26 results match your criteria reconstruction vpd

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Performance of unanchored matching-adjusted indirect comparison (MAIC) for the evidence synthesis of single-arm trials with time-to-event outcomes.

BMC Med Res Methodol 2020 09 29;20(1):241. Epub 2020 Sep 29.

Department of Pharmaceutical and Health Economics, University of Southern California, 635 Downey Way, Verna & Peter Dauterive Hall (VPD) Suite 210, Los Angeles, CA, 90089-3333, USA.

Background: The objectives of the present study were to evaluate the performance of a time-to-event data reconstruction method, to assess the bias and efficiency of unanchored matching-adjusted indirect comparison (MAIC) methods for the analysis of time-to-event outcomes, and to propose an approach to adjust the bias of unanchored MAIC when omitted confounders across trials may exist.

Methods: To evaluate the methods using a Monte Carlo approach, a thousand repetitions of simulated data sets were generated for two single-arm trials. In each repetition, researchers were assumed to have access to individual-level patient data (IPD) for one of the trials and the published Kaplan-Meier curve of another. Read More

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September 2020

Palatal lengthening by double opposing buccal flaps for surgical correction of velopharyngeal insufficiency in cleft patients.

J Craniomaxillofac Surg 2020 Oct 3;48(10):977-984. Epub 2020 Sep 3.

Department of Audiology and Speech-Language Pathology, CHL Hospitals, AB Road, LIG Square, Indore, Madhya Pradesh, India. Electronic address:

Aim: To assess the efficacy of double opposing buccal flap in lengthening the soft palate for velopharyngeal insufficiency correction, and its potential complications in different age groups.

Case Series: From March 2016 to June 2019, 50 patients (24 children, 12 adolescents and 14 adults) underwent palatal lengthening using double opposing buccinator myomucosal flaps. Postoperative complications were assessed by two surgeons and the speech outcomes were evaluated by two speech-language pathologists after assessing changes in the hypernasality and intelligibility using a scoring approach. Read More

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October 2020

Recent atmospheric drying in Siberia is not unprecedented over the last 1,500 years.

Sci Rep 2020 09 14;10(1):15024. Epub 2020 Sep 14.

Siberian Federal University, Svobodny pr. 79, Krasnoyarsk, Russian Federation, 660041.

Newly developed millennial δC larch tree-ring chronology from Siberia allows reconstruction of summer (July) vapor pressure deficit (VPD) changes in a temperature-limited environment. VPD increased recently, but does not yet exceed the maximum values reconstructed during the Medieval Warm Anomaly. The most humid conditions in the Siberian North were recorded in the Early Medieval Period and during the Little Ice Age. Read More

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September 2020

Comparison of contrast-enhanced videofluoroscopy to unenhanced dynamic MRI in minor patients following surgical correction of velopharyngeal dysfunction.

Eur Radiol 2021 Jan 1;31(1):76-84. Epub 2020 Aug 1.

Institute for Neuroradiology, University Hospital Frankfurt, Frankfurt am Main, Germany.

Objectives: To compare dynamic magnetic resonance imaging (MRI) with videofluoroscopy (VFS) regarding image quality and assessment of gap size between soft palate (SP) and posterior pharyngeal wall (PPW) in children and adolescents following surgical correction of velopharyngeal dysfunction (VPD).

Methods: Twenty-one patients undergoing unenhanced 3-T MRI and contrast-enhanced VFS were included in this IRB-approved prospective study. The MRI scan protocol comprised refocused gradient-echo sequences in transverse and sagittal planes during speech, with TE 1. Read More

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January 2021

Automatic prostate segmentation using deep learning on clinically diverse 3D transrectal ultrasound images.

Med Phys 2020 Jun 8;47(6):2413-2426. Epub 2020 Apr 8.

Department of Medical Biophysics, Western University, London, ON, N6A 3K7, Canada.

