141,340 results match your criteria receptors involved


Chemical signaling regulates axon regeneration via the GPCR-Gqα pathway in .

J Neurosci 2021 Dec 2. Epub 2021 Dec 2.

Division of Biological Science, Graduate School of Science, Nagoya University, Chikusa-ku, Nagoya 464-8602, Japan

Chemical communication controls a wide range of behaviors via conserved signaling networks. Axon regeneration in response to injury is determined by the interaction between the extracellular environment and intrinsic growth potential. In this study, we investigated the role of chemical signaling in axon regeneration in We find that the enzymes involved in ascaroside pheromone biosynthesis, ACOX-1. Read More

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December 2021

CCL2/ACKR2 interaction participate in breast cancer metastasis especially in patients with altered lipid metabolism.

Med Hypotheses 2021 Nov 9;158:110734. Epub 2021 Nov 9.

Department of Breast Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, China. Electronic address:

Breast cancer is the most prevalent cancer worldwide and metastasis accounts for the majority of associated deaths. Altered lipid metabolism has been proved to be involved with breast cancer, yet the underlying mechanism in lipid metabolism mediated metastasis in breast cancer remains inadequately understood. Evidence have indicated that adipocytes can produce chemokine ligand 2 (CCL2), and several studies have shown that tumor metastasis and patient survival is associated with atypical chemokine receptors/chemokine decoy receptors. Read More

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November 2021

Role of TRP Ion Channels in Pruritus.

Neurosci Lett 2021 Nov 30:136379. Epub 2021 Nov 30.

Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA; Comparative Medicine Institute, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA; The WM Keck Behavioral Center, North Carolina State University, Raleigh, NC, USA; Program in Genetics, North Carolina State University, Raleigh, NC, USA. Electronic address:

The transient receptor potential (TRP) channel superfamily responds to various physical, chemical, and environmental stimuli including the detection of sensations both harmful and non-harmful. Among these sensations is pruritus, or itch. There are at least 27 different TRP channels and about six of them are involved in pruriception. Read More

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November 2021

Dual-agonist incretin peptides from fish with potential for obesity-related Type 2 diabetes therapy - a review.

Peptides 2021 Nov 30:170706. Epub 2021 Nov 30.

Diabetes Research Group, School of Biomedical Sciences, Ulster University, Cromore Road, Coleraine, BT52 1SA, Northern Ireland, UK.

The long-acting glucagon-like peptide-1 receptor (GLP1R) agonist, semaglutide and the unimolecular glucose-dependent insulinotropic polypeptide receptor (GIPR)/GLP1R dual-agonist, tirzepatide have been successfully introduced as therapeutic options for patients with Type-2 diabetes (T2DM) and obesity. Proglucagon-derived peptides from phylogenetically ancient fish act as naturally occurring dual agonists at the GLP1R and the glucagon receptor (GCGR) with lamprey GLP-1 and paddlefish glucagon being the most potent and effective in stimulating insulin release from BRIN-BD11 clonal β-cells. These peptides were also the most effective in lowering blood glucose and elevating plasma insulin concentrations when administered intraperitoneally to overnight-fasted mice together with a glucose load. Read More

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November 2021

The role of melatonin in the molecular mechanisms underlying metaflammation and infections in obesity: A narrative review.

Obes Rev 2021 Dec 3:e13390. Epub 2021 Dec 3.

Dipartimento di Medicina Clinica e Chirurgia, Sezione di Endocrinologia, Università Federico II di Napoli, Naples, Italy.

Obesity is a chronic condition whose management is a critical challenge for physicians. The scientific community has increased its focus on the molecular mechanisms involved in obesity etiopathogenesis to better manage patients with obesity and its associated complications. The tight connection between adipose tissue and the immune system has been demonstrated to play a crucial role in inflammation, and melatonin is important for circadian rhythm regulation and metabolic homeostasis, in which it orchestrates several molecular mechanisms involved in obesity and associated inflammation. Read More

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December 2021

Consolidation and maintenance of long-term memory involve dual functions of the developmental regulator Apterous in clock neurons and mushroom bodies in the Drosophila brain.

PLoS Biol 2021 Dec 3;19(12):e3001459. Epub 2021 Dec 3.

Department of Biological Sciences, Tokyo Metropolitan University, Tokyo, Japan.

