84,326 results match your criteria recognition disorders

Narrative recognition and identification: a qualitative pilot study into reading literary texts with advanced cancer patients.

J Cancer Surviv 2021 Jun 15. Epub 2021 Jun 15.

Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam University Medical Centers, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands.

Purpose: Patients with advanced cancer can experience their disease as a contingent life event. The sudden interruption of their life stories can obscure life goals and disrupt meaning making. In the context of the research project "In search of stories," we aim to investigate the reading and discussion of selected stories which present ways of dealing with a contingent life event. Read More

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Combination of Biomedical Techniques and Paradigms to Improve Prognostications for Disorders of Consciousness.

Neurosci Bull 2021 Jun 15. Epub 2021 Jun 15.

National Laboratory of Pattern Recognition, Institute of Automation, The Chinese Academy of Sciences, Beijing, 100190, China.

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Headache Related to PPE Use during the COVID-19 Pandemic.

Curr Pain Headache Rep 2021 Jun 15;25(8):53. Epub 2021 Jun 15.

Division of Neurology, National University Hospital and Yong Loo Lin School of Medicine, National University of Singapore, NUHS Tower Block, Level 10, 1E Kent Ridge Road, Singapore, 119228, Singapore.

Purpose Of Review: Personal protection equipment (PPE)-associated headache is an unusual secondary headache disorder that predominantly occurs in healthcare workers as a consequence of the donning of protective respirators, face masks and/or eyewear. The appreciation of this entity is important given the significant ramifications upon the occupational health of healthcare workers and could additionally have an impact on persons living with pre-existing headache disorder(s).

Recent Findings: There has been a renewed interest and recognition of PPE-associated headaches amongst healthcare professionals, largely brought about by the ongoing COVID-19 pandemic which has besieged healthcare systems worldwide. Read More

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HoxD transcription factors define monosynaptic sensory-motor specificity in the developing spinal cord.

Development 2021 Jun 15;148(12). Epub 2021 Jun 15.

Neural Connectivity Development in Physiology and Disease Laboratory, Burke Neurological Institute, White Plains, NY 10605, USA.

The specificity of monosynaptic connections between proprioceptive sensory neurons and their recipient spinal motor neurons depends on multiple factors, including motor neuron positioning and dendrite morphology, axon projection patterns of proprioceptive sensory neurons in the spinal cord, and the ligand-receptor molecules involved in cell-to-cell recognition. However, with few exceptions, the transcription factors engaged in this process are poorly characterized. Here, we show that members of the HoxD family of transcription factors play a crucial role in the specificity of monosynaptic sensory-motor connections. Read More

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Plasma 1,3-beta-D-glucan levels predict adverse clinical outcomes in critical illness.

JCI Insight 2021 Jun 15. Epub 2021 Jun 15.

Department of Medicine, University of Pittsburgh Medical Center, School of Medicine, Pittsburgh, United States of America.

Background: The fungal cell-wall constituent 1,3-beta-D-glucan (BDG) is a pathogen-associated molecular pattern that can stimulate innate immunity. We hypothesized that BDG from colonizing fungi in critically-ill patients may translocate into the systemic circulation and be associated with host inflammation and outcomes.

Methods: We enrolled 453 mechanically-ventilated patients with acute respiratory failure (ARF) without invasive fungal infection and measured BDG, innate immunity and epithelial permeability biomarkers in serially collected plasma samples. Read More

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Constructing High-Fidelity Phenotype Knowledge Graphs for Infectious Diseases With a Fine-Grained Semantic Information Model: Development and Usability Study.

J Med Internet Res 2021 Jun 15;23(6):e26892. Epub 2021 Jun 15.

Suzhou Institute of Systems Medicine, Suzhou, China.

