13,573 results match your criteria recovery impaired

Ambulatory activity in stroke survivors associated with functional outcome and quality of life: an observational cohort study.

Ann Phys Rehabil Med 2021 May 10:101540. Epub 2021 May 10.

The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Victoria, Australia; Department of Neurology, Austin Health, Heidelberg, Victoria, Australia.

Background: Physical activity is beneficial in stroke prevention and recovery. Understanding activity dynamics and its effect on outcome after stroke is important to improve recommendations and develop interventions.

Objectives: We examined serial changes in daily ambulatory activity (AA) averaged over 1 week in people with subacute to chronic stroke and its association with functional outcome (modified Rankin scale [mRS]) and quality of life (EQ-5D-3L). Read More

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Soil exposure accelerates recovery of the gut microbiota in antibiotic-treated mice.

Environ Microbiol Rep 2021 May 12. Epub 2021 May 12.

Key Laboratory of Child Development and Learning Sciences (Ministry of Education), Southeast University, Nanjing, 210096, China.

Environmental exposure to low cleanliness prevents the occurrence of allergic diseases and increases the richness and diversity of the intestinal microbiota. Antibiotics are widely used in clinical infection therapy but destroy the balance of the gut microbiota. In this study, the effects of cleanliness of the living environment on the gut microbiota are evaluated after administration of antibiotics. Read More

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Brief hypoxia in late gestation sheep causes prolonged disruption of fetal electrographic, breathing behaviours and can result in early labour.

J Physiol 2021 May 11. Epub 2021 May 11.

School of Health and Biomedical Sciences, RMIT University, Melbourne, VIC, Australia.

Key Points: Brief episodes of severe fetal hypoxia can arise in late gestation due to interruption of normal umbilical blood flow Systemic parameters and blood chemistry indicate complete recovery within 1-2 hours, but the long-term effects on fetal brain functions are unknown Fetal sheep were subjected to umbilical cord occlusion (UCO) for 10 mins at 131 days gestation, and then monitored intensively until onset of labour or delivery (<145 days gestation) Normal patterns of fetal behaviour, including breathing movements, episodes of high and low voltage electorcortical activity, eye movements, and postural (neck) muscle activity were disrupted for 3-10 days after the UCO Preterm labour and delivery occurred in a significant number of the pregnancies after UCO, compared to the control (sham-UCO) cohort.

Abstract: Complications arising from antepartum events such as impaired umbilical blood flow can cause significant fetal hypoxia. These complications can be unpredictable, difficult to detect, and thus we lack a detailed understanding of the (patho)physiological changes that occur between the antenatal in utero event and birth. Read More

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Clinical Significance of Isolated Third Cranial Nerve Palsy in Traumatic Brain Injury: A Detailed Description of Four Different Mechanisms of Injury through the Analysis of Our Case Series and Review of the Literature.

Emerg Med Int 2021 23;2021:5550371. Epub 2021 Apr 23.

Department of Neurosurgery, The Royal London Hospital, London E1 1FR, UK.

Third cranial nerve palsy (3cnP) following traumatic brain injury (TBI) is a worrying neurological sign and is often associated with an expanding mass lesion, such as extradural or acute subdural haematomas. Isolated 3cnP can be found in the absence of posttraumatic space-occupying mass lesion, yet it is often considered as a devastating prognostic factor in the context of diffuse axonal injury (DAI). Through the analysis of five exemplificative cases and a thorough review of the literature, we identified four possible mechanisms leading to 3cnP: (1) a partial rootlet avulsion at the site of exit from the midbrain, representing a direct shearing injury to the nerve; (2) a direct traction injury due to the nerve stretching against the posterior petroclinoid ligament at the base of the oculomotor triangle secondary to the downward displacement of the brainstem at the time of impact; (3) a direct vascular compression as a result of internal carotid artery (ICA) dissection or pseudoaneurysm; (4) an indirect injury caused by impaired blood supply to the third nerve in addition to the detrimental biochemical effects of the underlying brain injury itself. Read More

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Intermittent hypoxia and respiratory recovery in pre-clinical rodent models of incomplete cervical spinal cord injury.

Exp Neurol 2021 May 8:113751. Epub 2021 May 8.

Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung, Taiwan; Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung, Taiwan. Electronic address:

Impaired respiratory function is a common and devastating consequence of cervical spinal cord injury. Accordingly, the development of safe and effective treatments to restore breathing function is critical. Acute intermittent hypoxia has emerged as a promising therapeutic strategy to treat respiratory insufficiency in individuals with spinal cord injury. Read More

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Monitoring muscle mass using ultrasound: a key role in critical care.

Curr Opin Crit Care 2021 May 11. Epub 2021 May 11.

Department of Adult Intensive Care Medicine Department of Nutrition and Dietetics, Amsterdam University Medical Centers, VU University, Amsterdam Division of Dietetics, Department of Internal Medicine, Erasmus University Medical Center, Erasmus University, Rotterdam, The Netherlands Department of Nutrition and Dietetics, Faculty of Sports and Nutrition, Center of Expertise Urban Vitality, Amsterdam University of Applied Sciences, Amsterdam, The Netherlands Department of Intensive Care Medicine, Erasmus University Medical Center, Erasmus University, Rotterdam Amsterdam Nutritional Assessment Center, Faculty of Sports and Nutrition, Center of Expertise Urban Vitality, Amsterdam University of Applied Sciences, Amsterdam, The Netherlands.

Purpose Of Review: The loss of muscle mass in critically ill patients contributes to morbidity and mortality, and results in impaired recovery of physical functioning. The number of publications on the topic is increasing. However, there is a lack of consistent methodology and the most optimal methodology remains unclear, hampering its broad use in clinical practice. Read More

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Secreted C-type lectin regulation of neuromuscular junction synaptic vesicle dynamics modulates coordinated movement.

J Cell Sci 2021 May 11;134(9). Epub 2021 May 11.

Department of Biological Sciences, Vanderbilt University and Medical Center, Nashville, TN 37235, USA.

The synaptic cleft manifests enriched glycosylation, with structured glycans coordinating signaling between presynaptic and postsynaptic cells. Glycosylated signaling ligands orchestrating communication are tightly regulated by secreted glycan-binding lectins. Using the Drosophila neuromuscular junction (NMJ) as a model glutamatergic synapse, we identify a new Ca2+-binding (C-type) lectin, Lectin-galC1 (LGC1), which modulates presynaptic function and neurotransmission strength. Read More

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Mild hyperbaric oxygen for the early improvement of mood disturbance induced by high-intensity exercise.

J Sports Med Phys Fitness 2021 May 10. Epub 2021 May 10.

Department of Sports Research, Japan Institute of Sport Sciences, Kita-ku, Tokyo, Japan.

Background: Excessive training stress can result in decreased performance and deep fatigue due to hormonal changes. There are few available data on recovery methods for mood disturbance, especially fatigue, after high-intensity training. This study, therefore, aimed to examine the effects of mild hyperbaric oxygen at 1. Read More

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Medullary Noradrenergic Neurons Mediate Hemodynamic Responses to Osmotic and Volume Challenges.

Front Physiol 2021 23;12:649535. Epub 2021 Apr 23.

Department of Physiology, Biological Sciences Institute, Federal University of Goiás, Goiânia, Brazil.

Despite being involved in homeostatic control and hydro-electrolyte balance, the contribution of medullary (A1 and A2) noradrenergic neurons to the hypertonic saline infusion (HSI)-induced cardiovascular response after hypotensive hemorrhage (HH) remains to be clarified. Hence, the present study sought to determine the role of noradrenergic neurons in HSI-induced hemodynamic recovery in male Wistar rats (290-320 g) with HH. Medullary catecholaminergic neurons were lesioned by nanoinjection of antidopamine-β-hydroxylase-saporin (0. Read More

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MiR-182 Promotes Ischemia/Reperfusion-Induced Acute Kidney Injury in Rat by Targeting FoxO3.

Urol Int 2021 May 7:1-10. Epub 2021 May 7.

Department of Urology, Renmin Hospital of Wuhan University, Wuhan, China.

Background: Renal ischemia/reperfusion (I/R) injury (RIRI) is the main cause of acute kidney injury (AKI) in patients. We investigated the role of miR-182 after renal ischemia/reperfusion (I/R) in rat to characterize the microRNA (miRNA) network activated during development and recovery from RIRI.

Methods And Results: 12 h after lethal (45 min) renal ischemia, AKI was verified by renal histology (tubular necrosis and regeneration), blood urea nitrogen level, and renal mRNA expression in Wistar rats. Read More

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Incidence of concussion and recovery of neurocognitive dysfunction on ImPACT assessment among youth athletes with premorbid depression or anxiety taking antidepressants.