Memory is initially labile but can be consolidated into stable long-term memory (LTM) that is stored in the brain for extended periods. Despite recent progress, the molecular and cellular mechanisms underlying the intriguing neurobiological processes of LTM remain incompletely understood. Using the Drosophila courtship conditioning assay as a memory paradigm, here, we show that the LIM homeodomain (LIM-HD) transcription factor Apterous (Ap), which is known to regulate various developmental events, is required for both the consolidation and maintenance of LTM. Read More

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December 2021

Estradiol promotes cell survival and induces Greb1 expression in granulosa cell tumors of the ovary through an ERα-dependent mechanism.

J Pathol 2021 Dec 3. Epub 2021 Dec 3.

Université de Paris, BFA, UMR 8251, CNRS, ERL U1133, Inserm, F-75013, Paris, France.

Granulosa cell tumor (GCT) is a form of ovarian tumor characterized by its tendency to recur years after surgical ablation. Little is known on the mechanisms involved in GCT development and progression. GCTs can produce estradiol (E2), but whether this hormone could play a role in this cancer through its nuclear receptors, i. Read More

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December 2021

G protein-coupled receptors that influence lifespan of human and animal models.

Biogerontology 2021 Dec 3. Epub 2021 Dec 3.

Department of Neuroscience, Functional Pharmacology, Uppsala University, Husargatan 3, BMC Box 593, 751 24, Uppsala, Sweden.

Humanity has always sought to live longer and for this, multiple strategies have been tried with varying results. In this sense, G protein-coupled receptors (GPCRs) may be a good option to try to prolong our life while maintaining good health since they have a substantial participation in a wide variety of processes of human pathophysiology and are one of the main therapeutic targets. In this way, we present the analysis of a series of GPCRs whose activity has been shown to affect the lifespan of animal and human models, and in which we put a special interest in describing the molecular mechanisms involved. Read More

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December 2021

CRMP4-mediated fornix development involves semaphorin-3E signaling pathway.

Elife 2021 Dec 3;10. Epub 2021 Dec 3.

Inserm, U1216, CEA, Grenoble Institut Neurosciences, University Grenoble Alpes, Grenoble, France.

Neurodevelopmental axonal pathfinding plays a central role in correct brain wiring and subsequent cognitive abilities. Within the growth cone, various intracellular effectors transduce axonal guidance signals by remodeling the cytoskeleton. Semaphorin-3E (Sema3E) is a guidance cue implicated in development of the fornix, a neuronal tract connecting the hippocampus to the hypothalamus. Read More

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December 2021

Identification of hub genes and transcription factors involved in periodontitis on the basis of multiple microarray analysis.

Hua Xi Kou Qiang Yi Xue Za Zhi 2021 Dec;39(6):633-641

Shanghai Engineering Research Center of Tooth Restoration and Regeneration; Dept. of Prosthodontics, School and Hospital of Stomatology, Tongji University, Shanghai 200072, China.

Objectives: To identify the differentially expressed genes (DEGs) during the pathogenesis of periodontitis by bioinformatics analysis.

Methods: GEO2R was used to screen DEGs in GSE10334 and GSE16134. Then, the overlapped DEGs were used for further analysis. Read More

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December 2021

The Transcriptional Differences of Avian CD4CD8 Double-Positive T Cells and CD8 T Cells From Peripheral Blood of ALV-J Infected Chickens Revealed by Smart-Seq2.

Front Cell Infect Microbiol 2021 10;11:747094. Epub 2021 Nov 10.

National and Regional Joint Engineering Laboratory for Medicament of Zoonosis Prevention and Control, Guangdong Provincial Key Laboratory of Zoonosis Prevention and Control, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.

It is well known that chicken CD8 T cell response is vital to clearing viral infections. However, the differences between T cell subsets expressing CD8 receptors in chicken peripheral blood mononuclear cells (PBMCs) have not been compared. Herein, we used Smart-Seq2 scRNA-seq technology to characterize the difference of chicken CD8, CD8 αα, CD8 αβ, CD8, and CD4CD8 T cell subsets from PBMCs of avian leukosis virus subgroup J (ALV-J)-infected chickens. Read More

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November 2021

High-Throughput RNA Sequencing Reveals the Effect of NB-UVB Phototherapy on Major Inflammatory Molecules of Lesional Psoriasis.

