1,467 results match your criteria received rtms


Transcranial Magnetic Stimulation for Posttraumatic Stress Disorder and Major Depression: Comparing Commonly Used Clinical Protocols.

J Trauma Stress 2021 May 11. Epub 2021 May 11.

VA RR&D Center for Neurorestoration and Neurotechnology, Providence VA Healthcare System, Providence, Rhode Island, USA.

Transcranial magnetic stimulation (TMS) is increasingly being used to treat posttraumatic stress disorder (PTSD) comorbid with major depressive disorder (MDD). Yet, identifying the most effective stimulation parameters remains an active area of research. We recently reported on the use of 5 Hz TMS to reduce PTSD and MDD symptoms. Read More

View Article and Full-Text PDF

Inducing Cortical Plasticity to Manipulate and Consolidate Subjective Time Interval Production.

Neuromodulation 2021 May 7. Epub 2021 May 7.

Department of Medical Physiology, Kyorin University School of Medicine, Tokyo, Japan.

Objectives: Time awareness may change depending on the mental state or disease conditions, although each individual perceives his/her own sense of time as stable and accurate. Nevertheless, the processes that consolidate altered duration production remain unclear. The present study aimed to manipulate the subjective duration production via memory consolidation through the modulation of neural plasticity. Read More

View Article and Full-Text PDF

Auditory N2 Correlates of Treatment Response in Posttraumatic Stress Disorder.

J Trauma Stress 2021 May 6. Epub 2021 May 6.

Departments of Neurology & Neurotherapeutics and Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Emotional processing and cognitive control are implicated as being dysfunctional in posttraumatic stress disorder (PTSD) and targeted in cognitive processing therapy (CPT), a trauma-focused treatment for PTSD. The N2 event-related potential has been interpreted in the context of emotional processing and cognitive control. In this analysis of secondary outcome measures from a randomized controlled trial, we investigated the latency and amplitude changes of the N2 in responses to task-relevant target tones and task-irrelevant distractor sounds (e. Read More

View Article and Full-Text PDF

Short-lived Alpha Power Suppression Induced by Low-intensity Arrhythmic rTMS.

Neuroscience 2021 May 2. Epub 2021 May 2.

Department of Clinical Neurophysiology, University Medical Center Göttingen, Germany; Department of Neuroanatomy, Institute of Anatomy and Cell Biology, University of Freiburg, Germany. Electronic address:

This study was conducted to provide a better understanding of the role of electric field strength in the production of aftereffects in resting state scalp electroencephalography by repetitive transcranial magnetic stimulation (rTMS) in humans. We conducted two separate experiments in which we applied rTMS over the left parietal-occipital region. Prospective electric field simulation guided the choice of the individual stimulation intensities. Read More

View Article and Full-Text PDF

Motor and cognitive outcomes of cerebello-spinal stimulation in neurodegenerative ataxia.

Brain 2021 May 5. Epub 2021 May 5.

Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.

Cerebellar ataxias represent a heterogeneous group of disabling disorders characterized by motor and cognitive disturbances, for which no effective treatment is currently available. In this randomized, double-blind, sham-controlled trial, followed by an open-label phase, we investigated whether treatment with cerebello-spinal transcranial direct current stimulation (tDCS) could improve both motor and cognitive symptoms in patients with neurodegenerative ataxia at short and long-term. Sixty-one patients were randomized in two groups for the first controlled phase. Read More

View Article and Full-Text PDF

Targeting repetitive transcranial magnetic stimulation in depression: do we really know what we are stimulating and how best to do it?

Brain Stimul 2021 Apr 30;14(3):730-736. Epub 2021 Apr 30.

Background: Repetitive transcranial magnetic stimulation (rTMS) is an established treatment for patients with depression who have not achieved optimal outcomes with one or more trials of antidepressant medication. It is an effective antidepressant treatment but there remains considerable scope for improving clinical outcomes. One method to potentially enhance the efficacy of rTMS is through the improvement of methods of stimulation localization. Read More

View Article and Full-Text PDF

Concurrent TMS-fMRI for causal network perturbation and proof of target engagement.

Neuroimage 2021 Apr 30;237:118093. Epub 2021 Apr 30.

Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Kettegård Allé 30, 2650, Hvidovre, Denmark; Department of Neurology, Copenhagen University Hospital Bispebjerg, Bispebjerg Bakke 23, 2400 København NV, Denmark; Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark.

