand.

Background: Artemisinin and artemisinin-based combination therapy (ACT) partner drug resistance in Plasmodium falciparum have spread across the Greater Mekong Subregion compromising antimalarial treatment. The current 3-day artemether-lumefantrine regimen has been associated with high treatment failure rates in pregnant women. Although ACTs are recommended for treating Plasmodium vivax malaria, no clinical trials in pregnancy have been reported. Read More

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The role of CTCF in the organization of the centromeric 11p15 imprinted domain interactome.

Nucleic Acids Res 2021 Jun 9. Epub 2021 Jun 9.

Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.

DNA methylation, chromatin-binding proteins, and DNA looping are common components regulating genomic imprinting which leads to parent-specific monoallelic gene expression. Loss of methylation (LOM) at the human imprinting center 2 (IC2) on chromosome 11p15 is the most common cause of the imprinting overgrowth disorder Beckwith-Wiedemann Syndrome (BWS). Here, we report a familial transmission of a 7. Read More

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Epidemiology of COVID-19 in Indonesia: common source and propagated source as a cause for outbreaks.

J Infect Dev Ctries 2021 05 31;15(5):646-652. Epub 2021 May 31.

Departement of Epidemiology, Universitas Muhammadiyah Purwokerto, Banyumas, Indonesia.

Introduction: The COVID-19 outbreak first occurred in China and has developed throughout the world, including Indonesia. The Indonesian government reports that up to May 22, 2020 there have been 21,430 confirmed cases. The purpose of this study is to describe the epidemiology, clinical symptoms and comorbidities of COVID-19 as well as the various government interventions to reduce the rate of incidence. Read More

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[Rupture of abdominal aortic aneurysm into the duodenum: uncommon cause of massive gastrointestinal bleeding].

Rev Med Chil 2021 Jan;149(1):132-136

Departamento de Cirugía Vascular y Endovascular, Pontificia Universidad Católica de Chile, Santiago, Chile.

Primary aortoenteric fistula is the spontaneous communication between the lumen of the aorta and a portion of the digestive tract. The most common cause is the erosion of an abdominal aortic aneurysm into the 3rd or 4th portion of the duodenum. It manifests clinically as gastrointestinal bleeding, with or without abdominal pain and a pulsatile abdominal mass on physical exam. Read More

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January 2021

Focal epilepsy due to de novo SCN1A mutation.

Epileptic Disord 2021 Jun 8. Epub 2021 Jun 8.

Service de Neurologie Pédiatrique, Hôpital Robert Debré, Paris, France, Université de Paris, INSERM U1141, F-75019, Paris, France.

Objective: Our aim was to identify patients with SCN1A-related epilepsy with a phenotype of pure focal epilepsy.

Methods: We conducted a retrospective study and a systematic review in Pubmed to identify patients with focal epilepsy associated with SCN1A pathogenic variants.

Results: We found three patients among 1,191 in our rare epilepsy database in 2017. Read More

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Gestational thrombocytopenia: a case-control study of over 3,500 pregnancies.

Br J Haematol 2021 Jun 9. Epub 2021 Jun 9.

Pathology, Massachusetts General Hospital, Boston, MA, USA.

Gestational thrombocytopenia (GT) affects an estimated nine million women annually. Women with GT have recurrent episodes on subsequent pregnancies suggesting that GT is related to a maternal factor rather than a factor unique to the individual pregnancy. We performed a case-control study of over 3 500 pregnancies at a single hospital during 2017. Read More

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Multimodality cardiac imaging for management of a cardiac mass in the era of COVID-19: a case report.

Eur Heart J Case Rep 2021 Mar 4;5(3):ytab062. Epub 2021 Mar 4.

Icahn School of Medicine at Mount Sinai, New York, USA.

Background : Atrial myxomas are the most common benign cardiac tumours. This case highlights an unusual presentation and complex management of a patient who was incidentally found to have a left atrial tumour concerning for a myxoma.

