41,178 results match your criteria received antibiotics

Clinical characteristics and outcome of bacteremia caused by Enterobacter cloacae and Klebsiella aerogenes: more similarities than differences.

J Glob Antimicrob Resist 2021 May 5. Epub 2021 May 5.

Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Infectious Diseases Research Group, Institute of Biomedicine of Seville (IBiS), University of Seville/CSIC/ Virgen del Rocío University Hospital, Seville, Spain.

Introduction: The genus Enterobacter is a common cause of nosocomial infections. Historically, the most frequent Enterobacter species were those of the Enterobacter cloacae complex and Enterobacter aerogenes. In 2019, E. Read More

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Treating high-risk moderate acute malnutrition using therapeutic food compared with nutrition counseling (Hi-MAM Study): a cluster-randomized controlled trial.

Am J Clin Nutr 2021 May 8. Epub 2021 May 8.

Project Peanut Butter, Freetown, Sierra Leone.

Background: There is a lack of consensus on what is the most appropriate treatment of moderate acute malnutrition (MAM).

Objectives: We aimed to determine if provision of ready-to-use-therapeutic food (RUTF) and antibiotics to "high-risk" MAM (HR-MAM) children in addition to nutritional counseling would result in higher recovery and less deterioration than nutrition counseling alone.

Methods: At the 11 intervention clinics, HR-MAM children were given RUTF and amoxicillin along with standard nutrition counseling, for 2-12 wk. Read More

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The efficacy and safety of 5-Aminolevulinic acid photodynamic therapy (ALA-PDT) as an adjunct therapy for symptoms in patients with dissecting cellulitis of the scalp: A retrospective study.

Photodiagnosis Photodyn Ther 2021 May 4:102322. Epub 2021 May 4.

Department of Dermatology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical Collage Hospital, Chinese Academy of Medical Science and Peking Union Medical Collage, 100730, Beijing, China. Electronic address:

Background: Medicinal therapies such as systemic retinoids and antibiotics have shown efficacy in the treatment of dissecting cellulitis of the scalp (DCS), but refractory cases are common. 5-Aminolevulinic acid photodynamic therapy (ALA-PDT) has been successfully used in medicine-resistant cases in recent years.

Methods: 12 patients who received ALA-PDT in addition to formally failed medicinal therapies were interviewed by telephone regarding improvement of symptoms, satisfaction, and side effects. Read More

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[Current approach to diagnosis of chronic prostatitis].

Urologiia 2021 May(2):32-39

TB Research Institute of Ministry of Health of Russia, Novosibirsk, Russia.

Introduction: The problem of chronic prostatitis is still to be resolved.

Aim: to compare the frequency of the main symptoms (pain, dysuria, sexual dysfunction) in patients with chronic bacterial and abacterial prostatitis, as well as prostate tuberculosis (PTB); to determine the prevalence of latent infectious prostatitis in patients with chronic abacterial prostatitis (CAP).

Materials And Methods: A total 73 men who were followed with a diagnosis of chronic prostatitis for at least two years and had a history of at least three exacerbations per year were included in the study. Read More

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Clinical Randomized Comparison of Medetomidine and Xylazine for Isoflurane Balanced Anesthesia in Horses.

Front Vet Sci 2021 20;8:603695. Epub 2021 Apr 20.

Section Anesthesiology, Department of Clinical Diagnostics and Services, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.

To assess drug plasma levels, preanesthetic sedation, cardiopulmonary effects during anesthesia and recovery in horses anesthetized with isoflurane combined with medetomidine or xylazine. Prospective blinded randomized clinical study. Sixty horses undergoing elective surgery. Read More

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Safety of fecal microbiota transplantation for infection focusing on pathobionts and SARS-CoV-2.

Therap Adv Gastroenterol 2021 21;14:17562848211009694. Epub 2021 Apr 21.

Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA.

infection (CDI) is a consequence of flagrant use of antibiotics, an aging population with increasing comorbidities, and increased hospitalizations. The treatment of choice for CDI is antibiotics (vancomycin or fidaxomicin), with a possibility of recurrent CDI despite lack of additional risk factors for CDI. For the last 10 years, fecal microbiota transplantation (FMT) has emerged as a promising therapy for recurrent CDI, with success rates of over 85% compared with less than 50% with antibiotics for multiple recurrent CDI. Read More

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Transplant-associated thrombotic microangiopathy and immune haematological complications following intestine-containing organ transplantation: experience from over 100 consecutive cases.

