2,081 results match your criteria recovered covid-19


Modeling the evolution of COVID-19 via compartmental and particle-based approaches: Application to the Cyprus case.

PLoS One 2021 6;16(5):e0250709. Epub 2021 May 6.

Computation-based Science and Technology Research Center, The Cyprus Institute, Nicosia, Cyprus.

We present two different approaches for modeling the spread of the COVID-19 pandemic. Both approaches are based on the population classes susceptible, exposed, infectious, quarantined, and recovered and allow for an arbitrary number of subgroups with different infection rates and different levels of testing. The first model is derived from a set of ordinary differential equations that incorporates the rates at which population transitions take place among classes. Read More

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One dose of SARS-CoV-2 vaccine exponentially increases antibodies in recovered individuals with symptomatic COVID-19.

J Clin Invest 2021 May 6. Epub 2021 May 6.

Department of Biomedical Sciences, Humanitas University, Milan, Italy.

Background: Currently used COVID-19 vaccines require two doses to achieve optimal vaccination, and there is no indication as to whether individuals who have been exposed to SARS-CoV-2 should be vaccinated, or should receive one or two vaccine doses.

Methods: Here, we tested the antibody response developed after administration of the Pfizer/BioNTech vaccine in 124 healthcare professionals of which 57 had a previous history of SARS-CoV-2 exposure (SARS-CoV-2-Exp), with or without symptoms.

Results: Post-vaccine antibodies in SARS-CoV-2 exposed individuals increased exponentially within 5-18 days after the first dose compared to naïve subjects (P < 0. Read More

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Emergency Department Visits for Emergent Conditions Among Older Adults During the COVID-19 Pandemic.

J Am Geriatr Soc 2021 May 6. Epub 2021 May 6.

Department of Emergency Medicine, Yale University School of Medicine, New Haven, CT.

Background/objective: Emergency department (ED) visits have declined while excess mortality, not attributable to COVID-19, has grown. It is not known whether older adults are accessing emergency care differently from their younger counterparts. Our objective was to determine patterns of ED visit counts for emergent conditions during the COVID-19 pandemic for older adults. Read More

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Triage and Recovery of STEM Laboratory Skills.

J Microbiol Biol Educ 2021 31;22(1). Epub 2021 Mar 31.

Department of Biological Sciences and Geology, Queensborough Community College, City University of New York, Bayside, NY 11364.

The global COVID-19 pandemic left universities with few options but to turn to remote learning. With much effort, STEM courses made this change in modality; however, many laboratory skills, such as measurement and handling equipment, are more difficult to teach in an online learning environment. A cohort of instructors who are part of the NSF RCN-UBE funded Sustainable, Transformative Engagement across a Multi-Institution/Multidisciplinary STEM (STEM) Network (a working group of faculty from two community colleges and three 4-year universities) analyzed introductory biology and chemistry courses to identify essential laboratory skills that students will need in advanced courses. Read More

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Aseptic Meningitis after Recovery from SARS-CoV-2 in an Allogeneic Stem Cell Transplant Recipient.

Clin Med Insights Case Rep 2021 19;14:11795476211009811. Epub 2021 Apr 19.

Division of Transplantation and Cellular Therapy, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.

SARS-CoV-2 emerged as a worldwide pandemic in late 2019 and initially was described as a primary respiratory illness. The clinical manifestations of COVID-19 are now known to encompass nearly all organ systems, including the central nervous system. We present a case of an allogeneic hematopoietic stem cell transplant recipient who recovered from documented SARS-CoV-2 infection and later presented with symptoms of meningitis. Read More

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The epidemiological characteristics and effectiveness of countermeasures to contain coronavirus disease 2019 in Ningbo City, Zhejiang Province, China.

Sci Rep 2021 05 5;11(1):9545. Epub 2021 May 5.

State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, 4221-117 South Xiang'an Road, Xiang'an District, Xiamen, Fujian Province, People's Republic of China.

