5,022 results match your criteria recurrence-free rfs

Serial circulating tumor DNA to predict early recurrence in patients with hepatocellular carcinoma: a prospective study.

Mol Oncol 2021 Sep 20. Epub 2021 Sep 20.

Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Shanghai, China.

We studied the value of circulating tumor DNA (ctDNA) in predicting early postoperative tumor recurrence and monitoring tumor burden in patients with hepatocellular carcinoma (HCC). Plasma-free DNA, germline DNA and tissue DNA were isolated from 41 patients with HCC. Serial ctDNAs were analyzed by next-generation sequencing before and after operation. Read More

View Article and Full-Text PDF
September 2021

Proteomics Analysis Identified ASNS as a Novel Biomarker for Predicting Recurrence of Skull Base Chordoma.

Front Oncol 2021 1;11:698497. Epub 2021 Sep 1.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Background: The prognostic factors of skull base chordoma associated with outcomes of patients after surgery remain inadequately identified. This study was designed to identify a novel prognostic factor for patients with skull base chordoma.

Method: Using a proteomic technique, the tumor biomarkers that were upregulated in the rapid-recurrence group of chordoma were screened and then narrowed down by bioinformatic analysis. Read More

View Article and Full-Text PDF
September 2021

Management of Non-High-Risk Salivary Gland Carcinomas With Surgery Alone.

Cureus 2021 Aug 7;13(8):e16970. Epub 2021 Aug 7.

Otolaryngology - Head and Neck Surgery, University of South Florida Morsani College of Medicine, Tampa, USA.

Background Risk stratification and appropriate treatment selection are essential for the management of head and neck malignancies, in order to optimize long-term outcomes. Salivary gland carcinomas (SGCs) pose a particular challenge due to their extensive biologic heterogeneity. Primary surgical resection remains the mainstay of treatment; however, outcomes with single modality therapy for 'non-high-risk' lesions are less elucidated in the literature present on the subject. Read More

View Article and Full-Text PDF

Preoperative Versus Postoperative Transarterial Chemoembolization on Prognosis of Large Hepatocellular Carcinoma.

J Cancer 2021 28;12(20):6231-6241. Epub 2021 Aug 28.

Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, 510060, P. R. China.

Transarterial chemoembolization (TACE) has proven to be an effective adjuvant therapy with liver resection (LR) to treat patients with hepatocellular carcinoma (HCC). The aim of this study was to evaluate outcomes in patients with HCC larger than 5 cm, comparing those who had TACE before LR to those who had TACE after LR. A total of 320 consecutive patients who underwent LR in combination with TACE for HCC larger than 5 cm from January 2009 to December 2014 were enrolled in study. Read More

View Article and Full-Text PDF

BRAF mutation correlates with worse local-regional control following radiation therapy in patients with stage III melanoma.

Radiat Oncol 2021 Sep 18;16(1):181. Epub 2021 Sep 18.

Department of Radiation Oncology, City of Hope National Medical Center, 1500 E. Duarte Road, Duarte, CA, 91010, USA.

Background: In patients with stage III melanoma, the use of adjuvant radiation therapy (RT) after lymph node dissection (LND) may be currently considered in selected high-risk patients to improve tumor control. Melanomas harbor BRAF mutations (BRAF+) in 40-50% of cases, the majority of which are on the V600E residue. This study sought to compare the clinical outcomes after RT between patients with BRAF+ and BRAF- melanoma. Read More

View Article and Full-Text PDF
September 2021

Adjuvant Therapy for Stage III Melanoma Without Immediate Completion Lymph Node Dissection.

Ann Surg Oncol 2021 Sep 19. Epub 2021 Sep 19.

Division of Surgical Oncology, Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

Introduction: For patients with stage III melanoma with occult lymph node metastasis, the use of adjuvant therapy is increasing, and completion lymph node dissection (CLND) is decreasing. We sought to evaluate the use of modern adjuvant therapy and outcomes for patients with stage III melanoma who did not undergo CLND.

Methods: Patients with a positive SLNB from 2015 to 2020 who did not undergo CLND were evaluated retrospectively. Read More

View Article and Full-Text PDF
September 2021

Regression in melanoma is significantly associated with a lower regional recurrence rate and better recurrence-free survival.

J Surg Oncol 2021 Sep 17. Epub 2021 Sep 17.

