167,449 results match your criteria received three

Structural competency in the post-prison period for people who inject drugs: A qualitative case study.

Int J Drug Policy 2021 May 11;95:103261. Epub 2021 May 11.

Behaviours and Health Risks Program, Burnet Institute, Melbourne, Victoria, Australia; National Drug Research Institute, Curtin University, Melbourne, Victoria, Australia.

Introduction: Access to services is key to successful community (re-)integration following release from prison. But many people experience disengagement from services, including people who inject drugs (PWID). We use a case study approach and the notion of structural competency to examine influences on access to services among a group of PWID recently released from prison. Read More

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Molecular phylogeny, classification, biogeography and diversification patterns of a diverse group of moths (Geometridae: Boarmiini).

Mol Phylogenet Evol 2021 May 11:107198. Epub 2021 May 11.

Department of Biology, Lund University, Sweden. Electronic address:

Understanding how and why some groups have become more species-rich than others, and how past biogeography may have shaped their current distribution, are questions that evolutionary biologists have long attempted to answer. We investigated diversification patterns and historical biogeography of a hyperdiverse lineage of Lepidoptera, the geometrid moths, by studying its most species-rich tribe Boarmiini, which comprises ca. 200 genera and ca. Read More

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Efficacy of Intravenous Paracetamol and Ibuprofen on Postoperative Pain and Morphine Consumption in Lumbar Disc Surgery: Prospective, Randomized, Double-Blind, Placebo-Controlled Clinical Trial.

Neurochirurgie 2021 May 11. Epub 2021 May 11.

Department of Biostatistics, Inonu University Medical Faculty, Malatya, Turkey.

Objectives: Effective postoperative pain management after lumbar disc surgery reduces complications and improves postoperative care. The purpose of this prospective, randomized, double-blind, placebo-controlled clinical study is to evaluate the effects of IV paracetamol and ibuprofen on postoperative pain, morphine consumption and side effects of morphine in patients who underwent lumbar disc surgery.

Materials And Methods: Seventy-five patients aged 18-85 years scheduled for lumbar disk surgery with a single level laminectomy included in this study. Read More

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Pembrolizumab plus cetuximab in patients with recurrent or metastatic head and neck squamous cell carcinoma: an open-label, multi-arm, non-randomised, multicentre, phase 2 trial.

Lancet Oncol 2021 May 11. Epub 2021 May 11.

Moores Comprehensive Cancer Center, University of California, San Diego, La Jolla, CA, USA.

Background: Pembrolizumab (PD-1 inhibitor) and cetuximab (EGFR inhibitor) are active as single agents and in combination with cytotoxic chemotherapy for recurrent or metastatic head and neck squamous cell carcinoma (HNSCC). Given each drug's single agent activity and unique mechanism of action, we aimed to evaluate the anti-tumour activity of PD-1 blockade with EGFR inhibition in recurrent or metastatic HNSCC.

Methods: This study is an open-label, non-randomised, multi-arm, phase 2 trial done at four academic centres in the USA. Read More

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Evaluation of two communication tools, slideshow and theater, to improve participants' understanding of a clinical trial in the informed consent procedure on Pemba Island, Tanzania.

PLoS Negl Trop Dis 2021 May 14;15(5):e0009409. Epub 2021 May 14.

Swiss Tropical and Public Health Institute, Basel, Switzerland.

Background: Clinical trial participants are required to sign an informed consent form (ICF). However, information is lacking on the most effective methods to convey trial relevant information prior to inviting participants to sign the ICF, being particularly pertinent in low income countries. A previous study on Pemba Island, Tanzania, found that an oral information session (IS) was significantly better than providing an ICF alone. Read More

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Evaluating changes in workplace culture: Effectiveness of a caregiver-friendly workplace program in a public post-secondary educational institution.

PLoS One 2021 14;16(5):e0250978. Epub 2021 May 14.

Offord Center for Child Health Study, McMaster University, Hamilton, Ontario, Canada.

Background: Workplace experience, defined as the evaluation of the work environment and performance, and a characteristic of workplace culture, can influence an employee's work-life balance. Most carer-employees, who combine paid full-time work and informal caregiving responsibilities, struggle to maintain a healthy work-life balance. Caregiver-Friendly Workplace Programs are designed to improve the work experience, and ultimately, the work-life balance of carer-employees. Read More

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Family-centered music therapy-Empowering premature infants and their primary caregivers through music: Results of a pilot study.

PLoS One 2021 14;16(5):e0250071. Epub 2021 May 14.

Department of Neonatology, University Children's Hospital, Heidelberg, Germany.

