5,953 results match your criteria received respective


Implementation of the Institute of Medicine Treatment Plan in Oncology Practice.

Am J Med Qual 2021 May 12. Epub 2021 May 12.

Penn Medicine at Lancaster General Health, Ann B. Barshinger Cancer Institute, Lancaster PA Texas Oncology, PA, Dallas, TX Divisions of Hematology and Oncology and Gerontology, Geriatrics, and Palliative Care, University of Alabama at Birmingham, Birmingham, AL.

Participation in the Centers for Medicare & Medicaid Services (CMS) value-based payment reform, the Oncology Care Model (OCM), requires that every beneficiary has a documented 13-point Institute of Medicine treatment plan (TP) when commencing antineoplastic therapy. The intent is to enhance shared decision-making between the patient and care team by providing transparent treatment recommendations and engaging patients and caregivers in meaningful discussion. There is limited discussion in the literature about how to adapt the CMS recommendations to diverse practice settings while maintaining fidelity to the intent of the TP. Read More

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Reducing antibiotic treatment duration for ventilator-associated pneumonia (REGARD-VAP): a trial protocol for a randomised clinical trial.

BMJ Open 2021 May 13;11(5):e050105. Epub 2021 May 13.

Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

Introduction: Ventilator-associated pneumonia (VAP) is the most common nosocomial infection in intensive care units (ICUs). Using short-course antibiotics to treat VAP caused by Gram-negative non-fermenting bacteria has been reported to be associated with excess pneumonia recurrences. The "REducinG Antibiotic tReatment Duration for Ventilator-Associated Pneumonia" (REGARD-VAP) trial aims to provide evidence for using a set of reproducible clinical criteria to shorten antibiotic duration for individualised treatment duration of VAP. Read More

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Reciprocal interactions between osteoclasts and nociceptive sensory neurons in bone cancer pain.

Pain Rep 2021 9;6(1):e867. Epub 2021 Mar 9.

Department of Anesthesiology, Center for Translational Pain Medicine, Duke University Medical Center, Durham, NC, USA.

Many common cancers such as breast, prostate, and lung cancer metastasize to bones at advanced stages, producing severe pain and functional impairment. At present, the current pharmacotherapies available for bone cancer pain are insufficient to provide safe and efficacious pain relief. In this narrative review, we discuss the mechanisms used by cancer cells within the bone tumor microenvironment (TME) to drive bone cancer pain. Read More

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Sequential Systemic Treatment in Advanced Hepatocellular Carcinoma Is Able to Prolong Median Survival to More than 3 Years in a Selected Real-World Cohort.

Visc Med 2021 Mar 7;37(2):87-93. Epub 2020 May 7.

I. Department of Internal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Introduction: The number of efficacious systemic agents for advanced hepatocellular carcinoma (HCC) has rapidly increased over the past 3 years. However, guidance for optimal sequential systemic treatment in patients with advanced disease and experience with outcome and safety profiles are lacking.

Objective: We aimed to assess efficacy and tolerability of sequential systemic therapy of advanced HCC. Read More

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Media and social media attention to retracted articles according to Altmetric.

PLoS One 2021 12;16(5):e0248625. Epub 2021 May 12.

Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, CA, United States of America.

The number of retracted articles has grown fast. However, the extent to which researchers and the public are made adequately aware of these retractions and how the media and social media respond to them remains unknown. Here, we aimed to evaluate the media and social media attention received by retracted articles and assess also the attention they receive post-retraction versus pre-retraction. Read More

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[Effects of the Computer-Based Grapho-Phonological Training in Children with Developmental Dyslexia].

Prax Kinderpsychol Kinderpsychiatr 2021 May;70(4):333-355

Technische Universität Kaiserslautern Center of Cognitive Science, Kognitive und Entwicklungspsychologie Deutschland https://www.tu-darmstadt.de/studieren/studieninteressierte/studienangebot_studiengaenge/studiengang_196608.de.jsp.

The effects of the computer-based training program Lautarium on phonological awareness and literacy skills were investigated in 41 third-grade children with developmental dyslexia who attended special dyslexia classes in a primary school in Saxony, Germany. Based on the proven efficacy of phonics-based instruction, Lautarium combines training of phoneme perception and phonological awareness with training of grapheme-phoneme-relationships and reading and spelling of transparent words. In addition, rapid access from written words to meaning is included. Read More

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Health-related quality of life in bladder cancer patients: bladder cancer-specific instruments and domains. Part 2.