The experimental manipulation of neural activity by neurostimulation techniques overcomes the inherent limitations of correlative recordings, enabling the researcher to investigate causal brain-behavior relationships. But only when stimulation and recordings are combined, the direct impact of the stimulation on neural activity can be evaluated. In humans, this can be achieved non-invasively through the concurrent combination of transcranial magnetic stimulation (TMS) with functional magnetic resonance imaging (fMRI). Read More

View Article and Full-Text PDF

The Effect of High-Frequency Repetitive Transcranial Magnetic Stimulation on Functional Indices of Affected Upper Limb in Patients with Subacute Stroke.

J Biomed Phys Eng 2021 Apr 1;11(2):175-184. Epub 2021 Apr 1.

PhD, Department of Physiotherapy, School of Rehabilitation Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: Repetitive transcranial magnetic stimulation (rTMS) is a novel technique that may improve recovery in patients with stoke, but the role of rTMS as an applied and practical treatment modality for stroke rehabilitation has not been established yet.

Objective: This study was conducted to determine the effects of a rehabilitation program (RP) in conjunction with rTMS on functional indices of the paretic upper limb in the subacute phase of stroke.

Material And Methods: In this experimental study, twenty patients in the subacute phase of stroke were randomly assigned into two groups: The high frequency rTMS (HF-rTMS) in conjunction with RP (experimental group), and the RP group (control group). Read More

View Article and Full-Text PDF

Verbal Fluency in Mild Alzheimer's Disease: Transcranial Direct Current Stimulation over the Dorsolateral Prefrontal Cortex.

J Alzheimers Dis 2021 Apr 28. Epub 2021 Apr 28.

Department of Psychology, Educational Science and Human Movement, University of Palermo, Palermo, Italy.

Background: Recent studies showed that in healthy controls and in aphasic patients, inhibitory trains of repetitive transcranial magnetic stimulation (rTMS) over the right prefrontal cortex can improve phonemic fluency performance, while anodal transcranial direct current stimulation (tDCS) over the left prefrontal cortex can improve performance in naming and semantic fluency tasks.

Objective: This study aimed at investigating the effects of cathodal tDCS over the left or the right dorsolateral prefrontal cortex (DLPFC) on verbal fluency tasks (VFT) in patients with mild Alzheimer's disease (AD).

Methods: Forty mild AD patients participated in the study (mean age 73. Read More

View Article and Full-Text PDF

Associative memory improvement after 5 days of magnetic stimulation: A replication experiment with active controls.

Brain Res 2021 Apr 29;1765:147510. Epub 2021 Apr 29.

Department of Neurology, The First Affiliated Hospital of Anhui Medical University, The School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, 230032, China; Institute of Artificial Intelligence, Hefei Comprehensive National Science Center, Hefei 230088, China. Electronic address:

Associative memory (AM) is an essential function of everyday life, but is often disrupted in many neurological diseases. Recent studies have found that repetitive transcranial magnetic stimulation (rTMS) can effectively enhance AM and have shown its potential in clinical applications. In this study, we aimed to reproduce the 5-day rTMS effect on AM in a Chinese version of a face-cued word recall task. Read More

View Article and Full-Text PDF

Null Effect of Transcranial Static Magnetic Field Stimulation over the Dorsolateral Prefrontal Cortex on Behavioral Performance in a Go/NoGo Task.

Brain Sci 2021 Apr 11;11(4). Epub 2021 Apr 11.

Department of Sensorimotor Neuroscience, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan.

The purpose of this pilot study was to investigate whether transcranial static magnetic field stimulation (tSMS), which can modulate cortical excitability, would influence inhibitory control function when applied over the dorsolateral prefrontal cortex (DLPFC). Young healthy adults ( = 8, mean age ± SD = 24.4 ± 4. Read More

View Article and Full-Text PDF

Investigating Parietal and Premotor Influence on Motor Cortical Excitability Associated with Visuomotor Associative Plasticity.

Brain Sci 2021 Apr 2;11(4). Epub 2021 Apr 2.

Department of Kinesiology, University of Waterloo, 200 University Ave. Waterloo, ON N2L 3G1, Canada.

The brain changes in response to sensory signals it is exposed to. It has been shown that long term potentiation-like neuroplasticity can be experimentally induced via visual paired-associative stimulation (V-PAS). V-PAS combines afferent visual stimuli with a transcranial magnetic stimulation pulse to induce plasticity. Read More

View Article and Full-Text PDF

Neuro-Cardiac-Guided TMS (NCG TMS): A replication and extension study.

Biol Psychol 2021 Apr 22;162:108097. Epub 2021 Apr 22.