Background: Phenotypes characterize the clinical manifestations of diseases and provide important information for diagnosis. Therefore, the construction of phenotype knowledge graphs for diseases is valuable to the development of artificial intelligence in medicine. However, phenotype knowledge graphs in current knowledge bases such as WikiData and DBpedia are coarse-grained knowledge graphs because they only consider the core concepts of phenotypes while neglecting the details (attributes) associated with these phenotypes. Read More

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Microglia proliferation plays distinct roles in acquired epilepsy depending on disease stages.

Epilepsia 2021 Jun 15. Epub 2021 Jun 15.

Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.

Objective: Microgliosis occurs in animal models of acquired epilepsy and in patients. It includes cell proliferation that is associated with seizure frequency and decreased neuronal cells in human epilepsy. The role of microglia proliferation in the development of acquired epilepsy is unknown; thus, we examined its contribution to spontaneous seizure, neurodegeneration, and cognitive deficits in different disease phases. Read More

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Bone and Mineral Disease in Kidney Transplant Recipients.

Clin J Am Soc Nephrol 2021 Jun 14. Epub 2021 Jun 14.

T Nickolas, Division of Nephrology, Columbia University Irving Medical Center, New York, United States

After kidney transplantation mineral and bone disorders are associated with higher risk of fractures and consequent morbidity and mortality. Disorders of calcium and phosphorus, vitamin D deficiency and hyperparathyroidism are also common. The epidemiology of bone disease has evolved over the past several decades due to changes in immunosuppressive regimens, mainly glucocorticoid minimization or avoidance. Read More

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Challenges in Treating Tardive Dyskinesia: Assessing the Impact of Virtual Medical Education.

CNS Spectr 2021 Apr;26(2):165

Global Medical Education, New York, NY, USA.

Introduction: Tardive Dyskinesia (TD) refers to abnormal, involuntary, choreoathetoid movements of the tongue, lips, face, trunk, and extremities and is associated with long-term exposure to dopamine-blocking agents, such as antipsychotic medications. Once established, these movements usually persist. The movements are disfiguring and can bring unwanted attention to affected individuals. Read More

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Maple syrup urine disease: magnetic resonance imaging findings in three patients.

J Pak Med Assoc 2021 Apr;71(4):1309-1313

Department of Paediatrics and Child Health, Aga Khan University, Karachi, Pakistan.

Maple syrup urine disease (MSUD) is an autosomal recessive inherited metabolic disorder, caused by branched-chain alpha-ketoacid dehydrogenase (BCKD) deficiency, leading to toxic accumulation of branched-chain amino acids (BCAAs) including leucine, isoleucine and valine and their corresponding a-ketoacids. The diagnosis of MSUD is based on elevated BCAAs and allo-isoleucine in plasma, and branched-chain hydroxyacids and ketoacids in urine. The identification of alloisoleucine >5 µmol/L is considered pathognomonic. Read More

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Gut microbiota-CRAMP axis shapes intestinal barrier function and immune responses in dietary gluten-induced enteropathy.

EMBO Mol Med 2021 Jun 14:e14059. Epub 2021 Jun 14.

State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, China.

In the gut, cathelicidin-related antimicrobial peptide (CRAMP) has been largely described for its anti-infective activities. With an increasing recognition of its immune regulatory effects in extra-intestinal diseases, the role of CRAMP in gluten-induced small intestinal enteropathy celiac disease remains unknown. This study aimed to investigate the unexplored role of CRAMP in celiac disease. Read More

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Genetic approaches to understand cellular responses to oxygen availability.

FEBS J 2021 Jun 14. Epub 2021 Jun 14.

Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Jeffrey Cheah Biomedical Centre, Department of Medicine, University of Cambridge, Cambridge, CB2 0AW.

Oxygen-sensing mechanisms have evolved to allow organisms to respond and adapt to oxygen availability. In metazoans, oxygen-sensing is predominantly mediated by the Hypoxia Inducible Factors (HIFs). These transcription factors are stabilised when oxygen is limiting, activating genes involved in angiogenesis, cell growth, pH regulation and metabolism to reset cell function and adapt to the cellular environment. Read More

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The circuit of symbolic violence in chronic fatigue syndrome (CFS)/myalgic encephalomyelitis (ME) (I): A preliminary study.

