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The Difficult Path to Correct Diagnosis of Hepatolithiasis: A Case Report.

Acta Medica (Hradec Kralove) 2021 ;64(2):125-128

Department of Surgery and Transplant Unit, Comenius University in Bratislava, Jessenius Medical Faculty in Martin, University Hospital Martin, Slovak Republic.

Hepatolithiasis is a benign disease, where stones are localized proximal to the confluence of hepatic ducts. The clinical picture may differ depending on whether the stones cause complete, partial, or intermittent biliary obstruction. The course can vary from asymptomatic to fatal, thus, early diagnosis and treatment is critical for a good prognosis. Read More

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January 2021

Mfn2 localization in the ER is necessary for its bioenergetic function and neuritic development.

EMBO Rep 2021 Jul 23:e51954. Epub 2021 Jul 23.

Department of Cell Biology, Physiology and Immunology, Celltec-UB, University of Barcelona, Barcelona, Spain.

Mfn2 is a mitochondrial fusion protein with bioenergetic functions implicated in the pathophysiology of neuronal and metabolic disorders. Understanding the bioenergetic mechanism of Mfn2 may aid in designing therapeutic approaches for these disorders. Here we show using endoplasmic reticulum (ER) or mitochondria-targeted Mfn2 that Mfn2 stimulation of the mitochondrial metabolism requires its localization in the ER, which is independent of its fusion function. Read More

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Intravenous versus inhalational maintenance of anesthesia for quality of recovery in adult patients undergoing non-cardiac surgery: A systematic review with meta-analysis and trial sequential analysis.

PLoS One 2021 16;16(7):e0254271. Epub 2021 Jul 16.

Department of Anesthesiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.

Background: Intravenous and inhalational agents are commonly used in general anesthesia. However, it is still controversial which technique is superior for the quality of postoperative recovery. This meta-analysis aimed at comparing impact of total intravenous anesthesia (TIVA) versus inhalational maintenance of anesthesia on the quality of recovery in patients undergoing non-cardiac surgery. Read More

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Management of intrapulmonary hemorrhage in patients undergoing pulmonary thrombo-endarterectomy.

Ann Card Anaesth 2021 Jul-Sep;24(3):384-388

Department of Anaesthesiology, University of Minnesota, Minneapolis, MN, United States of America.

Massive pulmonary hemorrhage during pulmonary thromboendarterectomy (PTE) can be managed by a conservative approach with mechanical ventilatory support, positive end-expiratory pressure, lung isolation, reversal of heparin, and correct of coagulopathy. We present three challenging cases that developed intrapulmonary hemorrhage during/after PTE and managed successfully. The first patient had bleeding from the bronchial artery and right internal mammary collaterals, which was managed by coil-embolization. Read More

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Posterior wedge osteotomy assisted by O-arm navigation for treating ankylosing spondylitis with thoracolumbar fractures: an early clinical evaluation.

Ann Palliat Med 2021 Jun;10(6):6694-6705

Department of Orthopedics, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China.

Background: To explore the feasibility and efficiency of posterior wedge osteotomy assisted by O-arm navigation treatment of ankylosing spondylitis (AS) patients with thoracolumbar fracture.

Methods: This is a case series study. A total of 16 cases of AS accompanied by thoracolumbar fractures from January 2012 to July 2015 were retrospectively analyzed. Read More

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A study on the clinical application of greater omental pedicle flap transplantation to correct anterior resection syndrome in patients with low rectal cancer.

Regen Ther 2021 Dec 17;18:146-151. Epub 2021 Jun 17.

Guangxi Clinical Research Center for Colorectal Cancer, Guangxi Medical University Cancer Hospital, Nanning, 530021, Guangxi Autonomous Region, China.

Introduction: Low anterior resection syndrome (LARS) is the most common complication after total mesorectal excision (TME) in patients with low rectal cancer and has been a challenge in colorectal surgery that severely impacts the quality of life of patients. This study aimed to introduce a revised surgical procedure which could effectively maintain rectal compliance and significantly improve LARS after the operation.