Research Institute Brainclinics, Brainclinics Foundation, Nijmegen, the Netherlands; neuroCare Group, Munich, Germany; Amsterdam UMC, Department of Psychiatry, University of Amsterdam, Location AMC, Amsterdam, the Netherlands; Maastricht University, Faculty of Psychology & Neuroscience, Maastricht, the Netherlands. Electronic address:

Neuro-Cardiac-Guided Transcranial Magnetic Stimulation (NCG-TMS) was studied for its potential to specifically target the frontal-vagal network. Previous research demonstrated that prefrontal stimulation led to significant heartrate slowing. We aimed to replicate these results in a larger sample and extend the findings to investigate dose-response relationships, reproducibility and stimulation frequency (10 Hz and intermittent theta burst (iTBS)). Read More

View Article and Full-Text PDF

Task-Modulated Brain Activity Predicts Antidepressant Responses of Prefrontal Repetitive Transcranial Magnetic Stimulation: A Randomized Sham-Control Study.

Chronic Stress (Thousand Oaks) 2021 Jan-Dec;5:24705470211006855. Epub 2021 Apr 8.

Department of Psychiatry, Taipei Veterans General Hospital, Taipei.

Background: Prolonged intermittent theta-burst stimulation (piTBS) and repetitive transcranial magnetic stimulation (rTMS) are effective antidepressant interventions for major depressive disorder (MDD). Cognition-modulated frontal theta (frontalθ) activity had been identified to predict the antidepressant response to 10-Hz left prefrontal rTMS. However, whether this marker also predicts that of piTBS needs further investigation. Read More

View Article and Full-Text PDF

Treatment for Major Depressive Disorder by Repetitive Transcranial Magnetic Stimulation in Different Parameters: A Randomized Double-Blinded Controlled Trial.

Front Psychiatry 2021 6;12:623765. Epub 2021 Apr 6.

National Health Commission Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University Sixth Hospital, Peking University Institute of Mental Health, Beijing, China.

Repetitive transcranial magnetic stimulation (rTMS) has been proven to be safe and effective in treating major depressive disorder (MDD). However, the treatment parameters of rTMS are still divergent and need to be optimized further. The aim of this study was to compare the efficacy of rTMS in treating MDD with different parameters of stimulating frequency and location, and course of treatment. Read More

View Article and Full-Text PDF

Does pericentral mu-rhythm "power" corticomotor excitability? - A matter of EEG perspective.

Brain Stimul 2021 Apr 20;14(3):713-722. Epub 2021 Apr 20.

Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital, Amager and Hvidovre, Hvidovre, Denmark; Department of Neurology, Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark; Institute for Clinical Medicine, Faculty of Medical and Health Sciences, University of Copenhagen, Copenhagen, Denmark.

Background: Electroencephalography (EEG) and single-pulse transcranial magnetic stimulation (spTMS) of the primary motor hand area (M1-HAND) have been combined to explore whether the instantaneous expression of pericentral mu-rhythm drives fluctuations in corticomotor excitability, but this line of research has yielded diverging results.

Objectives: To re-assess the relationship between the mu-rhythm power expressed in left pericentral cortex and the amplitude of motor potentials (MEP) evoked with spTMS in left M1-HAND.

Methods: 15 non-preselected healthy young participants received spTMS to the motor hot spot of left M1-HAND. Read More

View Article and Full-Text PDF

Augmentation of fear extinction by theta-burst transcranial magnetic stimulation of the prefrontal cortex in humans.

J Psychiatry Neurosci 2021 Apr 12;46(2):E292-E302. Epub 2021 Apr 12.

From the Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Chinese Academy of Medical Sciences Research Unit (No. 2018RU006), Peking University, Beijing 100191, China (Deng, Gong, Li, Su, Sun, Lu, Shi, Sun); the Psychological Hospital Affiliated with Anhui Medical University, Anhui Mental Health Center, Hefei Fourth People's Hospital, Hefei 230022, China (Feng); the National Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence, Peking University, Beijing 100191, China (Bao); and the Peking-Tsinghua Center for Life Sciences and PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing 100191, China (Lu).

Background: Fear extinction alone does not erase the original fear memory. Interventions that enhance extinction can be beneficial for the treatment of fear-related disorders. Repetitive transcranial magnetic stimulation has been shown to improve memory performance. Read More

View Article and Full-Text PDF

A Retrospective Comparative Study in Patients With Cocaine Use Disorder Comorbid With Attention Deficit Hyperactivity Disorder Undergoing an rTMS Protocol Treatment.