Curr Opin Urol 2021 May 10. Epub 2021 May 10.

Department of Urology, Federal Armed Services Hospital Koblenz, Koblenz, Germany Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria Department of Urology, The Jikei University School of Medicine, Tokyo, Japan Research Center for Evidence-Based Medicine, Tabriz University of Medical Sciences, Tabriz, Iran Department of Urology, Uro-Oncology, Robot-Assisted and Specialized Urologic Surgery, University Hospital Cologne, Cologne, Germany Department of Urology, University of Texas Southwestern Medical Center, Dallas, Texas, USA Department of Urology, Second Faculty of Medicine, Charles University, Prague, Czech Republic Department of Urology, Weill Cornell Medical College, New York, New York, USA Karl Landsteiner Institute of Urology and Andrology, Vienna, Austria Department of Urology, University of Jordan, Amman, Jordan.

Purpose Of Review: Several instruments have been designed to evaluate health-related quality of life (HRQoL) in patients with bladder cancer (BC). However, they vary in purpose, domains, and quality. To identify QoL instruments that have been validated for BC patients and to critically assess their domains and limitations. Read More

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Impacts of Specific Cryoprotectants on Sperm Freezing and Relationships Between Cryodamage and Oxidation Stress Parameters in Awassi Ram Sperm.

Cryo Letters 2021 Mar-Apr;42(2):87-95

Faculty of Health Sciences, Harran University, Şanlıurfa, Turkey.

Background: The role of oxidative stress during cryoprotectant treatment has received little attention. OBJECTİVE: To assess the effects of different cryoprotectants and discover relationships between cryodamage and oxidative stress parameters on Awassi ram sperm.

Materials And Methods: The sperm samples diluted with Salamon's tris-citrate (TRIS) containing 20% centrifuged egg yolk and 0. Read More

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Perioperative administration of cefazolin and metronidazole in obese and non-obese patients: a pharmacokinetic study in plasma and interstitial fluid.

J Antimicrob Chemother 2021 May 10. Epub 2021 May 10.

Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, Leipzig, Germany.

Objectives: To assess plasma and tissue pharmacokinetics of cefazolin and metronidazole in obese patients undergoing bariatric surgery and non-obese patients undergoing intra-abdominal surgery.

Patients And Methods: Fifteen obese and 15 non-obese patients received an IV short infusion of 2 g cefazolin and 0.5 g metronidazole for perioperative prophylaxis. Read More

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Heart failure in adults with congenital heart disease: a narrative review.

Cardiovasc Diagn Ther 2021 Apr;11(2):529-537

Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, UK.

The number of adults with congenital heart disease (ACHD) has increased over the last decades due to advancements in medical care, including interventional and surgical therapies. We are therefore more frequently challenged by the long-term consequences of palliative or corrective surgery carried out during childhood. Although patients with ACHD may develop conditions related to general cardiovascular risk factors, such as coronary artery disease, the most common complications leading to morbidity and mortality are arrhythmias, heart failure and thromboembolic events. Read More

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Angiotensin II Receptor Blockers but Not Angiotensin-Converting Enzyme Inhibitors Are Associated With a Reduced Risk of Acute Kidney Injury After Major Surgery.

Front Pharmacol 2021 23;12:662301. Epub 2021 Apr 23.

Department of Internal Medicine, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan.

We investigated the respective effects of preoperative angiotensin-converting-enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) on the incidence of postoperative acute kidney injury (AKI) and mortality. In this nested case-control study, we enrolled 20,276 patients who received major surgery. We collected their baseline demographic data, comorbidities and prescribed medication, the outcomes of postoperative AKI and mortality. Read More

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L-carnitine extenuates endocrine disruption, inflammatory burst and oxidative stress in carbendazim-challenged male rats via upregulation of testicular StAR and FABP9, and downregulation of P38-MAPK pathways.

Toxicology 2021 May 6:152808. Epub 2021 May 6.

Cairo University, Cairo, Egypt.

We have addressed in the current study the potential of L-carnitine (LC) to extenuate the reproductive toxic insults of carbendazim (CBZ) in male rats, and the molecular mechanisms whereby carnitine would modify the spermatogenic and steroidogenic derangements invoked by the endocrine disruptor. Herein, animals received daily doses of carbendazim (100 mg/kg) by gavage for 8 weeks. Another CBZ-challenged group was co-supplemented with LC (500 mg/kg, IP) twice weekly for 8 weeks. Read More

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The Efficacy of Platelet-Rich Plasma on Improving Pain and Function for Lateral Epicondylitis: A Systematic Review and Meta-analysis with Risk-of-Bias Assessment.