Division of Surgical Oncology, Oregon Health & Science University, Portland, Oregon, USA.

Background And Objectives: The prognostic significance of regression in predicting melanoma recurrences is unknown. We present a large multicenter study correlating regression with recurrence.

Methods: The Sentinel Lymph Node Working Group database was queried from 1993 to 2018 for cases with regression data. Read More

View Article and Full-Text PDF
September 2021

Whether histologic subtyping affect the oncological outcomes of patients with papillary renal cell carcinoma: evidence from a systematic review and meta-analysis.

Transl Androl Urol 2021 Aug;10(8):3255-3266

Department of Urology, Peking University First Hospital, Institute of Urology, Peking University, National Urological Cancer Centre, Beijing, China.

Background: Whether the histologic subtype (type 1 and type 2) of papillary renal cell carcinoma (pRCC) is a tool to predict the prognosis is of great debate. This study is aimed to evaluate the prognostic significance of histologic subtype in patients with pRCC after surgery through a systematic review and meta-analysis.

Methods: We searched PubMed, the Web of Science, Cochrane library and EMBASE databases to identify studies published until January 20, 2021 according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Read More

View Article and Full-Text PDF

Prognostic Significance of a Scoring System Combining p16, Smoking, and Drinking Status in a Series of 131 Patients with Oropharyngeal Cancers.

Int J Otolaryngol 2021 7;2021:8020826. Epub 2021 Sep 7.

Department of Otolaryngolology-Head & Neck Surgery, CHU Saint Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium.

Background: Tobacco and alcohol are two main risk factors associated with head and neck squamous cell carcinoma (HNSCC). Studies showed that human papillomavirus (HPV) plays a role in the etiology of this cancer. HPV-positive oropharyngeal squamous cell carcinoma (OSCC) patients present in general a better response to conventional therapy and better overall survival (OS). Read More

View Article and Full-Text PDF
September 2021

Features from MRI texture analysis associated with survival outcomes in triple-negative breast cancer patients.

Breast Cancer 2021 Sep 16. Epub 2021 Sep 16.

Department of Radiology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, 466-8550, Japan.

Purpose: The purpose of the study is to evaluate the associations between intratumoral or peritumoral textural features derived from pretreatment magnetic resonance imaging (MRI) and recurrence-free survival (RFS) in triple-negative breast cancer (TNBC) patients.

Methods: Forty-three patients with TNBC who underwent preoperative MRI between February 2008 and March 2014 were included. We performed two-dimensional texture analysis on the intratumoral or peritumoral region of interest (ROI) on axial of T2-weighted image (T2WI), dynamic contrast-enhanced (DCE)-MRI and DCE-MRI subtraction images. Read More

View Article and Full-Text PDF
September 2021

Prognostic implications of histological organ involvement in retroperitoneal sarcoma.

BJS Open 2021 Sep;5(5)

Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust, Edgbaston, Birmingham, UK.

Background: The prognostic significance of histological organ involvement by retroperitoneal sarcoma subtype is unknown. The present study aimed to describe organ involvement across the subtypes, and the implications for survival.

Methods: Patients undergoing surgery for primary retroperitoneal sarcoma at the Queen Elizabeth Hospital, Birmingham from April 2005 to September 2018 were identified retrospectively. Read More

View Article and Full-Text PDF
September 2021

Minimally invasive versus open pelvic exenterations for rectal cancer: a comparative analysis of perioperative and 3-year oncological outcomes.

BJS Open 2021 Sep;5(5)

Department of Colorectal Surgical Oncology, Tata Memorial Centre, Homi Bhabha National Institute (HBNI), Mumbai, India.

Background: This study compared the surgical and oncological outcomes of open and minimally invasive pelvic exenteration.

Methods: Patients who underwent pelvic exenterations for primary locally advanced rectal cancers with invasion of the urogenital organs (central and anterior disease) between August 2013 and September 2020 were reviewed retrospectively. Patients were categorized as undergoing open or minimally invasive surgery (MIS) and these groups were compared for perioperative outcomes and 3-year survival (overall, recurrence-free and local relapse-free survival). Read More

View Article and Full-Text PDF
September 2021

Laparoscopic and open surgery in patients with transverse colon cancer: short-term and oncological outcomes.

BJS Open 2021 Sep;5(5)

Department of Health Information System Management Technology Room, Tsuchiura Kyodo General Hospital, Tsuchiura, Japan.