A novel coronavirus (SARS-CoV-2) has spread worldwide and led to high disease burden around the world. This study aimed to explore the key parameters of SARS-CoV-2 infection and to assess the effectiveness of interventions to control the coronavirus disease 2019 (COVID-19). A susceptible-exposed-infectious-asymptomatic-recovered (SEIAR) model was developed for the assessment. Read More

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Estimating effects of intervention measures on COVID-19 outbreak in Wuhan taking account of improving diagnostic capabilities using a modelling approach.

BMC Infect Dis 2021 May 5;21(1):424. Epub 2021 May 5.

Centre for Applied One Health Research and Policy Advice, City University of Hong Kong, Hong Kong, China.

Background: Although by late February 2020 the COVID-19 epidemic was effectively controlled in Wuhan, China, estimating the effects of interventions, such as transportation restrictions and quarantine measures, on the early COVID-19 transmission dynamics in Wuhan is critical for guiding future virus containment strategies. Since the exact number of infected cases is unknown, the number of documented cases was used by many disease transmission models to infer epidemiological parameters. This means that it was possible to produce biased estimates of epidemiological parameters and hence of the effects of intervention measures, because the percentage of all cases that were documented changed during the first 2 months of the epidemic, as a consequence of a gradually improving diagnostic capability. Read More

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Ethical issues in managing the COVID-19 pandemic.

Bioethics 2021 May 5. Epub 2021 May 5.

Ghent University Hospital, Gent, Belgium.

The COVID-19 pandemic has had an immense and worldwide impact. In light of future pandemics or subsequent waves of COVID-19 it is crucial to focus on the ethical issues that were and still are raised in this COVID-19 crisis. In this paper, we look at issues that are raised in the testing and tracing of patients with COVID-19. Read More

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Putative mechanism of neurological damage in COVID-19 infection.

Acta Neurobiol Exp (Wars) 2021 ;81(1):69-79

División de Neurociencias , Instituto Nacional de Rehabilitación , México.

The recent pandemic of the coronavirus infectious disease 2019 (COVID-19) has affected around 192 countries, and projections have shown that around 40% to 70% of world population could be infected in the next months. COVID-19 is caused by the virus SARS- CoV-2, it enters the cells through the ACE2 receptor (angiotensin converting enzyme 2). It is well known that SARS-CoV-2 could develop mild, moderate, and severe respiratory symptoms that could lead to death. Read More

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January 2021

Longitudinal analysis shows durable and broad immune memory after SARS-CoV-2 infection with persisting antibody responses and memory B and T cells.

medRxiv 2021 Apr 27. Epub 2021 Apr 27.

Ending the COVID-19 pandemic will require long-lived immunity to SARS-CoV-2. We evaluated 254 COVID-19 patients longitudinally from early infection and for eight months thereafter and found a predominant broad-based immune memory response. SARS-CoV-2 spike binding and neutralizing antibodies exhibited a bi-phasic decay with an extended half-life of >200 days suggesting the generation of longer-lived plasma cells. Read More

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Previously infected vaccinees broadly neutralize SARS-CoV-2 variants.

medRxiv 2021 Apr 29. Epub 2021 Apr 29.

We compared the serum neutralizing antibody titers before and after two doses of the BNT162b2 COVID-19 vaccine in ten individuals who recovered from SARS-CoV-2 infection prior to vaccination to 20 individuals with no history of infection, against clinical isolates of B.1.1. Read More

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Protracted yet coordinated differentiation of long-lived SARS-CoV-2-specific CD8+ T cells during COVID-19 convalescence.

bioRxiv 2021 Apr 29. Epub 2021 Apr 29.

