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The role of eHealth, telehealth, and telemedicine for chronic disease patients during COVID-19 pandemic: A rapid systematic review.

Digit Health 2021 Jan-Dec;7:20552076211009396. Epub 2021 Apr 19.

Center for Information Systems & Technology, Claremont Graduate University, Claremont, USA.

Objective: To summarize the current status of, and the current expert opinions, recommendation and evidence associated with the use and implementation of electronic health (eHealth), telemedicine, and/or telehealth to provide healthcare services for chronic disease patients during the COVID-19 pandemic.

Materials And Methods: We searched four electronic databases (PubMed, Google Scholar, Science Direct, and Web of Science Core Collection) to identify relevant articles published between 2019 and 2020. Searches were restricted to English language articles only. Read More

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Sequential chemo-hypofractionated RT versus concurrent standard CRT for locally advanced NSCLC: GRADE recommendation by the Italian Association of Radiotherapy and Clinical Oncology (AIRO).

Radiol Med 2021 May 5. Epub 2021 May 5.

Department of Radiation Oncology, Policlinico S. Gerardo and University of Milan "Bicocca", Milan, Italy.

Introduction: Almost 30% of non-small cell lung cancer (NSCLC) patients have locally advanced-stage disease. In this setting, definitive radiotherapy concurrent to chemotherapy plus adjuvant immunotherapy (cCRT + IO) is the standard of care, although only 40% of these patients are eligible for this approach.

Aims: A comparison between cCRT and hypofractionated radiotherapy regimens (hypo-fx RT) with the addition of sequential chemotherapy (sCHT) could be useful for future combinations with immunotherapy. Read More

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Individual level and community level factors affecting exclusive breast feeding among infants under-six months in Ethiopia using multilevel analysis.

Ital J Pediatr 2021 May 5;47(1):106. Epub 2021 May 5.

Department of Epidemiology and Biostatistics, School of Public Health, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.

Background: Exclusive breastfeeding (EBF) is the safest and healthiest option of feeding among infants in the first 6 months throughout the world. Thus, promotion of EBF is essential to prevent complex infant health problems even at the adulthood level. But majority of previous studies focused on individual level determinants of EBF by using basic regression models in localized areas. Read More

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Sensing Architecture for Terrestrial Crop Monitoring: Harvesting Data as an Asset.

Sensors (Basel) 2021 Apr 30;21(9). Epub 2021 Apr 30.

Agricultural Robotics Laboratory, Universitat Politècnica de València, Valencia 46022, Spain.

Very often, the root of problems found to produce food sustainably, as well as the origin of many environmental issues, derive from making decisions with unreliable or inexistent data. Data-driven agriculture has emerged as a way to palliate the lack of meaningful information when taking critical steps in the field. However, many decisive parameters still require manual measurements and proximity to the target, which results in the typical undersampling that impedes statistical significance and the application of AI techniques that rely on massive data. Read More

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Diagnostic layering: Patient accounts of breast cancer classification in the molecular era.

Soc Sci Med 2021 Apr 28;278:113965. Epub 2021 Apr 28.

Centre for Biomedicine, Self and Society, Usher Institute, Old Medical School, University of Edinburgh, Edinburgh, Scotland, EH8 9AG, UK.

Social scientific work has considered the promise of genomic medicine to transform healthcare by personalising treatment. However, little qualitative research attends to already well-established molecular techniques in routine care. In this article we consider women's experiences of routine breast cancer diagnosis in the UK NHS. Read More

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Design of Clinical Trials Evaluating Sedation in Critically Ill Adults Undergoing Mechanical Ventilation: Recommendations From Sedation Consortium on Endpoints and Procedures for Treatment, Education, and Research (SCEPTER) Recommendation III.

Crit Care Med 2021 Apr 28. Epub 2021 Apr 28.