Front Psychiatry 2021 25;12:659527. Epub 2021 Mar 25.

Fondazione Novella Fronda, Piazza Castello, Padova, Italy.

Adult attention-deficit/hyperactivity disorder (ADHD) is associated with high comorbidity with other psychiatric diseases, including cocaine use disorder (CocUD). Given the common fronto-striatal dysfunction, ADHD patients often use cocaine as self-medication for ameliorating symptoms by increasing striatal dopamine release. Yet, comorbidity with ADHD is related to poor treatment outcomes. Read More

View Article and Full-Text PDF

Effectiveness and safety of repetitive transcranial magnetic stimulation for the treatment of morphine dependence: A retrospective study.

Medicine (Baltimore) 2021 Apr;100(14):e25208

Jiamusi University School of Basic Medicine, Jiamusi, China.

Abstract: Morphine dependence (MD) is a very common complication because of the chronic morphine consumption. Studies suggest that repetitive transcranial magnetic stimulation (rTMS) can be used for the treatment of MD. However, there is still lacking evidence to support rTMS for MD. Read More

View Article and Full-Text PDF

The frontal pole as a target for transcranial magnetic stimulation: A retrospective analysis of feasibility and tolerability.

Brain Stimul 2021 Apr 4;14(3):655-657. Epub 2021 Apr 4.

Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC, USA; Department of Physiology & Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC, USA; Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA. Electronic address:

View Article and Full-Text PDF

Modulation of the Corticomotor Excitability by Repetitive Peripheral Magnetic Stimulation on the Median Nerve in Healthy Subjects.

Front Neural Circuits 2021 18;15:616084. Epub 2021 Mar 18.

Department of Sport Rehabilitation, Shanghai University of Sport, Shanghai, China.

We aimed to examine the effects of repetitive peripheral nerve magnetic stimulation (rPNMS) on the excitability of the contralateral motor cortex and motor function of the upper limb in healthy subjects. Forty-six healthy subjects were randomly assigned to either a repetitive peripheral nerve magnetic stimulation group ( = 23) or a sham group ( = 23). The repetitive peripheral nerve magnetic stimulation group received stimulation using magnetic pulses at 20 Hz, which were applied on the median nerve of the non-dominant hand, whereas the sham group underwent the same protocol without the stimulation output. Read More

View Article and Full-Text PDF

In vivo local transcranial static magnetic field stimulation alters motor behavior in normal rats.

Neurosci Lett 2021 05 1;753:135864. Epub 2021 Apr 1.

Department of Rehabilitation Science, Faculty of Health Sciences, Hokkaido University, Kita 12 Nishi 5, Kita-ku, Sapporo 060-0812, Japan.

Transcranial static magnetic field stimulation (tSMS) has inhibitory neuromodulatory effects on the human brain. Most of the studies on static magnetic fields have been performed in vitro. To further understand the biological mechanisms of tSMS, we investigated the effects of in vivo tSMS on motor behavior in normal awake rats. Read More

View Article and Full-Text PDF

Single-Pulse TMS to the Temporo-Occipital and Dorsolateral Prefrontal Cortex Evokes Lateralized Long Latency EEG Responses at the Stimulation Site.

Front Neurosci 2021 12;15:616667. Epub 2021 Mar 12.

Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.

Introduction: Transcranial magnetic stimulation (TMS)-evoked potentials (TEPs) allow for probing cortical functions in health and pathology. However, there is uncertainty whether long-latency TMS-evoked potentials reflect functioning of the targeted cortical area. It has been suggested that components such as the TMS-evoked N100 are stereotypical and related to nonspecific sensory processes rather than transcranial effects of the changing magnetic field. Read More

View Article and Full-Text PDF

Assessing cerebellar-cortical connectivity using concurrent TMS-EEG: a feasibility study.

J Neurophysiol 2021 May 31;125(5):1768-1787. Epub 2021 Mar 31.

Cognitive Neuroscience Unit, School of Psychology, Deakin University, Victoria, Australia.

Combined single-pulse transcranial magnetic stimulation (TMS) and electroencephalography (EEG) has been used to probe the features of local networks in the cerebral cortex. Here, we investigated whether we can use this approach to explore long-range connections between the cerebellum and cerebral cortex. Ten healthy adults received single-pulse suprathreshold TMS to the cerebellum and an occipital/parietal control site with double-cone and figure-of-eight coils while cerebral activity was recorded. Read More

View Article and Full-Text PDF

[Electroacupuncture-induced plasticity between hand and face representations in the motor cortex in healthy subjects].

