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Hydro-alcoholic extract of reduces fasting blood glucose and HbA1c% in diabetic patients, probably via competitive and allosteric interaction with alpha-glucosidase enzyme; a clinical trial and analysis.

J Complement Integr Med 2021 May 5. Epub 2021 May 5.

Department of Nursing, Khomein University of Medical Sciences, Khomein, Iran.

Objectives: 1-Deoxynojirimycin (1-DNJ), the main active component found in () is reported to be effective in controlling diabetes. We have evaluated the effect of hydro-alcoholic extract of leaves on the fasting blood glucose (FBS) and hemoglobin A1c% (HbA1c%) in diabetic patients. Furthermore, we compared the interaction of 1-DNJ and glucose molecules with the alpha-glucosidase enzyme, which has a critical role in the lysis of glucose-based polymers in human cells. Read More

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Imaging characteristics of nontuberculous mycobacterial pulmonary nodules.

Rom J Intern Med 2021 Apr 30. Epub 2021 Apr 30.

Division of Respiratory Medicine, Mito Medical Center, University of Tsukuba-Mito Kyodo General Hospital, Miya-macho 3-2-7, Mito-city, Ibaraki, 310-0015, Japan.

: Nontuberculous mycobacteriosis (NTM) of the lungs can develop nodules. In order to clarify some of the characteristics of lung NTM nodules, we examined volume doubling time (VDT) and maximum standardized uptake value (SUVmax) in positron emission tomography (PET) of pathologically diagnosed NTM nodules.: From November 2012 to August 2018, clinical and radiological information were retrospectively investigated in 8 patients who were surgically resected and diagnosed as NTM. Read More

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Blood alcohol screening and outcomes in trauma team activation patients at a level 1 trauma centre in New Zealand.

Emerg Med Australas 2021 May 4. Epub 2021 May 4.

Midland Trauma System, Waikato District Health Board, Hamilton, New Zealand.

Objective: A causal relationship between alcohol consumption and injury exists and the prevalence of harmful alcohol intakes in New Zealand adults is high. The present study investigates compliance to blood alcohol (BA) screening policy and the epidemiological profile and hospital-related outcomes of trauma team activation (TTA) patients with positive BA at a New Zealand level 1 trauma centre.

Methods: A retrospective review of Midland Trauma Registry hospitalisation data between January 2012 and December 2019 was conducted. Read More

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Mobilization in the evening to prevent delirium: A pilot randomized trial.

Nurs Crit Care 2021 May 4. Epub 2021 May 4.

Department of Anaesthesiology, University Hospital Mannheim, Heidelberg, Germany.

Background: Delirium is a common complication in patients in Intensive Care Units (ICU). Interventions such as mobilization are effective in the prevention and treatment of delirium, although this is usually completed during the daytime.

Aim: The aim of this study was to assess the feasibility of mobilization in the evening to prevent and treat ICU patients from delirium by an additional mobility team over 2 weeks. Read More

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EMICIZUMAB DOSING IN CHILDREN AND ADULTS WITH HEMOPHILIA A: SIMULATING A USER-FRIENDLY AND COST-EFFICIENT REGIMEN.

Thromb Haemost 2021 May 4. Epub 2021 May 4.

Hospital Pharmacy-Clinical Pharmacology, Amsterdam University Medical Centres, Amsterdam, Netherlands.

Background: When emicizumab is dosed according to label, clinicians are obligated to discard or overdose medication due to discrepancies between calculated dose and vial content. The aim of this study was to compose a cost-efficient emicizumab maintenance dosing regimen using Monte Carlo simulation based on vial size, patient friendly intervals and patient characteristics, while striving for similar plasma concentrations as observed in clinical trials.

Methods: Monte Carlo simulations were used to investigate alternative dosing regimens in patients weighing 3 to 150 kg. Read More

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Treatment of Periprosthetic Joint Infection in Total Knee Arthroplasty with a Temporary Intramedullary Nail: Is a Long or Short Nail Better?

J Knee Surg 2021 May 4. Epub 2021 May 4.

Center for Joint Preservation and Replacement, Rubin Institute for Advanced Orthopedics, Sinai Hospital of Baltimore, Baltimore, Maryland.