Background: In Neonatal Intensive Care Units (NICUs) premature infants are exposed to various acoustic, environmental and emotional stressors which have a negative impact on their development and the mental health of their parents. Family-centred music therapy bears the potential to positively influence these stressors. The few existing studies indicate that interactive live-improvised music therapy interventions both reduce parental stress factors and support preterm infants' development. Read More

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Increasing uptake of long-acting reversible contraception with structured contraceptive counselling: cluster randomised controlled trial (the LOWE trial).

BJOG 2021 May 14. Epub 2021 May 14.

Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.

Objectives: To evaluate the effect of structured contraceptive counselling on uptake of long-acting reversible contraceptives (LARCs), and pregnancy rates.

Design: Cluster randomised trial SETTING: Abortion, youth, and maternal health clinics in Stockholm, Sweden.

Population: Sexually active women ≥18 years without a wish for pregnancy seeking abortion and/or contraceptive counselling. Read More

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Efficacy of fractional laser, radiofrequency and IPL rejuvenation of periorbital region.

Lasers Med Sci 2021 May 14. Epub 2021 May 14.

Department of Cosmetology and Aesthetic Dermatology, Faculty of Pharmacy, Medical University of Łódź, Muszyńskiego 1 Street, 91-151, Łódź, Poland.

The purpose of this study was to assess skin elasticity, the reduction in the number and the depth of wrinkles and changes in the other skin defects (bags under the eyes, dark circles under the eyes, skin hyperpigmentation in the ageing eye area following the use of non-ablative fractional laser, bipolar radiofrequency and intense pulsed light). Moreover, the study was also comparison which device brought better results than the others. This study included 71 patients (66 women, 5 men), aged 33-63 years (the average age was 45. Read More

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Utility of inflammatory biomarkers in patients with COVID-19 infections: Bahrain experience.

Biomark Med 2021 May 14. Epub 2021 May 14.

Department of Internal Medicine/Infectious Diseases, Salmaniya Medical Complex, Ministry of Health, Manama, Kingdom of Bahrain, PO Box 12.

COVID-19 pandemic continues and dearth of information remains considering the utility of various inflammatory biomarkers. We carried out the present study to delineate the roles of these biomarkers in various strata of patients with coronavirus infection. A retrospective study was carried out after obtaining approval from the relevant Ethics Committee. Read More

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Feasibility and tolerability of ophthalmic virtual reality as a medical communication tool in children and young people.

Acta Ophthalmol 2021 May 14. Epub 2021 May 14.

Center for medical Image Analysis & Navigation, University, Basel, Switzerland.

Purpose: Virtual reality (VR) can be useful in explaining diseases and complications that affect children in order to improve medical communications with this vulnerable patient group. So far, children and young people's responses to high-end medical VR environments have never been assessed.

Methods: An unprecedented number of 320 children and young people were given the opportunity to interact with a VR application displaying original ophthalmic volume data via a commercially available tethered head-mounted display (HMD). Read More

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A retrospective examination of care pathways in individuals with treatment-resistant depression.

BJPsych Open 2021 May 14;7(3):e101. Epub 2021 May 14.

Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK.

Background: Individuals with treatment-resistant depression (TRD) experience a high burden of illness. Current guidelines recommend a stepped care approach for treating depression, but the extent to which best-practice care pathways are adhered to is unclear.

Aims: To explore the extent and nature of 'treatment gaps' (non-adherence to stepped care pathways) experienced by a sample of patients with established TRD (non-response to two or more adequate treatments in the current depressive episode) across three cities in the UK. Read More

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Who let the dogs In? An epidemiological study quantifying domestically sourced and imported dogs in Southern Ontario, Canada.

Zoonoses Public Health 2021 May 14. Epub 2021 May 14.

Department of Population Medicine, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada.

Dogs are reservoirs for many zoonoses. In southern Ontario, Canada, minimal data exist on the sources from which domestic dogs are acquired (i.e. Read More

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Conversion factors to derive organ doses for canine subjects undergoing CT examinations.

Vet Radiol Ultrasound 2021 May 14. Epub 2021 May 14.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland, USA.

Although a large number of CT scans are being conducted on small animals, especially in Western countries, little is known of absorbed dose from veterinary CT scans. In the current retrospective analytical study, we estimated the radiation dose delivered to dogs from CT scans with various scan protocols and compared the results with those of human patients. We adopted a total of three computerized canine models with three sizes combined with a computer simulation model of a CT scanner. Read More

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Intrapartum antibiotic prophylaxis for women who are screened positive for group B streptococcal colonisation: Clinical compliance with the guideline.

Aust N Z J Obstet Gynaecol 2021 May 13. Epub 2021 May 13.

Hunter New England Local Health District, Nurses and Midwives Research Centre, The University of Newcastle, Callaghan, New South Wales, Australia.