Br J Haematol 2021 May 5. Epub 2021 May 5.

Department of Gastroenterology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.

Descriptions of passenger lymphocyte syndrome (PLS), immune cytopenias and transplant-associated thrombotic microangiopathy (TA-TMA) after intestine-containing transplants remain scarce. We describe our centre's experience of these complications from 2007 to 2019. Ninety-six patients received 103 transplants. Read More

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Evaluation of a risk assessment model to predict infection with healthcare facility-onset Clostridioides difficile.

Am J Health Syst Pharm 2021 May 6. Epub 2021 May 6.

Department of Pharmacy, Emory University Hospital, Atlanta, GA, and Department of Pharmacy Practice, Mercer University College of Pharmacy, Atlanta, GA, USA.

Disclaimer: In an effort to expedite the publication of articles related to the COVID-19 pandemic, AJHP is posting these manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time. Read More

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Outpatient Management of Diabetic Hand Infections.

Cureus 2021 Apr 2;13(4):e14263. Epub 2021 Apr 2.

Surgery, Henry Ford Health System, Detroit, USA.

Purpose For many providers, hand infections among diabetic patients is a condition that necessitates focused inpatient care. These patients are believed to have decreased innate immunity to fight infection, a more virulent course, and difficulty with recovery. Diabetes is considered by some to represent an additional risk factor that can result in an unfavorable outcome if not managed in an aggressive manner. Read More

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A Clinical Case Report of a Potential Acute Allergic Reaction with Titanium Dental Implant.

Case Rep Dent 2021 10;2021:5592934. Epub 2021 Apr 10.

Department of Periodontology, College of Dentistry, University of Florida, USA.

Titanium hypersensitivity is rare, but it may exist among patients who need dental implant treatment. It could contribute to mild or severe peri-implant tissue hypersensitivity reactions and affect patients' oral and general health according to some clinical reports. In extreme cases, it may lead to implant failure or extraction. Read More

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Outcomes in Patients with SARS-CoV-2 and Coinfection.

Infect Drug Resist 2021 28;14:1645-1648. Epub 2021 Apr 28.

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.

Background: Coronavirus infectious disease 2019 (COVID-19) is primarily a respiratory disease. However, it may manifest with gastrointestinal symptoms that may overlap with infection (CDI). COVID-19 appears to have higher mortality in those with comorbidities. Read More

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Hepatic Inflammatory Pseudotumor Mimicking Malignant Tumor With Rare Onset of Intra-abdominal Hemorrhage.

Anticancer Res 2021 May;41(5):2727-2732

Department of Surgery, Yamaga City Medical Center, Kumamoto, Japan.

Background: Hepatic inflammatory pseudotumor (HIPT) is an uncommon benign tumor-like mass that mimics malignant tumors.

Case Report: A 73-year-old man was admitted with severe epigastric pain and high fever. He had received choledocojejunostomy. Read More

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Peptide-coated polyurethane material reduces wound infection and inflammation.

Acta Biomater 2021 May 2. Epub 2021 May 2.

Division of Dermatology and Venereology, Department of Clinical Sciences, Lund University, SE, 22184 Lund, Sweden. Electronic address:

There is an urgent need for treatments that not only reduce bacterial infection that occurs during wounding but that also target the accompanying excessive inflammatory response. TCP-25, a thrombin-derived antibacterial peptide, scavenges toll-like receptor agonists such as endotoxins and lipoteichoic acid and prevents toll-like receptor-4 dimerization to reduce infection-related inflammation in vivo. Using a combination of biophysical, cellular, and microbiological assays followed by experimental studies in mouse and pig models, we show that TCP-25, when delivered from a polyurethane (PU) material, exerts anti-infective and anti-inflammatory effects in vitro and in vivo. Read More

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Mycoplasma hominis Lumbar Wound Infection After Posterior Decompression and Instrumented Fusion: A Case Report.