Case Summary : A 54-year-old-woman presented with symptoms of nausea and vomiting and was found to have a left atrial mass incidentally in addition to a renal infarct. Read More

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Frequency of Vitamin D Deficiency in Patients of Asthma.

Cureus 2021 May 3;13(5):e14828. Epub 2021 May 3.

Gastroenterology, Jinnah Postgraduate Medical Centre, Karachi, PAK.

Introduction Asthma is a clinical syndrome characterized by reversible and recurrent airway obstruction leading to the symptoms of wheezing, cough, shortness of breath, fatigue, and respiratory distress. It is one of the most common lung pathologies worldwide. Its incidence is on the rise in Pakistan, which may be due to overt environmental pollution or improving screening protocols. Read More

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The Unforeseen Diagnosis: Hyperparathyroidism-Jaw Tumour Syndrome Case Report and Review of the Literature.

Case Rep Endocrinol 2021 20;2021:5551203. Epub 2021 May 20.

Milton Keynes University Hospital, Standing Way, Eaglestone, Milton Keynes MK6 5LD, UK.

Hypercalcaemia and its systemic sequelae are a relatively common finding amongst patients in the field of endocrinology. Primary hyperparathyroidism, a frequent cause of hypercalcaemia, is often seen among middle-aged female patients, typically resulting from an underlying single-gland adenoma. Although patients may present with symptoms (nephrolithiasis, musculoskeletal discomfort, dehydration, or mood disturbance, to name a few), hypercalcaemia is rather frequently identified incidentally. Read More

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The interplay of infection and inflammatory bowel disease.

Therap Adv Gastroenterol 2021 30;14:17562848211020285. Epub 2021 May 30.

Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA.

Inflammatory bowel disease (IBD) is a chronic disease of the intestinal tract that commonly presents with diarrhea. infection (CDI) is one of the most common complications associated with IBD that lead to flare-ups of underlying IBD. The pathophysiology of CDI includes perturbations of the gut microbiota, which makes IBD a risk factor due to the gut microbial alterations that occur in IBD, predisposing patients CDI even in the absence of antibiotics. Read More

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Economic burden and cost-effectiveness of therapies for infection: a narrative review.

Therap Adv Gastroenterol 2021 30;14:17562848211018654. Epub 2021 May 30.

Division of Gastroenterology, Massachusetts General Hospital, 165 Cambridge Street, 9th Floor, Boston, MA 02114, USA.

is the most common cause of healthcare-associated diarrhea. Disease complications as well as recurrent infections contribute significantly to morbidity and mortality. Over the past decades, there has been a rapid increase in the incidence of infection (CDI), with a rise in the number of community-acquired cases. Read More

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A Robust Functional EM Algorithm for Incomplete Panel Count Data.

Adv Neural Inf Process Syst 2020 Dec;33:19828-19838

Georgia Institute of Technology.

Panel count data describes aggregated counts of recurrent events observed at discrete time points. To understand dynamics of health behaviors and predict future negative events, the field of quantitative behavioral research has evolved to increasingly rely upon panel count data collected via multiple self reports, for example, about frequencies of smoking using in-the-moment surveys on mobile devices. However, missing reports are common and present a major barrier to downstream statistical learning. Read More

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December 2020

Comparative molecular analysis of testicular Leydig cell tumors demonstrates distinct subsets of neoplasms with aggressive histopathologic features.

Mod Pathol 2021 Jun 8. Epub 2021 Jun 8.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Testicular Leydig cell tumor (LCT), the most common sex-cord stromal tumor in men, represents a small fraction of all testicular tumors (~1 to 3%). Although most testicular LCTs are indolent and cured by radical orchiectomy, 5-10% have aggressive biology and metastatic potential. In primary LCTs, large size, cytologic atypia, necrosis, increased mitotic activity, and vascular invasion have been associated with clinically aggressive tumors. Read More

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