Background: In high income countries, ~30% of pregnant women are provided with intrapartum antibiotic prophylaxis (IAP) for early-onset group B streptococcal infection (EOGBSI). The infection rate is low, 0.2/1000 livebirths in our jurisdiction, and others. Read More

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Statement in Support of Revising the Uniform Determination of Death Act and in Opposition to a Proposed Revision.

D Alan Shewmon

J Med Philos 2021 May 14. Epub 2021 May 14.

University of California Los Angeles, Los Angeles, California, USA.

Discrepancies between the Uniform Determination of Death Act (UDDA) and the adult and pediatric diagnostic guidelines for brain death (BD) (the "Guidelines") have motivated proposals to revise the UDDA. A revision proposed by Lewis, Bonnie and Pope (the RUDDA), has received particular attention, the three novelties of which would be: (1) to specify the Guidelines as the legally recognized "medical standard," (2) to exclude hypothalamic function from the category of "brain function," and (3) to authorize physicians to conduct an apnea test without consent and even over a proxy's objection. One hundred seven experts in medicine, bioethics, philosophy, and law, spanning a wide variety of perspectives, have come together in agreement that while the UDDA needs revision, the RUDDA is not the way to do it. Read More

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Effects of alfalfa and alfalfa-grass mixtures with nitrogen fertilization on dry matter yield and forage nutritive value.

J Anim Sci Technol 2021 Mar 31;63(2):305-318. Epub 2021 Mar 31.

Department of Agronomy, Kansas State University, Manhattan, KS 66506, USA.

Alfalfa ( L.) is an important forage legume grown in Kansas, USA and its productivity with cool-season grasses however is unknown. The objective of this study was to determine the dry matter yield (DMY) and forage nutritive value of alfalfa-grass mixtures compared to those of alfalfa and grasses grown in monoculture with and without nitrogen fertilization. Read More

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Disparities of SARS-CoV-2 Nucleoprotein-Specific IgG in Healthcare Workers in East London, UK.

Front Med (Lausanne) 2021 27;8:642723. Epub 2021 Apr 27.

Centre for Immunobiology, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.

SARS-CoV-2 antibody detection serves as an important diagnostic marker for past SARS-CoV-2 infection and is essential to determine the spread of COVID-19, monitor potential COVID-19 long-term effects, and to evaluate possible protection from reinfection. A study was conducted across three hospital sites in a large central London NHS Trust in the UK, to evaluate the prevalence and duration of SARS-CoV-2 IgG antibody positivity in healthcare workers. A matrix equivalence study consisting of 228 participants was undertaken to evaluate the Abbott Panbio™ COVID-19 IgG/IgM rapid test device. Read More

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Pupillary Response to Postural Demand in Parkinson's Disease.

Front Bioeng Biotechnol 2021 27;9:617028. Epub 2021 Apr 27.

Department of Physical Therapy and Rehabilitation Science, School of Health Professions, University of Kansas Medical Center, Kansas City, KS, United States.

Individuals with Parkinson's disease (PD) may need to spend more mental and physical effort (i.e., cognitive workload) to maintain postural control. Read More

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An Exploratory Qualitative Study With Older Malaysian Stroke Survivors, Caregivers, and Healthcare Practitioners About Falls and Rehabilitation for Falls After Stroke.

Front Public Health 2021 27;9:611814. Epub 2021 Apr 27.

Discipline of Occupational Therapy, School of Health Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.

Studies on rehabilitation for falls after a stroke remain limited despite its impact being profound. This scenario justifies a deeper understanding of why falls in stroke rehabilitation received less attention. Current investigations on the perception of falls and stroke also proved inadequate. Read More

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Initial Experience of Intentional Internal High-Dose Policy Volumetric Modulated Arc Therapy of Neck Lymph Node Metastases ≥ 2 cm in Patients With Head and Neck Squamous Cell Carcinoma.

Front Oncol 2021 27;11:651409. Epub 2021 Apr 27.

Department of Radiation Therapy in National Cancer Center Hospital, Tokyo, Japan.

Background And Purpose: Most locoregional recurrences after definitive radiotherapy for head and neck squamous cell carcinoma (HNSCC) develop "in-field." Dose escalation while sparing organs at risk can be a good solution for improving local control without increasing adverse effects. This study investigated the safety and effectiveness of volumetric modulated arc therapy (VMAT) using intentionally internal high-dose policy (IIHDP) to treat neck lymph node metastases (NLNM) ≥ 2 cm in HNSCC patients. Read More

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Clinical Profile, Risk Factors and Outcomes of Children With Cutaneous Larva Migrans Infection: A Hospital-Based Study.

Cureus 2021 Apr 11;13(4):e14416. Epub 2021 Apr 11.

Internal Medicine-Pediatrics, Base Hospital, Mahaoya, LKA.