1 Department of Anesthesiology and Perioperative Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY. 2 University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. 3School of Health Sciences, University of London, London, United Kingdom. 4 School of Nursing and Midwifery, Griffith University, Brisbane, QLD, Australia. 5 Center of Healthy Aging, Self-Management, and Complex Care, The Ohio State University, College of Nursing, Columbus, OH. 6 Clear Consults, LLC, Hayward, WI. 7 Leslie Dan Faculty of Pharmacy, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada. 8 Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University School of Medicine, Baltimore, MD. 9 Departments of Anesthesiology and Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI. 10 School of Pharmacy, Northeastern University, Boston, MA 11 Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA. 12 Department of Anesthesia, University of Iowa, Iowa City, IA. 13 Department of Anesthesiology and Perioperative Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY. 14 Department of Anesthesiology, University of Utah, Salt Lake City, UT. 15 Faculty of Health, University of Technology Sydney, Sydney, NSW, Australia. 16 Intensive Care Unit, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. 17 Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University, Palo Alto, CA. 18 Department of Medicine, Tufts University School of Medicine, Maine Medical Center, Portland, ME. 9 Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA. 20 Division of Anesthesiology and CCM, Hadassah Medical Center, The Hebrew University School of Medicine, Jerusalem, Israel. 21 Psychology Department and Neuroscience Center, Brigham Young University, Provo, UT. 22 Center for Humanizing Critical Care, Intermountain Medical Center, Murray, UT. 23 Department of Medicine, Section of Pulmonary and Critical Care, The University of Chicago, Chicago, IL. 24 Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, CA. 25 Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, Baltimore, MD. 26 Department of Anesthesiology and the Critical Illness, Vanderbilt University Medical Center, Nashville, TN. 27 Department of Critical Care Services, Maine Medical Center, Portland, ME. 28 Department of Outcomes Research, Cleveland Clinic, Cleveland, OH. 29 Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University, Palo Alto, CA. 30 Monash Health School of Clinical Sciences - Department of Intensive Care Medicine - Critical Care Research, Melbourne, VIC, Australia. 31 Department of Anesthesiology and Operative Intensive Care Medicine, Charité - Universitätsmedizin Berlin, Campus Charité Mitte & Campus Virchow-Klinikum, Berlin, Germany. 32 Department of Anesthesiology, Columbia University Medical Center, New York, NY. 33 Department of Anesthesia and Critical Care, The University of Chicago, Chicago, IL. 34 Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Objectives: Clinical trials evaluating the safety and effectiveness of sedative medication use in critically ill adults undergoing mechanical ventilation differ considerably in their methodological approach. This heterogeneity impedes the ability to compare results across studies. The Sedation Consortium on Endpoints and Procedures for Treatment, Education, and Research Recommendations convened a meeting of multidisciplinary experts to develop recommendations for key methodologic elements of sedation trials in the ICU to help guide academic and industry clinical investigators. Read More

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Decision Making of Artificial Nutrition and Hydration for cancer patients at terminal stage- A systematic review of the views from patients, families and healthcare professionals.

J Pain Symptom Manage 2021 Apr 29. Epub 2021 Apr 29.

Peking University School of Nursing.

Background: Decision making on nutrition and hydration for cancer patients during terminal stage cause critical impacts toward patient's comfort and living quality. The management of nutrition is the main dilemma that arises in these final situations and has been the subject of intense debate over the last few decades.

Aim: To find the views of patients, families and healthcare professionals related to how decisions are made when cancer patients are at terminal stage. Read More

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Trastuzumab treatment of patients with early, HER2-positive breast cancer in 17 certified German breast cancer centers.

J Cancer Res Clin Oncol 2021 Apr 29. Epub 2021 Apr 29.

Department of Gynaecology, Caritas-Krankenhaus St. Josef, Landshuter Straße 65, 93053, Regensburg, Germany.