CD8+ T cells are important antiviral effectors that can potentiate long-lived immunity against COVID-19, but a detailed characterization of these cells has been hampered by technical challenges. We screened 21 well-characterized, longitudinally-sampled convalescent donors that recovered from mild COVID-19 against a collection of SARS-CoV-2 tetramers, and identified one participant with an immunodominant response against Nuc , a peptide that is conserved in all the SARS-CoV-2 variants-of-concern reported to date. We conducted 38- parameter CyTOF phenotyping on tetramer-identified Nuc -specific CD8+ T cells, and on CD4+ and CD8+ T cells recognizing the entire nucleocapsid and spike proteins from SARS- CoV-2, and took 32 serological measurements on longitudinal specimens from this participant. Read More

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Cerebral Venous Thrombosis in Acute Lymphoblastic Leukemia with Severe COVID-19: a Case Report.

SN Compr Clin Med 2021 Apr 30:1-5. Epub 2021 Apr 30.

Department of Medicine, Command Hospital, Kolkata, India.

Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has brought an unprecedented upheaval in our health-care systems. Amongst the many challenges posed by the disease, increased risk of thromboembolism has presented a distinct new front for increased mortality and morbidity. While there are multiple documented evidences for the same, the exact mechanism, knowledge of groups at-risk, and mitigation strategies are evolving. Read More

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Convalescent plasma for adults with acute COVID-19 respiratory illness (CONCOR-1): study protocol for an international, multicentre, randomized, open-label trial.

Trials 2021 May 4;22(1):323. Epub 2021 May 4.

McMaster Centre for Transfusion Research, McMaster University, Hamilton, Ontario, Canada.

Background: Convalescent plasma has been used for numerous viral diseases including influenza, severe acute respiratory syndrome, Middle East respiratory syndrome and Ebola virus; however, evidence to support its use is weak. SARS-CoV-2 is a novel coronavirus responsible for the 2019 global pandemic of COVID-19 community acquired pneumonia. We have undertaken a randomized controlled trial to assess the efficacy and safety of COVID-19 convalescent plasma (CCP) in patients with SARS-CoV-2 infection. Read More

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Immunoglobulin Response and Prognostic Factors in Repeated SARS-CoV-2 Positive Patients: A Systematic Review and Meta-Analysis.

Viruses 2021 04 30;13(5). Epub 2021 Apr 30.

Institute for Translational Medicine, Medical School, University of Pécs, 7624 Pécs, Hungary.

With repeated positivity being an undiscovered and major concern, we aimed to evaluate which prognostic factors may impact repeated SARS-CoV-2 positivity (RSP) and their association with immunoglobulin detectability among recovered patients. A systematic literature search was performed on 5 April 2021. Cohort studies with risk factors for repeated RSP or information about the immunoglobulin response (immunoglobulin M (IgM) and/or immunoglobulin G (IgG)) were included in this analysis. Read More

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Knowledge, Attitudes, Practices and Some Characteristic Features of People Recovered from COVID-19 in Turkey.

Medicina (Kaunas) 2021 Apr 30;57(5). Epub 2021 Apr 30.

Department of Microbiology, Faculty of Veterinary Medicine, University of Firat, 23119 Elazig, Turkey.

The whole world is spending an extraordinary effort by implementing various measures to control and prevent the COVID-19 pandemic. The effectiveness of the preventive measures is greatly influenced by the public's knowledge, attitudes, and practices (KAP) towards the disease. In this study, KAP values and some characteristic features of people recovered from COVID-19 were determined by conducting a questionnaire survey. Read More

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CD8 T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope cross-react with selective seasonal coronaviruses.

Immunity 2021 Apr 13. Epub 2021 Apr 13.

Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086, Australia. Electronic address:

Efforts are being made worldwide to understand the immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for the coronavirus disease 2019 (COVID-19) pandemic, including the impact of T cell immunity and cross-recognition with seasonal coronaviruses. Screening of SARS-CoV-2 peptide pools revealed that the nucleocapsid (N) protein induced an immunodominant response in HLA-B7 COVID-19-recovered individuals that was also detectable in unexposed donors. A single N-encoded epitope that was highly conserved across circulating coronaviruses drove this immunodominant response. Read More

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A toddler diagnosed with severe postinfectious bronchiolitis obliterans and COVID-19 infection.

Pediatr Pulmonol 2021 May 4. Epub 2021 May 4.