Methods: We performed mesorectal reconstruction after routine Dixon TME using greater omental pedicle flap transplantation in 11 patients with low rectal cancer (5 cases of preoperative neoadjuvant chemoradiotherapy, 5 cases of preoperative neoadjuvant chemotherapy, and 1 case of postoperative adjuvant chemotherapy), thereby simulating the initial anatomical structure of the mesorectum and significantly reducing the postoperative anterior resection syndrome. Read More

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December 2021

Climate influence the human leptospirosis cases in Brazil, 2007-2019: a time series analysis.

Trans R Soc Trop Med Hyg 2021 Jun 30. Epub 2021 Jun 30.

Departamento de Medicina Veterinária, Universidade Federal de Lavras, Lavras, 37200-900, Minas Gerais, Brazil.

Background: Human leptospirosis is responsible for great losses and deaths, especially in developing countries, which can be mitigated by knowing the correct health indicators and climate influence on the disease.

Methods: Leptospirosis cases and deaths, population and precipitation were recovered from different databases (2007-2019). Annual incidence, mortality and case fatality rates (CFRs) of human leptospirosis and average precipitation were calculated for Brazil and its regions. Read More

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ResNet and CycleGAN for pulse shape discrimination of He-4 detector pulses: Recovering pulses conventional algorithms fail to label unanimously.

Appl Radiat Isot 2021 Jun 9;176:109819. Epub 2021 Jun 9.

Nuclear Engineering Program, University of Florida, Gainesville, FL, 32611, USA.

Pulse shape discrimination (PSD) capable detectors, such as He-4, that respond to neutron and gamma-ray interactions have a threshold deposited energy value below which n/γ discrimination vanishes when using conventional PSD algorithms. Recent attempts in applying supervised learning based artificial neural networks for PSD use the pulses in the separated regions to train the networks so they can be used to classify another set of separated pulses. In doing so, pulses previously indistinguishable are not recovered for classification, which would have increased the number of neutron and gamma-ray pulses that could be used for further analysis. Read More

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The Case of Insertional Adductor Tendinopathy of an International-Level 3,000-m Steeplechase Runner.

Front Sports Act Living 2021 8;3:688280. Epub 2021 Jun 8.

Sport and Exercise Research Unit, Department of Psychology, Educational Science and Human Movement, University of Palermo, Palermo, Italy.

Groin pain is a frequent condition among athletes. One of the causes of groin pain is tendinopathy, a frequently diagnosed medical condition, which can also occur in the adductor muscles. Despite the high prevalence of this medical condition among athletes, it is infrequent to observe tendinopathic groin pain in steeplechase runners. Read More

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Epidemic spread simulation in an area with a high-density crowd using a SEIR-based model.

PLoS One 2021 17;16(6):e0253220. Epub 2021 Jun 17.

School of Civil Engineering and Transportation, Hohai University, Nanjing, China.

Understanding the spread of infectious diseases is an extremely essential step to preventing them. Thus, correct modeling and simulation approaches are critical for elucidating the transmission of infectious diseases and improving the control of epidemics. The primary objective of this study is to simulate the spread of communicable diseases in an urban rail transit station. Read More

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Rhabdomyolysis-induced acute kidney injury in a patient with non-compliance to levothyroxine therapy.

Endocrinol Diabetes Metab Case Rep 2021 Jun 1;2021. Epub 2021 Jun 1.

Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Pikeville Medical Center, Pikeville, Kentucky, USA.

Summary: Hypothyroidism is a common medical condition and is often easily managed with excellent outcomes, when treated adequately. Compliance with levothyroxine (LT4) therapy is often compromised because of the need for a daily and lasting schedule. Overt rhabdomyolysis due to under-treatment or non-compliance is a rare occurrence. Read More

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Clinical efficacy and therapeutic value of delayed surgery in patients with symptomatic old thoracolumbar fractures.

