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Do tick-borne diseases affect outdoor teaching in Slovenian preschools?

Ticks Tick Borne Dis 2021 Apr 8;12(4):101728. Epub 2021 Apr 8.

Faculty of Education, University of Ljubljana, Slovenia.

Childhood experiences with nature are decisive for children's wellbeing. The need for outdoor activities has been duly recognized in the preschool curriculum in Slovenia. However, there are some obstacles to this approach-specifically, tick-borne diseases. Read More

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The Ligamentum condylicum posterius as a precursor structure of the Processus condylicus posterior, another Proatlas-Manifestation of the human occipital bone.

J Anat 2021 Apr 12. Epub 2021 Apr 12.

Institute for Molecular and Cellular Anatomy (MOCA) - Prosektur, Faculty of Medicine, RWTH Aachen, Aachen, Germany.

This article presents the results of a dissection series investigating a previously neglected ligamentous structure attached to the human occipital bone, the Ligamentum condylicum posterius or posterior condylar ligament, and relates these results to the manifestation of a likewise poorly recognized occipital bony variation, the Processus condylicus posterior. The dissection of 50 human cranio-cervical junctions revealed the existence of the posterior condylar ligament in 98% of all cases, sometimes containing free elongated ossicles and osseous spurs at the insertion points at the occipital bone. In two cases the osseous formation of a Processus condylicus posterior became apparent (4%), which further provided the opportunity to study the behaviour of the ligament in these cases. Read More

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An Approach to Drug-Induced Liver Injury from the Geriatric Perspective.

Curr Gastroenterol Rep 2021 Apr 12;23(4). Epub 2021 Apr 12.

Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.

Purpose Of Review: With its high variability in both presentation and severity, drug-induced liver injury (DILI) is a complex condition increasingly confronting all providers. DILI has an even more muddled presentation among the geriatric population due to age-related changes in liver physiology and biochemistry as well as polypharmacy common in the geriatric population.

Recent Findings: Most cases of DILI are idiosyncratic and unpredictable. Read More

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Long non‑coding RNA MIR4435‑2HG promotes the progression of head and neck squamous cell carcinoma by regulating the miR‑383‑5p/RBM3 axis.

Oncol Rep 2021 Jun 13;45(6). Epub 2021 Apr 13.

Center for Tumor Diagnosis and Therapy, Jinshan Hospital, Fudan University, Shanghai 201508, P.R. China.

Recent studies have shown that long non‑coding RNAs (lncRNAs) are strongly related to the progression of various types of cancer. The lncRNA MIR4435‑2 host gene (MIR4435‑2HG) has been recently recognized as a tumor‑related lncRNA that is upregulated in several tumors. However, its possible functions in head and neck squamous cell carcinoma (HNSCC) remain unclear. Read More

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The neurology of IGG4-related disease.

J Neurol Sci 2021 Mar 27:117420. Epub 2021 Mar 27.

Division of Neuro-Ophthalmology, Department of Ophthalmology, Massachusetts Eye & Ear Infirmary/Harvard Medical School, Boston, MA, USA; Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA. Electronic address:

Purpose Of Review: IgG4-related disease (IgG4-RD) is emerging as a fibro-inflammatory entity affecting multiple organs, including manifold neurologic manifestations. This review discusses general characteristics of IgG4-RD neurologic disease including epidemiology, histology, clinical picture and treatment approaches.

Recent Findings: IgG4-RD is increasingly recognized as an important underlying pathophysiology in multiple disorders of neurologic interest, including orbital inflammation, infundibulo-hypophysitis, hypertrophic pachymeningitis, and even in rare cases CNS parenchymal disease and cranial vascular involvement. Read More

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[Acute hepatitis C. Report of seven cases].

Rev Med Chil 2020 Dec;148(12):1813-1818

Servicio de Medicina Interna, Hospital Clínico, Universidad de Chile, Santiago, Chile.

Hepatitis C virus infection is a major global public health problem. Treatment with direct-acting antivirals is intended to eradicate the chronic form of this infection by 2030. Although uncommon, the acute form of presentation is increasingly recognized, especially in some high-risk populations, such as men who have sex with men without protection. Read More

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December 2020

Elevated Ambulatory Blood Pressure Measurements are Associated with a Progressive Form of Fabry Disease.