J Neurosurg Pediatr 2021 May 7:1-7. Epub 2021 May 7.

1Neurosurgery Department, Icahn School of Medicine at Mount Sinai, New York.

Objective: Concussions in youth sports comprise an estimated 1.6-3.8 million annual injuries in the US. Read More

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Detection of blood flow perfusion and post occlusive reactive hyperemia in the skeletal muscle of rats.

Life Sci 2021 May 4:119571. Epub 2021 May 4.

Laboratory of Cardiovascular Biology and Department of Pharmacology, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, 88049-970 Florianópolis, Santa Catarina, Brazil. Electronic address:

Aims: Post-occlusive reactive hyperemia (PORH) remains poorly understood in the skeletal muscle system. This study was designed to validate an alternative strategy of PORH detection in rodents. Additionally, we explored the hypothesis that PORH is influenced by experimental models associated with impaired function of the skeletal muscle. Read More

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Fertility and mortality impacts of thermal stress from experimental heatwaves on different life stages and their recovery in a model insect.

R Soc Open Sci 2021 Mar 10;8(3):201717. Epub 2021 Mar 10.

School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, UK.

With climate change creating a more volatile atmosphere, heatwaves that create thermal stress for living systems will become stronger and more frequent. Using the flour beetle , we measure the impacts of thermal stress from experimental heatwaves in the laboratory on reproduction and survival across different insect life stages, and the extent and pace of any recovery. We exposed larvae, pupae, juvenile and mature adult male beetles to 5-day periods of heat stress where temperatures were maintained at either 40°C or 42°C, a few degrees above the 35°C optimum for this species' population productivity, and then measured survival and reproduction compared with controls at 30°C. Read More

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Improved Functional Outcome After Peripheral Nerve Stimulation of the Impaired Forelimb Post-stroke.

Front Neurol 2021 20;12:610434. Epub 2021 Apr 20.

Department of Neurological Surgery, Loyola University Medical Center, Maywood, IL, United States.

Lack of blood flow to the brain, i.e., ischemic stroke, results in loss of nerve cells and therefore loss of function in the effected brain regions. Read More

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Lost in Translation: Simple Steps in Experimental Design of Neurorehabilitation-Based Research Interventions to Promote Motor Recovery Post-Stroke.

Front Hum Neurosci 2021 20;15:644335. Epub 2021 Apr 20.

Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, CA, United States.

Stroke continues to be a leading cause of disability. Basic neurorehabilitation research is necessary to inform the neuropathophysiology of impaired motor control, and to develop targeted interventions with potential to remediate disability post-stroke. Despite knowledge gained from basic research studies, the effectiveness of research-based interventions for reducing motor impairment has been no greater than standard of practice interventions. Read More

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Combined real-time fMRI and real time fNIRS brain computer interface (BCI): Training of volitional wrist extension after stroke, a case series pilot study.

PLoS One 2021 6;16(5):e0250431. Epub 2021 May 6.

Brain Rehabilitation Research Center, Malcom Randall VA Medical Center, Gainesville, Florida, United States of America.

Objective: Pilot testing of real time functional magnetic resonance imaging (rt-fMRI) and real time functional near infrared spectroscopy (rt-fNIRS) as brain computer interface (BCI) neural feedback systems combined with motor learning for motor recovery in chronic severely impaired stroke survivors.

Approach: We enrolled a four-case series and administered three sequential rt-fMRI and ten rt-fNIRS neural feedback sessions interleaved with motor learning sessions. Measures were: Arm Motor Assessment Tool, functional domain (AMAT-F; 13 complex functional tasks), Fugl-Meyer arm coordination scale (FM); active wrist extension range of motion (ROM); volume of activation (fMRI); and fNIRS HbO concentration. Read More

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Burnout and self-regulation failure: A diary study of self-undermining and job crafting among nurses.

J Adv Nurs 2021 May 6. Epub 2021 May 6.

Center of Excellence for Positive Organizational Psychology, Erasmus University Rotterdam, Rotterdam, The Netherlands.

Aim: The objective was to test how nurse burnout impairs day-to-day adaptive self-regulation strategies that link levels of regulatory resources with employee job performance.

Background: Regulatory resources help employees manage their thoughts, feelings, and behaviours on a daily basis. On days when these resources are low, employees may engage in maladaptive self-regulation: more self-undermining (i. Read More

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Delayed production of neutralizing antibodies correlates with fatal COVID-19.