Purpose: Needle-based procedures for diagnosing and treating prostate cancer, such as biopsy and brachytherapy, have incorporated three-dimensional (3D) transrectal ultrasound (TRUS) imaging to improve needle guidance. Using these images effectively typically requires the physician to manually segment the prostate to define the margins used for accurate registration, targeting, and other guidance techniques. However, manual prostate segmentation is a time-consuming and difficult intraoperative process, often occurring while the patient is under sedation (biopsy) or anesthetic (brachytherapy). Read More

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Regenerative potential of cultured gingival fibroblasts in treatment of periodontal intrabony defects (randomized clinical and biochemical trial).

J Periodontal Res 2020 Jun 21;55(3):441-452. Epub 2020 Feb 21.

Department of Periodontology, Faculty of Dentistry, Nahda University, Cairo, Egypt.

Background: Defective cellular elements constitute an important challenge to achieve predictable periodontal regeneration. In an attempt to improve the cellularity of periodontal defects, gingival fibroblasts were implanted without their associated extracellular elements in periodontal defects to expose them to periodontal tissue mediators. In order to investigate the regenerative potential of gingival fibroblasts translocated into periodontal defects, the present study was designed to clinically and biochemically investigate the use of gingival fibroblasts (GF) and their associated mesenchymal stem cells (GMSC) in the treatment of intrabony periodontal defects. Read More

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Impact of CT reconstruction algorithm on auto-segmentation performance.

J Appl Clin Med Phys 2019 Sep;20(9):95-103

Department of Radiation Oncology, Henry Ford Cancer Institute, Detroit, MI, USA.

Model-based iterative reconstruction (MBIR) reduces CT imaging dose while maintaining image quality. However, MBIR reduces noise while preserving edges which may impact intensity-based tasks such as auto-segmentation. This work evaluates the sensitivity of an auto-contouring prostate atlas across multiple MBIR reconstruction protocols and benchmarks the results against filtered back projection (FBP). Read More

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September 2019

Surgical, Speech, and Audiologic Outcomes in Patients With Orofacial Cleft and Van der Woude Syndrome.

J Craniofac Surg 2019 Jul;30(5):1484-1487

Division of Plastic and Reconstructive Surgery, Washington University School of Medicine.

Objective: The purpose of this study was to investigate the surgical, speech, and audiologic outcomes in patients with Van der Woude syndrome (VWS) and compare them to patients with nonsyndromic cleft palate with or without cleft lip (NS-CP ± L) treated at the same institution.

Design: Retrospective chart review.

Setting: A single children's hospital at a major academic institution. Read More

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Management of velopharyngeal dysfunction in patients with 22q11.2 deletion syndrome: A survey of practice patterns.

Int J Pediatr Otorhinolaryngol 2019 Jan 12;116:43-48. Epub 2018 Oct 12.

The Children's Hospital of Philadelphia, 3400 Civic Center Boulevard, Philadelphia, PA, 19104, USA.

Objective: To determine demographics and practice patterns of surgeons treating velopharyngeal dysfunction (VPD) in patients with 22q11.2 deletion syndrome (22q11.2DS). Read More

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January 2019

Hydraulics Regulate Stomatal Responses to Changes in Leaf Water Status in the Fern -.

Plant Physiol 2019 02 11;179(2):533-543. Epub 2018 Dec 11.

Purdue Center for Plant Biology, Department of Botany and Plant Pathology, Purdue University, West Lafayette, Indiana 47907

Stomatal responses to changes in leaf water status are important for the diurnal regulation of gas exchange and the survival of plants during drought. These stomatal responses in angiosperm species are well characterized, yet in species of nonseed plants, an ongoing debate surrounds the role of metabolism, particularly the role of the hormone abscisic acid (ABA), in functionally regulating stomatal responses to changes in leaf water status. Here, we measured the stomatal response to changes in vapor pressure difference (VPD) in two natural forms of the fern species -, recently suggested to have stomata that are regulated by ABA. Read More

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February 2019

Reconstructing vapor pressure deficit from leaf wax lipid molecular distributions.