High Blood Press Cardiovasc Prev 2021 Apr 12. Epub 2021 Apr 12.

Department of Medicine and Surgery, University of Milano-Bicocca, Via G.B. Pergolesi, 33, 20900, Monza, Italy.

 INTRODUCTION: Published data on hypertension incidence and management in Anderson-Fabry disease are scant and the contribution of elevated blood pressure to organ damage is not well recognized.

Aim: Therefore, we have assessed blood pressure values and their possible correlations with clinical findings in a well described cohort of Fabry patients.

Methods: Between January 2015 and May 2019, all adult Fabry patients (n = 24 females, n = 8 males) referred to our institute were prospectively enrolled. Read More

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Pulmonary aspergillosis and mucormycosis in a patient with COVID-19.

Med Mycol Case Rep 2021 Apr 7. Epub 2021 Apr 7.

Riverside Community Hospital, Division of Infectious Diseases, 4445 Magnolia Avenue, Riverside, CA, 92501, USA.

Invasive pulmonary mucormycosis and aspergillosis are rare, life-threatening fungal infections. Most documented cases have been reported in patients with diabetes mellitus, neutropenia, or treatment with corticosteroids. Both infections have been recognized as secondary complications of COVID-19, especially among critically ill patients. Read More

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Prevalence of impacted teeth and supernumerary teeth by radiographic evaluation in three Latin American countries: A cross-sectional study.

J Clin Exp Dent 2021 Apr 1;13(4):e363-e368. Epub 2021 Apr 1.

Ph.D. and Associate Professor of the Division of Oral and Maxillofacial Radiology, School of Dentistry, Universidad Científica del Sur, Lima, Perú.

Background: Supernumerary teeth are those that exceed the usual dental formula. There are different classifications depending on their anatomical location, shape and number. The objective of this study was to determine the prevalence of impacted and supernumerary teeth in a sample of panoramic radiographs from three Latin American countries. Read More

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Usefulness of electron microscopy in the diagnosis of wild-type transthyretin cardiac amyloidosis.

J Cardiol Cases 2021 Apr 19;23(4):166-169. Epub 2021 Jan 19.

Department of Cardiovascular Medicine, National Hospital Organization, Osaka-Minami Medical Center, 2-1, Kido-higashi cho, Kawachi-Nagano City, Osaka, Japan.

Wild-type transthyretin cardiac amyloidosis (ATTRwt) has been recognized as an important cause of heart failure with preserved ejection fraction; thus, its accurate diagnosis is crucial. Herein, we describe the case of a 76-year-old man who presented with dyspnea and palpitation. On observing the laboratory evaluations and clinical course, we suspected cardiac amyloidosis. Read More

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Cerebral amyloid angiopathy and related inflammatory disorders.

Authors:
B K Chwalisz

J Neurol Sci 2021 Mar 27:117425. Epub 2021 Mar 27.

Department of Neurology, Massachusetts General Hospital/Harvard Medical School, 15 Parkman Street, Suite 835, Boston, MA 02114, USA; Division of Neuro-Ophthalmology, Department of Ophthalmology, Massachusetts Eye & Ear Infirmary/Harvard Medical School, Boston, MA, USA. Electronic address:

Inflammatory cerebral amyloid angiopathy is a largely reversible inflammatory vasculopathy that develops in an acute or subacute fashion in reaction to amyloid protein deposition in the central nervous system blood vessels. There are two recognized pathologically characterized variants: cerebral amyloid angiopathy-related inflammation (CAAri) and A beta-related angiitis (ABRA). Both variants produce a clinical picture that resembles primary angiitis of the CNS but is distinguished by a characteristic radiologic appearance. Read More

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Coagulopathy and Venous Thromboembolic Events Following Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy.

Ann Surg Oncol 2021 Apr 10. Epub 2021 Apr 10.

Department of Surgical Sciences, Department of Colorectal Surgery, Uppsala University, Uppsala, Sweden.

Background: Coagulopathy after cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) is recognized but few details have been studied.

