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Effects of Aging on Hemodynamic Kinetics in Different Intensities of Dynamic Exercise.

Int J Sports Med 2021 Jun 22. Epub 2021 Jun 22.

Department of Physiotherapy, UFSCar, Sao Carlos, Brazil.

Healthy aging hemodynamics is known to exhibit a time-dependent loss of function. We aimed at verifying whether older men would have a slowed cardiac output and stroke volume dynamics in response to the onset ("on") and on recovery ("off") of exercise in comparison to young men. Twenty healthy active men (10 young and 10 older) were recruited. Read More

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[Investigations on suckling piglets castrated under automated isoflurane anesthesia].

Tierarztl Prax Ausg G Grosstiere Nutztiere 2021 Jun 22;49(3):167-177. Epub 2021 Jun 22.

Klinik für Schweine, Zentrum für Klinische Tiermedizin, Ludwig-Maximilians-Universität München.

Objective: Investigation of defensive reactions, piglet losses, post-bleeding and recovery time of suckling piglets castrated under automated isoflurane anesthesia as well as measurements of isoflurane concentrations in ambient air and estimation of the cleaning and disinfection success of anesthesia masks.

Material And Methods: A total of 955 suckling piglets (age: 4.0 ± 1. Read More

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Hyperbaric oxygen treatment for intrauterine limb ischaemia: a newborn in the chamber.

Diving Hyperb Med 2021 Jun;51(2):220-223

Istanbul Faculty of Medicine, Underwater and Hyperbaric Medicine Department, Istanbul, Turkey.

Intrauterine limb ischaemia is a rare condition that may have devastating results. Various treatments are reported in the literature; however, results are not always promising and amputations may be required for some patients. Post-natal hyperbaric oxygen treatment (HBOT) may be a useful treatment option for the salvage of affected limbs. Read More

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Prolonged syncope with multifactorial pulmonary oedema related to dry apnoea training: Safety concerns in unsupervised dry static apnoea.

Diving Hyperb Med 2021 Jun;51(2):210-215

Department of Emergency Medicine, University of California San Diego, San Diego CA, USA.

Many competitive breath-hold divers use dry apnoea routines to improve their tolerance to hypoxia and hypercapnia, varying the amount of prior hyperventilation and lung volume. When hyperventilating and exhaling to residual volume prior to starting a breath-hold, hypoxia is reached quickly and without too much discomfort from respiratory drive. Cerebral hypoxia with loss of consciousness (LOC) can easily result. Read More

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MXenes: synthesis, incorporation, and applications in ultrafast lasers.

Nanotechnology 2021 Jun 22. Epub 2021 Jun 22.

Beihang University, Beijing, CHINA.

The rapid expansion of nanotechnology and material science prompts 2D materials to be extensively used in biomedicine, optoelectronic devices, and ultrafast photonics. Owing to the broadband operation, ultrafast recovery time, and saturable absorption properties, 2D materials become the promising candidate for being saturable absorbers in ultrafast pulsed lasers. In recent years, the novel 2D MXene materials have occupied the forefront due to their superior optical and electronic, as well as mechanical and chemical properties. Read More

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The effects of transcranial direct current stimulation on upper-limb function post-stroke: A meta-analysis of multiple-session studies.

Clin Neurophysiol 2021 Jun 11;132(8):1897-1918. Epub 2021 Jun 11.

REVAL Research Institute, Hasselt University, Diepenbeek, Belgium; Movement Control & Neuroplasticity Research Group, Department of Movement Sciences, Group Biomedical Sciences, KU Leuven, Heverlee, Belgium. Electronic address:

Objective: To systematically review how patient characteristics and/or transcranial direct current stimulation (tDCS) parameters influence tDCS effectiveness in respect to upper limb function post-stroke.

Methods: Three electronic databases were searched for sham-controlled randomised trials using the Fugl-Meyer Assessment for upper extremity as outcome measure. A meta-analysis and nine subgroup-analyses were performed to identify which tDCS parameters yielded the greatest impact on upper limb function recovery in stroke patients. Read More

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A scoping research literature review to map the evidence on grief triggers.

Soc Sci Med 2021 Jun 5;282:114109. Epub 2021 Jun 5.

