Microcirculation 2021 Apr 4:e12698. Epub 2021 Apr 4.
Division of BioMedical Sciences, Memorial University of Newfoundland, 300 Prince Philip Drive HSC 4311, St. John's, NL, A1B 3V6, Canada.
Objective: To develop and validate a novel liquid microfluidic approach to deliver drugs to microscale regions of tissue while simultaneously allowing for visualization and quantification of microvascular blood flow.
Methods: Microfluidic devices were fabricated using soft lithographic techniques, molded in polydimethylsiloxane, and bound to a coverslip with a 600x300μm micro-outlet. Sprague-Dawley rats, anaesthetized with pentobarbital, were instrumented to monitor systemic parameters. Read More