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Mouse Adenovirus Type 1 Persistence Exacerbates Inflammation Induced by Allogeneic Bone Marrow Transplantation.

J Virol 2022 Jan 19:JVI0170621. Epub 2022 Jan 19.

Department of Pediatrics, University of Michigan, Ann Arbor, Michigan.

Bone marrow transplantation (BMT) recipients are at risk for substantial morbidity and mortality from human adenovirus infections, often in the setting of reactivation of persistent virus. Human adenovirus persistence in mucosal lymphocytes has been described, but specific cellular reservoirs of persistence and effects of persistence on host responses to unrelated stimuli are not completely understood. We used mouse adenovirus type 1 (MAV-1) to characterize persistence of an adenovirus in its natural host and test the hypothesis that persistence increases complications of bone marrow transplantation (BMT). Read More

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January 2022

How does long-term care impact the psychological wellbeing of older adults in different care policy contexts in the Netherlands?: A comparison of 1998, 2008 and 2018: A comparison of 1998, 2008 and 2018.

Health Soc Care Community 2022 Jan 17. Epub 2022 Jan 17.

Department of Sociology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

Receipt of long-term care (LTC) is generally associated with worse psychological wellbeing for community-dwelling older adults. In addition to objective features of care use (e.g. Read More

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January 2022

Prevalence and factors associated with hyperkalaemia in stable kidney transplant recipients.

Clin Kidney J 2022 Jan 10;15(1):43-50. Epub 2021 Jul 10.

Clinic of Nephrology and Renal Transplantation, Laiko General Hospital, National and Kapodistrian University, Medical School of Athens, Athens, Greece.

Background: Hyperkalaemia is a frequent and potentially life-threatening condition in patients with chronic kidney disease (CKD). Even after successful kidney transplantation (KTx), KTx recipients have mild to severe CKD. Moreover, they share comorbid conditions and frequently use medications that predispose to hyperkalaemia. Read More

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January 2022

Immune Thrombocytopenia in a Kidney Transplant Recipient Treated with Romiplostim.

Am J Med Sci 2022 Jan 7;363(1):69-74. Epub 2020 Dec 7.

Department of Nephrology, Hypertension and Transplant Medicine, Augusta University Health, Augusta, GA, USA.

We present a case of immune thrombocytopenia following a living donor kidney transplant. Thrombocytopenia started two days after transplant and continued up to seven weeks after transplant, despite an extensive workup, treatment with steroids, intravenous immune globulin, and alterations in immunosuppression and other medications. In the absence of platelet transfusions, the patient's platelet count remained < 20,000/mm. Read More

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January 2022

Graft fibrosis over 10 to 15 years in pediatric liver transplant recipients: Multi-center study of paired, longitudinal surveillance biopsies.

Liver Transpl 2022 Jan 13. Epub 2022 Jan 13.

Department of Surgery, University of California San Francisco, San Francisco, CA, USA.

Background: Previous single-center, cross-sectional studies have reported a steep increase in the prevalence and severity of fibrosis through 10-15 years after pediatric liver transplantation. We report a multi-center study of paired surveillance biopsies in a contemporary cohort.

Methods: Children who underwent liver transplant at <6 years old and had paired surveillance liver biopsies were enrolled (n=78, 35% female, median 1. Read More

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January 2022

Non-typeable Haemophilus influenzae-Moraxella catarrhalis vaccine for the prevention of exacerbations in chronic obstructive pulmonary disease: a multicentre, randomised, placebo-controlled, observer-blinded, proof-of-concept, phase 2b trial.

Lancet Respir Med 2022 Jan 10. Epub 2022 Jan 10.

Centre de Recherche, l'Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval, QC, Canada.

Background: Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are associated with changes in the sputum microbiome, including an increased prevalence of pathogenic bacteria. Vaccination against the most frequent bacteria identified in AECOPD might reduce exacerbation frequency. We assessed the efficacy, safety, and immunogenicity of a candidate vaccine containing surface proteins from non-typeable Haemophilus influenzae (NTHi) and Moraxella catarrhalis (Mcat) in patients with COPD. Read More

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January 2022

Biological Variation of Donor-Derived Cell-Free DNA in Stable Lung Transplant Recipients.

J Appl Lab Med 2022 Jan 12. Epub 2022 Jan 12.

Laboratory of Applied Precision Omics (APO) and Genomic Research Alliance for Transplantation (GRAfT), National Institutes of Health, Bethesda, MD, USA.

