284,272 results match your criteria received medical

An intervention to increase hepatitis C virus diagnosis and treatment uptake among people in custody in Iran.

Int J Drug Policy 2021 May 12;95:103269. Epub 2021 May 12.

Digestive Oncology Research Center, Digestive Diseases Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Background: Iran is among countries with high opioid agonist therapy (OAT) coverage in prisons, which provides an infrastructure to increase feasibility of HCV programs. We aimed to evaluate the impact of an intervention to improve HCV screening, diagnosis, and treatment, including alongside the provision of OAT, in an Iranian prison.

Methods: During July-December 2018, in the Gorgan prison, all incarcerated adults (>18 years) received HCV antibody rapid testing and, if positive, provided a venepuncture sample for HCV RNA testing. Read More

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Patient expectations about a clinical diagnostic test may influence the clinician's test interpretation.

Musculoskelet Sci Pract 2021 May 6;54:102387. Epub 2021 May 6.

Menzies Health Institute Queensland, Griffith University, Brisbane & Gold Coast, Australia.

Background: With medical information widely available, patients often have preconceived ideas regarding diagnostic procedures and management strategies.

Objectives: To investigate whether expectations, such as beliefs about the source of symptoms and knowledge about diagnostic tests, influence pain perception during a clinical diagnostic test.

Design: Cross-sectional study. Read More

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The impact of time to first antimicrobial dose on length of stay and 30-day hospital readmission in patients with lower limb cellulitis.

J Glob Antimicrob Resist 2021 May 12. Epub 2021 May 12.

National Centre for Antimicrobial Stewardship (NCAS), Peter Doherty Research Institute for Infection and Immunity, University of Melbourne, Level 5, 792 Elizabeth St, Melbourne, VIC, Australia; University of Melbourne, Faculty of Medicine, Dentistry and Health Sciences, Department of Medicine- RMH, Royal Parade, Melbourne, VIC, Australia; Victorian Infectious Diseases Service, Royal Melbourne Hospital, 300 Grattan St, Melbourne, VIC, Australia; Department of Infectious Diseases, Peter Doherty Institute for Infection and Immunity, University of Melbourne, 792 Elizabeth St, Melbourne, Australia. Electronic address:

Objectives: There have been efforts to promote timely antimicrobial administration for patients with sepsis, but the importance for other infections is uncertain. This study analysed whether time to first antimicrobial dose (TFAD) in patients with lower limb cellulitis influenced outcome measures such as length of acute hospital stay (LOS) and 30-day hospital readmission rates for cellulitis.

Methods: Medical records of patients admitted with lower limb cellulitis or erysipelas over a 15-month period (1 May 2019 to 30 November 2019 & 1 March 2020 to 31 October 2020) were reviewed. Read More

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Relapse protection following early CMV reactivation after HSCT is limited to HLA-C KIR ligand homozygous recipients.

Transplant Cell Ther 2021 May 12. Epub 2021 May 12.

Department of Internal Medicine I: Hematology with Stem Cell Transplantation, Hemostaseology and Medical Oncology, Ordensklinikum Linz Elisabethinen, Linz, Austria; Medical Faculty, Johannes Kepler University, Linz, Austria.

Background: While the risk for non-relapse mortality (NRM) associated with early cytomegalovirus (CMV) reactivation (CMVR) after allogeneic hematopoietic stem cell transplantation (HSCT) is well established, debate is ongoing on whether CMVR may reduce the risk of primary disease relapse.

Objective: Relapse protection following early CMV reactivation after HSCT in the context of the HLA-C KIR ligands of the recipients.

Study Design: In this retrospective, bi-centric study, 406 matched-related or unrelated transplants for acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) were stratified by HLA-C KIRL groups (homozygous versus heterozygous) and were separately analyzed for the impact of early CMVR on the cumulative incidence of relapse, non-relapse mortality (NRM), acute and chronic graft-versus-host-disease (GVHD), using landmark and multi-state analyses. Read More

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Universal Engraftment after Allogeneic Hematopoietic Cell Transplantation Using Cryopreserved CD34 Selected Grafts.

