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Papillary Meningioma: Case Presentation with Emphasis on Surgical and Medical Therapy of a Rare Variant of Meningioma.

Diseases 2021 Sep 17;9(3). Epub 2021 Sep 17.

Section of Pathology, Department of Emergency and Organ Transplantation (DETO), University of Bari Aldo Moro, 70124 Bari, Italy.

Meningioma is one of the most frequent neoplasms of all in the central nervous system. Different variants are known, and of these some have peculiar characteristics, both from a morphological point of view and from a biological point of view. Here, we present a rare case of relapsed papillary meningioma in a young patient, focusing on histological characteristics, medical-surgical therapy and focusing on the risk of progression and/or recurrence of the lesion if not completely eradicated. Read More

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September 2021

Tumor distribution affects bladder recurrence but not survival outcome of multifocal upper tract urothelial carcinoma treated with radical nephroureterectomy.

Sci Rep 2021 Sep 24;11(1):19059. Epub 2021 Sep 24.

Department of Urology, Kaohsiung Medical University Hospital, No. 100, Shih-Chuan 1st Road, Sanmin Dist., Kaohsiung, 80708, Taiwan.

Tumor multifocality and location are prognostic factors for upper tract urothelial carcinoma (UTUC). However, confounding effects can appear when these two factors are analyzed together. Therefore, we aimed to investigate the impact of tumor distribution on the outcomes of multifocal UTUC after radical nephroureterectomy. Read More

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September 2021

Bladder cancer and exeRcise trAining during intraVesical thErapy-the BRAVE trial: a study protocol for a prospective, single-centre, phase II randomised controlled trial.

BMJ Open 2021 Sep 24;11(9):e055782. Epub 2021 Sep 24.

Faculty of Kinesiology, Sport, and Recreation, College of Health Sciences, University of Alberta, Edmonton, Alberta, Canada

Introduction: Non-muscle invasive bladder cancer (NMIBC) accounts for about 75% of newly diagnosed bladder cancers. The treatment for NMIBC involves surgical removal of the tumour followed by 6 weekly instillations of immunotherapy or chemotherapy directly into the bladder (ie, intravesical therapy). NMIBC has a high rate of recurrence (31%-78%) and progression (15%). Read More

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September 2021

BESPOKE study protocol: a multicentre, prospective observational study to evaluate the impact of circulating tumour DNA guided therapy on patients with colorectal cancer.

BMJ Open 2021 Sep 24;11(9):e047831. Epub 2021 Sep 24.

Natera Inc, San Carlos, California, USA

Introduction: Colorectal cancer (CRC) is a highly prevalent disease, wherein, ~30%-40% of patients with CRC relapse postresection. In some patients with CRC, adjuvant chemotherapy can help delay recurrence or be curative. However, current biomarkers show limited clinical utility in determining if/when chemotherapy should be administered, to provide benefit. Read More

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September 2021

CMTM3 suppresses chordoma progress through EGFR/STAT3 regulated EMT and TP53 signaling pathway.

Cancer Cell Int 2021 Sep 24;21(1):510. Epub 2021 Sep 24.

Department of Orthopedics, Peking University Third Hospital, 49 North Garden Road, Haidian District, Beijing, 100191, China.

Background: Chordomas are rare, slow-growing and locally aggressive bone sarcomas. At present, chordomas are difficult to manage due to their high recurrence rate, metastasis tendency and poor prognosis. The underlying mechanisms of chordoma tumorigenesis and progression urgently need to be explored to find the effective therapeutic targets. Read More

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September 2021

Treatment options for progression or recurrence of glioblastoma: a network meta-analysis.

Cochrane Database Syst Rev 2021 May 4;5:CD013579. Epub 2021 May 4.

Department of Oncology, Addenbrooke's Hospital, Cambridge, UK.

Background: Glioblastoma (GBM) is a highly malignant brain tumour that almost inevitably progresses or recurs after first line standard of care. There is no consensus regarding the best treatment/s to offer people upon disease progression or recurrence. For the purposes of this review, progression and recurrence are considered as one entity. Read More

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Parental Views on the Non-Operative Management of Simple Appendicitis in Children: Results of a Cross-Sectional Survey.