JBJS Case Connect 2021 05 5;11(2). Epub 2021 May 5.

Singhealth Orthopaedic Residency, Department of Orthopedic Surgery, Changi General Hospital, Singapore, Singapore.

Case: A 63-year-old man underwent L2-S1 decompression and fusion for spinal stenosis. He developed urinary retention postoperatively requiring catheterization. He developed fever, purulence, and foot-drop 8 days postoperatively and underwent debridement with implant retention. Read More

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A rare case of emphysematous gastritis caused by Lactobacillus fermentum in a patient with diabetes.

Rev Esp Enferm Dig 2021 May 5. Epub 2021 May 5.

Gastroenterología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México.

A 42-year-old man with a history of type 2 diabetes mellitus (complicated by end stage renal disease on peritoneal dialysis) and chronic diarrhea was admitted to the emergency department for having an exacerbation in the number of evacuations. The patient was hypotensive and lethargic. Arterial blood gases were obtained and reported pH 7. Read More

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Photodynamic Therapy for the Treatment of Infected Leg Ulcers-A Pilot Study.

Antibiotics (Basel) 2021 Apr 29;10(5). Epub 2021 Apr 29.

Department of Internal Medicine, Angiology and Physical Medicine, Centre for Laser Diagnostics and Therapy, Medical University of Silesia, Katowice, Batorego 15, 41-902 Bytom, Poland.

Chronic and infected leg ulcers (LUs) are painful, debilitating, resistant to antibiotics, and immensely reduce a patient's quality of life. The purpose of our study was to demonstrate the efficacy of photodynamic therapy (PDT) for the treatment of infected chronic LUs. Patients were randomized into two experimental groups: the first group received 5-aminolevulinic acid photodynamic therapy (ALA-PDT) (10 patients), and the second group of 10 patients received local octenidine dihydrochloride (Octenilin gel) exposed to a placebo light source with an inserted filter that mimiced red light. Read More

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Pembrolizumab-caused polyradiculoneuropathy as an immune-related adverse event.

Neuropathology 2021 May 3. Epub 2021 May 3.

Department of Neurology, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Kure, Hiroshima, Japan.

Immune-related adverse events (irAEs) commonly involve the gastrointestinal tract, endocrine glands, skin, and liver, and rarely the nervous system. The pathomechanism of irAEs in the nervous system is unclear, and so characterizing these severe toxic effects is a priority, even if irAEs are uncommon in the nervous system. Our patient presented subacute muscle weakness and dysesthesia with colitis as irAEs caused by pembrolizumab, one of the anti-programmed death-1 (PD-1) antibodies. Read More

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Interventions and symptom relief in hospital palliative cancer care: results from a prospective longitudinal study.

Support Care Cancer 2021 May 3. Epub 2021 May 3.

Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU - Norwegian University of Science and Technology, Trondheim, Norway.

Purpose: To study the use of interventions and symptom relief for adult patients with incurable cancer admitted to an acute palliative care unit providing integrated oncology and palliative care services.

Methods: All admissions during 1 year were assessed. The use of interventions was evaluated for all hospitalizations. Read More

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Quality Gaps in Management of Acute Pancreatitis: A Tertiary Care Center Experience.

Pancreas 2021 Apr;50(4):544-548

Division of Gastroenterology and Hepatology, Allegheny Health Network, Pittsburgh, PA.

Objectives: Acute pancreatitis (AP) is a leading cause of inpatient care among gastrointestinal conditions. Our study compares the management of AP and adherence to guidelines among teaching medicine, nonteaching medicine, and surgical services within the same center.

Methods: We performed a retrospective chart review of AP patients admitted to our center between January 2016 and January 2017 and analyzed the clinical and epidemiological data. Read More

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A multicentre point prevalence survey of patterns and quality of antibiotic prescribing in Indonesian hospitals.

JAC Antimicrob Resist 2021 Jun 26;3(2):dlab047. Epub 2021 Apr 26.

Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia.

Background: The global emergence of antimicrobial resistance is driven by antibiotic misuse and overuse. However, systematic data in Indonesian hospitals to adequately inform policy are scarce.