Psoriasis (Auckl) 2021 26;11:133-149. Epub 2021 Nov 26.

Department of Dermatology, Jichi Medical University, Tochigi, Japan.

Objective: To identify the narrowband ultraviolet B (NB-UVB)-induced molecular mechanisms that may account for their anti-inflammatory efficacy, gene expression and transcriptome profiling, which were performed using advanced molecular techniques.

Methods: This research was conducted on patients with moderate-to-severe plaque-type psoriasis who received NB-UVB treatment. RNA sequencing (RNA-Seq) was conducted to assay the transcriptomes and identify the differentially expressed transcripts that had been enriched during the major pathway analysis. Read More

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November 2021

Expanded Hemodialysis Therapy Ameliorates Uremia-Induced Systemic Microinflammation and Endothelial Dysfunction by Modulating VEGF, TNF-α and AP-1 Signaling.

Front Immunol 2021 11;12:774052. Epub 2021 Nov 11.

Department of Nephrology and Internal Intensive Care Medicine, Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Berlin, Germany.

Abstract: Systemic chronic microinflammation and altered cytokine signaling, with adjunct cardiovascular disease (CVD), endothelial maladaptation and dysfunction is common in dialysis patients suffering from end-stage renal disease and associated with increased morbidity and mortality. New hemodialysis filters might offer improvements. We here studied the impact of novel improved molecular cut-off hemodialysis filters on systemic microinflammation, uremia and endothelial dysfunction. Read More

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November 2021

Ion Channel Dysfunction and Neuroinflammation in Migraine and Depression.

Front Pharmacol 2021 10;12:777607. Epub 2021 Nov 10.

Institute of Neurological Sciences and Psychiatry, Hacettepe University, Ankara, Turkey.

Migraine and major depression are debilitating disorders with high lifetime prevalence rates. Interestingly these disorders are highly comorbid and show significant heritability, suggesting shared pathophysiological mechanisms. Non-homeostatic function of ion channels and neuroinflammation may be common mechanisms underlying both disorders: The excitation-inhibition balance of microcircuits and their modulation by monoaminergic systems, which depend on the expression and function of membrane located K, Na, and Ca channels, have been reported to be disturbed in both depression and migraine. Read More

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November 2021

Alpha-(1,6)-fucosyltransferase (FUT8) affects the survival strategy of osteosarcoma by remodeling TNF/NF-κB2 signaling.

Cell Death Dis 2021 Dec 2;12(12):1124. Epub 2021 Dec 2.

Institute of Microsurgery on Extremities, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Glycosylation is an important modification of membrane proteins that results in functional changes in many cellular activities, from cell-cell recognition to regulatory signaling. Fucosyltransferase 8 (FUT8) is the sole enzyme responsible for core fucosylation, and aberrant fucosylation by dysregulated expression of fucosyltransferases is responsible for the growth of various types of carcinomas. However, the function of FUT8 in the progress of osteosarcoma (OS) has not been reported. Read More

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December 2021

Regulation of transporters by perfluorinated carboxylic acids in HepaRG cells.

Drug Metab Dispos 2021 Dec 2. Epub 2021 Dec 2.

Environmental and Occupational Health Sciences, University of Washington, United States

Perfluorinated carboxylic acids (PFCAs) are environmental pollutants for which human exposure has been documented. PFCAs at high doses were known regulate xenobiotic transporters partly through PPARα and CAR in rodents. Less is known regarding how various PFCAs at a lower concentration modulate transporters for endogenous substrates such as amino acids in human hepatocytes. Read More

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December 2021

Non-histone methylation of SET7/9 and its biological functions.

Recent Pat Anticancer Drug Discov 2021 Dec 2. Epub 2021 Dec 2.

Department of Pathology, Pudong New Area People's Hospital, Shanghai 201299. China.

Background: (su(var)-3-9,enhancer-of-zeste,trithorax) domain-containing protein 7/9 (SET7/9) is a member of the protein lysine methyltransferases (PLMTs or PKMTs) family. It contains a SET domain. Recent studies demonstrate that SET7/9 methylates both lysine 4 of histone 3 (H3-K4) and lysine(s) of non-histone proteins, including transcription factors, tumor suppressors, and membrane-associated receptors. Read More

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December 2021

A Comprehensive Review on PCSK9 as Mechanistic Target Approach in Cancer Therapy.