To our knowledge, no studies have compared postoperative outcomes between patients who received a temporary short or long intramedullary (IM) nail in the setting of infected total knee arthroplasty (TKA). Therefore, the aim of this study was to compare short-term outcomes for patients who underwent long or short IM nail insertion for treatment of periprosthetic knee infection. Specifically, we compared: (1) success rates; (2) patient reported/functional outcomes; and (3) complications between patients implanted with a short or a long IM nail following PJI of the knee. Read More

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Can text messages encourage flossing among orthodontic patients?

Angle Orthod 2021 May 4. Epub 2021 May 4.

Objectives: To assess the extent to which text messages on WhatsApp play a role in patient awareness of the importance of proper oral hygiene and flossing on a daily basis and to test the null hypothesis that daily text messages do not influence the flossing habits of orthodontics patients.

Materials And Methods: Forty-four patients wearing fixed orthodontic appliances with a mean age of 14.3 years participated in the study. Read More

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α2-Adrenergic Agonists or Stimulants for Preschool-Age Children With Attention-Deficit/Hyperactivity Disorder.

JAMA 2021 May 4. Epub 2021 May 4.

Perelman School of Medicine at University of Pennsylvania.

Importance: Attention-deficit/hyperactivity disorder (ADHD) is diagnosed in approximately 2.4% of preschool-age children. Stimulants are recommended as first-line medication treatment. Read More

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Retrospective Analysis of the Clinical Presentation, Treatment and Outcome of Angiosarcoma in a Sarcoma Referral Center.

Oncol Res Treat 2021 May 4:1-10. Epub 2021 May 4.

Department of General Medical Oncology, University Hospitals Leuven, Leuven, Belgium.

Introduction: Angiosarcoma (AS) is a rare subtype of soft tissue sarcoma. We performed a retrospective analysis of patient characteristics, treatments and prognostic factors in patients treated in a single sarcoma center.

Methods: We reviewed records of patients treated between 1987 and 2018, categorized in 7 different subtypes according to tissue of origin and underlying risk factors. Read More

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The Efficacy of Posttreatment with Synthetic C-Reactive Protein in Murine Bacterial Peritonitis via Activation of FcγRI-Expressing Kupffer Cells.

J Innate Immun 2021 May 4:1-13. Epub 2021 May 4.

Department of Immunology and Microbiology, National Defense Medical College, Tokorozawa, Saitama, Japan.

Pretreatment with synthetic C-reactive protein (CRP), a functional CRP peptide, has the potential to augment macrophage phagocytosis by bacterial challenge. However, the posttreatment is clinically ideal. We investigated the efficacy of posttreatment with synthetic CRP on murine cecal ligation and puncture (CLP), focusing on liver macrophages. Read More

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Efficacy and Safety of Lenvatinib-Transcatheter Arterial Chemoembolization Sequential Therapy for Patients with Intermediate-Stage Hepatocellular Carcinoma.

Oncology 2021 May 4:1-11. Epub 2021 May 4.

Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

Introduction: We evaluated the efficacy and safety of lenvatinib-transcatheter arterial chemoembolization (LEN-TACE) sequential therapy for patients (n = 88) with intermediate-stage hepatocellular carcinoma (HCC).

Methods: Eighty-eight patients who obtained tumor control by LEN treatment were analyzed; 30 received LEN followed by TACE (LEN-TACE sequential therapy), and 58 received LEN monotherapy. Propensity score matching was performed, and the outcomes of 19 patients in the LEN-TACE group and 19 patients in the LEN-alone group were compared. Read More

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Effect of eight-week curcumin supplementation with endurance training on glycemic indexes in middle age women with type 2 diabetes in Iran, A preliminary study.

Diabetes Metab Syndr 2021 Apr 26;15(3):963-967. Epub 2021 Apr 26.

Faculty of Educational Sciences, Islamic Azad University, Zanjan, Iran. Electronic address:

Background And Aims: The purpose of this study was to determine the effects of curcumin supplementation & endurance training on glycemic indexes in middle-aged women with type 2 diabetes.

Methods: 40 middle-aged women with type 2 diabetes were randomly divided into four groups (control, curcumin, training & curcumin + training). Endurance training protocol included running on treadmill for eight weeks, three sessions per week and each session for 45-60 min, with a maximum intensity of 50-70% of MHR. Read More

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Efficacy of lateral stair walking training in patients with chronic stroke: A pilot randomized controlled study.

Gait Posture 2021 Apr 20;88:10-15. Epub 2021 Apr 20.