Aghia Sophia Children's Hospital, National and Kapodistrian University of Athens, Athens, Greece.

During the COVID-19 pandemic, management of SARS-CoV-2 infection in children with underlying chronic lung disease has been challenging. There are limited studies in children with respiratory comorbidities, apart from asthma, presumably due to low morbidity of SARS-CoV-2 infection in the general pediatric population along with the low incidence of certain pulmonary conditions. Compassionate use of remdesivir has been shown to reduce time to clinical improvement in adults and has been retrospectively studied in small pediatric cohorts with promising results. Read More

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Pattern of vaccination delivery around COVID-19 lockdown in Nigeria.

Authors:
Ryoko Sato

Hum Vaccin Immunother 2021 May 4:1-3. Epub 2021 May 4.

Center for Health Decision Science, Harvard T.H Chan School of Public Health, Boston, MA, USA.

COVID-19 pandemic has affected the world, including developing countries in various aspects. This pandemic might have severe consequences in terms of population health, especially in places where the health system is already weak. Using the health facility-level data over time, we evaluated the impact of COVID-19 lockdown on the vaccination service delivery in Nigeria. Read More

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Child health services during a COVID-19 outbreak in KwaZulu-Natal Province, South Africa.

S Afr Med J 2020 12 15;111(2):114-119. Epub 2020 Dec 15.

Health Systems Strengthening Unit, Health Systems Trust, Durban, South Africa.

Background: Current evidence indicates that children are relatively spared from direct COVID-19-related morbidity and mortality, but that the indirect effects of the pandemic pose significant risks to their health and wellbeing.

Objectives: To assess the impact of the local COVID-19 outbreak on routine child health services.

Methods: The District Health Information System data set for KwaZulu-Natal (KZN) provincial health services was accessed, and monthly child health-related data were extracted for the period January 2018 - June 2020. Read More

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December 2020

Post-COVID-19 Syndrome: Theoretical Basis, Identification, and Management.

AACN Adv Crit Care 2021 May 4:e1-e8. Epub 2021 May 4.

Nancy Munro is Acute Care Nurse Practitioner, Critical Care Medicine Department, National Institutes of Health, Bethesda, Maryland.

As COVID-19 continues to spread, with the United States surpassing 29 million cases, health care workers are beginning to see patients who have been infected with SARS-CoV-2 return seeking treatment for its longer-term physical and mental effects. The term long-haulers is used to identify patients who have not fully recovered from the illness after weeks or months. Although the acute symptoms of COVID-19 have been widely described, the longer-term effects are less well known because of the relatively short history of the pandemic. Read More

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News Sentiment Informed Time-series Analyzing AI (SITALA) to curb the spread of COVID-19 in Houston.

Expert Syst Appl 2021 Apr 29:115104. Epub 2021 Apr 29.

Address: Rice University, 6100 Main St, MS-321, Houston, TX 77005, USA.

Coronavirus disease (COVID-19) has evolved into a pandemic with many unknowns. Houston, located in the Harris County of Texas, is becoming the next hotspot of this pandemic. With a severe decline in international and inter-state travel, a model at the county level is needed as opposed to the state or country level. Read More

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ACRAL GANGRENE: UGLY COUSIN OF "COVID TOES" IN MULTISYSTEM INFLAMMATORY SYNDROME IN CHILDREN ASSOCIATED WITH SARS-COV-2?

Pediatr Infect Dis J 2021 May 3. Epub 2021 May 3.

From the Allergy Immunology Unit, Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India Pediatric Intensive Care Unit, Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India. DOI: 10.1097/INF.0000000000003181.

A spectrum of dermatologic manifestations has been reported in multisystem inflammatory syndrome in children associated with SARS-CoV-2 infection. We report 2 patients with multisystem inflammatory syndrome in children and severe cardiovascular dysfunction who developed acral gangrene. Both responded well to therapy and recovered in the follow-up. Read More

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First-dose mRNA vaccination is sufficient to reactivate immunological memory to SARS-CoV-2 in recovered COVID-19 subjects.