Arthroscopy 2021 May 5. Epub 2021 May 5.

Department of Orthopaedic Surgery, Keck School of Medicine of USC, Los Angeles, California. Electronic address:

Purpose: To assess the efficacy of PRP for lateral epicondylitis and evaluate its impact on pain and functional outcomes.

Methods: This study followed Preferred Reporting Items and Systematic Reviews and Meta-Analyses guidelines. A comprehensive literature search was conducted in September 2019 and repeated in April 2020 using electronic databases PubMed, MEDLINE, and the Cochrane Library. Read More

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Pediatric Pleomorphic Xanthoastrocytoma: A National Database Inquiry on Current Treatment Approaches in the United States.

Cancer Rep (Hoboken) 2021 May 8:e1415. Epub 2021 May 8.

Department of Radiation Medicine, Oregon Health & Science University, Portland, Oregon, USA.

Background: Pleomorphic xanthoastrocytomas (PXAs) account for <1% of primary brain tumors, occurring predominantly in children and young adults. Surgical resection serves as the primary treatment for PXAs, while radiotherapy (RT) and chemotherapy protocols remain poorly defined.

Aim: This study aims to determine current care patterns utilized for pediatric patients (≤ 18 years) diagnosed with PXAs and their effect on overall survival. Read More

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Oncogenic driver mutations in non-small cell lung cancer: Past, present and future.

World J Clin Oncol 2021 Apr;12(4):217-237

Department of Oncology, University Hospital Geneva, Geneva 1205, Switzerland.

Lung cancer, of which non-small lung cancer is the most common subtype, represents the leading cause of cancer related-death worldwide. It is now recognized that a significant proportion of these patients present alterations in certain genes that drive oncogenesis. In recent years, more of these so-called oncogenic drivers have been identified, and a better understanding of their biology has allowed the development new targeted agents. Read More

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Current decision support tools fail to agree or predict therapeutic decisions in a single cohort of unruptured intracranial aneurysms.

Acta Neurochir (Wien) 2021 May 6. Epub 2021 May 6.

Department of Neurosurgery, King's College Hospital, Denmark Hill, Brixton, London, SE5 9RS, UK.

Background: There is limited evidence to direct the management of unruptured intracranial aneurysms. Models extrapolated from existing data have been proposed to guide treatment recommendations. The aim of this study is to assess whether a consensus-based treatment score (UIATS) or rupture rate estimation model (PHASES) can be used to benchmark UK multi-disciplinary team (MDT) practice. Read More

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Can 3D pseudo-continuous arterial spin labeling perfusion imaging be applied to predict early response to chemoradiotherapy in patients with advanced nasopharyngeal carcinoma?

Radiother Oncol 2021 May 2. Epub 2021 May 2.

GE Healthcare, MR Research China, Beijing, 100176, China.

Background And Purpose: Chemoradiotherapy (CRT) has been widely applied in patients with advanced nasopharyngeal carcinoma (ANPC). However, limited imaging modality exists on the evaluation of early response to CRT. The purpose of this study was therefore to investigate whether 3D pseudo-continuous arterial spin labeling (3D pCASL) perfusion imaging could predict early response to CRT in ANPC patients. Read More

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Evaluating a CTSA-funded pilot grant program.

J Clin Transl Sci 2020 Nov 16;5(1):e63. Epub 2020 Nov 16.

North Carolina Translational and Clinical Sciences Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Introduction: Pilot programs are integral to catalyzing and accelerating research at Clinical and Translational Science Award (CTSA) hubs. However, little has been published about the structure and operationalization of pilot programs or how they impact the translational research enterprise at CTSAs. The North Carolina Translational and Clinical Science Institute (NC TraCS), the CTSA hub at the University of North Carolina at Chapel Hill (UNC-CH) conducted an evaluation case study to describe the pilot program structure, assess process outcomes, and provide a framework for other institutions to utilize for the evaluation of their respective pilot programs. Read More

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November 2020

Comparative study of patient outcomes between direct to implant and two-stage implant-based breast reconstruction after mastectomy.

J Plast Reconstr Aesthet Surg 2021 Mar 30. Epub 2021 Mar 30.

Plastic and Reconstructive Surgery, Azienda Ospedaliera Universitaria Integrata di Verona, Piazzale Stefani 1, 37100 Verona, Italy.