Background: Studies evaluating the outcomes after laparoscopic resections of transverse colon cancers are scant. This manuscript aimed to compare surgical and oncological outcomes after laparoscopic (Lap) and open procedures for transverse colon carcinomas.

Methods: All consecutive patients who underwent resection for a cancer located in the transverse colon between 2003 and 2019 were reviewed. Read More

View Article and Full-Text PDF
September 2021

Immediate breast reconstruction is oncologically safe for node-positive patients: Comparison using propensity score matching.

Medicine (Baltimore) 2021 Sep;100(36):e27184

Department of Specialized Surgery, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan.

Abstract: The oncological safety of immediate breast reconstruction (IBR) in lymph node-positive patients is unclear. In the present study, the impact of IBR on recurrence based on data of patients with axillary lymph node metastases only was examined.The subjects were 232 patients who underwent breast surgery. Read More

View Article and Full-Text PDF
September 2021

Development and Validation of a Model Including Distinct Vascular Patterns to Estimate Survival in Hepatocellular Carcinoma.

JAMA Netw Open 2021 Sep 1;4(9):e2125055. Epub 2021 Sep 1.

Department of Hepatobiliary Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, China.

Importance: Because of tumor heterogeneity, traditional clinical variables remain insufficient to predict recurrence, which impairs long-term survival among patients undergoing radical hepatectomy for hepatocellular carcinoma (HCC). Vessels encapsulating tumor clusters (VETC) constitute a novel vascular pattern distinct from microvascular invasion (MVI), representing biological aggressiveness of HCC.

Objective: To establish a model to estimate individualized recurrence-free survival (RFS) in HCC by integrating VETC and MVI. Read More

View Article and Full-Text PDF
September 2021

Survival Outcomes of Gemcitabine Plus S-1 Adjuvant Chemotherapy after Surgical Resection for Advanced Biliary Tract Cancer.

Oncology 2021 Aug 25:1-10. Epub 2021 Aug 25.

Division of Gastroenterological, Hepato-Biliary-Pancreatic, Transplantation and Pediatric Surgery, Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan.

Introduction: The usefulness of adjuvant chemotherapy in biliary tract cancer (BTC) is poorly reported. This study aimed to evaluate the effectiveness and safety of adjuvant gemcitabine plus S-1 (GS) chemotherapy after curative surgical resection for BTC.

Methods: 225 BTC patients who underwent surgical resection between January 2006 and May 2019 were enrolled in this study. Read More

View Article and Full-Text PDF

Is Adjuvant Chemotherapy Beneficial to All Patients With pT3N0M0 Stage Gastric Cancer?

Front Oncol 2021 26;11:712432. Epub 2021 Aug 26.

Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, China.

Background: The efficacy and benefits of adjuvant chemotherapy (AC) for patients with gastric cancer pT3N0M0 remain controversial.

Methods: We prospectively collected and retrospectively analyzed 235 patients with pT3N0M0 gastric cancer who underwent radical resection between February 2010 and January 2016. Patients were divided into two groups: the surgery-alone (SA) group (n = 82) and the AC group (n = 153). Read More

View Article and Full-Text PDF

The Ratio of CD86+/CD163+ Macrophages Predicts Postoperative Recurrence in Stage II-III Colorectal Cancer.

Front Immunol 2021 26;12:724429. Epub 2021 Aug 26.

Department of Medical Oncology, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China.

Tumor-associated macrophages (TAMs) are pivotal for tumor progression and metastasis. We investigated the stromal CD86+TAM/CD163+TAM (CD86/CD163) ratio as a novel prognostic biomarker for stage II-III colorectal cancer (CRC). Two independently clinical cohorts of stage II-III CRC were retrospectively enrolled in this study. Read More

View Article and Full-Text PDF

A Metabolic-associated Nomogram Predicts Recurrence Survival of Thyroid Cancer.

Curr Med Sci 2021 Sep 2. Epub 2021 Sep 2.

Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Objective: Various studies have suggested that metabolic genes play a significant role in papillary thyroid cancer (PTC). The current study aimed to identify a metabolic signature related biomarker to predict the prognosis of patients with PTC.

Methods: We conducted a comprehensive analysis on the data obtained from the Cancer Genome Atlas (TCGA) database. Read More

View Article and Full-Text PDF
September 2021

Optimal Timing of Administration of Direct-acting Antivirals for Patients With Hepatitis C-associated Hepatocellular Carcinoma Undergoing Liver Transplantation.