Health Care Women Int 2021 Jun 14:1-36. Epub 2021 Jun 14.

Department of Sociology, Universitat Autònoma de Barcelona (Autonomous University of Barcelona), Bellaterra, Spain.

Objective: How can it be that a disease as serious as CFS affecting such a large number of people could be so unknown to the general population? The answer given to this question is based on Pierre Bourdieu's analyzes of symbolic violence.

Method: The "letters to the editor" by CFS patients to three national Spanish newspapers were subjected to various qualitative and quantitative analyzes.

Results: Based on the qualitative analyzes and their theoretical interpretation, 13 mechanisms of symbolic violence were identified: non-recognition, institutionalized un-care, condescension, authorized imposition of illegitimate verdicts, delegitimization, disintegration, imposition of discourse, euphemization, silencing, invisibilization, isolation, uncommunication, and self-blaming. Read More

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Trend of recognizing depression symptoms and antidepressants use in newly diagnosed Parkinson's disease: Population-based study.

Brain Behav 2021 Jun 14. Epub 2021 Jun 14.

Department of Clinical Pharmacy, College of Pharmacy, King Khalid University, Abha, Saudi Arabia.

Objectives: Although depression symptoms are common among patients with Parkinson's disease (PD), the medical literature still reports underrecognition of depression in patients with PD. Our main objective is to examine the trend of depression recognition during the first year of PD diagnosis using large population data.

Methods: We conducted a population-based study of residents in Wales, using the Secure Anonymized Information Linkage (SAIL) Databank. Read More

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Equine "Idiopathic" and Infundibular Caries-Related Cheek Teeth Fractures: A Long-Term Study of 486 Fractured Teeth in 300 Horses.

Front Vet Sci 2021 28;8:646870. Epub 2021 May 28.

The Royal (Dick) School of Veterinary Studies and The Roslin Institute, The University of Edinburgh, Edinburgh, United Kingdom.

Limited objective information is available on the prevalence of non-traumatic equine cheek teeth fractures, the signalment of affected horses, and the clinical features and treatment of these fractures. This study aims to document patterns of idiopathic and infundibular caries-related cheek teeth fractures in a referral population and evaluate associations between fracture patterns and horse age, Triadan position of affected teeth, clinical signs, and deemed necessity for treatment. A retrospective case review. Read More

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Outcomes in Juvenile-Onset Spondyloarthritis.

Front Med (Lausanne) 2021 28;8:680916. Epub 2021 May 28.

Departamento de Reumatologia, Hospital General de Mexico, Mexico City, Mexico.

Some studies have suggested children with juvenile onset spondyloarthritis (JoSpA) have a relatively poor outcome compared to other juvenile idiopathic arthritis (JIA) categories, in regards to functional status and failure to attain remission. Thus, in the interest of earlier recognition and risk stratification, awareness of the unique characteristics of this group is critical. Herein, we review the clinical burden of disease, prognostic indicators and outcomes in JoSpA. Read More

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Early Prediction of Sepsis in the ICU Using Machine Learning: A Systematic Review.

Front Med (Lausanne) 2021 28;8:607952. Epub 2021 May 28.

Machine Learning and Computational Biology Lab, Department of Biosystems Science and Engineering, Eidgenössische Technische Hochschule Zürich (ETH Zurich), Basel, Switzerland.

Sepsis is among the leading causes of death in intensive care units (ICUs) worldwide and its recognition, particularly in the early stages of the disease, remains a medical challenge. The advent of an affluence of available digital health data has created a setting in which machine learning can be used for digital biomarker discovery, with the ultimate goal to advance the early recognition of sepsis. To systematically review and evaluate studies employing machine learning for the prediction of sepsis in the ICU. Read More

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Invasive Mediastinal Mucormycosis with Pulmonary and Cardiac Involvement in an Adult with Chronic Granulomatous Disease: Case Report and Review of the Literature.