Background: Breast reconstruction plays a central role in the outcome management of patients with breast cancer, particularly in terms of quality of life (QoL), which must be weighed carefully when considering the available surgical options. In the context of implant-based breast reconstruction, immediate replacement with prosthesis (direct-to-implant (DTI)) and acellular dermal matrix (ADM) is gaining popularity, at the expense of the traditional two-stage implant-based breast reconstruction with tissue expander (TE), and the literature suggests that patients tend to prefer interventions with "immediate" therapeutic efficacy and aesthetic satisfaction that obviate the need for further invasive surgery. We investigated this hypothesis by administering the BREAST-Q™ questionnaire to two groups of patients who had undergone the respective procedures. Read More

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The Influence of Specific Bioactive Collagen Peptides on Body Composition and Muscle Strength in Middle-Aged, Untrained Men: A Randomized Controlled Trial.

Int J Environ Res Public Health 2021 Apr 30;18(9). Epub 2021 Apr 30.

Centre of Sports Science, Department for Nutrition, Exercise and Health, University of Vienna, Auf der Schmelz 6, 1150 Vienna, Austria.

It has been shown that specific collagen peptides combined with resistance training (RT) improves body composition and muscle strength in elderly sarcopenic men. The main purpose of this RCT study was to investigate the efficacy of the identical specific collagen peptides combined with RT on body composition and muscle strength in middle-aged, untrained men. Furthermore, in the exploratory part of the study, these results were compared with another group that had received whey protein in addition to the RT. Read More

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EMICIZUMAB DOSING IN CHILDREN AND ADULTS WITH HEMOPHILIA A: SIMULATING A USER-FRIENDLY AND COST-EFFICIENT REGIMEN.

Thromb Haemost 2021 May 4. Epub 2021 May 4.

Hospital Pharmacy-Clinical Pharmacology, Amsterdam University Medical Centres, Amsterdam, Netherlands.

Background: When emicizumab is dosed according to label, clinicians are obligated to discard or overdose medication due to discrepancies between calculated dose and vial content. The aim of this study was to compose a cost-efficient emicizumab maintenance dosing regimen using Monte Carlo simulation based on vial size, patient friendly intervals and patient characteristics, while striving for similar plasma concentrations as observed in clinical trials.

Methods: Monte Carlo simulations were used to investigate alternative dosing regimens in patients weighing 3 to 150 kg. Read More

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Effective water/wastewater treatment methodologies for toxic pollutants removal: Processes and applications towards sustainable development.

Chemosphere 2021 Apr 27;280:130595. Epub 2021 Apr 27.

Deprtament of Chemical Engineering, Sri Sivasubramaniya Nadar College of Engineering, Chennai, 603110, India.

Release of pollutants due to inflating anthropogenic activities has a conspicuous effect on the environment. As water is uniquely vulnerable to pollution, water pollution control has received a considerable attention among the most critical environmental challenges. Diverse sources such as heavy metals, dyes, pathogenic and organic compounds lead to deterioration in water quality. Read More

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Family medicine provision of online medication abortion in three US states during COVID-19.

Contraception 2021 Apr 30. Epub 2021 Apr 30.

Women on Web/Aid Access, Amsterdam, the Netherlands.

Objective: To examine provision of direct-to-patient medication abortion during COVID-19 by United States family physicians through a clinician-supported, asynchronous online service, Aid Access.

Study Design: We analyzed data from United States residents in New Jersey, New York, and Washington who requested medication abortion from 3 family physicians using the online service from Aid Access between April and November 2020. This study seeks to examine individual characteristics, motivations, and geographic locations of patients receiving abortion care through the Aid Access platform. Read More

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A Randomized, Double-Blind, and Placebo-Controlled Trial of Chinese Herbal Medicine in the Treatment of Childhood Constipation.

Clin Transl Gastroenterol 2021 May 3;12(5):e00345. Epub 2021 May 3.

Departments of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, P.R. China.

Objectives: Management of constipation is still challenging in childhood. The pharmacological effect of XiaojiDaozhi Decoction, a prescription of Chinese Herbal Medicine (CHM), has been well described for the treatment of food and Qi stagnation which account for childhood constipation. However, the efficacy and safety of XiaojiDaozhi Decoction in childhood constipation remains unclear. Read More

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Encapsulation of Recombinant MOMP in Extended-Releasing PLGA 85:15 Nanoparticles Confer Protective Immunity Against a Genital Challenge and Re-Challenge.

