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Geographical variation in surgical care and mortality following hip fracture in England: a cohort study using the National Hip Fracture Database (NHFD).

Osteoporos Int 2021 Mar 25. Epub 2021 Mar 25.

Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Windmill Road, Oxford, OX3 7LD, UK.

We describe variation across geographical regions of England in operations undertaken following presentation of hip fracture and in 30-day mortality. Some significant geographic variation in 30-day mortality was observed particularly for patients with trochanteric hip fractures and warrants further investigation of other aspects of post-hip fracture care INTRODUCTION: Mortality after hip fracture has improved considerably in the UK over recent decades. Our aim here was to describe geographical variation in type of operation performed and 30-day mortality amongst patients in England with hip fracture. Read More

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Incidence and risk factors associated with venous thromboembolism following primary total hip arthroplasty in low-risk patients when using aspirin for prophylaxis.

Hip Int 2021 Feb 17:1120700021994530. Epub 2021 Feb 17.

Department of Trauma and Orthopaedics, The Royal Infirmary of Edinburgh, Edinburgh, UK.

Aims: The primary aim was to assess the incidence of venous thromboembolism (VTE) following total hip replacements (THR) in a low-risk patient group when using 150 mg aspirin as the pharmacological component of VTE prophylaxis on discharge. The secondary aim was to identify factors associated with an increased risk of a VTE event in this low-risk group.

Patients And Methods: Retrospective review of a consecutive cohort of patients undergoing THR during a 63-month period. Read More

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February 2021

Prospective Study Showing Results of Large-Diameter Femoral Heads After Cementless Total Hip Replacement.

Cureus 2021 Jan 10;13(1):e12610. Epub 2021 Jan 10.

Trauma and Orthopaedics, University Hospitals of Derby and Burton, Burton, GBR.

Introduction Large-diameter femoral heads (≥36 mm) were introduced to decrease instability and improve the range of motion of the hip. We hypothesized regarding the clinical outcome and complications (dislocation, implant survivorship, and functional scores) following total hip replacement (THR) surgery in an Indian population who have smaller acetabulum compared to the western population. Methodology A prospective study was conducted at a tertiary hospital from November 2011 to July 2013. Read More

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January 2021

Endogenous Opioid Signaling in the Mouse Retina Modulates Pupillary Light Reflex.

Int J Mol Sci 2021 Jan 8;22(2). Epub 2021 Jan 8.

Department of Biomedical Sciences, Colorado State University, Ft. Collins, CO 80523, USA.

Opioid peptides and their receptors are expressed in the mammalian retina; however, little is known about how they might affect visual processing. The melanopsin-expressing intrinsically photosensitive retinal ganglion cells (ipRGCs), which mediate important non-image-forming visual processes such as the pupillary light reflex (PLR), express β-endorphin-preferring, µ-opioid receptors (MORs). The objective of the present study was to elucidate if opioids, endogenous or exogenous, modulate pupillary light reflex (PLR) via MORs expressed by ipRGCs. Read More

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January 2021

Expandable Proximal Femoral Nail versus Gamma Proximal Femoral Nail for the treatment of hip reverse oblique fractures.

Arch Orthop Trauma Surg 2021 Jan 8. Epub 2021 Jan 8.

Department of Orthopaedic Surgery, Medical Center, Affiliated with the Faculty of Health and Science and Ben Gurion University, Ha-Refu'a St 7, 7747629, Ashdod, Israel.

Background: Reverse oblique intertrochanteric fractures are classified by the AO/OTA as 31A3 and account for 2-23% of all trochanteric fractures. The Gamma 3-Proximal Femoral Nail (GPFN) and the Expendable Proximal Femoral Nail (EPFN) are among the various devises used to treat this fracture. The aim of this study was to compare outcomes and complication rates in patients with AO/OTA 31A1-3 fractures, treated by either a GPFN or an EPFN. Read More

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January 2021

[Mu-opioid receptors in the paraventricular nucleus regulate ejaculatory behaviors via the sympathetic nerve system in male rats].

Zhonghua Nan Ke Xue 2020 Nov;26(10):867-874

Department of Urology, Jiangsu Provincial Hospital / The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China.

Objective: To explore the effects of the mu-opioid receptor (MOR) in the paraventricular nucleus (PVN) on the ejaculatory behaviors of male rats and its potential mechanisms.