Eur J Case Rep Intern Med 2021 5;8(5):002435. Epub 2021 May 5.

Department of Critical Care Medicine at King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.

Mucormycosis is a rare fungal infection that often causes rhinocerebral disease. However, there have been rare cases of mediastinal involvement. These patients remain a therapeutic challenge and mortality in this group is very high. Read More

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Necrotizing Cellulitis and Myositis in a Neutropenic Leukemic Patient.

Cureus 2021 May 10;13(5):e14941. Epub 2021 May 10.

Internal Medicine, Moffitt Cancer Center, Tampa, USA.

In this article, we review a case of necrotizing cellulitis and myositis in a neutropenic leukemic patient. He underwent a series of investigations to reach the diagnosis of pyoderma gangrenosum (PG). The lesion improved dramatically after pertinent identification and initiation of appropriate treatment. Read More

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A near-infrared fluorescence probe for imaging of pantetheinase in cells and mice .

Chem Sci 2020 Sep 25;11(47):12802-12806. Epub 2020 Sep 25.

Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences Beijing 100190 China

Pantetheinase is an amidohydrolase that cleaves pantetheine into pantothenic acid and cysteamine. Functional studies have found that ubiquitous expression of this enzyme is associated with many inflammatory diseases. However, the lack of near-infrared fluorescence probes limits the better understanding of the functions of the enzyme. Read More

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September 2020

Anti-SARS-CoV-2 Natural Products as Potentially Therapeutic Agents.

Cheorl-Ho Kim

Front Pharmacol 2021 27;12:590509. Epub 2021 May 27.

Molecular and Cellular Glycobiology Unit, Department of Biological Sciences, Sungkyunkhwan University, Suwon, South Korea.

Severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2), a β-coronavirus, is the cause of the recently emerged pandemic and worldwide outbreak of respiratory disease. Researchers exchange information on COVID-19 to enable collaborative searches. Although there is as yet no effective antiviral agent, like tamiflu against influenza, to block SARS-CoV-2 infection to its host cells, various candidates to mitigate or treat the disease are currently being investigated. Read More

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A voting-based ensemble deep learning method focusing on image augmentation and preprocessing variations for tuberculosis detection.

Neural Comput Appl 2021 Jun 7:1-15. Epub 2021 Jun 7.

Computer Engineering Department, Ege University, Izmir, Turkey.

Tuberculosis (TB) is known as a potentially dangerous and infectious disease that affects mostly lungs worldwide. The detection and treatment of TB at an early stage are critical for preventing the disease and decreasing the risk of mortality and transmission of it to others. Nowadays, as the most common medical imaging technique, chest radiography (CXR) is useful for determining thoracic diseases. Read More

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A Young Woman with Excessive Fat in Lower Extremities Develops Disordered Eating and Is Subsequently Diagnosed with Anorexia Nervosa, Lipedema, and Hypermobile Ehlers-Danlos Syndrome.

Am J Case Rep 2021 Jun 14;22:e930840. Epub 2021 Jun 14.

Department of Endocrinology and Research, Total Lipedema Care, Los Angeles, CA, USA.

BACKGROUND Lipedema is a loose connective tissue disease that causes disproportionate subcutaneous fat accumulation on the extremities. As a result of the increased subcutaneous tissue accumulation, lipedema is often confused with obesity by both physicians and patients. Poor awareness and limited diagnosis of lipedema contribute to the confusion of lipedema with obesity and can lead to decreased body image acceptance. Read More

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Symptom perception management education improves self-care in patients with heart failure.

Work 2021 Jun 5. Epub 2021 Jun 5.

Centro de Investigação Interdisciplinar em Saúde-Porto, Instituto de Ciências da Saúde, Universidade Católica Portuguesa, Porto, Portugal.

Background: Patients with heart failure often have difficulty recognizing signs and symptoms of the disease, which delays seeking help, and therefore interferes with patient engagement and self-care management. Early detection of these symptoms could lead to care-seeking and avoid hospitalizations.