Faculty of Nursing, University of Navarra, Pamplona, Spain.

Grief is understandably severe in the first days, if not weeks or months, following the death of a beloved person. Unless the mourner develops complicated grief, which is prolonged severe and impactful grief, the initial acute grief lessens in severity over time, although waves of significant grief will still occur with grief triggers. A scoping research literature review was undertaken in early 2021 to determine how often grief triggers occur, what the most common grief triggers are, the impact of triggered grief, and what can be done (by those not diagnosed with complicated grief) to manage grief triggers and mitigate the effect of them. Read More

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A case report on non-specific synovitis of the knee due to septic foreign body in the Hoffa fat pad causing diagnostic dilemma.

Int J Surg Case Rep 2021 Jun 18;84:106124. Epub 2021 Jun 18.

Teaching Hospital-Batticaloa, Sri Lanka.

Introduction & Importance: Recurrent chronic synovitis due to foreign body is a rare entity and it may progress into chronic septic arthritis. Chronic recurrent synovitis or septic arthritis may leave permanent damage to the articular cartilage and renders the child with permanent disabilities.

Case Presentation: A 03-year-old girl has been transferred to a tertiary centre with a history of recurrent pain and swelling of the right knee and on and off limping for six weeks duration. Read More

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Targeted and semi-untargeted determination of phenolic compounds in plant matrices by high performance liquid chromatography-tandem mass spectrometry.

J Chromatogr A 2021 Jun 19;1651:462315. Epub 2021 Jun 19.

University of Teramo, Faculty of Bioscience and Technology for Food, Agriculture and Environment, Teramo, Italy.

In this work two different acquisition approaches were used for the quantification and/or tentative identification of phenolic compounds (PCs) in plant matrices by HPLC-MS/MS. A targeted approach, based on MRM acquisition mode, was used for the identification and quantification of a list of target analytes by comparison with standards; a semi-targeted approach was also developed by the precursor ion scan and neutral loss for the tentative identification of compounds not included in the target list. Analysis of phenolic content in three different plant matrices (curry leaves, hemp and blueberry) was carried out. Read More

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Management of vascular complications following facial hyaluronic acid injection: high-dose hyaluronidase protocol: a technical note.

J Stomatol Oral Maxillofac Surg 2021 Jun 19. Epub 2021 Jun 19.

Department of ENT and Maxillofacial surgery, Head and Neck Institute, University Hospital of Nice, France.. Electronic address:

Aesthetic medicine has experienced major developments in recent years, which is illustrated by the increasing number of hyaluronic acid injected in the area of facial rejuvenation. Although considered low risk, it can rarely result in arterial embolization with potentially major aesthetic and functional consequences. These vascular complications range from livedo to skin necrosis to permanent blindness. Read More

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Comparison of anaerobic co-digestion of pig manure and sludge at different mixing ratios at thermophilic and mesophilic temperatures.

Bioresour Technol 2021 Jun 17;337:125425. Epub 2021 Jun 17.

College of Petrochemical Engineering, Lanzhou University of Technology, Lanzhou 730050, China; Jiangxi Province Engineering Research Center of Ecological Chemical Industry (Jiujiang University), Jiujiang 332005, China. Electronic address:

The objective of this study is to assess the effects of the mixing ratio on the methane production and digestate dewaterability of co-digestion of pig manure (P) and sludge (S). Batch experiments were carried out at five different P/S mixing ratios at mesophilic and thermophilic temperatures. Compared to sludge anaerobic digestion, co-digestion of pig manure with sludge increased methane yield 83. Read More

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Cultivation of edible filamentous fungus Aspergillus oryzae on volatile fatty acids derived from anaerobic digestion of food waste and cow manure.

Bioresour Technol 2021 Jun 15;337:125410. Epub 2021 Jun 15.

Swedish Centre for Resource Recovery, University of Borås, 50190 Borås, Sweden. Electronic address:

In a circular economy approach, edible filamentous fungi (single cell protein) can be cultivated on volatile fatty acids (VFAs) derived from anaerobic digestion (AD) of organic-rich waste streams. In this study, the effect of pH, concentration/distribution of VFAs, nutrient supplementation, and type of waste on Aspergillus oryzae cultivation on synthetic VFAs, and actual VFAs derived from AD of food waste and cow manure were investigated. The optimal pH for A. Read More

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Is convalescent plasma futile in COVID-19? A Bayesian re-analysis of the RECOVERY randomised controlled trial.