Transplant Cell Ther 2021 May 12. Epub 2021 May 12.

Department of Medicine, Adult Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York, NY; Department of Medicine, Weill Cornell Medical College, New York, NY.

Background: As a result of the COVID-19 pandemic, most centers performing allogeneic hematopoietic cell transplant (allo-HCT) have switched to the use of cryopreserved grafts. Previous investigators have suggested that cryopreserved allografts may heighten risk of nonengraftment. To date, no study has investigated the effect of cryopreservation of CD34-selected hematopoietic progenitor cells (CD34+HPC) used as the sole graft source. Read More

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Total IgE variability is associated with future asthma exacerbations: a one-year prospective cohort study.

J Allergy Clin Immunol Pract 2021 May 12. Epub 2021 May 12.

Airway Physiology and Imaging Group and the Woolcock Emphysema Centre, The Woolcock Institute of Medical Research, Sydney, NSW, Australia; Discipline of Medical Sciences, School of Life Sciences, University of Technology Sydney, Sydney, NSW, Australia.

Background: Few prospective studies have investigated the relationship between IgE variability and risk of asthma exacerbations (AEs).

Objective: To explore the relationship between IgE variability and AEs.

Methods: Recruited patients with stable asthma underwent two serum total IgE tests within a month (at screening [baseline IgE] and one-month) to obtain coefficient of variation (CV) of base-10 log-transformed IgE. Read More

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Dose Escalated Radiotherapy for Glioblastoma Multiforme: An International Systematic Review and Meta-Analysis of 22 Prospective Trials.

Int J Radiat Oncol Biol Phys 2021 May 12. Epub 2021 May 12.

Department of Radiation Oncology and Neurosurgery, The James Cancer Hospital at the Ohio State University Wexner Medical Center, Columbus, OH, USA. Electronic address:

Background: Limited evidence is available on the utility of dose-escalated radiation therapy (DE-RT) +/- (TMZ) vs. standard-of-care RT (SoC-RT) for patients with newly diagnosed glioblastoma multiforme (GBM). We performed a systematic review/meta-analysis to compare overall survival (OS) and progression-free survival (PFS) between DE-RT and SoC-RT. Read More

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Enfortumab vedotin after PD-1 or PD-L1 inhibitors in cisplatin-ineligible patients with advanced urothelial carcinoma (EV‑201): a multicentre, single-arm, phase 2 trial.

Lancet Oncol 2021 May 12. Epub 2021 May 12.

Perlmutter Cancer Center at NYU Langone Health, New York, NY, USA.

Background: Locally advanced or metastatic urothelial carcinoma is generally incurable and has scarce treatment options, especially for cisplatin-ineligible patients previously treated with PD-1 or PD-L1 therapy. Enfortumab vedotin is an antibody-drug conjugate directed at Nectin-4, a protein highly expressed in urothelial carcinoma. We aimed to evaluate the efficacy and safety of enfortumab vedotin in the post-immunotherapy setting in cisplatin-ineligible patients. Read More

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Investigation of therapeutic effect of Curcumin α and β Glucoside anomers against Alzheimer's disease by the nose to brain drug delivery.

Brain Res 2021 May 12:147517. Epub 2021 May 12.

Zanjan Applied Pharmacology Research Center, Zanjan University of Medical Sciences, Zanjan, Iran; Department of Pharmacology and toxicology, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran.

Alzheimer's disease (AD) is one of the greatest geriatric medicinal challenges of our century and is the main disease leading to dementia. Despite extensive scientific research advances, available disease-modifying treatment strategies remained limited; thus, increasing demand for new drugs. In recent years, medicinal plants attracted attention due to their potential role in dementia. Read More

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Ovarian cancer population screening and mortality after long-term follow-up in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS): a randomised controlled trial.

Lancet 2021 May 12. Epub 2021 May 12.

MRC Clinical Trials Unit, Institute of Clinical Trials and Methodology, University College London, London, UK.