Mini Rev Med Chem 2021 Dec 1. Epub 2021 Dec 1.

Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Vidya Vihar, Raibareli Road, Lucknow 226025. India.

PCSK9 is a strongly expressed protein in the liver and brain that binds to the LDLR and regulates cholesterol in the liver effectively. Other receptors with which it interacts include VLDLR, LRP1, ApoER2, and OLR1. PCSK9 gain-of-function results in lysosomal degradation of these receptors, which may result in hyperlipidemia. Read More

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December 2021

Inflammasome-independent functions of NAIPs and NLRs in the intestinal epithelium.

Biochem Soc Trans 2021 Dec 2. Epub 2021 Dec 2.

Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, U.K.

The gut relies on the complex interaction between epithelial, stromal and immune cells to maintain gut health in the face of food particles and pathogens. Innate sensing by the intestinal epithelium is critical for maintaining epithelial barrier function and also orchestrating mucosal immune responses. Numerous innate pattern recognition receptors (PRRs) are involved in such sensing. Read More

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December 2021

PFOA induces alteration in DNA methylation regulators and SARS-CoV-2 targets and in mouse lung tissues.

Toxicol Rep 2021 26;8:1892-1898. Epub 2021 Nov 26.

Biomedical Research Center in Mills Breast Cancer Institute, Carle Foundation Hospital, Urbana, IL, 61801, USA.

Perfluorooctanoic acid (PFOA), a ubiquitous environmental toxicant from the Per- and polyfluoroalkyl substances (PFAS) family has been implicated in toxicity of various organs. Several epidemiological studies have linked PFOA to different lung injuries and diseased conditions. However, the implication of PFOA in affecting epigenetic regulators and SARS-CoV-2 infection pathways in the lung are unknown. Read More

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November 2021

Antiviral activity of bacterial TIR domains via immune signalling molecules.

Nature 2021 Dec 1;600(7887):116-120. Epub 2021 Dec 1.

Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.

The Toll/interleukin-1 receptor (TIR) domain is a canonical component of animal and plant immune systems. In plants, intracellular pathogen sensing by immune receptors triggers their TIR domains to generate a molecule that is a variant of cyclic ADP-ribose. This molecule is hypothesized to mediate plant cell death through a pathway that has yet to be resolved. Read More

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December 2021

Association between in vitro nuclear receptor-activating profiles of chemical compounds and their in vivo hepatotoxicity in rats.

J Toxicol Sci 2021 ;46(12):569-587

Laboratory of Toxicology, Division of Pharmaceutical Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University.

The liver plays critical roles to maintain homeostasis of living organisms and is also a major target organ of chemical toxicity. Meanwhile, nuclear receptors (NRs) are known to regulate major liver functions and also as a critical target for hepatotoxic compounds. In this study, we established mammalian one-hybrid assay systems for five rat-derived NRs, namely PXR, PPARα, LXRα, FXR and RXRα, and evaluated a total of 326 compounds for their NR-activating profiles. Read More

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January 2021

[Recent Findings on the Mechanism of Cough Hypersensitivity as a Cause of Chronic Cough].

Authors:
Junzo Kamei

Yakugaku Zasshi 2021 ;141(12):1333-1342

Department of Biomolecular Pharmacology, Hoshi University.

An increasing number of patients complain to medical institutions about a cough that persists for more than 8 weeks, namely chronic cough. The cough observed in patients with chronic cough is not responsive to conventional antitussive agents such as dihydrocodeine and dextromethorphan, and this is a major clinical problem. The most common pathology of chronic cough in Japan is dry cough. Read More

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January 2021

Vitamin D endocrine system in breast cancer.

Acta Biochim Pol 2021 Nov;68(4):493-497

Department of Human Biology, Institute of Biology, Faculty of Biological and Veterinary Sciences, Nicolaus Copernicus University in Toruń, Toruń, Poland.

Vitamin D is a steroid hormone of great importance in the human body. It is produced in the skin from 7-dehydrocholesterol, upon UV radiation. In order to exert its functions, vitamin D has to be hydroxylated (via CYP27A1 and CYP27B1 hydroxylases), which is followed by its interaction with the vitamin D receptor (VDR) or retinoic acid-related orphan receptors α or γ (RORα and RORγ). Read More

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November 2021

Time-series transcriptomic analysis of bronchoalveolar lavage cells from virulent and low virulent PRRSV-1-infected piglets.