Background: Prior studies demonstrate that donor-derived cell-free DNA (dd-cfDNA) in lung transplant recipients may serve as a marker of allograft injury for detecting allograft rejection and infection. Clinical interpretation of dd-cfDNA requires understanding its biological variation in stable lung transplant patients in order to identify abnormal results suggesting underlying allograft dysfunction. This study establishes the biological variation and reference change values (RCV) of dd-cfDNA in stable lung transplant recipients using an analytically validated assay with an established analytic coefficient of variation (CVA). Read More

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January 2022

Elevated number of IL-21+ TFH and CD86+CD38+ B cells in blood of renal transplant recipients with AMR under conventional immuno-suppression.

Int J Immunopathol Pharmacol 2022 Jan-Dec;36:20587384211048027

Key Laboratory of Organ Regeneration & Transplantation of the Ministry of Education, Genetic Diagnosis Center, 117971The First Hospital of Jilin University, Changchun, China.

The objective of this study is to detect the number of different subsets of TFH and B cells in renal transplant recipients (RTR) with antibody-mediated acute rejection (AMR), acute rejection (AR), chronic rejection (CR), or transplant stable (TS). The present study was a prospective study. The numbers of ICOS +, PD-1+ and IL-21+ TFH, CD86+, CD38+, CD27+, and IgD- B cells in 21 patients with end-stage renal disease (ESRD) and post-transplant times were measured by flow cytometry. Read More

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January 2022

Usefulness of the MAGGIC Score in Predicting the Competing Risk of Non-Sudden Death in Heart Failure Patients Receiving an Implantable Cardioverter-Defibrillator: A Sub-Analysis of the OBSERVO-ICD Registry.

J Clin Med 2021 Dec 27;11(1). Epub 2021 Dec 27.

Cardiology and Arrhythmology Clinic, Marche Polytechnic University, 60121 Ancona, Italy.

The role of prognostic risk scores in predicting the competing risk of non-sudden death in heart failure patients with reduced ejection fraction (HFrEF) receiving an implantable cardioverter-defibrillator (ICD) is unclear. To this goal, we evaluated the accuracy and usefulness of the Meta-Analysis Global Group in Chronic Heart Failure (MAGGIC) score. The present analysis included 1089 HFrEF ICD recipients enrolled in the OBSERVO-ICD registry (NCT02735811). Read More

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December 2021

Interaction between ischemic time and donor age under the new donor heart allocation system: Effect on post-transplant survival.

Clin Transplant 2022 Jan 7:e14584. Epub 2022 Jan 7.

Department of Cardiac Surgery, Tufts Medical Center, Boston, Massachusetts, USA.

Background: Ischemic time (IT) under the new heart transplant (HTx) allocation system has increased compared to the old system. We investigated the effect of IT and donor age on post-HTx survival.

Methods: The United Network for Organ Sharing (UNOS) database was analyzed to identify adult HTx between October 2015 and August 2020. Read More

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January 2022

Analysis of HIV quasispecies and virological outcome of an HIV D+/R+ kidney-liver transplantation.

Virol J 2022 Jan 6;19(1). Epub 2022 Jan 6.

Virology Unit, National Institute for Infectious Diseases, I.R.C.C.S. L.Spallanzani, Via Portuense, 292, 00149, Rome, Italy.

Introduction: Transplantation among HIV positive patients may be a valuable therapeutic intervention. This study involves an HIV D+/R+ kidney-liver transplantation, where PBMC-associated HIV quasispecies were analyzed in donor and transplant recipients (TR) prior to transplantation and thereafter, together with standard viral monitoring.

Methods: The donor was a 54 year of age HIV infected woman: kidney and liver recipients were two HIV infected men, aged 49 and 61. Read More

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January 2022

CD45-targeted antibody-drug-conjugate successfully conditions for allogeneic hematopoietic stem cell transplantation.

Blood 2022 Jan 5. Epub 2022 Jan 5.

University of Minnesota, Minneapolis, Minnesota, United States.

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative treatment for patients with non-malignant or malignant blood disorders. Its success has been limited by graft-versus-host disease (GVHD). Current genotoxic conditioning regimens mediate tissue injury and potentially incite and amplify GVHD, limiting use of this potentially curative treatment beyond malignant disorders. Read More

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January 2022

Expression of Programmed Cell Death 1 and Helios Genes Correlates With rs872071A>G and rs12203592C>T Single-Nucleotide Polymorphisms of InterferonRegulatory Factor 4 in Patients with T-Cell-Mediated Rejection of Renal Allograft.