Ann Surg 2021 10;274(4):613-620

University of Michigan, Ann Arbor, Michigan.

Objective: To investigate the optimal timing of direct acting antiviral (DAA) administration in patients with hepatitis C-associated hepatocellular carcinoma (HCC) undergoing liver transplantation (LT).

Summary Of Background Data: In patients with hepatitis C (HCV) associated HCC undergoing LT, the optimal timing of direct-acting antivirals (DAA) administration to achieve sustained virologic response (SVR) and improved oncologic outcomes remains a topic of much debate.

Methods: The United States HCC LT Consortium (2015-2019) was reviewed for patients with primary HCV-associated HCC who underwent LT and received DAA therapy at 20 institutions. Read More

View Article and Full-Text PDF
October 2021

CK19 Predicts Recurrence and Prognosis of HBV Positive HCC.

J Gastrointest Surg 2021 Sep 10. Epub 2021 Sep 10.

Department of Clinical Laboratory, The 940Th Hospital of Joint Logistics Support Force of Chinese People's Liberation Army, Lanzhou, 730050, China.

Background: Cytokeratin is associated with the recurrence and metastasis of some cancers and tends to increase the malignancy of the disease. It is getting more and more attention in cancer research. Abnormal expression of cytokeratin 19 (CK19) has been reported as an important prognostic factor in cancers. Read More

View Article and Full-Text PDF
September 2021

ALBI grade: Evidence for an improved model for liver functional estimation in patients with hepatocellular carcinoma.

JHEP Rep 2021 Oct 5;3(5):100347. Epub 2021 Aug 5.

Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital, London, UK.

Hepatocellular carcinoma (HCC) usually arises in the context of a chronically damaged liver. Liver functional estimation is of paramount importance in clinical decision making. The Child-Pugh score (CPS) can be used to categorise patients into 3 classes (A to C) based on the severity of liver functional impairment according to 5 parameters (albumin, bilirubin, prothrombin time, presence of ascites and hepatic encephalopathy). Read More

View Article and Full-Text PDF
October 2021

T1 Bladder Cancer: Comparison of the Prognostic Impact of Two Substaging Systems on Disease Recurrence and Progression and Suggestion of a Novel Nomogram.

Front Surg 2021 23;8:704902. Epub 2021 Aug 23.

Urology Unit ICOT, Department of Medico-Surgical Sciences and Biotechnologies, Faculty of Pharmacy and Medicine, Sapienza University of Rome, Latina, Italy.

The T1 substaging of bladder cancer (BCa) potentially impacts disease progression. The objective of the study was to compare the prognostic accuracy of two substaging systems on the recurrence and progression of primary pathologic T1 (pT1) BCa and to test a nomogram based on pT1 substaging for predicting recurrence-free survival (RFS) and progression-free survival (PFS). The medical records of 204 patients affected by pT1 BCa were retrospectively reviewed. Read More

View Article and Full-Text PDF

Comparison of Hepatic Resection with Percutaneous Ablation for Hepatocellular Carcinoma in the Caudate Lobe Within Milan Criteria.

J Gastrointest Surg 2021 Sep 7. Epub 2021 Sep 7.

Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-Sen University, No.58, Zhongshan Road 2, Guangzhou, 510080, People's Republic of China.

Purpose: We aimed to compare the efficacy of hepatic resection and percutaneous ablation for resectable caudate HCC within Milan criteria and to investigate the prognostic factors.

Methods: Between August 2006 and August 2020, a total of 67 eligible patients with resectable caudate HCC within Milan criteria in three centers were retrospectively analyzed and divided into hepatic resection group (n = 46) and percutaneous ablation group (n = 21). Recurrence-free survival (RFS) and overall survival (OS) rates were compared between groups of hepatic resection and percutaneous ablation for these resectable caudate HCC patients with Kaplan-Meier curves and log-rank test. Read More

View Article and Full-Text PDF
September 2021

The effectiveness of high-dose-rate brachytherapy with external beam radiotherapy for clinically locally advanced and node-positive prostate cancer: long-term results of a retrospective study.

Int J Clin Oncol 2021 Sep 7. Epub 2021 Sep 7.

Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, 13-1 Takara-machi, Kanazawa, Ishikawa, 920-8641, Japan.