Methods: Male SD rats with normal ejaculation ability were mated with female ones in hormone-induced estrus. After bilateral PVN microinjection of D-Ala-2-Me-Phe-4-Gly-ol enkephalin (DAGO) or D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 (CTAP) with an inserted catheter, the male animals were observed for mount latency (ML), mount frequency (MF), intromission latency (IL), intromission frequency (IF), ejaculation latency (EL), ejaculation frequency (EF), post-ejaculation interval (PEI), and intromission ratio (IR). Read More

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November 2020

Robotic-Arm Assisted Direct Anterior Total Hip Arthroplasty; Improving Implant Accuracy.

Surg Technol Int 2020 12 23;38. Epub 2020 Dec 23.

Department of Orthopaedic Surgery, Singapore General Hospital, Outram, Singapore.

Introduction: The aim of this study was to investigate the accuracy of implant position of robotic-arm assisted total hip arthroplasty (THA) via the direct anterior approach (DAA).

Materials And Methods: All patients who underwent robotic-arm assisted DAA THA (MAKO Surgical Corp., Ft. Read More

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December 2020

Micro- and Nanoscale Spectroscopic Investigations of Threonine Influence on the Corrosion Process of the Modified Fe Surface by Cu Nanoparticles.

Materials (Basel) 2020 Oct 10;13(20). Epub 2020 Oct 10.

Institute of Nuclear Physics Polish Academy of Sciences, PL-31342 Krakow, Poland.

The work presents a comprehensive vibrational analysis of the process of adsorption of threonine (Thr) onto an Fe surface with deposited Cu nanoparticles (NPs) (of about 4-5 nm in size) in a corrosive environment. The application of surface-enhanced Raman spectroscopy (SERS) and surface-enhanced infrared absorption spectroscopy (SEIRA) provides the opportunity for detailed description of adsorption geometry of amino acid onto a metal surface. The combination of conventional infrared spectroscopy (IR) with atomic force microscopy (AFM) resulted in a nano-SEIRA technique which made it possible to provide a precise description of adsorbate binding to the metal surface. Read More

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October 2020

Mandibular advancement devices shorten desaturation duration in patients at high risk for obstructive sleep apnea syndrome during intravenous propofol sedation in the decubitus position.

J Chin Med Assoc 2021 Feb;84(2):221-226

Department of Anesthesiology, Taipei Veterans General Hospital, and National Yang-Ming University School of Medicine, Taipei, Taiwan, ROC.

Background: The purpose of this study was to determine the efficacy of a mandibular advancement device (MAD) for increasing patient safety during sedated total knee arthroplasty (TKA) and total hip replacement (THR).

Methods: Forty patients undergoing TKA or THR surgery in the supine or lateral recumbent positions under spinal anesthesia were enrolled. Sedation and oxygenation were administered. Read More

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February 2021

Structure-activity relationship study on new hemorphin-4 analogues containing steric restricted amino acids moiety for evaluation of their anticonvulsant activity.

Amino Acids 2020 Oct 3;52(10):1375-1390. Epub 2020 Oct 3.

Institute of Biodiversity and Ecosystem Research, Bulgarian Academy of Sciences, 1113, Sofia, Bulgaria.

In the present study, several new analogues of hemorphin-4, modified with unnatural conformationally restricted amino acids followed the structure Aaa-Tyr-Xxx-Trp-Thr-NH, where Aaa is the low-molecular-weight lipophilic adamantyl building block, and Xxx is Ac5c (1-aminocyclopentanecarboxylic acid) or Ac6c (1-aminocyclohexane carboxylic acid) was synthesized, characterized and investigated for anticonvulsant activity in three seizure tests, the maximal electroshock test (MES), 6-Hz psychomotor seizure test and timed intravenous pentylenetetrazole infusion (ivPTZ) test. The acute neurological toxicity was determined using the rota-rod test. The new synthetic neuropeptide analogues were prepared by solid-phase peptide synthesis-Fmoc chemistry and were evaluated in three doses of 1, 3 and 5 µg, respectively, administered intracerebroventricularly in male ICR mice. Read More

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October 2020

Postablative 131I SPECT/CT Is Much More Sensitive Than Cervical Ultrasonography for the Detection of Thyroid Remnants in Patients After Total Thyroidectomy for Differentiated Thyroid Cancer.

Clin Nucl Med 2020 Dec;45(12):948-953

From the Department of Nuclear Medicine and Oncological Endocrinology, Maria Skłodowska-Curie Memorial District Hospital, Zgierz.

Purpose: Evaluation of utility of cervical ultrasound (US) for detection of thyroid remnants (ThR) in patients after thyroidectomy for differentiated thyroid cancer.