Objectives: The aim of this study was to investigate changes in coagulation biomarkers and their predictive ability for venous thromboembolism (VTE).

Methods: Patients undergoing CRS and HIPEC at Uppsala University Hospital, Sweden, from 2004 to 2014 were included in a prospective study of coagulation biomarkers. Read More

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The Usefulness of a Simple Classification for Bronchoscopic Findings for Diagnosis of Peripheral Pulmonary Tumour.

Respiration 2021 Apr 9:1-10. Epub 2021 Apr 9.

Department of Thoracic and Cardiovascular Surgery, Osaka Medical College, Takatsuki, Japan.

Background: Normal bronchial epithelium has been described in terms of transparency and smoothness. No studies have compared bronchoscopic and pathological findings in the identification of bronchial epithelium.

Objectives: This study aimed to classify bronchoscopic findings for peripheral pulmonary tumour (PPT) for accurate bronchoscopic diagnosis accounting for the presences of bronchial epithelium and bronchial stenosis using an ultrathin bronchoscope. Read More

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LINE-1 Methylation Mediates the Inverse Association Between Body Mass Index and Breast Cancer Risk: a pilot study in the Lebanese population.

Environ Res 2021 Apr 8:111094. Epub 2021 Apr 8.

International Agency for Research on Cancer, Lyon, France. Electronic address:

Introduction: Lebanon is among the top countries worldwide in combined incidence and mortality of breast cancer, which raises concern about risk factors peculiar to this country. The underlying molecular mechanisms of breast cancer require elucidation, particularly epigenetics, which is recognized as a molecular sensor to environmental exposures.

Purpose: We aim to explore whether DNA methylation levels of AHRR (marker of cigarette smoking), SLC1A5 and TXLNA (markers of alcohol consumption), and LINE-1 (a genome-wide repetitive retrotransposon) can act as molecular mediators underlying putative associations between breast cancer risk and pertinent extrinsic (tobacco smoking and alcohol consumption) and intrinsic factors [age and body mass index (BMI)]. Read More

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Healthy Aging-Nutrition Matters: Start Early and Screen Often.

Adv Nutr 2021 Apr 10. Epub 2021 Apr 10.

Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA.

The amount of time spent in poor health at the end of life is increasing. This narrative review summarizes consistent evidence indicating that healthy dietary patterns and maintenance of a healthy weight in the years leading to old age are associated with broad prevention of all the archetypal diseases and impairments associated with aging including: noncommunicable diseases, sarcopenia, cognitive decline and dementia, osteoporosis, age-related macular degeneration, diabetic retinopathy, hearing loss, obstructive sleep apnea, urinary incontinence, and constipation. In addition, randomized clinical trials show that disease-specific nutrition interventions can attenuate progression-and in some cases effectively treat-many established aging-associated conditions. Read More

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Characterizing Immune-Mediated Cytopenias After Allogeneic Hematopoietic Cell Transplantation for Pediatric Nonmalignant Disorders.

Transplant Cell Ther 2021 Apr 20;27(4):316.e1-316.e8. Epub 2021 Jan 20.

University of Minnesota, Department of Pediatric Blood and Marrow Transplant; Minneapolis, MN, USA. Electronic address:

Immune-mediated cytopenias (IMC)-isolated or combined hemolytic anemia, thrombocytopenia, or neutropenia-are increasingly recognized as serious complications after allogeneic hematopoietic cell transplantation (HCT) for nonmalignant disorders (NMD). However, IMC incidence, duration, response to therapy, and risk factors are not well defined. This retrospective chart review identified cases of IMC with serologic confirmation among patients who underwent HCT for NMD at a single institution between 2010 and 2017. Read More

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Quantification of the misidentification of Plasmodium knowlesi as Plasmodium malariae by microscopy: an analysis of 1569 P. knowlesi cases.

Malar J 2021 Apr 9;20(1):179. Epub 2021 Apr 9.

Medical Technology, School of Allied Health Sciences, Walailak University, Tha Sala, Nakhon Si Thammarat, Thailand.