World J Surg 2021 Sep 23. Epub 2021 Sep 23.

Departments of Paediatrics & Surgery, Faculty of Medicine, Nursing and Health Sciences, School of Clinical Sciences, Monash University, Melbourne, Australia.

Background: To determine parental attitudes for the non-operative management of simple appendicitis and determine willingness to participate in research evaluating different management options.

Method: Voluntary cross-sectional survey of parents/guardians presenting to paediatric outpatient department. Likert scale of 0-10 (strongly disagree-strongly agree) was utilised, analysis by individual question responses. Read More

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September 2021

Liquid biopsy with droplet digital PCR targeted to specific mutations in plasma cell-free tumor DNA can detect ovarian cancer recurrence earlier than CA125.

Gynecol Oncol Rep 2021 Nov 17;38:100847. Epub 2021 Aug 17.

Division of Molecular and Cellular Oncology, 5 Division of Cancer Stem cell, and 7 Division of Cancer Chemotherapy, Miyagi Cancer Center Research Institute, 47-1, Nodayama, Medeshima-Shiode, Natori, Miyagi 981-1293 Japan.

Objective: Ovarian cancer (OC) is an intractable gynecological tumor, and frequent recurrence is experienced within a few years even after the complete eradication of tumor tissues by radical resection and neo-adjuvant chemotherapies. The conventional recurrence marker, CA125, is widely used for follow-up after resection of OC, but CA125 has a long half-life in blood and lacks dynamic responses to tumor recurrence. Recent developments in liquid biopsy procedures are expected to overcome the difficulties in early diagnosis of OC recurrence after surgery. Read More

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November 2021

Analysis of microRNA expression in CD133 positive cancer stem‑like cells of human osteosarcoma cell line MG-63.

PeerJ 2021 3;9:e12115. Epub 2021 Sep 3.

State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Osteosarcoma (OS) is a primary malignant tumor of bone occurring in young adults. OS stem cells (OSCs) play an important role in the occurrence, growth, metastasis, drug resistance and recurrence of OS. CD133 is an integral membrane glycoprotein, which has been identified as an OSC marker. Read More

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September 2021

Glycolysis-related gene expression profiling serves as a novel prognosis risk predictor for human hepatocellular carcinoma.

Sci Rep 2021 Sep 23;11(1):18875. Epub 2021 Sep 23.

Department of Laboratory Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, 310009, Zhejiang, People's Republic of China.

Metabolic pattern reconstruction is an important factor in tumor progression. Metabolism of tumor cells is characterized by abnormal increase in anaerobic glycolysis, regardless of high oxygen concentration, resulting in a significant accumulation of energy from glucose sources. These changes promotes rapid cell proliferation and tumor growth, which is further referenced a process known as the Warburg effect. Read More

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September 2021

Accelerating drug access from advanced to early breast cancer: the special case of oral selective estrogen receptor degraders.

Curr Opin Oncol 2021 Sep 22. Epub 2021 Sep 22.

Division of Medical Oncology & Hematology, Department of Medicine, Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada University of New South Wales, Kensington, New South Wales, Australia.

Purpose Of Review: For hormone receptor positive breast cancer, the development of endocrine resistance commonly occurs, presenting as either disease progression in the metastatic setting or recurrence during or following adjuvant endocrine therapy. Various mechanisms of resistance have been described. In order to reduce or overcome endocrine resistance, there has been substantial interest in developing potent and orally bioavailable selective estrogen receptor degraders (SERDs) for metastatic disease and select patients with early-stage estrogen receptor positive breast cancer. Read More

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September 2021

Caveolin-1 Deficiency Induces Atrial Fibrosis and Increases Susceptibility to Atrial Fibrillation by the STAT3 Signaling Pathway.

J Cardiovasc Pharmacol 2021 Aug;78(2):175-183

Departments of Cardiology; and.