Methods: Included were 154 consecutive patients (17-89 years, 123 female and 31 male patients), without known cancer residues or cervical lymph nodes metastases, admitted for ThR ablation with I, 14 to 20 weeks after surgery. Neck uptake of I (Tup) and thyroglobulin were determined, and location and volume of ThR detected by cervical US were recorded. Read More

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December 2020

Total hip replacement in dogs with contralateral pelvic limb amputation: A retrospective evaluation of 13 cases.

Vet Surg 2020 Dec 11;49(8):1487-1496. Epub 2020 Sep 11.

Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio.

Objective: To report the clinical characteristics, surgical management, and medium-term outcomes of total hip replacement (THR) performed in dogs with previous contralateral pelvic limb amputation.

Animals: Thirteen client-owned dogs.

Study Design: Multi-institutional retrospective clinical study. Read More

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December 2020

3D kinematic analysis of patients' gait before and after unilateral total hip replacement.

Acta Bioeng Biomech 2020 ;22(2):165-171

Department of Orthopedic Surgery, Faculty Hospital Brno - Adult Age Medicine, Brno, Czech Republic.

Purpose: The purpose of the study was to describe changes in the kinematic parameters in the patients' gait after total hip replacement.

Methods: Research group of men in the end stage of osteoarthritis indicated to the THR (n = 10; age 54.1 ± 7. Read More

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January 2020

Prevalence of a postoperative troponin leak in patients with cardiac risk factors undergoing knee and hip arthroplasty in a South African population.

S Afr Med J 2020 Mar 30;110(4):320-326. Epub 2020 Mar 30.

Division of Orthopaedic Surgery, Department of Surgical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University and Tygerberg Hospital, Cape Town, South Africa.

Background: Patients undergoing arthroplasty may have comorbidities that put them at risk of myocardial injury after non-cardiac surgery (MINS). MINS, a new clinical concept that has a different pathophysiology from conventional myocardial infarction, is related to a supply-demand mismatch ischaemia in the perioperative setting. MINS is often a silent event, and the diagnosis relies on cardiac biomarker testing such as troponin T. Read More

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Salinization and wastewater effects on the growth and some cell contents of .

Saudi J Biol Sci 2020 Jul 20;27(7):1773-1780. Epub 2020 May 20.

Department of Biology, College of Science and Humanities in Al-Kharj, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia.

The aim of this study is to determine the effect of salinization and wastewater stresses on the growth, some cellular contents (total soluble proteins, total soluble carbohydrates, nucleic acids, and amino acids composition) and ultrastructure using TEM of unicellular green alga . Treatment of by NaCl at 10 and 50 mg L significantly increased the growth of this alga and its cellular macro-molecules. While, treatment above this concentration with NaCl significantly inhibited the growth and cellular macro-molecules. Read More

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Targeted disruption of TORC1 retards young squab growth by inhibiting the synthesis of crop milk protein in breeding pigeon (Columba livia).

Poult Sci 2020 Jan 30;99(1):416-422. Epub 2019 Dec 30.

College of Animal Science, South China Agricultural University/Guangdong Provincial Key Laboratory of Animal Nutrition Control/National Engineering Research Center for Breeding Swine Industry, Guangzhou, Guangdong 510642, China. Electronic address:

This study was conducted to explore the regulatory role of the target of rapamycin complex 1 (TORC1) signaling pathway in crop milk synthesis in breeding pigeons (Columba livia). Three groups of breeding pigeons in the lactation period (n = 30 pairs/group) were respectively injected with rapamycin (RAPA, a specific inhibitor of the target of rapamycin complex) at doses of 0 (vehicle, control), 0.6, or 1. Read More

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January 2020

Solid-state vibrational circular dichroism studies on the conformation of an amino acid molecule in crystalline state.

Biochim Biophys Acta Proteins Proteom 2020 08 1;1868(8):140439. Epub 2020 May 1.

Graduate School of Engineering Science, Yokohama National University, 240-8501 Yokohama, Japan. Electronic address:

The present article reviews the results of solid-state vibrational circular dichroism (SD-VCD) measurements on the crystals of amino acids. The investigated series were Ala, Ile, Leu, Phe, Ser, Val, and Thr. Spectra were recorded for the samples containing both D- and L-enantiomers. Read More

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Does surgical approach influence mid- to long-term patient-reported outcomes after primary total hip replacement? A comparison of the 3 main surgical approaches.

Can J Surg 2020 Apr 17;63(22):E181-E189. Epub 2020 Apr 17.