Int J Infect Dis 2021 Jun 19. Epub 2021 Jun 19.

Institute of Applied Health Research, University of Birmingham, UK.

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Comparison of Surgical Embolectomy and Veno-arterial Extracorporeal Membrane Oxygenation for Massive Pulmonary Embolism.

Semin Thorac Cardiovasc Surg 2021 Jun 19. Epub 2021 Jun 19.

Section of Cardiothoracic Surgery, Westchester Medical Center, New York Medical College.

Massive pulmonary embolism (MPE) is associated with a 20-50% mortality rate with guideline directed therapy. MPE treatment with surgical embolectomy (SE) or venoarterial extracorporeal membrane oxygenation (VA-ECMO) have shown promising results. In the context of a surgical management strategy for MPE, a comparison of outcomes associated with VA-ECMO or SE was performed. Read More

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Prevalence and characteristics of myocardial injury during COVID-19 pandemic: A new role for high-sensitive troponin.

Int J Cardiol 2021 Jun 19. Epub 2021 Jun 19.

Department of Cardiovascular Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; Department of Cardiovascular and Pulmonary Sciences, Università Cattolica Sacro Cuore, Rome, Italy.

Background: Coronavirus disease 2019 (COVID-19) is a pandemic disease that is causing a public health emergency. Characteristics and clinical significance of myocardial injury remain unclear.

Methods: This retrospective single-center study analyzed analyzed 189 patients who received a COVID-19 diagnosis out of all 758 subjects with a high sensitive troponin I (Hs-TnI) measurement within the first 24 h of admission at the Policlinico A. Read More

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Physically cross-linked chitosan/dextrin cryogels entrapping Thymus vulgaris essential oil with enhanced mechanical, antioxidant and antifungal properties.

Int J Biol Macromol 2021 Jun 19. Epub 2021 Jun 19.

"Grigore T. Popa" University of Medicine and Pharmacy, Universitatii Street 16, Iasi 700115, Romania.

Herein, we entrapped Thymus vulgaris essential oil (EO) within the physically cross-linked sponge-like architecture of cryogels by ice template-assisted freeze-drying. Their 3D cryogenically-structured network was built through hydrogen bonding formed by blending two naturally-derived polysaccharides, chitosan and dextrin. The embedment of EOs within the cryogel matrix generates sponge-like films with an increased elasticity that allows their fast shape recovery after full compression. Read More

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Pharmacodynamics and pharmacokinetics of a copper intrauterine contraceptive system releasing ulipristal acetate: a randomized proof-of-concept study.

Contraception 2021 Jun 19. Epub 2021 Jun 19.

Population Council. 1230 York Avenue, New York City, NY, 10065, USA.

Objectives: To assess pharmacodynamic and pharmacokinetic outcomes of a novel copper (Cu) intrauterine system (IUS) releasing ulipristal acetate (UPA) in healthy women.

Study Design: In this single-blinded, randomized proof-of-concept study, ovulatory women received one of three Cu-IUSs releasing low-dose UPA (5, 20 or 40 µg/d) for 12 weeks. The study included a baseline cycle, three 4-week treatment-cycles and two recovery cycles. Read More

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Anti-inflammatory Pharmacotherapy for the Prevention of Cystoid Macular Edema after Cataract Surgery.

Am J Ophthalmol 2021 Jun 19. Epub 2021 Jun 19.

Department of Ophthalmology, University of Warmia and Mazury, Olsztyn, Poland; Institute for Research in Ophthalmology, Foundation for Ophthalmology Development, Poznan Poland. Electronic address:

Purpose: To elucidate strategies for and controversies surrounding the use of anti-inflammatory medications after uneventful cataract surgery, with a focus on the prevention of irreversible vision loss due to cystoid macular edema (CME).

Design: Perspective.

Methods: Expert commentary on the management of inflammation after cataract surgery. Read More

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Ecology: E-rat-ication to restore reefs.