Department of Physical Medicine and Rehabilitation, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan. Electronic address:

Background: Patients with chronic stroke have reduced capacity for performing activities of daily living (ADLs) and are at increased risk for falls during walking due to long-term changes to muscle tone and force, as well as movement control.

Research Question: To investigate the efficacy of lateral stair walking training on muscle strength of affected lower extremities, balance, ADLs, and gait ability in patients with chronic stroke.

Methods: The experimental group received 15 min of lateral stair walking exercise along with 15 min of traditional physiotherapy, whereas the control group received only traditional physiotherapy for 30 min. Read More

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Pediatric adverse reactions to antiseizure medications - An analysis of data from the Italian spontaneous reporting system (2001-2019).

Epilepsy Behav 2021 May 1;119:107989. Epub 2021 May 1.

Division of Clinical and Experimental Pharmacology, Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy. Electronic address:

Introduction: Spontaneous reports of adverse drug reactions (ADRs) are a valuable supplement to clinical studies in informing about the safety of medications. This is especially relevant for pediatric populations, which are not often included in large-scale clinical trials.

Objectives: To evaluate patterns of pediatric ADRs to antiseizure medications (ASMs) reported to the Italian Spontaneous Reporting System (SRS) database during the period November 1, 2001─May 31, 2019. Read More

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The 6th International Lafora Epilepsy Workshop: Advances in the search for a cure.

Epilepsy Behav 2021 May 1;119:107975. Epub 2021 May 1.

Department of Molecular and Cellular Biochemistry, Epilepsy and Brain Metabolism Alliance, and Epilepsy Research Center, University of Kentucky College of Medicine, Lexington, KY 40536, USA; Lafora Epilepsy Cure Initiative (LECI), USA. Electronic address:

Lafora disease (LD) is a fatal childhood dementia with severe epilepsy and also a glycogen storage disease that is caused by recessive mutations in either the EPM2A or EPM2B genes. Aberrant, cytoplasmic carbohydrate aggregates called Lafora bodies (LBs) are both a hallmark and driver of the disease. The 6 International Lafora Epilepsy Workshop was held online due to the pandemic. Read More

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Immediate effect of insoles on balance in older adults.

Foot (Edinb) 2021 Jan 8;47:101768. Epub 2021 Jan 8.

Department of Healthcare and Public Health Research, National Rehabilitation Center (Ministry of Health and Welfare), Gangbuk-gu, Seoul, Republic of Korea.

Background: In recent years, fall prevention in older adults has received considerable attention in healthcare. Among many interventions, insoles are considered cost-effective and easily adopted tools to improve balance in older people. Numerous studies have verified the immediate effects of insoles on balance in older adults. Read More

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January 2021

Hormonal combinations aiming to improve reproductive outcomes of Bos indicus cows submitted to estradiol/progesterone-based timed AI protocols.

Theriogenology 2021 Apr 18;169:89-99. Epub 2021 Apr 18.

Department of Animal Science, Luiz de Queiroz College of Agriculture, University of São Paulo (ESALQ/USP), Piracicaba, SP, 13418-900, Brazil. Electronic address:

The aim was to study reproductive outcomes of Nelore (Bos indicus) cows submitted to a 7-d estradiol (E2)/progesterone (P4)-based timed artificial insemination (TAI) protocol, receiving various combinations of doses and hormones. Primiparous (n = 962) and multiparous (n = 1935) cows were submitted to synchronization (n = 2012) and resynchronization (n = 885 non-pregnant cows at pregnancy diagnosis 30 d after TAI) protocols, following a 2 × 2 × 2 factorial arrangement of eight treatments. At the initiation of the TAI protocol (Day -9), all cows received a 1. Read More

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Non-invasive brain stimulation shows possible cerebellar contribution in transfer of prism adaptation after-effects from pointing to throwing movements.

Brain Cogn 2021 May 1;151:105735. Epub 2021 May 1.

Lyon Neuroscience Research Center (CRNL), Trajectoires team, INSERM UMR-S U1028, CNRS UMS 5292, 69500 Bron, France; "Mouvement et Handicap" platform, Hôpital Henry Gabrielle & Hôpital Neurologique, Hospices Civils de Lyon, 69500 Bron, France.