J Virol 2021 Dec 1:JVI0114021. Epub 2021 Dec 1.

Department of Anatomy and Comparative Pathology and Toxicology, Faculty of Veterinary Medicine, University of Córdoba, 14014, Córdoba, Spain.

Porcine reproductive and respiratory syndrome virus (PRRSV) has evolved to escape the immune surveillance for a survival advantage leading to a strong modulation of host's immune responses and favoring secondary bacterial infections. However, limited data are available on how the immunological and transcriptional responses elicited by virulent and low virulent PRRSV-1 strains are comparable and how are them conserved along the infection. To explore the kinetic transcriptional signature associated with the modulation of host immune response at lung level a time-series transcriptomic analysis was performed in bronchoalveolar lavage cells upon experimental infection with two PRRSV-1 strains of different virulence, virulent subtype 3 Lena strain or the low virulent subtype 1 3249 strain. Read More

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December 2021

Recurrent expansions of B30.2-associated immune receptor families in fish.

Immunogenetics 2021 Dec 1. Epub 2021 Dec 1.

Université Paris-Saclay, INRAE, UVSQ, Virologie et Immunologie Moléculaires, 78350, Jouy-en-Josas, France.

B30.2 domains, also known as PRY/SPRY, are key components of specific subsets of two large families of proteins involved in innate immunity: the tripartite motif proteins (TRIMs) and the Nod-like receptors (NLRs). TRIM proteins are important, often inducible factors of antiviral innate immunity, targeting multiple steps of viral cycles through a variety of mechanisms. Read More

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December 2021

Deciphering the role of plant plasma membrane lipids in response to invasion patterns: how biology and biophysics could help?

J Exp Bot 2021 Nov 30. Epub 2021 Nov 30.

Université de Reims Champagne Ardenne, RIBP EA 4707, USC INRAE 1488, SFR Condorcet FR CNRS 3417, 51100 Reims, France.

Plants have to constantly face pathogen attacks. To cope with diseases, they have to detect as early as possible the invader via the sensing of conserved motifs called invasion patterns (IPs). The first step of perception occurs at the plasma membrane. Read More

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November 2021

A newly intervention strategy in preeclampsia: Targeting PD-1/Tim-3 signaling pathways to modulate the polarization of decidual macrophages.

FASEB J 2022 Jan;36(1):e22073

Institute of Reproductive Health, Center for Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Programmed cell death-1 (PD-1) and T-cell immunoglobulin mucin-3 (Tim-3) are important immune checkpoint receptors that prevent an overreacted maternal immune response to fetal antigens during pregnancy. Disruption of complex immune regulation mechanisms is associated with adverse pregnancy outcomes, including preeclampsia (PE). Our recent study showed that the Tim-3 pathway was involved in the regulation of decidual macrophage polarization. Read More

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January 2022

The Involvement of Glial Cell-Derived Neurotrophic Factor in Inflammatory Bowel Disease.

J Interferon Cytokine Res 2021 Nov 26. Epub 2021 Nov 26.

Department of Gastroenterology, Lanzhou University Second Hospital, Gansu, P.R. China.

Inflammatory bowel diseases (IBD) are chronic inflammatory gastrointestinal diseases characterized by dysregulation of the intestinal epithelial barrier (IEB) and intermittent relapses. Recent data show that the glial cell line-derived neurotrophic factor (GDNF) promotes IEB function and wound healing. Apart from protective effects of GDNF on enteric nervous system and IEB, an immunomodulatory role has been assumed. Read More

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November 2021

Oxidized Phospholipids Promote NETosis and Arterial Thrombosis in LNK(SH2B3) Deficiency.

Circulation 2021 Nov 30. Epub 2021 Nov 30.

Molecular Medicine, Columbia University Medical Center, New York, NY.

Background: LNK/SH2B3 inhibits JAK/STAT signaling by hematopoietic cytokine receptors. GWAS have shown association of a common SNP in (R262W, T allele) with neutrophilia, thrombocytosis and coronary artery disease (CAD). We have shown that reduces LNK function and that LNK deficient mice display prominent platelet-neutrophil aggregates, accelerated atherosclerosis and thrombosis. Read More

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November 2021