Sci Rep 2018 03 2;8(1):3967. Epub 2018 Mar 2.

Center for Integrative Geosciences, University of Connecticut, Storrs, Mansfield, CT, 06269, USA.

Estimates of atmospheric moisture are critical for understanding the links and feedbacks between atmospheric CO and global climate. At present, there are few quantitative moisture proxies that are applicable to deep time. We present a new proxy for atmospheric moisture derived from modern climate and leaf biomarker data from North and Central America. Read More

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Paget's Disease of the Vulva: A Review of 20 Years' Experience.

Int J Gynecol Cancer 2017 05;27(4):791-793

*Department of Gyn Oncology, Hereford Hospital, Hereford; †Department of Gyn Oncology, University of Bristol, Bristol; and ‡Department of Gyn Oncology, St James's Institute of Oncology, Leeds, United Kingdom.

Background: Extramammary Paget's disease is a rare condition, and the vulva is a common site for it to occur. Despite this, there is a paucity of literature on Paget's disease of the vulva (VPD). A Cochrane meta-analysis could not draw any conclusions on interventions in VPD. Read More

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Reducing scan angle using adaptive prior knowledge for a limited-angle intrafraction verification (LIVE) system for conformal arc radiotherapy.

Phys Med Biol 2017 05 24;62(9):3859-3882. Epub 2017 Mar 24.

Department of Radiation Oncology, Duke University Medical Center, DUMC Box 3295, Durham, NC 27710, United States of America.

The purpose of this study is to develop an adaptive prior knowledge guided image estimation technique to reduce the scan angle needed in the limited-angle intrafraction verification (LIVE) system for 4D-CBCT reconstruction. The LIVE system has been previously developed to reconstruct 4D volumetric images on-the-fly during arc treatment for intrafraction target verification and dose calculation. In this study, we developed an adaptive constrained free-form deformation reconstruction technique in LIVE to further reduce the scanning angle needed to reconstruct the 4D-CBCT images for faster intrafraction verification. Read More

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Estimating 4D-CBCT from prior information and extremely limited angle projections using structural PCA and weighted free-form deformation for lung radiotherapy.

Med Phys 2017 Mar;44(3):1089-1104

Medical Physics Graduate Program, Duke University, Durham, NC, 27705, USA.

Purpose: To investigate the feasibility of using structural-based principal component analysis (PCA) motion-modeling and weighted free-form deformation to estimate on-board 4D-CBCT using prior information and extremely limited angle projections for potential 4D target verification of lung radiotherapy.

Methods: A technique for lung 4D-CBCT reconstruction has been previously developed using a deformation field map (DFM)-based strategy. In the previous method, each phase of the 4D-CBCT was generated by deforming a prior CT volume. Read More

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Intensive Care Unit Monitoring After Pharyngeal Flap Surgery: Is It Necessary?

J Oral Maxillofac Surg 2017 May 1;75(5):1005-1009. Epub 2016 Dec 1.

Associate Professor, Department of Plastic and Reconstructive Surgery, Johns Hopkins Children's Center, Baltimore, MD. Electronic address:

Purpose: To assess the incidence of perioperative complications and the utility of intensive care monitoring in patients undergoing posterior pharyngeal flap surgery for velopharyngeal dysfunction (VPD).

Materials And Methods: This study was a retrospective evaluation of patients who underwent posterior pharyngeal flap surgery for treatment of VPD and an assessment of the incidence of perioperative complications. Descriptive statistics were computed. Read More

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Velopharyngeal Dysfunction Evaluation and Treatment.