From the Ottawa, Hospital, Ottawa, Ont. (Galmiche, Dobransky, Kim, Feibel, Gofton, Abdelbary, Beaulé); and the School of Rehabilitation, University of Ottawa, Ottawa, Ont. (Poitras).

Background: The most effective surgical approach to total hip replacement (THR) remains controversial. Most studies that have compared approaches have reported only short-term outcome data. It is therefore unclear in the literature if a particular surgical approach offers long-term advantages. Read More

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Mechanisms of Lolium rigidum multiple resistance to ALS- and ACCase-inhibiting herbicides and their impact on plant fitness.

Pestic Biochem Physiol 2020 Mar 28;164:65-72. Epub 2019 Dec 28.

Aristotle University of Thessaloniki, School of Agriculture, Thessaloniki, Greece. Electronic address:

Three putative resistant (R1, R2, R3) and one susceptible (S) Lolium rigidum populations originating from Greece were studied for resistance to ALS and ACCase inhibiting herbicides, using whole plant, sequencing of als and accase gene, and in vitro ALS activity assays. The S and two R (R1, R2) populations were also evaluated for fitness in competition with wheat. The whole plant assay indicated unsatisfactory control of the R populations with mesosulfuron-methyl + iodosulfuron-methyl or pinoxaden application, whereas sequencing of the als gene revealed that all ALS-resistant individuals had a Pro-197 substitution by Leu, Glu, Ser, Ala, Thr, or Gln. Read More

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The results of a stepwise implementation of a fast-track program in total hip and knee replacement patients.

J Orthop 2020 Sep-Oct;21:100-108. Epub 2020 Mar 25.

Faculty of Medicine, Democritus University of Thrace, University General Hospital of Alexandroupolis, Alexandroupolis, PO Box 68100, Greece.

Background: Several reports have shown that enhanced recovery or fast-track (FT) regime introduction in patients undergoing total knee replacement (TKR) and total hip replacement (THR) results in significant reduction in length of stay (LOS) with no associated increase of complications or readmission rate. Despite that, FT programs for arthroplasty have has not been uniformly recognized or accepted by many orthopaedic surgeons and there is still no consensus on the best implementation process. The aim of this study was to report the results of a stepwise implementation of a FT regime in TKR and THR patients in a general orthopaedic department. Read More

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Effect of dexmedetomidine on dynamic cerebral autoregulation and carbon dioxide reactivity during sevoflurane anesthesia in healthy patients.

Korean J Anesthesiol 2020 08 25;73(4):311-318. Epub 2020 Mar 25.

Department of Anesthesia and OR Administration, King Fahd Medical City, Riyadh, Saudi Arabia.

Background: There are conflicting opinions on the effect of dexmedetomidine on cerebral autoregulation. This study assessed its effect on dynamic cerebral autoregulation (dCA) using a transcranial Doppler (TCD).

Methods: Thirty American Society of Anesthesiologists physical status I and II patients between 18 and 60 years, who underwent lumbar spine surgery, received infusions of dexmedetomidine (Group D) or normal saline (Group C), followed by anesthesia with propofol and fentanyl, and maintenance with oxygen, nitrous oxide and sevoflurane. Read More

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An in vivo and in silico analysis of novel variation in TMBIM6 gene affecting cardiopulmonary traits of Indian goats.

J Therm Biol 2020 Feb 28;88:102491. Epub 2019 Dec 28.

Department of Animal Genetics, Central Institute for Research on Goats, Makhdoom, Mathura, India. Electronic address:

Transmembrane Bax Inhibitor Motif-containing 6 (TMBIM6) gene acts as calcium leak channel and negatively regulates autophagy and autophagosome formation. The TMBIM6 gene was amplified and searched for variation in three different goat populations (i.e. Read More

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February 2020

Comparison of femoral stem subsidence between three types of press-fit cementless total hip replacement in dogs.

Vet Surg 2020 May 21;49(4):787-793. Epub 2020 Feb 21.

Gulf Coast Veterinary Specialists, Houston, Texas.

Objective: To compare femoral stem subsidence and determine contributing factors in dogs undergoing total hip replacement (THR) with the traditional BFX, collared BFX, and BFX lateral bolt stems.

Study Design: Retrospective radiographic study.

Sample Population: Ninety-three dogs with 101 THR including dogs undergoing THR with a BFX lateral bolt femoral stem (n = 40), BFX collared stem (n = 21), and traditional BFX stem (n = 40). Read More

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Demographic and geographical variability in physiotherapy provision following hip and knee replacement. An analysis from the National Joint Registry for England, Wales, Northern Ireland and the Isle of Man.