Background Cutaneous larva migrans (CLM) is a neglected parasitic skin disease caused by hookworm larvae such as and . It is more common in tropical and subtropical countries. Evidence regarding clinical profiles, risk factors and outcomes of children with CLM in the Eastern province of Sri Lanka is scarce. Read More

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Intact tactile anisotropy despite altered hand perception in complex regional pain syndrome: rethinking the role of the primary sensory cortex in tactile and perceptual dysfunction.

PeerJ 2021 3;9:e11156. Epub 2021 May 3.

Neuroscience Research Australia, NEURA, University of New South Wales, Sydney, New South Wales, Australia.

Complex Regional Pain Syndrome (CRPS) is characterised by pain, autonomic, sensory and motor abnormalities. It is associated with changes in the primary somatosensory cortex (S1 representation), reductions in tactile sensitivity (tested by two-point discrimination), and alterations in perceived hand size or shape (hand perception). The frequent co-occurrence of these three phenomena has led to the assumption that S1 changes underlie tactile sensitivity and perceptual disturbances. Read More

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Effect of a Multistage Educational Skill-Based Program on Nurse's Stress and Anxiety in the Intensive Care Setting: A Randomized Controlled Trial.

Behav Neurol 2021 26;2021:8811347. Epub 2021 Apr 26.

Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Background: Psychological problems such as stress and anxiety are prevalent among working nurses in the intensive care units (ICUs). This study was aimed at investigating the effects of three skill-based educational programs on stress and anxiety among critical care nurses.

Methods: Using a randomized controlled trial, 160 nurses were assigned to four groups including one control and three intervention groups. Read More

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Informing About the Nocebo Effect Affects Patients' Need for Information About Antidepressants-An Experimental Online Study.

Front Psychiatry 2021 27;12:587122. Epub 2021 Apr 27.

Psychosomatic Medicine and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Understanding patients' informational needs and adapting drug-related information are the prerequisites for a contextualized informed consent. Current information practices might rather harm by inducing nocebo effects. To investigate whether informing about the nocebo effect using a short information sheet affects patients' need for information about antidepressants. Read More

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Ten years on: an online questionnaire evaluation of the UK special care dentistry specialist workforce.

Br Dent J 2021 May 13. Epub 2021 May 13.

Peterborough City Hospital, Edith Cavell Campus, Bretton Gate, Peterborough, PE3 9GZ, UK.

Aims To provide information on the demographics and work patterns of the UK special care dentistry (SCD) specialist workforce.Design A self-administered electronic questionnaire.Setting All UK-based SCD specialists on the membership of the British Society for Disability and Oral Health and the British Society of Gerodontology. Read More

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Effect of pre-operative administration of ibuprofen in children undergoing extraction for reducing post-operative pain: a double-blind randomised controlled clinical trial.

Br Dent J 2021 May 13. Epub 2021 May 13.

Dental Intern, Princess Nourah bint Abdulrahman University, Airport Road, King Khalid International Airport, Riyadh, 84428, Saudi Arabia.

Introduction Administration of non-steroidal anti-inflammatory drugs (NSAIDs) before tooth extraction may reduce post-surgical pain, but there is a lack of research.Aims To compare pain and anxiety in paediatric tooth extraction patients receiving a pre-operative NSAID vs placebo.Design Randomised, double-blind, placebo-controlled clinical trial. Read More

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Faster monitoring of the invasive alien species (IAS) Dreissena polymorpha in river basins through isothermal amplification.

Sci Rep 2021 May 13;11(1):10175. Epub 2021 May 13.

Food Quality and Safety Research Group, International Iberian Nanotechnology Laboratory (INL), Av. Mestre José Veiga s/n, 4715-330, Braga, Portugal.

Zebra mussel (Dreissena polymorpha) is considered as one of the 100 most harmful IAS in the world. Traditional detection methods have limitations, and PCR based environmental DNA detection has provided interesting results for early warning. However, in the last years, the development of isothermal amplification methods has received increasing attention. Read More

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Serum alanine aminotransferase as an early marker of outcomes in patients receiving anti-PD-1 or anti-CTLA-4 antibody.

Sci Rep 2021 May 13;11(1):10264. Epub 2021 May 13.

Division of Respiratory Medicine and Medical Oncology, Tokyo Metropolitan Tama Medical Center, 2-8-29 Musashinodai, Fuchu, Tokyo, 183-8524, Japan.

Immune-oncology (IO) drug therapy is effective against various types of cancer. Although several, potential, clinical predictive markers have been identified, none so far have proven reliable. Herein we evaluated changes in serum alanine aminotransferase (ALT), which is upregulated by the accumulation of activated CD8+T cells in the liver, as a potentially reliable predictive marker. Read More

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