Facial Plast Surg Clin North Am 2016 Nov;24(4):477-485

Division of Otolaryngology, University of Utah School of Medicine, 50 North Medical Drive, Room 3C120 SOM, Salt Lake City, UT 84132, USA. Electronic address:

Velopharyngeal dysfunction (VPD) can significantly impair a child's quality of life and may have lasting consequences if inadequately treated. This article reviews the work-up and management options for patients with VPD. An accurate perceptual speech analysis, nasometry, and nasal endoscopy are helpful to appropriately evaluate patients with VPD. Read More

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November 2016

Surgical considerations in 22Q11.2 deletion syndrome.

Clin Plast Surg 2014 Apr;41(2):271-82

Section of Plastic and Reconstructive Surgery, Department of Plastic Surgery, Nationwide Children's Hospital, The Ohio State University College of Medicine, 700 Children's Drive, Columbus, OH 43205, USA.

The 22q11.2 deletion syndrome (22q11DS) may be associated with several palatal abnormalities, including overt cleft palate, submucosal cleft palate, palatopharyngeal disproportion, and velar hypotonia. The syndrome is the genetic disorder most commonly associated with velopharyngeal dysfunction (VPD). Read More

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A limited-angle intrafraction verification (LIVE) system for radiation therapy.

Med Phys 2014 Feb;41(2):020701

Department of Radiation Oncology, Duke University Medical Center, DUMC Box 3295, Durham, North Carolina 27710 and Medical Physics Graduate Program, Duke University, 2424 Erwin Road, Suite 101, Durham, North Carolina 27705.

Purpose: Currently, no 3D or 4D volumetric x-ray imaging techniques are available for intrafraction verification of target position during actual treatment delivery or in-between treatment beams, which is critical for stereotactic radiosurgery (SRS) and stereotactic body radiation therapy (SBRT) treatments. This study aims to develop a limited-angle intrafraction verification (LIVE) system to use prior information, deformation models, and limited angle kV-MV projections to verify target position intrafractionally.

Methods: The LIVE system acquires limited-angle kV projections simultaneously during arc treatment delivery or in-between static 3D/IMRT treatment beams as the gantry moves from one beam to the next. Read More

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February 2014

Clinical and radiographic evaluation of Bio-Gen with biocollagen compared with Bio-Gen with connective tissue in the treatment of class II furcation defects: a randomized clinical trial.

J Appl Oral Sci 2013 Sep-Oct;21(5):422-9

Department of Periodontics, Dental Faculty, Dental Materials Research Center, Babol University of Medical Sciences, Babol, Iran.

Objective: Treatment of furcation defects are thought to be challenging. The purpose of this study was to evaluate the clinical and radiographic parameters of Bio-Gen with Biocollagen compared with Bio-Gen with connective tissue in the treatment of Class II furcation defects.

Material And Methods: In this clinical trial, 24 patients with Class II furcation defect on a buccal or lingual mandibular molar were recruited. Read More

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Regeneration of degree ii furcation defects with a 4% doxycycline hyclate bioabsorbable barrier.

J Periodontol 2008 Jan;79(1):72-9

Department of Periodontics, The University of Texas Dental Branch at Houston, Houston, TX 77030, USA.

Background: Bacterial contamination of a healing regenerative site has been shown to affect the response to therapy adversely. Doxycycline possesses antibacterial properties as well as other biologic actions that may result in an increased production and maintenance of collagen and bone. The purpose of this study was to assess if the sustained release of 4% doxycycline through a bioabsorbable barrier would enhance the regenerative outcomes of healing furcation sites. Read More

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January 2008

A clinical evaluation of anorganic bovine bone graft plus 10% collagen with or without a barrier in the treatment of class II furcation defects.

J Contemp Dent Pract 2006 Feb 15;7(1):60-70. Epub 2006 Feb 15.

Department of Periodontics, Manipal College of Dental Sciences, Mangalore, Kamataka State, India.