Purpose: Since 2008, guidelines recommend that patients with HER2-positive early breast cancer (BC) should receive adjuvant chemotherapy in combination with trastuzumab in Germany. However, recent studies highlight that a substantial share of patients do not receive trastuzumab. We investigate which patient characteristics are associated with a tumor board recommendation for trastuzumab in Breast Cancer Centers (BCC) certified by the German Cancer Society (DKG) and the German Society for Senology, and if the recommendation differs between BCCs. Read More

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Consensus Recommendations for Blood Culture Use in Critically Ill Children Using a Modified Delphi Approach.

Pediatr Crit Care Med 2021 04 23. Epub 2021 Apr 23.

Division of Critical Care Medicine, The Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA. The Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA. Division of Infectious Diseases, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD. Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD. Armstrong Institute for Patient Safety and Quality, Johns Hopkins University School of Medicine, Baltimore, MD. Division of General Internal Medicine, Department of Medicine and Leonard Davis Institute of Health Economics, Philadelphia, PA. Rainbow Babies and Children's Hospital, Cleveland, OH. Case Western Reserve University School of Medicine, Cleveland, OH. Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.

Objectives: Blood cultures are fundamental in evaluating for sepsis, but excessive cultures can lead to false-positive results and unnecessary antibiotics. Our objective was to create consensus recommendations focusing on when to safely avoid blood cultures in PICU patients.

Design: A panel of 29 multidisciplinary experts engaged in a two-part modified Delphi process. Read More

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The utilization of caudal hydromorphone for fast-tracking in congenital cardiac surgery in a tertiary-care Children's hospital: An audit.

J Clin Anesth 2021 Apr 22;72:110314. Epub 2021 Apr 22.

Department of Pediatric Anesthesiology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, United States of America; Department of Anesthesiology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States of America.

Study Objective: Our study sought to audit our institutional practice of routine single-shot caudal epidural hydromorphone injection in children undergoing congenital cardiothoracic surgery to assess perioperative pain control and evaluate for any caudal complications.

Design: Retrospective observational study of all patients that received a caudal hydromorphone injection as part of the anesthetic for their cardiac surgical operation between January 2017 and July 2019.

Setting: Pediatric Cardiothoracic Operating Room (OR), Cardiac Intensive Care Unit. Read More

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Gastroenterology visitation and reminders predict surveillance uptake for patients with adenomas with high-risk features.

Sci Rep 2021 Apr 22;11(1):8764. Epub 2021 Apr 22.

Department of Medicine, Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.

Individuals diagnosed with colorectal adenomas with high-risk features during screening colonoscopy have increased risk for the development of subsequent adenomas and colorectal cancer. While US guidelines recommend surveillance colonoscopy at 3 years in this high-risk population, surveillance uptake is suboptimal. To inform future interventions to improve surveillance uptake, we sought to assess surveillance rates and identify facilitators of uptake in a large integrated health system. Read More

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Efficacy and Safety of First-line Single-Agent Carboplatin vs Carboplatin Plus Paclitaxel for Vulnerable Older Adult Women With Ovarian Cancer: A Randomized Clinical Trial.

JAMA Oncol 2021 Apr 22. Epub 2021 Apr 22.

GINECO and Centre Hospitalier Lyon-Sud, Lyon, France.

Importance: Single-agent carboplatin is often proposed instead of a conventional carboplatin-paclitaxel doublet in vulnerable older patients with ovarian cancer. Such an approach could have a detrimental effect on outcomes for these patients.

Objective: To compare the feasibility, efficacy, and safety of single-agent carboplatin every 3 weeks, weekly carboplatin-paclitaxel, or conventional every-3-weeks carboplatin-paclitaxel in vulnerable older patients with ovarian cancer. Read More

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IAP Guideline on Practicing Safely During COVID-19 Era: Clinics and Small Establishments.

Indian Pediatr 2021 Apr;58(4):383-390

Department of Pediatrics, Max Superspeciality Hospital, Shalimar Bagh, New Delhi, India.

Justification: The unprecedented COVID-19 pandemic has had a formidable impact on Indian health care. With no sight of its end as yet, various establishments including the smaller clinics and nursing homes are restarting full operations. Hence, there is the need for recommendations to allow safe practice ensuring the safety of both the heath care worker (HCW) and patients. Read More

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Multimodal assessment of disease activity in glioblastoma : A single center experience.