BMC Surg 2021 Jun 11;21(1):290. Epub 2021 Jun 11.

Department of Orthopaedics, Xijing Hospital, Air Force Medical University, 127 West Changle Road, Xi'an, 710032, China.

Background: To investigate the clinical efficacy and therapeutic value of posterior decompression reduction, bone grafting fusion, and internal fixation for treatment of symptomatic old thoracolumbar fractures.

Method: Retrospective analysis was conducted for 14 patients (9 men, 5 women; average age 40.1 years) with old thoracolumbar fractures who underwent posterior operation. Read More

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Early assessment of lung function in coronavirus patients using invariant markers from chest X-rays images.

Sci Rep 2021 06 8;11(1):12095. Epub 2021 Jun 8.

BioImaging Laboratory, Department of Bioengineering, University of Louisville, Louisville, KY, USA.

The primary goal of this manuscript is to develop a computer assisted diagnostic (CAD) system to assess pulmonary function and risk of mortality in patients with coronavirus disease 2019 (COVID-19). The CAD system processes chest X-ray data and provides accurate, objective imaging markers to assist in the determination of patients with a higher risk of death and thus are more likely to require mechanical ventilation and/or more intensive clinical care.To obtain an accurate stochastic model that has the ability to detect the severity of lung infection, we develop a second-order Markov-Gibbs random field (MGRF) invariant under rigid transformation (translation or rotation of the image) as well as scale (i. Read More

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Georgian Med News 2021 Apr(313):72-79

First Moscow State Medical University I.M. Sechenov (Sechenov University), Russian Federation.

The aim of the study was to evaluate the effectiveness of the global coagulation test of thrombodynamics for monitoring and correcting the hemostatic system and improving the results of complex treatment in patients with SARS-CoV-2 in the COVID hospital. From April 2020 to December 2020 on the basis of the University Clinical Hospital No. 4 of the First Moscow State Medical University named I. Read More

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Transient oculomotor paralysis after cerebral angiography: A case report.

Medicine (Baltimore) 2021 Jun;100(22):e26242

Department of Neurology.

Rationale: A special case of transient oculomotor nerve palsy after cerebral angiography.

Patient Concerns: A 55-year-old man developed oculomotor nerve dysfunction after right radial artery puncture angiography.

Diagnoses: Cerebral angiography-induced oculomotor nerve palsy. Read More

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Role of Huntington procedure as a limb salvage surgery for complex gap nonunion of tibia in children.

J Clin Orthop Trauma 2021 Jul 19;18:20-24. Epub 2021 Apr 19.

Department of Orthopaedic Surgery, J. N. Medical College, Faculty of Medicine, AMU, Aligarh, UP, India.

Back Ground: Complex gap nonunion of tibia following open fractures and osteomyelitis with pathological fractures in children is a treatment challenge with unpredictable outcome. Treatment options available are bone transport bone grafting, induced membrane technique, allograft reconstruction and Huntington procedure (ipsilateral transposition of vascularized fibula). There is no consensus in the literature about which technique is optimal in the given situation. Read More

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Artificial stone-associated silicosis with concurrent Cryptococcus infection.

Respirol Case Rep 2021 Jun 6;9(6):e00765. Epub 2021 May 6.

Institute of Emergency and Critical Care Medicine National Yang Ming Chiao Tung University Taipei Taiwan.

Acute silicoproteinosis is a disease that develops in weeks, and lasting for years, after massive exposure to silica dust in relatively closed spaces. It was rare, but the cases have recently increased worldwide due to the development of artificial stone industry. Compared with traditional silicosis, artificial stone-associated silicosis is more rapidly progressive and lethal. Read More

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Variable selection methods for identifying predictor interactions in data with repeatedly measured binary outcomes.

J Clin Transl Sci 2020 Nov 16;5(1):e59. Epub 2020 Nov 16.

Department of Medicine, Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, USA.