Whether sensorimotor adaptation can be generalized from one context to others represents a crucial interest in the field of neurological rehabilitation. Nonetheless, the mechanisms underlying transfer to another task remain unclear. Prism Adaptation (PA) is a useful method employed both to study short-term plasticity and for rehabilitation. Read More

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Structure-activity relationship study of THZ531 derivatives enables the discovery of BSJ-01-175 as a dual CDK12/13 covalent inhibitor with efficacy in Ewing sarcoma.

Eur J Med Chem 2021 Apr 20;221:113481. Epub 2021 Apr 20.

Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA. Electronic address:

Development of inhibitors targeting CDK12/13 is of increasing interest as a potential therapy for cancers as these compounds inhibit transcription of DNA damage response (DDR) genes. We previously described THZ531, a covalent inhibitor with selectivity for CDK12/13. In order to elucidate structure-activity relationship (SAR), we have undertaken a medicinal chemistry campaign and established a focused library of THZ531 analogs. Read More

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Timeliness and completeness of laboratory-based surveillance of COVID-19 cases in England.

Public Health 2021 Apr 1;194:163-166. Epub 2021 Apr 1.

Epidemiology Cell, Public Health England National Infection Service, London, UK.

Objectives: The aim of the study was to evaluate completeness and timeliness of the rapidly developed surveillance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in England using patient-level data.

Study Design: This is an observational study wherein public health surveillance systems are evaluated.

Methods: Data were collected in the Public Health England's Second-Generation Surveillance System through routine laboratory reporting processes, as well as via enhanced testing in collaboration with commercial partners. Read More

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Impact of a Firearm Safety Device Distribution Intervention on Storage Practices after an Emergent Mental Health Visit.

Acad Pediatr 2021 May 1. Epub 2021 May 1.

Department of Pediatrics, University of Washington, Seattle, WA. Electronic address:

Objective: To determine if providing firearm storage devices with training during clinical care improves safe storage practices in household members of children who present to a pediatric hospital with an emergent mental health complaint.

Methods: Prospective, pre-post study. Enrollment occurred in the emergency department or the inpatient psychiatric unit. Read More

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An Insight on the Anatomical and Functional Consequences of Aflibercept Therapy in Age-Related Macular Degeneration.

Photodiagnosis Photodyn Ther 2021 May 1:102307. Epub 2021 May 1.

Agri Ibrahim Cecen University Faculty of Medicine, Department of Ophthalmology, Agri, Turkey.

Background: Evaluation of anatomical and functional recovery of the retina after aflibercept therapy in neovascular age-related macular degeneration MATERIALS AND METHODS: This prospective study enrolled 33 eyes of 33 naive age-related macular degeneration patients with an average age of 69 (55-82) years. Following a thorough ophthalmological examination, baseline color fundus photography, optical coherence tomography and fluorescein angiography were used to assess the angiographic characteristics and classification of the lesions. Multifocal electroretinography and microperimetry were recorded. Read More

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Spectral power and theta-gamma coupling in the basolateral amygdala related with methamphetamine-induced conditioned place preference in mice.

Neurosci Lett 2021 May 1:135939. Epub 2021 May 1.

Physiology program, Division of Health and Applied Sciences, Faculty of Science, Prince of Songkla University, Hatyai Campus, Hatyai, Songkhla, 90110, Thailand; Biosignal Research Center for Health, Faculty of Science, Prince of Songkla University, Hatyai, Songkhla, 90112, Thailand. Electronic address:

The basolateral amygdala (BLA) plays a crucial role in conditioned place preference (CPP) for addictive drugs. However, neural signaling associated with methamphetamine (METH) craving and seeking remained to be investigated. This study characterized local field potential (LFP) oscillatory patterns in the BLA and conditioned place preference induced by METH-related context. Read More

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Lipid metabolism in cancer: New perspectives and emerging mechanisms.

Dev Cell 2021 May 3. Epub 2021 May 3.

Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, Belgium; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium. Electronic address:

Tumors undergo metabolic transformations to sustain uncontrolled proliferation, avoid cell death, and seed in secondary organs. An increased focus on cancer lipid metabolism has unveiled a number of mechanisms that promote tumor growth and survival, many of which are independent of classical cellular bioenergetics. These mechanisms include modulation of ferroptotic-mediated cell death, support during tumor metastasis, and interactions with the cells of the tumor microenvironment. Read More

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Working through centred on the body in the analysis of a psychotic adolescent.