Curr Biol 2021 Jun;31(12):R786-R788

Department of Ecology, Evolution and Marine Biology, University of California, Santa Barbara, CA 93106, USA; Marine Science Institute, University of California, Santa Barbara, CA 93106, USA. Electronic address:

Invasive species often drive native species to local extinction. A new study shows that removing invasive rats from tropical islands fosters recovery of native seabirds. Rising seabird populations reestablish key cross-ecosystem nutrient subsidies, reconnecting oceanic, island, and coral reef ecosystems. Read More

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Recovery homes provide inexpensive and accessible community-based support.

J Prev Interv Community 2021 Jun 22:1-7. Epub 2021 Jun 22.

American University in Bulgaria, Blagoevgrad, Bulgaria.

Substance abuse disorders (SUDs) create significant and pervasive health and economic burdens in the U.S. and the world. Read More

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The timeframe for safe resumption of high-level mobility following traumatic brain injury is currently unknown: a systematic review.

Disabil Rehabil 2021 Jun 22:1-11. Epub 2021 Jun 22.

Department of Physiotherapy, Epworth HealthCare, Melbourne, Australia.

Purpose: To examine the safety of high-level mobility (HLM) prescription in the early sub-acute phase of recovery following moderate-to-extremely severe traumatic brain injury (TBI) with specific focus on provocation of concussion-like symptoms.

Design: Systematic review. PROSPERO ID: CRD42017069369. Read More

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Predictive factors of smell recovery in a clinical series of 288 COVID-19 patients with olfactory dysfunction.

Eur J Neurol 2021 Jun 22. Epub 2021 Jun 22.

Institute for Medical Immunology, Université libre de Bruxelles, Charleroi, Belgium.

Objective: To evaluate potential predictive factors of smell recovery in a clinical series of 288 patients presenting olfactory dysfunction (OD) related to the COVID19. Potential correlations are sought between epidemiological, clinical and immunological characteristics of patients and the persistence of OD at 60 days.

Methods: COVID-19 positive patients presenting olfactory dysfunction were prospectively recruited from three European hospitals. Read More

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Omidubicel Versus Standard Myeloablative Umbilical Cord Blood Transplantation: Results of a Phase III Randomized Study.

Blood 2021 Jun 22. Epub 2021 Jun 22.

Hospital Universitario y Politécnico La Fe, Valencia, Spain and CIBERONC, Instituto de Salud Carlos III, Madrid, Spain, Valencia, Spain.

Omidubicel is an ex vivo expanded hematopoietic progenitor cell, and non-expanded myeloid and lymphoid cell product derived from a single umbilical cord blood unit. We report results of a phase III trial to evaluate the efficacy of omidubicel compared to standard umbilical cord blood transplantation (UCBT). Between January 2017 and January 2020, 125 patients aged 13-65 with hematologic malignancies were randomized to omidubicel versus standard UCBT. Read More

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Radial nerve palsy following humeral shaft fracture: a theoretical PNF rehabilitation approach for tendon and nerve transfers.

Physiother Theory Pract 2021 Jun 22:1-11. Epub 2021 Jun 22.

Athletic Training Program, Kosair Charities College of Health and Natural Sciences, Spalding University, Louisville, KY, USA.

Humerus fracture-induced radial nerve injury can create severe and permanent disabilities. Surgical management often relies on either tendon or nerve transfer. Regardless of which procedure is selected, physical therapists are challenged to restore functional outcomes without jeopardizing repair healing. Read More

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Open-Label Phase II Prospective, Randomized, Controlled Study of Romyelocel-L Myeloid Progenitor Cells to Reduce Infection During Induction Chemotherapy for Acute Myeloid Leukemia.

J Clin Oncol 2021 Jun 22:JCO2001739. Epub 2021 Jun 22.

Cellerant Therapeutics, San Carlos, CA.

Purpose: Standard cytotoxic induction chemotherapy for acute myeloid leukemia (AML) results in prolonged neutropenia and risk of infection. Romyelocel-L is a universal, allogeneic myeloid progenitor cell product being studied to reduce infection during induction chemotherapy.

Patients And Methods: One hundred sixty-three patients with de novo AML (age ≥ 55 years) receiving induction chemotherapy were randomly assigned on day 0 (d0), of whom 120 were evaluable. Read More

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Gonadal Function Recovery in Patients With Advanced Hodgkin Lymphoma Treated With a PET-Adapted Regimen: Prospective Analysis of a Randomized Phase III Trial (AHL2011).