Exp Clin Transplant 2022 Jan 3. Epub 2022 Jan 3.

From the Nephrology Research Center, Imam Khomeini hospital, Tehran University of Medical Sciences, Tehran, Iran.

Objectives: Acute T-cell-mediated rejection of the renal allograft is a serious posttransplant challenge that requires administration of high-dose immunosuppressive drugs with considerable side effects; therefore, specific targeting of T-cell responses may improve both prevention and treatment of T-cell-mediated rejection. A potential candidate for this purpose is interferon regulatory factor 4 because of its implication in differentiation and function of T cells. Our aim was to evaluate the frequency of the rs872071A>G and rs12203592C>T single-nucleotide polymorphisms of the interferon regulatory factor 4 gene and association of these 2 polymorphisms with the gene expression of programmed cell death 1 and Helios in patients with T-cell-mediated rejection versus stable recipients. Read More

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January 2022

Machine Retrograde Perfusion of Deceased Donor Kidneys: A Prospective Study.

Front Med (Lausanne) 2021 17;8:785953. Epub 2021 Dec 17.

Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.

To maximize the utilization of potential kidneys, improving perfusion and preservation techniques is necessary. We investigated the safety and efficacy of retrograde machine perfusion of kidneys from deceased donors. A total of 30 kidneys were included and all the grafts were preserved in the Kidney Transporter machines. Read More

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December 2021

Soluble Tim-3/Gal-9 as predictors of adverse outcomes after kidney transplantation: A cohort study.

Clin Biochem 2021 Dec 27. Epub 2021 Dec 27.

Department of Laboratory Medicine, West China Hospital, Sichuan University, No. 37 Guoxue Xiang, Wuhou District, Chengdu, Sichuan, China. Electronic address:

Background: In our previous study, serum soluble T-cell immunoglobulin and mucin structure-3 (sTim-3) and galactosin-9 (sGal-9) were found to be associated with renal function after kidney transplantation. However, it is unclear whether these two indicators can predict adverse outcomes after transplantation.

Methods: Ninety-one recipients of kidney transplantation were enrolled and divided into a stable group and an adverse outcome group (consisting of biopsy-proven rejection, graft loss, death and clinically diagnosed rejection). Read More

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December 2021

Proportion versus absolute counts of B cell populations in the assessment of immunological profiles of kidney transplant recipients.

Transpl Immunol 2022 Feb 24;70:101519. Epub 2021 Dec 24.

Transplantation Unit, Renal Division, Department of Medicine, University Health Center of Quebec, Faculty of Medicine, Laval University, Québec, QC, Canada. Electronic address:

Immunophenotyping lymphocytes in kidney transplant recipients often raises questions as to whether proportions or absolute counts should be considered, especially for longitudinal assessment. Several studies conclude the pathophysiology of rejection based on proportions of naive and memory B cells. We compared the two analytical methods for B cells sampled from 82 clinically stable, adult kidney transplant recipients. Read More

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February 2022

The diagnostic role of PD-1 CXCR5 follicular helper CD8 T cell in renal allograft dysfunction.

J Clin Lab Anal 2021 Dec 26:e24200. Epub 2021 Dec 26.

Department of Laboratory Medicine, West China Hospital, Sichuan University, Sichuan University, Chengdu, Sichuan Province, China.

Background: The roles of PD-1 CXCR5 follicular helper CD8 T cell were reported in different disease conditions, but their roles in transplantation are unclear. In this study, the association between PD-1 CXCR5 follicular helper CD8 T cell and renal allograft dysfunction in kidney transplant recipients (KTRs) was investigated.

Methods: 82 KTRs were enrolled in this study. Read More

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December 2021

Viruses, friends and foes: The case of Torque Teno virus and the net state of immunosuppression.

Transpl Infect Dis 2021 Dec 21. Epub 2021 Dec 21.

Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Madrid, Spain.

New reliable biomarkers are needed to improve individual risk assessment for post-transplant infection, acute graft rejection and other immune-related complications after solid organ transplantation (SOT) and allogeneic hematopoietic stem cell transplantation (allo-HSCT). One promising strategy relies on the monitoring of replication kinetics of virome components as functional surrogate for the net state of immunosuppression. Torque Teno Virus (TTV) is a small, non-enveloped, circular, single-stranded DNA anellovirus with no attributable pathological effects. Read More

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December 2021

Pregnancy After Simultaneous Pancreas-Kidney Transplantation in Treatment of End-Stage Diabetes Mellitus: a Review.