Nat Med 2021 May 5. Epub 2021 May 5.

Department of Medicine, Section of Infectious Diseases, Yale University School of Medicine, New Haven, CT, USA.

Recent studies have provided insights into innate and adaptive immune dynamics in coronavirus disease 2019 (COVID-19). However, the exact features of antibody responses that govern COVID-19 disease outcomes remain unclear. In this study, we analyzed humoral immune responses in 229 patients with asymptomatic, mild, moderate and severe COVID-19 over time to probe the nature of antibody responses in disease severity and mortality. Read More

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Heart transplantation from donors with left ventricular ejection fraction under 40.

Clin Transplant 2021 May 4:e14341. Epub 2021 May 4.

Schumakov National Medical Research Center, Moscow, Russia.

Background: Heart transplantation (HTx) remains the treatment of choice for patients with end-stage advanced heart failure. In 2016 the Schumakov National Medical Research Center commenced performing HTx from donors with abnormal left ventricular systolic function (LVEF <40%). The aim of this study was to evaluate early and late outcomes of recipients after HTx from donors with abnormal LV systolic function. Read More

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Activating transcription factor 4 regulates angiogenesis under lipid overload via methionine adenosyltransferase 2A-mediated endothelial epigenetic alteration.

FASEB J 2021 Jun;35(6):e21612

Department of Cardiology, West China Hospital, Sichuan University, Chengdu, P.R. China.

Lipid overload is intimately connected with the change of endothelial epigenetic status which impacts cellular signaling activities and endothelial function. Activating transcription factor 4 (ATF4) is involved in the regulation of lipid metabolism and meanwhile an epigenetic modifier. However, the role of ATF4 in the angiogenesis under lipid overload is not well understood. Read More

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Metformin pretreatment rescues olfactory memory associated with subependymal zone neurogenesis in a juvenile model of cranial irradiation.

Cell Rep Med 2021 Apr 6;2(4):100231. Epub 2021 Apr 6.

Institute of Medical Science, University of Toronto, Toronto, ON, Canada.

Cranial irradiation (IR) is an effective adjuvant therapy in the treatment of childhood brain tumors but results in long-lasting cognitive deficits associated with impaired neurogenesis, as evidenced in rodent models. Metformin has been shown to expand the endogenous neural stem cell (NSC) pool and promote neurogenesis under physiological conditions and in response to neonatal brain injury, suggesting a potential role in neurorepair. Here, we assess whether metformin pretreatment, a clinically feasible treatment for children receiving cranial IR, promotes neurorepair in a mouse cranial IR model. Read More

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Quantitative EEG (QEEG) Analysis of Emotional Interaction between Abusers and Victims in Intimate Partner Violence: A Pilot Study.

Brain Sci 2021 Apr 29;11(5). Epub 2021 Apr 29.

Department of Community Health & Epidemiology, University of Saskatchewan, Saskatoon, SK S7N 2Z4, Canada.

Background: The perpetrators of intimate partner violence (IPV) and their victims have different emotional states. Abusers typically have problems associated with low self-esteem, low self-awareness, violence, anger, and communication, whereas victims experience mental distress and physical pain. The emotions surrounding IPV for both abuser and victim are key influences on their behavior and their relationship. Read More

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A 19-Year Experience With Clavicular Defects: An Algorithm for Flap Selection and Surgical Outcomes.

Ann Plast Surg 2021 May;86(5):562-567

Background: The clavicle contributes to the stability and functional integrity of the shoulder. Clavicle bone defects are uncommon, and the strategy for their management is variable.

Method: Six patients presented with clavicle bone defects. Read More

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Protease Secretion Visualization and Metastatic Lymph Nodes Imaging a Cell Membrane-Anchored Upconversion Nanoprobe.

Anal Chem 2021 May 3. Epub 2021 May 3.

State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.

Matrix metalloproteinase (MMP) secretion is highly associated with tumor invasion and metastasis; therefore, monitoring MMP secretion is important for disease progression study and therapy choosing. Though working well for intracellular MMP imaging, the performance of current MMP detection probes is impaired in secretion monitoring due to the diffusion of MMP in an extracellular environment after secretion and low secreted amount. Here, we design a cell membrane-anchored ratiometric upconversion nanoprobe (UCNPs-Cy3/Pep-QSY7/Ab) for MMP secretion visualization. Read More

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Tertiary cystic white matter injury as a potential phenomenon after hypoxia-ischaemia in preterm f sheep.