Background: Ovarian cancer continues to have a poor prognosis with the majority of women diagnosed with advanced disease. Therefore, we undertook the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) to determine if population screening can reduce deaths due to the disease. We report on ovarian cancer mortality after long-term follow-up in UKCTOCS. Read More

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A phase II trial of continuous ixazomib, thalidomide and dexamethasone for relapsed and/or refractory multiple myeloma: the Australasian Myeloma Research Consortium (AMaRC) 16-02 trial.

Br J Haematol 2021 May 15. Epub 2021 May 15.

Alfred Health-Monash University, Melbourne, Victoria, Australia.

We evaluated the efficacy and tolerability of continuous ixazomib-thalidomide-dexamethasone (ITd: 4 mg, day 1, 8, 15; 100 mg daily; and 40 mg weekly). A total of 39 patients with relapsed/refractory multiple myeloma (RRMM) aged ≥18 years with one to three prior lines of therapy were enrolled from two tertiary centres in Victoria and South Australia, Australia. The overall response rate (ORR) was 56·4% with a clinical benefit rate of 71·8%. Read More

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Evaluating the efficacy of nitazoxanide in uncomplicated amebic liver abscess.

Indian J Gastroenterol 2021 May 15. Epub 2021 May 15.

Department of Gastroenterology, SMS Medical College and Hospital, Jaipur 302 004, India.

Background: Amebic liver abscess is treated successfully with metronidazole or another nitroimidazole drug followed by a luminal amebicide. Metronidazole has long been preferred, but has been associated with several adverse effects including intolerance in certain clinical situations. Mechanisms of metronidazole resistance and mutagenic potential have been described. Read More

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How hospitals can improve their public quality metrics: a decision-theoretic model.

Health Care Manag Sci 2021 May 15. Epub 2021 May 15.

School of Economics, Georgia Institute of Technology, Atlanta, GA, USA.

The public reporting of hospitals' quality of care is providing additional motivation for hospitals to deliver high-quality patient care. Hospital Compare, a consumer-oriented website by the Centers for Medicare and Medicaid Services (CMS), provides patients with detailed quality of care data on most US hospitals. Given that many quality metrics are the aggregate result of physicians' individual clinical decisions, the question arises if and how hospitals could influence their physicians so that their decisions positively contribute to hospitals' quality goals. Read More

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What do female university students know about pelvic floor disorders? A cross-sectional survey.

Int Urogynecol J 2021 May 15. Epub 2021 May 15.

Department of Obstetrics and Gynaecology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Mas Casanovas, 90, 08025, Barcelona, Spain.

Introduction And Hypothesis: Pelvic floor dysfunction (PFD) is common in women but few seek medical attention. Poor recognition of the condition as pathological and unawareness of treatments may account for low consultation rates.

Methods: This cross-sectional study was based on an online survey that was responded to in February and March 2020 by 768 female university students. Read More

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Effects of the new fasting standard on sedation in the pediatric emergency room.

Pediatr Int 2021 May 15. Epub 2021 May 15.

National Center for Global Health and Medicine. Bureau of International Health Cooperation. Department of Human Resources Development.

Background: The present study compared adherence to the fasting-time guidelines of the International Committee for the Advancement of Procedural Sedation (ICAPS) and the North American Society of Anesthesiologists (ASA) and complication rates in pediatric patients requiring procedure sedation and analgesia during treatment in the emergency room (ER).

Methods: The present, retrospective, single-center study was performed between 2016 and 2020 and enrolled patients who received procedural sedation and analgesia in the ER with the fasting times recommended in the ICAPS and ASA guidelines.

Results: In total, 857 patients were included. Read More

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Response to crizotinib in a patient with MET-amplified hepatocellular carcinoma.

Hepatol Res 2021 May 15. Epub 2021 May 15.

Department of Hepatobiliary Surgery, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.

Aims: Molecular profiling of hepatocellular carcinoma (HCC) has helped identify actionable genomic alterations that may guide therapeutic decision-making and clinical trial enrollment. However, in clinical practice, next-generation sequencing (NGS) is not extensively used in routine clinical care to identify patients with HCC who are likely to benefit from genome-directed targeted therapies.