Z Geburtshilfe Neonatol 2021 Dec 21. Epub 2021 Dec 21.

Emergency Department, Dubrava Clinical Hospital, Zagreb, Croatia.

The majority of patients with simultaneous pancreas and kidney transplant (SPKT) required transplantation owing to a long-standing history of insulin-dependent diabetes mellitus (IDDM). The disease causes multiple organ damage, impairs fertility, and affects quality of life. A successful kidney and pancreas transplant can improve health, ameliorate the consequences of pre-existent diabetes, and restore fertility. Read More

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December 2021

Morbidity, Prognostic Factors, and Competing Risk Nomogram for Combined Hepatocellular-Cholangiocarcinoma.

J Oncol 2021 10;2021:3002480. Epub 2021 Dec 10.

School of Medicine, Southeast University, Nanjing, China.

Background: Combined hepatocellular-cholangiocarcinoma (CHC) is a rare and heterogeneous histological subtype of primary liver cancer, which is still poorly understood. This study aimed to describe the epidemiological and clinical features, investigate the prognostic indicators, and develop a competing risk nomogram for CHC.

Methods: The study cohort was taken from the Surveillance, Epidemiology, and End Results database. Read More

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December 2021

Medicaid long-term care workforce training intervention and value-based payment metrics.

Health Serv Res 2021 Dec 18. Epub 2021 Dec 18.

Center for Home Care Policy & Research, Visiting Nurse Service of New York, New York, New York, USA.

Objective: To examine the impact of a scaled implementation of workforce training intervention on value-based payment measures in a large home-based Medicaid managed long-term care plan population in New York.

Data Sources: Managed long-term care clients' health assessments from the Uniform Assessment System of New York merged with paid claims, home health aide operational visit data, and workforce training rosters between 2018 and early-2020.

Study Design: A quasi-experimental design was used. Read More

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December 2021

Safety and metabolic advantages of steroid withdrawal after 6 months posttransplant in de novo kidney transplantation: A 1-year prospective cohort study.

Immun Inflamm Dis 2021 Dec 15. Epub 2021 Dec 15.

Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, South Korea.

Introduction: This prospective multicenter study aimed at investigating the safety and metabolic advantages of steroid withdrawal (SW) therapy in kidney transplant recipients with tacrolimus-mycophenolate mofetil-based immunosuppression.

Methods: We analyzed 179 recipients who received kidney transplantation from March 2016 and September 2018. In 179 recipients, 114 patients maintained an immunosuppressive regimen including steroids (steroid continuation [SC] group). Read More

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December 2021

Porcine Liver Normothermic Machine Perfusion: Methodological Framework and Potential Pitfalls.

Transplant Direct 2022 Jan 13;8(1):e1276. Epub 2021 Dec 13.

Department of Microbiology, Immunology, and Transplantation, Lab of Abdominal Transplantation, Transplantation Research Group, KU Leuven, Leuven, Belgium.

Porcine models of liver normothermic machine perfusion (NMP) are increasingly used in transplant research, although known to be challenging because of their complex methodology and their scarcely documented operational aspects. Here, we aimed to provide a methodological framework for researchers looking to adopt NMP technology in research setting by giving an in-detail account of the implementation of a previously validated porcine liver NMP model. We subjected groups of 3-5 porcine livers to 24 h NMP and, using a trial-and-error principle, introduced stepwise changes in the NMP setting with the objective to obtain stable preservation of liver function and histology for 24 h. Read More

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January 2022

Cytokine autoantibodies are stable throughout the haematopoietic stem cell transplantation course and are associated with distinct biomarker and blood cell profiles.

Sci Rep 2021 12 14;11(1):23971. Epub 2021 Dec 14.

Department of Clinical Immunology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

Cytokine-specific autoantibodies (c-aAbs) represent an emerging field in endogenous immunodeficiencies, and the immunomodulatory potential of c-aAbs is now well documented. Here, we investigated the hypothesis that c-aAbs affects inflammatory, immunoregulatory and injury-related processes and hence the clinical outcome of haematopoietic stem cell transplantation (HSCT). C-aAbs against IL-1α, IL-6, IL-10, IFNα, IFNγ and GM-CSF were measured in 131 HSCT recipients before and after (days + 7, + 14, + 28) HSCT and tested for associations with 33 different plasma biomarkers, leukocyte subsets, platelets and clinical outcomes, including engraftment, GvHD and infections. Read More

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December 2021

A randomized crossover study comparing different tacrolimus formulations to reduce intrapatient variability in tacrolimus exposure in kidney transplant recipients.