Background: No standard treatment exists for locally advanced prostate cancer (PC). This study evaluated the long-term treatment outcomes and toxicity in patients with clinically locally advanced and/or lymph node (LN)-positive PC who underwent high-dose-rate brachytherapy (HDR-BT) with external beam radiotherapy (EBRT).

Methods: The treatment outcomes and toxicities of 152 patients with PC who underwent HDR-BT with EBRT and had at least 2 years of observation were examined. Read More

View Article and Full-Text PDF
September 2021

Merkel Cell Carcinoma: Changing Practice Patterns and Impact on Recurrence-Free and Overall Survival at a Single Institution and Nationally.

Ann Surg Oncol 2021 Sep 7. Epub 2021 Sep 7.

Division of Surgical Oncology, Department of Surgery, Yale School of Medicine, New Haven, CT, USA.

Background: Merkel cell carcinoma (MCC) is an aggressive neuroendocrine carcinoma of the skin. Our report describes the evolution of management and characteristics associated with recurrence, disease-specific survival (DSS) and overall survival (OS) in the treatment of MCC.

Methods: A single institution retrospective review of MCC and SEER data to determine factors associated with RFS, DSS, and OS using a multivariable Cox regression on inverse-probability weighted cohorts. Read More

View Article and Full-Text PDF
September 2021

Postoperative controlling nutritional status score is an independent risk factor of survival for patients with small hepatocellular carcinoma: a retrospective study.

BMC Surg 2021 Sep 7;21(1):338. Epub 2021 Sep 7.

Chinese Evidence-based Medicine Center, West China Hospital, Sichuan University, Chengdu, 610041, China.

Background: The controlling nutritional status (CONUT) score has been widely used to evaluate the nutritional and immunological status. Clinical value of postoperative CONUT (PoCONUT) score in hepatocellular carcinoma (HCC) remains unknown. This study assessed whether PoCONUT score could serve as a useful predictor of survival for patients with small HCC. Read More

View Article and Full-Text PDF
September 2021

Prognostic significance of EZH2 and ARID1A expression in urothelial carcinoma: an immunohistochemical study.

J Histotechnol 2021 Sep 8:1-8. Epub 2021 Sep 8.

Urology Department, Faculty of Human Medicine, Zagazig University, Zagazig, Egypt.

Enhancer of zeste homolog 2 () and AT-rich interactive domain 1A () expression in urothelial carcinoma (UC) has not been well studied. is a novel tumor suppressor gene coding for a chromatin remodeling protein that is mutated in urinary bladder cancer. The enhancer of zeste homolog 2 () is a transcriptional repressor involved in gene silencing. Read More

View Article and Full-Text PDF
September 2021

The Association of Controlling Nutritional Status (CONUT) Score with Survival in Patients with Surgically Treated Renal Cell Carcinoma and Upper Tract Urothelial Carcinoma: A Systematic Review and Meta-Analysis.

Nutr Cancer 2021 Sep 7:1-10. Epub 2021 Sep 7.

Beijing Youan Hospital of Capital Medical University, Beijing, Fengtai District, China.

In recent years, Controlling Nutritional Status (CONUT) Score has become widely recognized as a novel index to evaluate the survival in urological neoplasms patients, especially with renal cell carcinoma (RCC) and upper tract urothelial carcinoma (UTUC). The aim of this meta-analysis is to evaluate the prognostic value of CONUT score in patients with RCC and UTUC. PubMed, Web of Science and Embase were searched for data on the association between CONUT score and RCC/UTUC prognosis up to July 29, 2021. Read More

View Article and Full-Text PDF
September 2021

Multiple-level copy number variations in cell-free DNA for prognostic prediction of HCC with radical treatments.

Cancer Sci 2021 Sep 6. Epub 2021 Sep 6.

Department of Physiology and Pathophysiology, State Key Laboratory of Cancer Biology, Fourth Military Medical University, Xi'an, China.

Copy number variations (CNVs) in cell-free DNA (cfDNA) are emerging as noninvasive biomarkers for various cancers. However, multiple-level analysis of cfDNA CNVs for hepatocellular carcinoma (HCC) patients with radical treatments remains uninvestigated. Here, CNVs at genome-wide, chromosomal-arm, and bin levels were analyzed in cfDNA from 117 HCC patients receiving radical treatments. Read More

View Article and Full-Text PDF
September 2021