Abstract: Atrial fibrillation (AF) is a common arrhythmia in the clinic. Ablation failure and recurrence after cardioversion have become medical problems worldwide. An important pathological feature of AF is atrial fibrosis, which increases susceptibility to AF. Read More

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The Status of Adjuvant and Neoadjuvant Melanoma Therapy, New Developments and Upcoming Challenges.

Target Oncol 2021 Sep 23. Epub 2021 Sep 23.

Department of Dermatology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.

The global incidence of malignant melanoma, the leading cause of skin cancer death, has steadily increased in recent years. Surgical excision is the treatment of choice for early-stage melanoma. However, 40-60% of patients with high-risk melanoma or with nodal involvement eventually experience loco-regional relapse or tumor progression. Read More

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September 2021

Malignant Transformation and Treatment Recommendations of Chronic Hyperplastic Candidiasis- A Six-year Retrospective Cohort Study.

Mycoses 2021 Sep 22. Epub 2021 Sep 22.

Department of Oral Medicine, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing, PR China.

Background: Oral chronic hyperplastic candidiasis (CHC) is the most uncommon type of oral candidiasis with diverse manifestations. Up to date the diagnosis, long term management and prognosis of this oral potentially malignant disorder remain obscure.

Objectives: The aim of this study was to provide the recommendations guiding the diagnostic procedure, clinical management and prognosis assessment of CHC. Read More

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September 2021

CTLA-4 promotes lymphoma progression through tumor stem cell enrichment and immunosuppression.

Open Life Sci 2021 6;16(1):909-919. Epub 2021 Sep 6.

Department of Pathology, The 8th Medical Center, Chinese PLA General Hospital, Beijing 100091, China.

The recurrence rate of lymphoma is very high, and tumor stem cells may be an important mechanism. Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) can inhibit antitumor immunity and promote cancer progression, but its role and mechanism in lymphoma are still unclear. Here we collected lymphoma tissue and peripheral blood from patients with diffuse large B-cell lymphoma (DLBCL). Read More

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September 2021

Genomic instability in lower-grade glioma: Prediction of prognosis based on lncRNA and immune infiltration.

Mol Ther Oncolytics 2021 Sep 29;22:431-443. Epub 2021 Jul 29.

Department of Radiation Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

Glioma is the most common type of primary malignant tumor in the central nervous system. Tumor recurrence and progression are common in lower-grade glioma (LGG). Immune checkpoint blockade (ICB), as an emerging immunotherapy, is expected to improve the prognosis of patients undergoing conventional treatment, but it currently performs poorly in glioma. Read More

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September 2021

Clinical Evaluation of FOXO1 as a Tumor Suppressor in Prostate Cancer.

Comput Math Methods Med 2021 13;2021:8773423. Epub 2021 Sep 13.

Department of Urology, Minhang Hospital, Fudan University, 170 Xin-Song Road, Shanghai 201199, China.

Objective: Prostate cancer (PCa) is considered the most serious cancer in the world. Nevertheless, the accuracy of current biomarkers, such as pathological staging, Gleason's score, and serum prostate-specific antigen (PSA) levels, is limited. FOXO1 is a key downstream effector of PTEN and a tumor suppressor in PCA, which has been reported extensively. Read More

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September 2021

Prognostic value of prostate volume in non-muscle invasive bladder cancer.

Sci Rep 2021 Sep 22;11(1):18784. Epub 2021 Sep 22.

Department of Urology and Urological Science Institute, Yonsei University College of Medicine, Seoul, South Korea.

There is evidence that a history of benign prostatic hyperplasia increases the incidence of bladder cancer, and treatment with 5-alpha reductase inhibitor or androgen deprivation therapy reduces recurrence of non-muscle invasive bladder cancer. We aimed to evaluate whether prostate volume affects its prognosis. We reviewed medical records of men who underwent transurethral resection of bladder tumor due to non-muscle invasive bladder cancer from January 2012 to December 2017. Read More

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September 2021

Arthroscopic Bankart versus open Latarjet as a primary operative treatment for traumatic anteroinferior instability in young males: a randomised controlled trial with 2-year follow-up.