Objective: The purpose of this study was to design a complex intervention through a systematic literature review and qualitative study. Read More

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Research on Emotion Recognition and Dementias: Foundations and Prospects.

J Alzheimers Dis 2021 Jun 7. Epub 2021 Jun 7.

Departamento de Psicología Evolutiva y de la Educación, Universitat de Valencia, Spain.

Background: The study of emotion recognition could be crucial for detecting alterations in certain cognitive areas or as an early sign of neurological disorders.

Objective: The main objective of the study is to characterize research development on emotion recognition, identifying the intellectual structure that supports this area of knowledge, and the main lines of research attracting investigators' interest.

Methods: We identified publications on emotion recognition and dementia included in the Web of Science Core Collection, analyzing the scientific output and main disciplines involved in generating knowledge in the area. Read More

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Global Perspectives on Brief Cognitive Assessments for Dementia Diagnosis.

J Alzheimers Dis 2021 Jun 9. Epub 2021 Jun 9.

Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, USA.

Background: Timely diagnosis of dementia is a global healthcare priority, particularly in low to middle income countries where rapid increases in older adult populations are expected.

Objective: To investigate global perspectives on the role of brief cognitive assessments (BCAs) in dementia diagnosis, strengths and limitations of existing measures, and future directions and needs.

Methods: This is a qualitative study of 18 dementia experts from different areas of the world. Read More

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Acute splanchnic vein thrombosis in patients with COVID-19: A systematic review.

Dig Liver Dis 2021 May 26. Epub 2021 May 26.

Hepatology, Department for Visceral Surgery and Medicine, Bern University Hospital, University of Bern, Switzerland; Hepatology, Department of Biomedical Research, University of Bern, Bern, Switzerland. Electronic address:

There is increasing evidence that coronavirus disease 2019 (COVID-19) is associated with a significant risk of venous thromboembolism. While information are mainly available for deep vein thrombosis of the lower limb and pulmonary embolism, scarce data exist regarding acute splanchnic vein thrombosis (SVT) in this setting. PubMed, EMBASE and Google Scholar English-language articles published up to 30 January 2021 on SVT in COVID-19 were searched. Read More

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Tocilizumab in COVID-19: The Cerrahpaşa-PREDICT score.

J Infect Chemother 2021 May 12. Epub 2021 May 12.

Department of Infectious Diseases and Clinical Microbiology, Cerrahpaşa Faculty of Medicine, Istanbul University-Cerrahpaşa, Istanbul, Turkey.

Background: Cytokine release syndrome (CRS), characterized by overproduction of proinflammatory cytokines in the course of severe coronavirus disease 2019 (COVID-19), has been suggested as the major cause of mortality. Tocilizumab, a recombinant humanized monoclonal antibody against human IL-6 receptor, poses a therapeutic option for the treatment of CRS leading to severe acute respiratory syndrome in coronavirus-2 (SARS-CoV-2) infection.

Methods: We performed a single-center retrospective study to reveal the outcome of COVID-19 patients on tocilizumab and proposed "the Cerrahpaşa-PREDICT score", a new clinical scoring system using clinical and laboratory parameters that would help predicting the 28-day mortality of COVID-19 patients receiving tocilizumab. Read More

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Recognition and management of rapid-onset gluten ataxias: case series.

Cerebellum Ataxias 2021 Jun 13;8(1):16. Epub 2021 Jun 13.

Academic department of neurosciences, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.

Background: Most immune-mediated cerebellar ataxias, including those associated with gluten sensitivity (Gluten Ataxia), tend to present subacutely and usually progress gradually. Acute presentations with rapid progression outside the context of paraneoplastic cerebellar degeneration require prompt diagnosis and early access to disease-modifying immunotherapy in order to avert severe and permanent neurological disability.

Case Presentations: We describe three cases of rapid-onset Gluten Ataxia, an immune-mediated cerebellar ataxia due to gluten sensitivity. Read More

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