Background: Plasmodium knowlesi is recognized as the fifth Plasmodium species causing malaria in humans. It is morphologically similar to the human malaria parasite Plasmodium malariae, so molecular detection should be used to clearly discriminate between these Plasmodium species. This study aimed to quantify the rate at which P. Read More

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The impact of Covid-19 on patients with suspected cancer: An analysis of ED presentation and referrals to a quick diagnosis unit.

Am J Emerg Med 2021 Apr 2;48:1-11. Epub 2021 Apr 2.

Department of Internal Medicine, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, 08036 Barcelona, Spain.

Purpose: Patients evaluated in the emergency department (ED) who have concerning symptoms suggestive of a cancer diagnosis are mostly referred to the quick diagnosis unit of our tertiary hospital. This study analyzed the impact of the Covid-19 pandemic on the volume, disease patterns, and accessibility to essential investigations of patients with suspected cancer referred by the ED to this unit.

Methods: Trends in referrals were analyzed from January 1 to July 8, 2020 and the corresponding dates of 2019. Read More

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Analysis of the Time-To-Onset and Factors Affecting Clinical Outcomes of Immune Reconstitution Inflammatory Syndrome in People Living with HIV Using Data from the Japanese Spontaneous Reporting Database.

J Pharm Pharm Sci 2021 ;24:153-160

Purpose: Data on immune reconstitution inflammatory syndrome (IRIS), despite being a widely recognized complication of antiretroviral therapy, remain limited. The objective of the present study was to evaluate the time-to-onset and factors affecting clinical outcomes of IRIS in people living with HIV (PLWH) using data from the Japanese Adverse Drug Event Report (JADER) database.

Methods: Data of PLWH who developed IRIS as an adverse event were extracted from the JADER database. Read More

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January 2021

Tophaceous Gout - When the Skin Comes First.

Acta Dermatovenerol Croat 2020 Dec;28(7):223-227

Professor Carmen Salavastru, MD, PhD, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania;

Gout represents a metabolic disorder with systemic echo, in which needle-like crystals of monosodium urate are deposited in various tissular structures. Crystals accumulation in the connective tissue (tophi) represents the late, chronic stage of this disease, usually emerging after an average of 10 years after disease onset. Herein we report three cases of patients aged 70, 33, and 53 who presented with painful subcutaneous nodules located on various body areas. Read More

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December 2020

Atypical presentation of immunoglobulin G4-related disease as subglottic stenosis: a case-based review.

Rheumatol Int 2021 Apr 8. Epub 2021 Apr 8.

Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, Avda. Valdecilla s/n, 39008, Santander, Spain.

Background: Immunoglobulin G4-related disease (IgG4-RD) is a recently recognized fibro-inflammatory pathology that has been reported to affect principally the retroperitoneum, hepatobiliary system, salivary glands, orbital structures or lymph nodes. However, IgG4-RD with laryngeal involvement is a very rare entity. Our aims were to describe a case of subglottic stenosis as first and only manifestation of IgG4-RD and review the literature. Read More

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Anatomic Variations and Malformations as Rare Causes of Median Nerve Compression in Adults: A Narrative Review.

Ann Plast Surg 2021 Mar 24. Epub 2021 Mar 24.

From the Department of Plastic and Reconstructive Surgery, Radboud University Medical Center Department of Plastic Surgery, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands.

Objective: The median nerve can become compressed at multiple points in the arm, causing carpal tunnel-, pronator-, anterior interosseous-, or lacertus syndrome. Anatomical variations are potential reasons of persisting or recurrent symptoms of median nerve compression and are often recognized late. The objective of this study is to provide a comprehensive list of rare anatomical variations and malformations causing median nerve compression. Read More

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Language barrier as a risk factor for obstetric anal sphincter injury - a Case-Control Study.

J Gynecol Obstet Hum Reprod 2021 Apr 5:102138. Epub 2021 Apr 5.

Service de Gynécologie Obstétrique et Médecine de la Reproduction, AP-HP Sorbonne Université site Tenon, 4 rue de la Chine, 75020 Paris, France.

Introduction: The incidence of grade 3-4 perineal tears, also known as obstetric anal sphincter injury (OASI), is reported to be between 0.5 and 2.5%. Read More

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