J Clin Oncol 2021 Jun 22:JCO2100068. Epub 2021 Jun 22.

Department of Haematology, University Hospital F Mitterrand and Inserm UMR1231, Dijon, France.

Purpose: The prospective, randomized AHL2011 trial demonstrated that the use of the doxorubicin, bleomycin, vinblastine, and dacarbazine regimen (ABVD) after two cycles of bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone (BEACOPP) in early responders on the basis of a positron emission tomography (PET)-driven strategy was safe and minimized toxicity compared with standard 6 BEACOPP cycles. This substudy investigated the benefit of this strategy in gonadal function and fertility in patients under 45 years old.

Methods: Ovarian function was assessed by serum measurement of follicle-stimulating hormone (FSH), estradiol, and anti-müllerian hormone in women, and semen analysis, FSH, and testosterone levels were used to evaluate testicular function in men at baseline, end of treatment, and during 5 years of follow-up. Read More

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Outcomes of Arthroscopic Nerve Release in Patients Treated for Large or Massive Rotator Cuff Tears and Associated Suprascapular Neuropathy: A Prospective, Randomized, Double-Blinded Clinical Trial.

Am J Sports Med 2021 Jun 22:3635465211021834. Epub 2021 Jun 22.

Second Orthopaedic Department, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Background: Suprascapular neuropathy has been observed in the setting of rotator cuff tears (RCTs), but its association with these tears and their treatment are unclear.

Hypothesis: Arthroscopic suprascapular nerve release during rotator cuff repair will not alter the outcomes of neuropathy.

Study Design: Randomized controlled trial; Level of evidence, 1. Read More

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Humanized CD19-Targeted Chimeric Antigen Receptor (CAR) T Cells in CAR-Naive and CAR-Exposed Children and Young Adults With Relapsed or Refractory Acute Lymphoblastic Leukemia.

J Clin Oncol 2021 Jun 22:JCO2003458. Epub 2021 Jun 22.

Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA.

Purpose: CD19-targeted chimeric antigen receptor (CAR)-modified T cells demonstrate unprecedented responses in B-cell acute lymphoblastic leukemia (B-ALL); however, relapse remains a substantial challenge. Short CAR T-cell persistence contributes to this risk; therefore, strategies to improve persistence are needed.

Methods: We conducted a pilot clinical trial of a humanized CD19 CAR T-cell product (huCART19) in children and young adults with relapsed or refractory B-ALL (n = 72) or B-lymphoblastic lymphoma (n = 2), treated in two cohorts: with (retreatment, n = 33) or without (CAR-naive, n = 41) prior CAR exposure. Read More

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Prevalence of Depression and Anxiety Disorders Following Mild Traumatic Brain Injury.

PM R 2021 Jun 22. Epub 2021 Jun 22.

Kaiser Foundation Rehabilitation Center, Kaiser Permanente Vallejo Medical Center, Vallejo, California.

Introduction: Previous studies have identified an association between traumatic brain injuries and the development of psychiatric disorders in general. However, these studies were subject to limitations that demonstrate the need for a study of a large, clearly defined mild traumatic brain injury (mTBI) population within an integrated healthcare system.

Objective: To determine the prevalence and relative risk of post-injury affective disorders over 4 years following mTBI. Read More

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Gas chromatography-mass spectrometry analysis of organic acid profiles in human serum: a protocol of direct ultrasound-assisted derivatization.

Rapid Commun Mass Spectrom 2021 Jun 22:e9149. Epub 2021 Jun 22.

Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, Harbin, P. R. China.

Rationale: Low-molecular weight organic acids that generally contain one to three carboxyl groups are involved in many important biological processes; therefore, it is important to develop a quantitative method for analyzing organic acids in serum in order to allow evaluation of metabolic changes. In this study, we evaluated a protocol for detecting 26 organic acids in serum based on ultrasound-assisted derivatization by gas chromatography-mass spectrometry (GC-MS).

Methods: Serum samples were prepared using ultrasound-assisted silane derivatization before GC-MS analysis to quantify concentrations of organic acids. Read More

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