Unlabelled: The use of bone replacement grafts with barrier membranes in class II furcation defects are aimed at improving the outcome of the regenerative technique. In this regard, however, there is a paucity of studies comparing the results obtained with bone grafts alone or in combination with barrier membranes. The aim of this study was to clinically compare an anorganic bovine bone graft plus 10% collagen (BO) with or without a bioresorbable collagen barrier (BG) in human mandibular molar class II furcation defects. Read More

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February 2006

The evaluation and management of velopharyngeal dysfunction.

Jeffrey L Marsh

Clin Plast Surg 2004 Apr;31(2):261-9

Cleft Lip/Palate and Craniofacial, St. John's Mercy Health Center, St. Louis, MO 63141, USA.

Several interventions are available for management of VPD. Using an approach of differential management based on differential diagnosis, VPD can be effectively treated in most patients. The current challenge for the VPD care team, however, is to resolve the signs and symptoms of VPD without exchanging them for a different but an equally or more morbid set of signs and symptoms. Read More

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Guided tissue regeneration for the treatment of periodontal intrabony and furcation defects. A systematic review.

Ann Periodontol 2003 Dec;8(1):266-302

Department of Periodontics, College of Dental Surgery, University of Maryland, Baltimore, USA.

Background: Many clinical studies have demonstrated that guided tissue regeneration (GTR) is a successful treatment modality of periodontal reconstructive surgery and it has become an accepted procedure in most periodontal practices.

Rationale: The purpose of this structured review was to assess the efficacy of guided tissue regeneration (GTR) procedures in patients with periodontal osseous defects compared with surgical controls on clinical, radiographic, adverse, and patient-centered outcomes. It extends the scope of previous GTR systematic reviews, which were limited to randomized controlled studies, by the scope of outcome measures examined, and the duration of the study. Read More

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December 2003

Periodontal regeneration in humans using recombinant human platelet-derived growth factor-BB (rhPDGF-BB) and allogenic bone.

J Periodontol 2003 Sep;74(9):1282-92

Institute for Advanced Dental Studies, Swampscott, MA, USA.

Background: Purified recombinant human platelet-derived growth factor BB (rhPDGF-BB) is a potent wound healing growth factor and stimulator of the proliferation and recruitment of both periodontal ligament (PDL) and bone cells. The hypothesis tested in this study was that application of rhPDGF-BB incorporated in bone allograft would induce regeneration of a complete new attachment apparatus, including bone, periodontal ligament, and cementum in human interproximal intrabony defects and molar Class II furcation lesions.

Methods: Nine adult patients (15 sites) with advanced periodontitis exhibiting at least one tooth requiring extraction due to an extensive interproximal intrabony and/or molar Class II furcation defect were entered into the study. Read More

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September 2003

Clinical evaluation of the treatment of class II furcation involvements with bioabsorbable barriers alone or associated with demineralized freeze-dried bone allografts.

J Periodontol 1999 Jan;70(1):8-12

Center for Dental Implants, Division of Oral and Maxillofacial Surgery, University of Miami, School of Medicine, FL, USA.

Background: Class II furcation lesions are a challenging scenario for periodontal therapy and a serious threat for tooth prognosis. Guided tissue regeneration represents a viable treatment option, but some aspects remain to be clarified as to the efficacy of bone substitutes used in GTR procedures. The clinical efficacy of demineralized freeze-dried bone allografts (DFDBA) for regenerative procedures is presently under scrutiny. Read More

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January 1999

Management of the hypodynamic velopharynx.

Cleft Palate Craniofac J 1995 May;32(3):179-87

Department of Surgery, Plastic and Reconstructive, St. Louis Children's Hospital, Washington University School of Medicine, MO 63110, USA.

Velopharyngeal dysfunction (VPD) resulting from an adynamic or hypodynamic velopharynx is an unusual pathology that poses vexing management problems for the Cleft Palate team. Correction of VPD has the potential for airway compromise. Endoscopically, this pathology is recognized by a large velopharyngeal (VP) gap size, which demonstrates little or no dynamic activity of the posterior or lateral pharyngeal walls nor of the velum in response to speech tasks or connected speech. Read More

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