Methods: Here, we describe the case of a 66-year-old man with advanced HCC. Read More

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H3F3A-mutated Giant Cell Tumour of Bone without Giant Cells - Clinical Presentation, Radiology, and Histology of Three Cases.

Histopathology 2021 May 15. Epub 2021 May 15.

Bone Tumour Reference Center at the Institute of Pathology, University Hospital Basel, Basel, Switzerland.

Aims: Giant cell tumour of bone (GCTB) is histologically defined as a lesion containing reactive giant cells and a neoplastic mononuclear cell population; in up to 92% GCTB is characterized by a specific mutation of the histone gene H3F3A. The cellular composition ranges from giant cell-rich to giant cell-poor tumours. The diagnosis of GCTB can be challenging and several other lesions need to be excluded, e. Read More

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Centrally acting anticholinergic drug trihexyphenidyl is highly effective in reducing nightmares associated with post-traumatic stress disorder.

Brain Behav 2021 May 14:e02147. Epub 2021 May 14.

Sogo PTSD Institute, Medical Corporation Sogokai, Hiroshima-city, Japan.

Introduction: Following a case study on scopolamine butyl bromide, an anticholinergic drug, we studied the effect of a central anticholinergic drug on post-traumatic stress disorder (PTSD)-related flashbacks and nightmares.

Methods: We administered trihexyphenidyl (TP) to 34 patients with refractory PTSD-related nightmares and flashbacks (open-label trial [n = 22]; single-blind trial [n = 12]), who had previously received psychiatric treatment for approximately 2-15 years, without therapeutic benefits. The effect of TP was determined using the Clinician-Administered PTSD Scale (CAPS) and the Impact of Event Scale-Revised (IES-R). Read More

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Myeloid/lymphoid neoplasms with FLT3 rearrangement.

Mod Pathol 2021 May 14. Epub 2021 May 14.

Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Myeloid/lymphoid neoplasms (M/LN) with 13q12/FLT3 rearrangement have been suggested as candidates for possible inclusion in the World Health Organization classification group of M/LN with eosinophilia (M/LN-eo). We report 12 patients with confirmed FLT3 rearrangement, six with t(12;13)/ETV6-FLT3; one with ins(13;22)/BCR-FLT3; and five with an unconfirmed partner gene located on chromosome bands 2p16, 3q27, 5q15, 5q35, and 7q36. Disease presentations were heterogeneous, including lymphoblastic leukemia/lymphoma, myeloid sarcoma, chronic eosinophilic leukemia, chronic myelomonocytic leukemia, and myelodysplastic syndrome. Read More

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Impact of the combination of donor age and HLA disparity on the outcomes of unrelated bone marrow transplantation.

Bone Marrow Transplant 2021 May 14. Epub 2021 May 14.

Department of Hematology and Oncology, Kyoto University, Kyoto, Japan.

Impact of donor age considering HLA disparity on hematopoietic cell transplantation (HCT) outcomes has not been fully evaluated. We evaluated 8486 patients who received unrelated bone marrow transplantation (UR-BMT) from 8/8 or 7/8 HLA-matched donors. Compared to 8/8 HLA-matched younger donors (<40 years), 8/8 HLA-matched older donors (subdistribution hazard ratio [SHR], 1. Read More

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First Asian population study of stereotactic body radiation therapy for ventricular arrhythmias.

Sci Rep 2021 May 14;11(1):10360. Epub 2021 May 14.

Division of Cardiology, Department of Internal Medicine, National Taiwan University College of Medicine and Hospital, No. 7, Chuang-Shan South Road, Taipei, 100, Taiwan.

We report the first Asian series on stereotactic body radiation (SBRT) for refractory ventricular arrhythmia (VA) in Taiwanese patients. Three-dimensional electroanatomic maps, delayed-enhancement magnetic resonance imaging (DE-MRI), and dual-energy computed tomography (CT) were used to identify scar substrates. The main target volume was treated with a single radiation dose of 25 Gy and the margin volume received 20 Gy using simultaneous integrated boost delivered by the Varian TrueBeam system. Read More

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Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption.