Br J Sports Med 2021 Sep 22. Epub 2021 Sep 22.

Orthopaedics and Traumatology, Turku University Hospital, Turku, Finland.

Objectives: To compare the success rates of arthroscopic Bankart and open Latarjet procedure in the treatment of traumatic shoulder instability in young males.

Design: Multicentre randomised controlled trial.

Setting: Orthopaedic departments in eight public hospitals in Finland. Read More

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September 2021

Long non-coding RNA NORAD promotes pancreatic cancer stem cell proliferation and self-renewal by blocking microRNA-202-5p-mediated ANP32E inhibition.

J Transl Med 2021 Sep 22;19(1):400. Epub 2021 Sep 22.

Department of Nuclear Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine, No. 301, Yanchang Middle Road, Jing'an District, Shanghai, 200072, China.

Background: Cancer stem cells (CSCs) are key regulators in the processes of tumor initiation, progression, and recurrence. The mechanism that maintains their stemness remains enigmatic, although the role of several long noncoding RNAs (lncRNAs) has been highlighted in the pancreatic cancer stem cells (PCSCs). In this study, we first established that PCSCs overexpressing lncRNA NORAD, and then investigated the effects of NORAD on the maintenance of PCSC stemness. Read More

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September 2021

Low tumor cell content predicts favorable prognosis in germinoma patients.

Neurooncol Adv 2021 Jan-Dec;3(1):vdab110. Epub 2021 Aug 10.

Department of Neurosurgery, Fujita Health University Hospital, Aichi, Japan.

Background: Germinoma preferentially occurs in pediatric and young adult age groups. Although they are responsive to treatment with chemotherapy and radiation, the treatment may cause long-term sequelae in their later lives. Here, we searched for clinical and histopathological features to predict the prognosis of germinoma and affect treatment response. Read More

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Expression and subcellular localization of Discoidin Domain Receptor 1 (DDR1) define prostate cancer aggressiveness.

Cancer Cell Int 2021 Sep 21;21(1):507. Epub 2021 Sep 21.

Department of Pathology, Wayne State University School of Medicine and Karmanos Cancer Institute, Scott Hall #8200, 540 E. Canfield St, Detroit, MI, 48201, USA.

Background: The Discoidin Domain Receptor 1 (DDR1) is one of the two members of a unique family of receptor tyrosine kinase receptors that signal in response to collagen, which has been implicated in cancer progression. Here, we examined the expression of DDR1 in prostate cancer (PCa), and assessed its potential value as a prognostic marker, as a function of grade, stage and other clinicopathologic parameters.

Methods: We investigated the association between the expression level and subcellular localization of DDR1 protein and PCa aggressiveness by immunohistochemistry, using tissue microarrays (TMAs) encompassing 200 cases of PCa with various Gleason scores (GS) and pathologic stages with matched normal tissue, and a highly specific monoclonal antibody. Read More

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September 2021

[A predictive model based on risk factors for early mortality in patients with newly diagnosed multiple myeloma].

Zhonghua Xue Ye Xue Za Zhi 2021 Aug;42(8):666-672

Department of Hematology, the First Hospital of Jilin University, Changchun 130021, China.

To investigate risk factors for early mortality (EM) in patients with newly diagnosed multiple myeloma (NDMM) and to build an EM-predictive model. In a cohort of 275 patients with NDMM, risk factors for EM at 6, 12, and 24 months after diagnosis (EM6, EM12, and EM24, respectively) were determined to establish a model to predict EM. The rates of EM6, EM12, and EM24 were 5. Read More

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Metronomic chemotherapy (mCHT) in metastatic triple-negative breast cancer (TNBC) patients: results of the VICTOR-6 study.

Breast Cancer Res Treat 2021 Sep 21. Epub 2021 Sep 21.

Medical Oncology, A. Ospedaliera-Universitaria, Sassari, Italy.