Wien Klin Wochenschr 2021 Apr 20. Epub 2021 Apr 20.

Department of Neurology, Unit for Neurooncology, University Hospital of St. Pölten-KLPU, St. Pölten, Austria.

Background: Assessment of disease activity in glioblastoma (GBM) can be challenging due to several clinical and radiological pitfalls. Besides MRI, FET-PET and neurocognitive assessment (NA) are used in several neuro-oncological centers in order to improve the specificity of response assessment. We performed a retrospective study to investigate whether the assessment by RANO (Response Assessment in NeuroOncology) corresponds to FET-PET imaging and NA results. Read More

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Ultrasound Evaluation of Gastric Emptying Time in Healthy Term Neonates after Formula Feeding.

Anesthesiology 2021 Apr 16. Epub 2021 Apr 16.

Background: The current American Society of Anesthesiologists fasting guideline for formula-fed infants in the periprocedural setting is 6 h. Prolonged fasting in very young infants is associated with an increased risk for hypoglycemia and dehydration as well as patient discomfort and patient/parental dissatisfaction. This study aimed to determine the time to gastric emptying in healthy neonates after formula feeding by serially evaluating the gastric antrum with ultrasound. Read More

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Development of national physical activity recommendations in 18 EU member states: a comparison of methodologies and the use of evidence.

BMJ Open 2021 Apr 15;11(4):e041710. Epub 2021 Apr 15.

European Office for the Prevention and Control of Noncommunicable Diseases, World Health Organization Regional Office for Europe, Moscow, Russian Federation.

Objectives: The aim of the study is to compare how member states of the European Union (EU) develop their national physical activity (PA) recommendations and to provide an overview of the methodologies they apply in doing so. Information was collected directly from the physical activity focal points of EU member states in 2018. Five countries were chosen for detailed case study analysis of development processes. Read More

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Consensus on pre-operative total knee replacement education and prehabilitation recommendations: a UK-based modified Delphi study.

BMC Musculoskelet Disord 2021 Apr 14;22(1):352. Epub 2021 Apr 14.

School of Healthcare, University of Leeds, Leeds, UK.

Background: Over 90,000 total knee replacement (TKR) procedures are performed annually in the United Kingdom (UK). Patients awaiting TKR face long delays whilst enduring severe pain and functional limitations. Almost 20% of patients who undergo TKR are not satisfied post-operatively. Read More

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Repeatedly negative PCR results in patients with COVID-19 symptoms: Do they have SARS-CoV-2 infection or not?

Epidemiol Mikrobiol Imunol 2021 ;70(1):3-9

Objective: To point out possible infection with SARS-CoV-2 in symptomatic patients despite repeated negative nasopharyngeal swab tests for SARS-CoV-2.

Material And Methods: A retrospective observational study carried out at the Na Bulovce Hospital from the beginning of the pandemic until November 2020 included patients (1) who had symptoms compatible with COVID-19; (2) whose nasopharyngeal swab PCR tests in the presence of acute respiratory infection symptoms yielded two consecutive negative results; (3) in whom SARS-CoV-2 infection was subsequently confirmed by serology. Basic demographic and epidemiological data, symptoms, laboratory test results, X-ray findings and timing of virological tests were analysed for these patients. Read More

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Chinese Association for the Study of Pain: Expert consensus on chronic postsurgical pain.

World J Clin Cases 2021 Mar;9(9):2090-2099

Department of Algology, The Affiliated T.C.M Hospital of Southwest Medical University, Luzhou 646000, Sichuan Province, China.

Chronic postsurgical pain is a common surgical complication that severely reduces a patient's quality of life. Many perioperative interventions and management strategies have been developed for reducing and managing chronic postsurgical pain. Under the leadership of the Chinese Association for the Study of Pain, an editorial committee was formed for chronic postsurgical pain diagnosis and treatment by experts in relevant fields. Read More

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Prevalence of Immature Survival Data for Anti-Cancer Drugs Presented to the National Institute for Health and Care Excellence and Impact on Decision Making.