Introduction: Identifying predictors of patient outcomes evaluated over time may require modeling interactions among variables while addressing within-subject correlation. Generalized linear mixed models (GLMMs) and generalized estimating equations (GEEs) address within-subject correlation, but identifying interactions can be difficult if not hypothesized . We evaluate the performance of several variable selection approaches for clustered binary outcomes to provide guidance for choosing between the methods. Read More

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November 2020

Primary Epiploic Appendagitis: A Case Report.

Cureus 2021 Mar 23;13(3):e14060. Epub 2021 Mar 23.

Health Management, Private Hurrem Sultan Hospital, Istanbul, TUR.

Primary epiploic appendagitis (PEA) is a rather uncommon and self-limiting cause of acute abdomen managed conservatively. Overlapping clinical features with other common causes of acute abdomen usually requiring surgical intervention, and rare occurrences have led to misdiagnosis of the condition and unnecessary surgical intervention. However, with identification of definite characteristic features on imaging (computed tomography [CT] scan) has led to easier diagnosis and avoidance of exploratory laparotomy. Read More

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Comments on the ochratoxin A degradation mechanism by Lysobacter sp. CW239 - Wei Wei et al. (2020).

Environ Pollut 2021 Jul 7;281:117063. Epub 2021 Apr 7.

State Key Laboratory of Tea Plant Biology and Utilization, School of Tea and Food Science Technology, Anhui Agricultural University, Heifei, 230036, China. Electronic address:

This is a research comment on the ochratoxin A (OTA) degradation mechanism by Lysobacter sp. CW239 regarding the previous publication in Environmental Pollution (Wei et al., 2020). Read More

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Using near-infrared spectroscopy to discriminate closely related species: a case study of neotropical ferns.

J Plant Res 2021 May 7;134(3):509-520. Epub 2021 Apr 7.

Universidade Federal do Oeste do Pará, Programa de Pós-graduação em Biodiversidade, Rua Vera Paz, s/n (Unidade Tapajós) Bairro Salé, Santarém, PA, 68040-255, Brazil.

Identifying plant species requires considerable knowledge and can be difficult without complete specimens. Fourier-transform near-infrared spectroscopy (FT-NIR) is an effective technique for discriminating plant species, especially angiosperms. However, its efficacy has never been tested on ferns. Read More

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A large retroperitoneal lipoblastoma as an incidental finding: a case report.

BMC Pediatr 2021 04 4;21(1):159. Epub 2021 Apr 4.

Department of Pathology, University of Würzburg, Josef-Schneider-Str. 2, 97080, Würzburg, Germany.

Background: Lipoblastoma is a rare benign mesenchymal neoplasm of infancy that most commonly occurs on the extremities and trunk but can arise at variable sites of the body. Retroperitoneal lipoblastomas are particularly rare but can grow to enormous size, and preoperative diagnosis is difficult with diverse, mostly malignant differential diagnoses that would lead to aggressive therapy. Since lipoblastoma is a benign tumor that has an excellent prognosis after resection, correct diagnosis is crucial. Read More

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Evaluation of ceftazidime as an antibiotic supplement of mannitol-yolk-polymyxin B agar used for the enumeration of Bacillus cereus in ready-to-eat vegetables.

J Food Prot 2021 Apr 1. Epub 2021 Apr 1.

Konkuk University Professor 1 Hwayang-dong, Gwangjin-gu KOREA, REPUBLIC OF Seoul 143-701.

Bacillus cereus, which causes foodborne disease, is detected using selective media. However, competing flora is the most common factor preventing the correct enumeration of B. cereus on selective agars. Read More

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Expression of tricellular tight junction proteins and the paracellular macromolecule barrier are recovered in remission of ulcerative colitis.

BMC Gastroenterol 2021 Mar 31;21(1):141. Epub 2021 Mar 31.

Clinical Physiology / Nutritional Medicine, Charité - Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany.