Nat Commun 2021 May 14;12(1):2830. Epub 2021 May 14.

Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, the Netherlands.

Coffee and tea are extensively consumed beverages worldwide which have received considerable attention regarding health. Intake of these beverages is consistently linked to, among others, reduced risk of diabetes and liver diseases; however, the mechanisms of action remain elusive. Epigenetics is suggested as a mechanism mediating the effects of dietary and lifestyle factors on disease onset. Read More

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Piloting the Feasibility and Preliminary Impact of Adding Birth HIV Polymerase Chain Reaction Testing to the Early Infant Diagnosis Guidelines in Kenya.

Pediatr Infect Dis J 2021 May 7. Epub 2021 May 7.

From the Department of Family Medicine, University of Kansas Medical Center, Kansas City, Missouri Children's Mercy Kansas City, Health Services and Outcomes Research, Kansas City, Missouri School of Medicine, University of Missouri-Kansas City, Kansas City, Missouri Center for Virus Research, Kenya Medical Research Institute, Nairobi, Kenya Department of Preventive Medicine, University of Kansas Medical Center, Kansas City, Missouri Global Health Innovations, Dallas, Texas Global Health Innovations-Kenya, Nairobi, Kenya.

Background: In Kenya, standard early infant diagnosis (EID) with polymerase chain reaction (PCR) testing at 6-week postnatal achieves early treatment initiation (<12 weeks) in <20% of HIV+ infants. Kenya's new early infant diagnosis guidelines tentatively proposed adding PCR testing at birth, pending results from pilot studies.

Methods: We piloted birth testing at 4 Kenyan hospitals between November 2017 and November 2018. Read More

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In-kind donations to healthcare facilities during COVID-19: Experiences from a large medical center in northern Taiwan.

J Chin Med Assoc 2021 May 10. Epub 2021 May 10.

Supply Office, Taipei Veterans General Hospital, Taipei, Taiwan, ROC Institute of Hospital and Health Care Administration, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC Department of Family Medicine, Kinmen Hospital, Kinmen, Taiwan, ROC Department of Long-Term Care, National Quemoy University, Kinmen, Taiwan, ROC School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC Department of Family Medicine, Taipei Veterans General Hospital, Taipei Taiwan, ROC Big Data Center, Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.

Background: In early 2020, a global outbreak of 2019 novel coronavirus disease (COVID-19) caused high mortality rates and public panic. Worldwide demand for personal protective equipment (PPE) has risen, with diminishing supplies and shortages reported. During the pandemic, charitable donations have been made by the public, aimed at helping medical staff. Read More

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Proposed Decannulation Criteria for COVID-19 patients: A Case report.

Am J Phys Med Rehabil 2021 May 13. Epub 2021 May 13.

Department of Physical Medicine and Rehabilitation, Rutgers University - New Jersey Medical School. Department of Cardiorespiratory Rehabilitation, Universidad Nacional de Asunción- Facultad de Ciencias Médicas. Hospital de Clinicas. San Lorenzo-Paraguay. Department of Pediatrics. Universidad de Chile. Hospital Clínico San Borja Arriarán, Santiago de Chile.

Abstract: A 66-year-old man had been intubated for 21 days for severe COVID-19 infection. He then underwent tracheotomy, retained the tube for 2 months, then was discharged home on 10 L/O2/min breathing via a tracheostomy collar. We were consulted for tracheostomy tube decannulation. Read More

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Creating a Resident Research Track in Synergy with the Rehabilitation Medicine Scientist Training Program.

Am J Phys Med Rehabil 2021 May 13. Epub 2021 May 13.

Department of Physical Medicine and Rehabilitation, University of Pittsburgh Medical Center, Pittsburgh, PA, 15213 Department of Physical Medicine and Rehabilitation, Mayo Clinic, Minneapolis, MN, 55403.