Value Health 2021 Apr 8;24(4):505-512. Epub 2020 Dec 8.

Modelling and Simulation, Evidera, London, England, UK.

Objectives: This research aims to explore how often the National Institute for Health and Care Excellence (NICE) uses immature overall survival data to inform reimbursement decisions on cancer treatments, and the implications of this for resource allocation decisions.

Methods: NICE cancer technology appraisals published between 2015 and 2017 were reviewed to determine the prevalence of using immature survival data. A case study was used to demonstrate the potential impact of basing decisions on immature data. Read More

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Assessment of gender differences in letters of recommendation for pharmacy residency applicants.

Am J Health Syst Pharm 2021 Apr 4. Epub 2021 Apr 4.

Department of Pharmacy, Mayo Clinic, Rochester, MN, USA.

Disclaimer: In an effort to expedite the publication of articles related to the COVID-19 pandemic, AJHP is posting these manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time. Read More

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Simulating Expansion of the Intracranial Space to Accommodate Brain Swelling after Decompressive Craniectomy: Volumetric Quantification in a 3D CAD Skull Model with Contour Elevation.

Brain Sci 2021 Mar 27;11(4). Epub 2021 Mar 27.

Division of Neurosurgery, Department of Surgery, Kuang Tien General Hospital, Taichung 43303, Taiwan.

: Decompressive craniectomy (DC) can be used to augment intracranial space and halt brainstem compromise. However, a widely adopted recommendation for optimal surgical extent of the DC procedure is lacking. In the current study, we utilized three-dimensional (3D) computer-assisted design (CAD) skull models with defect contour elevation for quantitative assessment. Read More

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Compliance with CDIM-APDIM Guidelines for Department of Medicine Letters: an Opportunity to Improve Communication Across the Continuum.

J Gen Intern Med 2021 Mar 31. Epub 2021 Mar 31.

Tufts University School of Medicine, Boston, MA, USA.

Background: With rising applications to internal medicine programs and pending changes in United States Medical Licensing Examination Step 1 score reporting, program directors desire transparent data for comparing applicants. The Department of Medicine Letters of Recommendation (DOM LORs) are frequently used to assess applicants and have the potential to provide clearly defined data on performance including stratification of a medical school class. Despite published guidelines on the expected content of the DOM LOR, these LORs do not always meet that need. Read More

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Effect of sintering process on microstructure, 4-point flexural strength, and grain size of yttria-stabilized tetragonal zirconia polycrystal for use in monolithic dental restorations.

J Prosthet Dent 2021 May 26;125(5):824.e1-824.e8. Epub 2021 Mar 26.

Full Professor, Department of Materials Science, Military Institute of Engineering (IME), Rio de Janeiro, RJ, Brazil.

Statement Of Problem: Modifications have been made in the microstructure and sintering parameters of monolithic zirconia to improve esthetics qualities and avoid chipping of 2-layer restorations. However, how these modifications affect the physical and mechanical properties of zirconia is unclear.

Purpose: The purpose of this in vitro study was to compare the influence of different sintering parameters on the microstructure, 4-point flexural strength, density, and grain size of 2 commercially available zirconia advocated for the fabrication of monolithic dental prostheses and 1 commercially available zirconia for use as a core material. Read More

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More Than One-third of Orthopaedic Applicants Are in the Top 10%: The Standardized Letter of Recommendation and Evaluation of Orthopaedic Resident Applicants.

Clin Orthop Relat Res 2021 Mar 16. Epub 2021 Mar 16.

M. J. Pacana, J. B. Jackson, D. E. Koon, G. Grabowski, University of South Carolina School of Medicine, Department of Orthopedic Surgery, Columbia, SC, USA.