Front Immunol 2021 14;12:660932. Epub 2021 Apr 14.

Center for NanoBiotechnology Research, Department of Biological Sciences, Alabama State University, Montgomery, AL, United States.

Recently we reported the immune-potentiating capacity of a nanovaccine (PLGA-rMOMP) comprising rMOMP (recombinant major outer membrane protein) encapsulated in extended-releasing PLGA [poly (D, L-lactide-co-glycolide) (85:15)] nanoparticles. Here we hypothesized that PLGA-rMOMP would bolster immune-effector mechanisms to confer protective efficacy in mice against a genital challenge and re-challenge. Female BALB/c mice received three immunizations, either subcutaneously (SC) or intranasally (IN), before receiving an intravaginal challenge with on day 49 and a re-challenge on day 170. Read More

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Observer's adrenal corticosterone secretion involvement in vicarious fear conditioning.

Psychoneuroendocrinology 2021 Apr 26;129:105246. Epub 2021 Apr 26.

Department of Physiology, National Cheng Kung University College of Medicine, Tainan 701, Taiwan, ROC; Institute of Basic Medical Sciences, National Cheng Kung University College of Medicine, Tainan 701, Taiwan, ROC. Electronic address:

Vicarious learning represents a far-reaching value for the survival of social animals. Adrenal hormones are known to affect many forms of learning, yet the roles of adrenal hormones in vicarious learning remain unexplored. This study was undertaken to assess whether observation-stimulated corticosterone (CORT) secretion may affect the magnitude of a vicarious fear conditioning. Read More

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The dosimetric benefit of in-advance respiratory training for deep inspiration breath holding is realized during daily treatment in left breast radiotherapy: A comparative retrospective study of serial surface motion tracking.

J Med Imaging Radiat Oncol 2021 May 1. Epub 2021 May 1.

Department of Radiation Oncology, University of Washington School of Medicine, Seattle, Washington, USA.

Introduction: A novel approach of in-advance preparatory respiratory training and practice for deep inspiration breath holding (DIBH) has been shown to further reduce cardiac dose in breast cancer radiotherapy patients, enabled by deeper (extended) DIBH. Here we investigated the consistency and stability of such training-induced extended DIBH after training completion and throughout the daily radiotherapy course.

Methods: Daily chestwall motion from real-time surface tracking transponder data was analysed in 67 left breast radiotherapy patients treated in DIBH. Read More

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Intracranial atherosclerotic disease mechanistic subtypes drive hypoperfusion patterns.

J Neuroimaging 2021 Apr 30. Epub 2021 Apr 30.

Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, California, USA.

Background And Purpose: In symptomatic intracranial atherosclerotic stenosis (ICAS), borderzone infarct pattern and perfusion mismatch are associated with increased risk of recurrent strokes, which may reflect the shared underlying mechanism of hypoperfusion distal to the intracranial atherosclerosis. Accordingly, we hypothesized a correlation between hypoperfusion volumes and ICAS infarct patterns based on the respective underlying mechanistic subtypes.

Methods: We conducted a retrospective analysis of consecutive symptomatic ICAS cases, acute strokes due to subocclusive (50%-99%) intracranial stenosis. Read More

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Rapamycin attenuates depression and anxiety like behaviours through modulation of the NLRP3 pathway in pentylenetetrazole-kindled male Wistar rats.

Fundam Clin Pharmacol 2021 Apr 30. Epub 2021 Apr 30.

Department of Animal Sciences and Biotechnology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran.

There is cumulative evidence that shows the effect of epilepsy on behavioral conditions like anxiety and depression. The effects of rapamycin on anxiety and depression caused by pentylenetetrazole (PTZ) in the rat and possible underlying mechanism were evaluated. Male Wistar rats were divided into experimental and control groups. Read More

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Clinical and therapeutic outcomes of COVID-19 intensive care units (ICU) patients: a retrospective study in Ghana.

Pan Afr Med J 2021 2;38:107. Epub 2021 Feb 2.

Department of Medicine and Therapeutics, College of Health Sciences, University of Ghana Medical School, University of Ghana, Accra, Ghana.

The COVID-19 pandemic had caused significant morbidity and mortality, with over a million deaths recorded to date. Mortality recorded among severe-critically ill patients admitted to intensive care units (ICU) has been significantly high, especially in most COVID-19 epicenters. Reports on the unique clinical characteristics and outcomes from the ICU admissions are on-going with isolated studies in Africa. Read More

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