Physiotherapy 2020 03 20;106:1-11. Epub 2019 Nov 20.

Norwich Medical School, University of East Anglia, Norwich, UK. Electronic address:

Background: Total hip (THR) and knee replacement (TKR) are two of the most common elective orthopaedic procedures worldwide. Physiotherapy is core to the recovery of people following joint replacement. However, there remains uncertainty as to physiotherapy provision at a national level. Read More

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A Cross-Subject SSVEP-BCI Based on Task Related Component Analysis.

Annu Int Conf IEEE Eng Med Biol Soc 2019 Jul;2019:3022-3025

SSVEP-BCIs have attracted extensive attention because of high information transfer rate. High-speed BCIs need to collect sufficient user's own data to train optimal subject-specific parameters. However, one of the challenges which limits the real-life application of BCIs is the time-consuming and tiring calibration process. Read More

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Medium Term Outcome For A Constrained Acetabular Component At A Single Institution: What Is Important For Success?

J Ayub Med Coll Abbottabad 2019 Oct-Dec;31(4):602-607

North Shore Hospital Auckland, New Zealand.

Background: The use of constrained Total Hip Replacements (THR) is controversial due to lack of definite indications and potentially high failure rates because of mechanical loosening or component failure. A review was performed to assess a departmental use of a single constrained acetabular component over a ten years period.

Methods: Patient demographics, operative indications, complications and patient follow-up were recorded. Read More

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Anatomic dual mobility compared to modular dual mobility in primary total hip arthroplasty: a matched cohort study.

Arthroplast Today 2019 Dec 6;5(4):509-514. Epub 2019 Dec 6.

Department of Orthopedic Surgery, Adult Reconstruction and Joint Replacement Service, Hospital for Special Surgery, New York, NY, USA.

Background: Dual mobility (DM) has been used in primary total hip arthroplasty recently for their low dislocation rates, low revision rates, and improved patient functional outcomes. We compared 2 DM systems, anatomic dual mobility (ADM; Stryker, Mahwah, NJ) and modular dual mobility (MDM; Stryker, Mahwah, NJ), to determine differences in dislocation rates, revision rates, and patient outcome scores.

Methods: The study was a single-center matched retrospective review of prospectively collected data of patients who underwent primary total hip arthroplasty surgery with an ADM or MDM system by a single surgeon from 2012 to 2017. Read More

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December 2019

Understanding the uptake of new hip replacement implants in the UK: a cohort study using data from the National Joint Registry for England and Wales.

BMJ Open 2019 11 25;9(11):e029572. Epub 2019 Nov 25.

Musculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.

Objectives: Primary: describe uptake of new implant components (femoral stem or acetabular cup/shell) for total hip replacements (THRs) in the National Joint Registry for England and Wales (NJR). Secondary: compare the characteristics of: (a) surgeons and (b) patients who used/received new rather than established components.

Design: Cohort of 618 393 primary THRs performed for osteoarthritis (±other indications) by 4979 surgeons between 2008 and 2017 in England and Wales from the NJR. Read More

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November 2019

Validation of revision data for total hip and knee replacements undertaken at a high volume orthopaedic centre against data held on the National Joint Registry.

J Orthop Surg Res 2019 Oct 10;14(1):318. Epub 2019 Oct 10.

South West London Elective Orthopaedic Centre, London, KT18 7EG, UK.

Background: With over 2.35 million records, the National Joint Registry (NJR) is the largest arthroplasty registry in the world. It provides a powerful tool to monitor implant survivorship and influence different surgical strategies. Read More

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October 2019

Targeted disruption of TORC1 retards young squab growth by inhibiting the synthesis of crop milk protein in breeding pigeon (Columba livia).

Poult Sci 2019 Sep 3. Epub 2019 Sep 3.

College of Animal Science, South China Agricultural University/Guangdong Provincial Key Laboratory of Animal Nutrition Control/National Engineering Research Center for Breeding Swine Industry, Guangzhou, Guangdong 510642, China.

This study was conducted to explore the regulatory role of the target of rapamycin complex 1 (TORC1) signaling pathway in crop milk synthesis in breeding pigeons (Columba livia). Three groups of breeding pigeons in the lactation period (n = 30 pairs/group) were respectively injected with rapamycin (RAPA, a specific inhibitor of the target of rapamycin complex) at doses of 0 (vehicle, control), 0.6, or 1. Read More

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September 2019