Background: The American Orthopaedic Association (AOA) released the standardized letter of recommendation (SLOR) form to provide standardized information to evaluators of orthopaedic residency applicants. The SLOR associates numerical data to an applicant's letter of recommendation. However, it remains unclear whether the new letter form effectively distinguishes among orthopaedic applicants, for whom letters are perceived to suffer from "grade inflation. Read More

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Exercise training and high-sensitivity cardiac troponin T in patients with heart failure with reduced ejection fraction.

ESC Heart Fail 2021 Mar 23. Epub 2021 Mar 23.

Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, Trondheim, Norway.

Aims: Whether an exercise training intervention is associated with reduction in long-term high-sensitivity cardiac troponin T (hs-cTnT) concentration (a biomarker of subclinical myocardial injury) in patients with heart failure with reduced ejection fraction (HFrEF) is unknown. The aims were to determine (i) the effect of a 12 week endurance exercise training intervention with different training intensities on hs-cTnT in stable patients with HFrEF (left ventricular ejection fraction ≤ 35%) and (ii) associations between hs-cTnT and peak oxygen uptake (VO ).

Methods And Results: In this sub-study of the SMARTEX-HF trial originally including 261 patients from nine European centres, 213 eligible patients were included after withdrawals and appropriate exclusions [19% women, mean age 61. Read More

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Spreader events and the limitations of projected networks for capturing dynamics on multipartite networks.

Phys Rev E 2021 Feb;103(2-1):022320

Department of Chemical and Biological Engineering, Northwestern University, Evanston, Illinois 60208, USA.

Many systems of scientific interest can be conceptualized as multipartite networks. Examples include the spread of sexually transmitted infections, scientific collaborations, human friendships, product recommendation systems, and metabolic networks. In practice, these systems are often studied after projection onto a single class of nodes, losing crucial information. Read More

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February 2021

Population pharmacokinetics and dose optimization of vancomycin in neonates.

Sci Rep 2021 Mar 17;11(1):6168. Epub 2021 Mar 17.

Department of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon, Republic of Korea.

The pharmacokinetics of vancomycin vary among neonates, and we aimed to conduct population pharmacokinetic analysis to determine the optimal dosage of vancomycin in Korean neonates. From a retrospective chart review, neonates treated with vancomycin from 2008 to 2017 in a neonatal intensive care unit (NICU) were included. Vancomycin concentrations were collected based on therapeutic drug monitoring, and other patient characteristics were gathered through electronic medical records. Read More

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Liberal blood transfusion strategies and associated infection in orthopedic patients: A meta-analysis.

Medicine (Baltimore) 2021 Mar;100(10):e24430

Department of Orthopedics, Affiliated Hospital of Hebei University of Engineering.

Objective: It remains unclear whether transfusion strategies during orthopedic surgery and infection are related. The purpose of this study is to evaluate whether liberal blood transfusion strategies contribute to infection risk in orthopedic patients by analyzing randomized controlled trials (RCTs).

Methods: RCTs with liberal versus restrictive red blood cell (RBC) transfusion strategies were identified by searching PubMed, Embase, the Cochrane Central Register of Controlled Trials from their inception to July 2019. Read More

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Adjuvant radiotherapy and radioiodine treatment for locally advanced differentiated thyroid cancer: systematic review and meta-analysis.

Tumori 2021 Mar 16:300891621996817. Epub 2021 Mar 16.

Radiation Oncology, Department of Biomedicine and Prevention, University of Rome "Tor Vergata," Rome, Italy.

Background: Treatment for locally advanced differentiated thyroid cancer is surgery followed by radioiodine while the role of adjuvant external beam radiotherapy (EBRT) is debated.

Methods: The panel of the Italian Association of Radiotherapy and Clinical Oncology developed a clinical recommendation on the addition of EBRT to radioiodine after surgery for locally advanced differentiated thyroid cancer by using the Grades of Recommendation, Assessment, Development, and Evaluation methodology and the Evidence to Decision framework. A systematic review with meta-analysis about this topic was conducted with a focus on outcome of benefits and toxicity. Read More

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