Background: Ulcerative colitis (UC) has a relapsing and remitting pattern, wherein the underlying mechanisms of the relapse might involve an enhanced uptake of luminal antigens which stimulate the immune response. The tricellular tight junction protein, tricellulin, takes charge of preventing paracellular passage of macromolecules. It is characterized by downregulated expression in active UC and its correct localization is regulated by angulins. Read More

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Passive Sampling and Dosing of Aquatic Organic Contaminant Mixtures for Ecotoxicological Analyses.

Environ Sci Technol 2021 Jul 22;55(14):9538-9547. Epub 2021 Mar 22.

Environmental Safety Group, KIST Europe, Korea Institute of Science and Technology, Campus E 7.1, Saarbrücken, Germany.

Toxicity results from exposure to mixtures of organic contaminants. Assessing this using ecotoxicity bioassays involves sampling of the environmental mixture and then introducing this into the test. The first step is accounting for the bioavailable levels of all mixture constituents. Read More

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Polishing the Oxford Nanopore long-read assemblies of bacterial pathogens with Illumina short reads to improve genomic analyses.

Genomics 2021 May 11;113(3):1366-1377. Epub 2021 Mar 11.

Joint Institute for Food Safety and Applied Nutrition, Center for Food Safety and Security Systems, University of Maryland, College Park, MD 20742, USA; Department of Nutrition and Food Science, University of Maryland, College Park, MD 20742, USA. Electronic address:

Oxford Nanopore sequencing has been widely used to achieve complete genomes of bacterial pathogens. However, the error rates of Oxford Nanopore long reads are high. Various polishing algorithms using Illumina short reads to correct the errors in Oxford Nanopore long-read assemblies have been developed. Read More

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Three-dimensional volumetric deconvolution in coherent optics and holography.

Appl Opt 2021 Feb;60(5):1304-1314

Methods of three-dimensional deconvolution (3DD) or volumetric deconvolution of optical complex-valued wavefronts diffracted by 3D samples with the 3D point spread function are presented. Particularly, the quantitative correctness of the recovered 3D sample distributions is addressed. Samples consisting of point-like objects can be retrieved from their 3D diffracted wavefronts with non-iterative (Wiener filter) 3DD. Read More

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February 2021

Nonoperative Management of Perforated Diverticulitis of the Duodenum: Report of Three Cases and Review of Literature.

Case Rep Surg 2021 20;2021:6647470. Epub 2021 Feb 20.

Department of Radiology, Haaglanden Medical Centre Westeinde, Lijnbaan 32 2512 VA The Hague, Netherlands.

Duodenal diverticula are relatively frequent but complications are uncommon. The mortality rate of perforated duodenal diverticulitis is high, and its management is controversial. We report three patients with a perforated duodenal diverticulitis who were successfully treated with conservative antibiotic therapy. Read More

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February 2021

Surgical treatment of a 72-year-old patient with headache, hyponatremia and oculomotor nerve palsy: a case report and literature review.

Gland Surg 2021 Jan;10(1):364-370

Department of Neurosurgery, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.

Pituitary apoplexy is a life-threatening syndrome caused by acute infarction of the pituitary gland. The most common symptoms associated with pituitary apoplexy are headache, nausea, vomiting, visual symptoms, hypopituitarism, and altered mental status. Both oculomotor nerve palsy and hyponatremia are relatively rare complications of pituitary apoplexy. Read More

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January 2021

[Follow-up of patients after COVID-19 pneumonia. Pulmonary sequelae].

Rev Alerg Mex 2020 Oct-Dec;67(4):350-369

Universidad de Especialidades Espíritu Santo, Samborondón, Ecuador.

Coronavirus disease 2019 (COVID-19) is an infection caused by SARS-CoV-2 that has caused an unprecedented pandemic with a high rate of morbidity and mortality worldwide. Although most cases are mild, there are a considerable number of patients who develop pneumonia or even acute respiratory distress syndrome (ARDS). After having recovered from the initial disease, many patients continue with various symptoms (fatigue, dry cough, fever, dyspnea, anosmia, and chest pain, among others. Read More

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