Purpose: Triple-negative breast cancer (TNBC) represents a subtype of breast cancer which lacks the expression of oestrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor-2 (HER2): TNBC accounts for approximately 20% of newly diagnosed breast cancers and is associated with younger age at diagnosis, greater recurrence risk and shorter survival time. Therapeutic options are very scarce. Aim of the present analysis is to provide further insights into the clinical activity of metronomic chemotherapy (mCHT), in a real-life setting. Read More

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September 2021

[Severe secondary sclerosing cholangitis as manifestation of a very rare underlying disease].

Internist (Berl) 2021 Sep 21. Epub 2021 Sep 21.

I. Medizinische Klinik und Poliklinik, Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Deutschland.

Langerhans cell histiocytosis (LCH) is a very rare cause of secondary sclerosing cholangitis. We report the case of a 42-year-old male patient with sclerosing cholangitis and histological evidence of LCH from a bile duct biopsy. Due to rapid disease progression and exhaustion of conservative therapeutic approaches the patient received a liver transplantation. Read More

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September 2021

Revisiting Prognosis After Liver Transplant in Patients Positive for Hepatitis C Virus: Focus on Hepatitis C Recurrence-Unrelated Complications.

Exp Clin Transplant 2021 Sep;19(9):935-942

From the Department of Gastroenterology and Hepatology, Nagoya University School of Medicine, Nagoya, Japan.

Objectives: In this study, we revisited the reasons for poorer prognosis afterlivertransplantin patients with hepatitis C virus, whose main causes of death were generally known to be recurrent disease.

Materials And Methods: Between April 2003 and March 2017, among 132 patients who underwent liver transplantbecause ofliver cirrhosis at ourinstitution, 40 patients (30.3%) were positive for hepatis C virus. Read More

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September 2021

MRI-guided percutaneous thermoablation as first-line treatment of recurrent hepatic malignancies following hepatic resection: single center long-term experience.

Int J Hyperthermia 2021 ;38(1):1401-1408

Department of Diagnostic and Interventional Radiology, Eberhard-Karls-University, Tübingen, Germany.

Purpose: Hepatic recurrence of liver malignancies is a leading problem in patients after liver resection with curative intention. Thermoablation is a promising treatment approach for patients after hepatic resection, especially in liver-limited conditions. This study aimed to investigate safety, survival, and local tumor control rates of MRI-guided percutaneous thermoablation of recurrent hepatic malignancies following hepatic resection. Read More

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January 2021

Circulating tumor DNA harboring the V600E mutation may predict poor outcomes of primary papillary thyroid cancer patients.

Thyroid 2021 Sep 19. Epub 2021 Sep 19.

The University of Tokyo Institute of Medical Science, 26430, Division of Molecular Pathology, Minato-ku, Tokyo, Japan;

Background: The significance of circulating tumor DNA (ctDNA) in primary papillary thyroid cancer (PTC) has yet to be well established. This study aimed to clarify whether ctDNA carrying the V600E mutation in plasma from primary PTC patients before and after surgery can predict outcomes.

Methods: Twenty-two primary PTC patients without distant metastasis, who underwent surgical resection at the University of Tokyo Hospital, were eligible for this study. Read More

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September 2021

Re-evaluation of the prognostic significance of retropharyngeal node metastasis in nasopharyngeal carcinoma patients treated with intensity-modulated radiotherapy.

Asia Pac J Clin Oncol 2021 Sep 19. Epub 2021 Sep 19.

Department of Radiotherapy, Fujian Medical University Cancer Hospital, Fujian Cancer Hospital, Fuzhou, China.

Background And Purpose: To investigate the prognostic value of retropharyngeal lymphadenopathy in nasopharyngeal carcinoma (NPC) after intensity-modulated radiotherapy.

Materials And Methods: Retrospective studies were performed in a total of 1197 patients. We evaluated the incidence of the retropharyngeal node (RPN) metastasis and the characteristics of the metastatic RPN including laterality, size, necrosis, and extranodal neoplastic spread. Read More

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September 2021