Abstract: Physician scientists play an important role in the translation of research findings to patient care; however, their training faces numerous challenges. Residency research track programs represent an opportunity to facilitate the training of future physician scientists in Physical Medicine and Rehabilitation (PM&R), although optimal program organization and long-term outcomes remain unknown. The Rehabilitation Medicine Scientist Training Program (RMSTP) is a National Institutes of Health (NIH) funded program aimed at addressing the shortage of physician researchers in the field of PM&R by providing instruction, mentorship, and networking opportunities for a successful research career. Read More

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Factors determining chance of type 2 diabetes remission after Roux-en-Y gastric bypass surgery: a nationwide cohort study in 8057 Swedish patients.

BMJ Open Diabetes Res Care 2021 May;9(1)

Faculty of Medicine and Health, Örebro Universitet, Örebro, Sweden.

Introduction: Bariatric and metabolic surgery is an effective treatment option for type 2 diabetes (T2D). Increased knowledge regarding factors associated with diabetes remission is essential in individual decision making and could guide postoperative care. Therefore, we aimed to explore factors known to affect the chance of achieving diabetes remission after bariatric and metabolic surgery and to further investigate the impact of socioeconomic factors. Read More

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Uptake of influenza vaccination among persons with inflammatory bowel disease, multiple sclerosis or rheumatoid arthritis: a population-based matched cohort study.

CMAJ Open 2021 Apr-Jun;9(2):E510-E521. Epub 2021 May 14.

Department of Internal Medicine (Marrie, Hitchon, Marriott, Bernstein), Department of Community Health Sciences (Marrie, Lix, Katz), Manitoba Centre for Health Policy (Walld, Katz), Department of Psychiatry (Bolton, Sareen), Department of Family Medicine (Singer, Katz), Department of Clinical Health Psychology (El-Gabalawy) and Department of Anesthesiology and Perioperative and Pain Medicine (El-Gabalawy), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Man.; Department of Community Health Sciences (Patten), Cumming School of Medicine, University of Calgary, Calgary, Alta.; Departments of Psychiatry (Fisk), of Psychology and Neuroscience (Fisk) and of Medicine (Fisk), Dalhousie University, Halifax, NS.

Background: Individuals with immune-mediated inflammatory diseases, such as inflammatory bowel disease, multiple sclerosis and rheumatoid arthritis, are at increased risk for influenza and related complications. We examined and compared the uptake of influenza vaccination among people with and without these diseases, as well as the influence of psychiatric comorbidity on vaccine uptake.

Methods: Using administrative data from Apr. Read More

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Cytoreductive surgery followed by chemotherapy and olaparib maintenance in BRCA 1/2 mutated recurrent ovarian cancer: a retrospective MITO group study.

Int J Gynecol Cancer 2021 May 14. Epub 2021 May 14.

Department of Urology and Gynecology, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale, Naples, Italy

Introduction: The role of cytoreductive surgery in the poly-ADP ribose polymerase inhibitors era is not fully investigated. We evaluated the impact of surgery performed prior to platinum-based chemotherapy followed by olaparib maintenance in platinum-sensitive BRCA-mutated recurrent ovarian cancer.

Methods: This retrospective study included platinum-sensitive recurrent ovarian cancer BRCA-mutated patients from 13 Multicenter Italian Trials in Ovarian cancer and gynecological malignancies centers treated between September 2015 and May 2019. Read More

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Utility of Intracardiac Echocardiography for Guiding Ablation of Ventricular Tachycardia in Nonischemic Cardiomyopathy.

Card Electrophysiol Clin 2021 Jun;13(2):337-343

Division of Cardiology, Section of Cardiac Electrophysiology, University of Colorado School of Medicine Anschutz Medical Campus, Aurora, CO, USA. Electronic address:

Intracardiac echocardiography (ICE) is a valuable tool in cardiac ablation procedures, especially in ablation of ventricular arrhythmias. The article details how ICE can aid in ablation of ventricular arrhythmias in nonischemic cardiomyopathy. Read More

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