J Clin Invest 2021 May 3. Epub 2021 May 3.

Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.

The characterization of the adaptive immune response to COVID-19 vaccination in individuals who recovered from SARS-CoV-2 infection may define current and future clinical practice. To determine the effect of two doses BNT162b2 mRNA COVID-19 vaccination schedule in individuals who recovered from COVID-19 (COVID-19 recovered) compared to naïve subjects, we evaluated SARS-CoV-2 Spike-specific T and B cell responses, as well as specific IgA, IgG, IgM and neutralizing antibodies titers in 22 individuals who received BNT162b2 mRNA COVID-19 vaccine, 11 of which had a previous history of SARS-CoV-2 infection. Evaluations were performed before vaccination and then weekly until 7 days post second injection. Read More

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Prehospital Sinus Node Dysfunction and Asystole in a Previously Healthy Patient With COVID-19.

Prehosp Emerg Care 2021 May 3:1-4. Epub 2021 May 3.

Montgomery County Hospital District, EMS, Conroe, 77304 United States.

We report a case of a previously healthy 47-year-old female with syncope due to multiple episodes of nodal dysfunction and asystole. During these brief episodes, she was hypoxic in the mid-80's as a result of COVID-19 pneumonia. The patient was admitted and treated for viral pneumonia and found to have normal electrocardiograms (ECG's), normal troponin levels and a normal echocardiogram during her hospital stay. Read More

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Unconventional Care at a Convention Center: An Overview of Patient Focused Care at a COVID-19 Alternative Care Site in New Orleans.

Disaster Med Public Health Prep 2021 May 3:1-18. Epub 2021 May 3.

State Health Officer and Medical Director, Louisiana Department of Health.

In March 2020, the State of Louisiana opened an alternative care site at the New Orleans Convention Center, known as the Medical Monitoring Station (MMS). The facility was designed, constructed, and staffed to serve a population with basic medical needs as they recovered from COVID-19. As the MMS prepared to open, local hospitals indicated a greater need for assistance with patients requiring a higher acuity of care and populations unable to be discharged due to infection risks. Read More

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Analysis of the potential impact of durability, timing, and transmission blocking of COVID-19 vaccine on morbidity and mortality.

EClinicalMedicine 2021 May 26;35:100863. Epub 2021 Apr 26.

Center for Disease Dynamics, Economics & Policy, Washington, D.C., USA.

Background: COVID-19 vaccines have been approved and made available. While questions of vaccine allocation strategies have received significant attention, important questions remain regarding the potential impact of the vaccine given uncertainties regarding efficacy against transmission, availability, timing, and durability.

Methods: We adapted a susceptible-exposed-infectious-recovered (SEIR) model to examine the potential impact on hospitalization and mortality assuming increasing rates of vaccine efficacy, coverage, and administration. Read More

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Pulmonary Embolism and Acute Psychosis, a Case Report of an Outpatient with a Mild Course of COVID-19.

SN Compr Clin Med 2021 Apr 27:1-6. Epub 2021 Apr 27.

Department of Cardiology, Klinik Landstrasse, Vienna, Austria.

The increased risk for thromboembolism in hospitalized COVID-19 patients has been communicated extensively. The fact that home quarantined patients can develop pulmonary embolism, however, has so far not been reported. Furthermore, attention should be brought to psychotic developments in COVID-19 patients. Read More

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An Unusual Presentation of Pyelonephritis: Is It COVID-19 Related?

SN Compr Clin Med 2021 Apr 24:1-6. Epub 2021 Apr 24.

Department of Urology, HagaZiekenhuis, The Hague, The Netherlands.

In severe cases of COVID-19, late complications such as coagulopathy and organ injury are increasingly described. In milder cases of the disease, the exact time frame and causal path of late-onset complications have not yet been determined. Although direct and indirect renal injury by SARS-CoV-2 has been confirmed, hemorrhagic renal infection or coagulative problems in the urinary tract have not yet been described. Read More

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