Brain Commun 2021 9;3(2):fcab024. Epub 2021 Mar 9.

The Fetal Physiology and Neuroscience Group, Department of Physiology, The University of Auckland, Auckland 1142, New Zealand.

White matter injury, including both diffuse and cystic elements, remains highly associated with neurodevelopmental disability and cerebral palsy in preterm infants, yet its pathogenesis and evolution are still poorly understood and there is no established treatment. We examined the long-term evolution of white matter injury in chronically instrumented preterm fetal sheep (0.7 gestation) after 25 min of complete umbilical cord occlusion or sham occlusion. Read More

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Self-curling electroconductive nerve dressing for enhancing peripheral nerve regeneration in diabetic rats.

Bioact Mater 2021 Nov 14;6(11):3892-3903. Epub 2021 Apr 14.

Department of Spine Surgery, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510630, China.

Conductive scaffolds have been shown to exert a therapeutic effect on patients suffering from peripheral nerve injuries (PNIs). However, conventional conductive conduits are made of rigid structures and have limited applications for impaired diabetic patients due to their mechanical mismatch with neural tissues and poor plasticity. We propose the development of biocompatible electroconductive hydrogels (ECHs) that are identical to a surgical dressing in this study. Read More

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November 2021

Interleukin-33-Dependent Accumulation of Regulatory T Cells Mediates Pulmonary Epithelial Regeneration During Acute Respiratory Distress Syndrome.

Front Immunol 2021 15;12:653803. Epub 2021 Apr 15.

Department of Cardiac Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Acute respiratory distress syndrome (ARDS) triggered mostly by infection, is a syndrome that involves respiratory failure. ARDS induces strong local infiltration of regulatory T cells (Treg cells) in the lungs, and Treg cells were recently highlighted as being related to the repair of various tissue. However, at present, there is still a lack of adequate evidence showing the impact of Treg cells on pulmonary regeneration during ARDS. Read More

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Does Cathodal vs. Sham Transcranial Direct Current Stimulation Over Contralesional Motor Cortex Enhance Upper Limb Motor Recovery Post-stroke? A Systematic Review and Meta-analysis.

Front Neurol 2021 15;12:626021. Epub 2021 Apr 15.

Heart and Stroke Foundation Canadian Partnership for Stroke Recovery, Sunnybrook Research Institute, Toronto, ON, Canada.

During recovery from stroke, the contralesional motor cortex (M1) may undergo maladaptive changes that contribute to impaired interhemispheric inhibition (IHI). Transcranial direct current stimulation (tDCS) with the cathode over contralesional M1 may inhibit this maladaptive plasticity, normalize IHI, and enhance motor recovery. The objective of this systematic review and meta-analysis was to evaluate available evidence to determine whether cathodal tDCS on contralesional M1 enhances motor re-learning or recovery post-stroke more than sham tDCS. Read More

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Liver inflammation at the time of spinal cord injury enhances intraspinal pathology, liver injury, metabolic syndrome and locomotor deficits.

Exp Neurol 2021 Apr 30;342:113725. Epub 2021 Apr 30.

The Belford Center for Spinal Cord Injury, Ohio State University, Columbus, OH, USA; Department of Neuroscience, College of Medicine, Ohio State University, Columbus, OH, USA. Electronic address:

The current high obesity rates mean that neurological injuries are increasingly sustained on a background of systemic pathology, including liver inflammation, which likely has a negative impact on outcomes. Because obesity involves complex pathology, the effect of hepatic inflammation alone on neurological recovery is unknown. Thus, here we used a gain-of-function model to test if liver inflammation worsens outcome from spinal cord injury (SCI) in rats. Read More

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Oxytocin ameliorates impaired social behavior in a Chd8 haploinsufficiency mouse model of autism.

BMC Neurosci 2021 May 1;22(1):32. Epub 2021 May 1.

Department of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University, Kanazawa, 920-8640, Japan.

Background: Autism spectrum disorder (ASD) is characterized by the core symptoms of impaired social interactions. Increasing evidence suggests that ASD has a strong genetic link with mutations in chromodomain helicase DNA binding protein 8 (CHD8), a gene encoding a chromatin remodeler. It has previously been shown that Chd8 haplodeficient male mice manifest ASD-like behavioral characteristics such as anxiety and altered social behavior. Read More

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