Clin Transl Sci 2021 Dec 14. Epub 2021 Dec 14.

Internal Medicine, Division of Nephrology and Transplantation, Erasmus University Medical Center, Rotterdam, The Netherlands.

A high intrapatient variability (IPV) in tacrolimus exposure is a risk factor for poor long-term outcomes after kidney transplantation. The main objective of this trial was to investigate whether tacrolimus IPV decreases after switching patients from immediate-release (IR)-tacrolimus to either extended-release (ER)-tacrolimus or LifeCyclePharma (LCP)-tacrolimus. In this randomized, prospective, open-label, cross-over trial, adult kidney transplant recipients on a stable immunosuppressive regimen, including IR-tacrolimus, were randomized for conversion to ER-tacrolimus or LCP-tacrolimus, and for the order in which IR-tacrolimus and the once-daily formulations were taken. Read More

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December 2021

An epigenetic switch activates bacterial quorum sensing and horizontal transfer of an integrative and conjugative element.

Nucleic Acids Res 2021 Dec 14. Epub 2021 Dec 14.

Department of Microbiology and Immunology, University of Otago, Dunedin, 9016, New Zealand.

Horizontal transfer of the integrative and conjugative element ICEMlSymR7A converts non-symbiotic Mesorhizobium spp. into nitrogen-fixing legume symbionts. Here, we discover subpopulations of Mesorhizobium japonicum R7A become epigenetically primed for quorum-sensing (QS) and QS-activated horizontal transfer. Read More

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December 2021

Grazoprevir/Elbasvir treatment in liver or kidney transplant recipients with genotype-1b hepatitis C virus infection.

Antimicrob Agents Chemother 2021 Dec 13:AAC0200321. Epub 2021 Dec 13.

School of Medicine, Chung Shan Medical University, Taichung, Taiwan.

More options regarding the choice of direct-acting antivirals (DAAs) are helpful for avoiding individual limitations in treating hepatitis C virus (HCV) infection. We aimed to assess the efficacy and tolerability of grazoprevir (GZR)/elbasvir (EBR) treatment in genotype-1b (GT-1b) HCV-infected liver or kidney transplant recipients. In this phase 4, single-arm, open-label, multicenter trial, patients received GZR 100mg/EBR 50mg daily for 12 weeks. Read More

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December 2021

Incident Care Trajectories for Older Adults with and without Dementia.

J Gerontol B Psychol Sci Soc Sci 2021 Dec 10. Epub 2021 Dec 10.

Johns Hopkins Bloomberg School of Public Health.

Objective: Despite cross-sectional evidence that persons living with dementia receive disproportionate hours of care, studies of how care intensity progresses over time and differs for those living with and without dementia have been lacking.

Methods: We used the 2011-2018 National Health and Aging Trends Study to estimate growth mixture models to identify incident care hour trajectories ("classes") among older adults (N=1,780).

Results: We identified four incident care hour classes: "Low, stable," "High, increasing," "24/7 then high, stable," and "Low then resolved. Read More

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December 2021

Monitoring intracellular tacrolimus concentrations and its relationship with rejection in the early phase after renal transplantation.

Clin Biochem 2021 Dec 8. Epub 2021 Dec 8.

Department of Internal Medicine, Division of Nephrology and Transplantation, Erasmus MC, University Medical Center Rotterdam, the Netherlands; Erasmus MC Transplant Institute, the Netherlands.

Introduction: After kidney transplantation, rejection and drug-related toxicity occur despite tacrolimus whole-blood pre-dose concentrations ([Tac]) being within the target range. The tacrolimus concentration within peripheral blood mononuclear cells ([Tac]) might correlate better with clinical outcomes. The aim of this study was to investigate the correlation between [Tac] and [Tac] the evolution of [Tac] and the [Tac]/[Tac] ratio, and to assess the relationship between tacrolimus concentrations and the occurrence of rejection. Read More

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December 2021

Donor Death Category Is an Effect Modifier Between Cold Ischemia Time and Post-transplant Graft Function in Deceased-Donor Kidney Transplant Recipients.

Front Med (Lausanne) 2021 23;8:743085. Epub 2021 Nov 23.

Department of Kidney Transplantation, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

We aimed to analyze the effect of cold ischemia time (CIT) on post-transplant graft function through mixed-effect model analysis to reduce the bias caused by paired mate kidneys. We reviewed all kidney transplantation records from 2015 to 2019 at our center. After applying the exclusion criteria, 561 cases were included for analysis. Read More

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November 2021