Authors:
Pierrette Poyet

Int J Psychoanal 2019 Jun;100(3):463-480

Former member of CFRP (Centre de Formation et de Recherche Psychanalytiques); former member of SPF (Société de Psychanalyse Freudienne) PARIS.

Through a few clinical sessions, the author demonstrates the complexity of psychoanalytic work with difficult adolescents, while also indicating its benefits when this approach is enhanced by working on the body-mind connection. The author shows how she establishes contact with a difficult adolescent patient who is experiencing immense fear and intense hatred of her body and how this patient then communicates through her body intense anxieties relating to body-mind dissociation. The bodily transference is central to this work. Read More

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A toddler diagnosed with severe postinfectious bronchiolitis obliterans and COVID-19 infection.

Pediatr Pulmonol 2021 May 4. Epub 2021 May 4.

Aghia Sophia Children's Hospital, National and Kapodistrian University of Athens, Athens, Greece.

During the COVID-19 pandemic, management of SARS-CoV-2 infection in children with underlying chronic lung disease has been challenging. There are limited studies in children with respiratory comorbidities, apart from asthma, presumably due to low morbidity of SARS-CoV-2 infection in the general pediatric population along with the low incidence of certain pulmonary conditions. Compassionate use of remdesivir has been shown to reduce time to clinical improvement in adults and has been retrospectively studied in small pediatric cohorts with promising results. Read More

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Low-burden TP53 mutations in CLL: Clinical impact and clonal evolution within the context of different treatment options.

Blood 2021 May 4. Epub 2021 May 4.

University Hospital Brno, Czech Republic.

Chronic lymphocytic leukemia (CLL) patients with TP53 mutations experience chemo-refractory disease and are therefore indicated for targeted therapy. However, the significance of low-burden TP53 mutations with <10% variant allele frequency (VAF) remains a matter of debate. Here we describe clonal evolution scenarios of low-burden TP53 mutations and analyzed their clinical impact in a "real-world" CLL cohort. Read More

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High rate of critical coronary stenosis in comatose patients with Non-ST-elevation out-of-hospital cardiac arrest (NSTE-OHCA) undergoing therapeutic hypothermia-Experience from the HAnnover COoling REgistry (HACORE).

PLoS One 2021 4;16(5):e0251178. Epub 2021 May 4.

Department of Cardiology and Angiology, Medizinische Hochschule Hannover, Hannover, Germany.

Background: Myocardial infarction is the most frequent cause for out-of-hospital cardiac arrest (OHCA) in adults. Patients with ST-segment elevations (STE) following return of spontaneous circulation (ROSC) are regularly admitted to the catheterisation laboratory for urgent coronary angiography. Whether patients without obvious STE (NSTE) should receive coronary angiography as part of a standardised diagnostic work-up following OHCA is still debated. Read More

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Project20: Does continuity of care and community-based antenatal care improve maternal and neonatal birth outcomes for women with social risk factors? A prospective, observational study.

PLoS One 2021 4;16(5):e0250947. Epub 2021 May 4.

Department of Women and Children's Health, Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom.

Background: Social factors associated with poor childbirth outcomes and experiences of maternity care include minority ethnicity, poverty, young motherhood, homelessness, difficulty speaking or understanding English, migrant or refugee status, domestic violence, mental illness and substance abuse. It is not known what specific aspects of maternity care work to improve the maternal and neonatal outcomes for these under-served, complex populations.

Methods: This study aimed to compare maternal and neonatal clinical birth outcomes for women with social risk factors accessing different models of maternity care. Read More

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Helicobacter pylori eradication improves motor fluctuations in advanced Parkinson's disease patients: A prospective cohort study (HP-PD trial).

PLoS One 2021 4;16(5):e0251042. Epub 2021 May 4.

Faculty of Medicine, Department of Internal Medicine, Gastroenterology Unit, Thammasat University, Pathumthani, Thailand.

Background: Helicobacter pylori (HP) is a bacterium associated with many gastrointestinal (GI) diseases and has shown a high prevalence in Parkinson's disease (PD). As HP-associated GI dysfunction could affect L-dopa (levodopa) absorption, HP eradication might improve the clinical response and decrease motor fluctuations.

Methods: A prospective cohort study was conducted on the clinical symptoms of PD patients with motor fluctuations. Read More

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