Zhen Ci Yan Jiu 2020 Oct;45(10):829-34

Second Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou 510405.

Objective: To observe the plasticity between hand and face representations of the motor cortex of healthy volunteers after electroacupuncture(EA) at Hegu(LI4), so as to provide a scientific basis for the theory of "Hegu is indicated for orofacial problems".

Methods: Using a cross-over design (self-controlled study), 10 healthy volunteers were randomly assigned to an acupuncture group and a sham acupuncture group (two-weeks wash-out period between the two groups). Subjects in the acupuncture group received EA stimulation (2 Hz, 0. Read More

View Article and Full-Text PDF
October 2020

Relationship between GABA levels and task-dependent cortical excitability in children with attention-deficit/hyperactivity disorder.

Clin Neurophysiol 2021 May 10;132(5):1163-1172. Epub 2021 Mar 10.

Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins School of Medicine, Baltimore, MD, United States; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States; Department of Forensic and Neurodevelopmental Sciences, Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.

Objective: Compared to typically developing (TD) peers, children with attention deficit hyperactivity disorder (ADHD) manifest reduced short interval cortical inhibition (SICI) in the dominant motor cortex measured with transcranial magnetic stimulation (TMS). This multimodal study investigates the inhibitory neurophysiology and neurochemistry by evaluating the relationship between SICI and γ-amino butyric acid (GABA+) levels, measured with magnetic resonance spectroscopy (MRS).

Methods: Across two sites, 37 children with ADHD and 45 TD children, ages 8-12 years, participated. Read More

View Article and Full-Text PDF

Personalising transcranial magnetic stimulation for depression using neuroimaging: A systematic review.

World J Biol Psychiatry 2021 Apr 21:1-23. Epub 2021 Apr 21.

Epworth Centre for Innovation in Mental Health, Epworth Healthcare and Department of Psychiatry, Monash University, Melbourne, Australia.

Objectives: Transcranial magnetic stimulation (TMS) is a well-established and effective treatment for depression, though response rates are suboptimal. Personalising TMS for depression with neuroimaging can take into account inter-individual differences in anatomical and electrophysiological characteristics; and thereby provide a potentially more efficacious form of treatment. The current systematic review aimed to critically appraise the literature relating to personalising TMS for depression with neuroimaging. Read More

View Article and Full-Text PDF

rTMS affects EEG microstates dynamic during evoked activity.

Cortex 2021 May 4;138:302-310. Epub 2021 Mar 4.

Department of Neuroscience Imaging and Clinical Science, ITAB, Institute for Advanced Biomedical Technologies, University "G. D'Annunzio", Chieti, Italy. Electronic address:

Electrophysiological (EEG) correlates both at time (i.e., event-related potentials, ERP) and frequency (i. Read More

View Article and Full-Text PDF

Chronic Neurophysiological Effects of Repeated Head Trauma in Retired Australian Male Sport Athletes.

Front Neurol 2021 9;12:633320. Epub 2021 Mar 9.

Department of Neuropathology, Royal Prince Alfred Hospital, Sydney, NSW, Australia.

This study investigated the somatosensory and corticomotor physiology of retired contact sport athletes with a history of repeated concussion/subconcussion head trauma. Retired male athletes with a history of playing contact sports and repeated head trauma ( = 122) were divided into two groups: those who expressed concerns regarding their mental and cognitive health ("symptomatic": = 83), and those who did not express any ongoing concerns ("asymptomatic": = 39). Both groups were compared to age-matched male controls ( = 50) with no history of concussions or participation in contact sports, an absence of self-reported cognitive, or mood impairments. Read More

View Article and Full-Text PDF

Multimodal Assessment of Precentral Anodal TDCS: Individual Rise in Supplementary Motor Activity Scales With Increase in Corticospinal Excitability.

Front Hum Neurosci 2021 25;15:639274. Epub 2021 Feb 25.

Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.

Background: Transcranial direct current stimulation (TDCS) targeting the primary motor hand area (M1-HAND) may induce lasting shifts in corticospinal excitability, but after-effects show substantial inter-individual variability. Functional magnetic resonance imaging (fMRI) can probe after-effects of TDCS on regional neural activity on a whole-brain level.

Objective: Using a double-blinded cross-over design, we investigated whether the individual change in corticospinal excitability after TDCS of M1-HAND is associated with changes in task-related regional activity in cortical motor areas. Read More

View Article and Full-Text PDF
February 2021