Objectives: To evaluate patterns and quality indicators of antibiotic prescribing in six general hospitals in Jakarta, Indonesia. Read More

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Minireview on Novel Anti-infectious Treatment Options and Optimized Drug Regimens for Sepsis.

Maya Hites

Front Med (Lausanne) 2021 15;8:640740. Epub 2021 Apr 15.

Clinic of Infectious Diseases, Cliniques Universitaires de Bruxelles (CUB)-Erasme Hospital, Brussels, Belgium.

Sepsis, a life-threatening organ dysfunction caused by a dysregulated response to infection is a major public health concern, as it is a leading cause of mortality and critical illness worldwide. Antibiotics are one of the cornerstones of the treatment of sepsis; administering appropriate antibiotics in a rapid fashion to obtain adequate drug concentrations at the site of the infection can improve survival of patients. Nevertheless, it is a challenge for clinicians to do so. Read More

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Evaluation of compliance with the 2017 Canadian Paediatric Society Position Statement for the management of newborns at risk for early-onset sepsis: A retrospective cohort study.

Paediatr Child Health 2021 Jun 8;26(3):e152-e157. Epub 2020 Apr 8.

Department of Maternity Care and Pediatrics, Victoria General Hospital, Victoria, British Columbia.

Introduction: Due to the nonspecific clinical presentation, clinicians often empirically treat newborns at risk of early-onset sepsis (EOS). Recently, the Canadian Paediatric Society (CPS) published updated recommendations that promote a more judicious approach to EOS management.

Objective: To examine the compliance with the CPS statement at a tertiary perinatal site and characterize the types of deviations. Read More

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Frequency, Local Dynamics, and Genomic Characteristics of ESBL-Producing Isolated From Specimens of Hospitalized Horses.

Front Microbiol 2021 16;12:671676. Epub 2021 Apr 16.

Advanced Light and Electron Microscopy (ZBS-4), Robert Koch Institute, Berlin, Germany.

Previous research identified veterinary clinics as hotspots with respect to accumulation and spread of multidrug resistant extended-spectrum β-lactamase (ESBL)-producing (EC). Therefore, promoting the prudent use of antibiotics to decrease selective pressure in that particular clinical environment is preferable to enhance biosecurity for animal patients and hospital staff. Accordingly, this study comparatively investigated the impact of two distinct perioperative antibiotic prophylaxis (PAP) regimens (short-term versus prolonged) on ESBL-EC carriage of horses subjected to colic surgery. Read More

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Stereoselective Bacterial Metabolism of Antibiotics in Environmental Bacteria - A Novel Biochemical Workflow.

Front Microbiol 2021 16;12:562157. Epub 2021 Apr 16.

Department of Chemistry, University of Bath, Bath, United Kingdom.

Although molecular genetic approaches have greatly increased our understanding of the evolution and spread of antibiotic resistance genes, there are fewer studies on the dynamics of antibiotic - bacterial (A-B) interactions, especially with respect to stereochemistry. Addressing this knowledge gap requires an interdisciplinary synthesis, and the development of sensitive and selective analytical tools. Here we describe SAM (stereoselective antimicrobial metabolism) workflow, a novel interdisciplinary approach for assessing bacterial resistance mechanisms in the context of A-B interactions that utilise a combination of whole genome sequencing and mass spectrometry. Read More

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Clinical Characteristics, Histopathology, and Treatment Outcomes of Keratitis: A Retrospective Cohort Study.

Clin Ophthalmol 2021 23;15:1691-1701. Epub 2021 Apr 23.

Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Purpose: To identify factors associated with the prognosis in keratitis.

Patients And Methods: The medical records of 25 patients (26 eyes) diagnosed with keratitis at a referral institution were reviewed. The demographic and clinical characteristics, treatment, microbiological diagnosis, histopathological features, and outcomes were recorded. Read More

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Antibiotic use and potential economic impact of implementing selective dry cow therapy in large US dairies.

J Dairy Sci 2021 Apr 29. Epub 2021 Apr 29.

Business Economics Group, Wageningen University and Research, Wageningen, 6700 EW the Netherlands.

In this study, our objectives were to evaluate the economic feasibility of implementing selective dry cow therapy (SDCT) in large US herds and to estimate the potential reduction in antibiotic use around the dry period if SDCT management is adopted. Cow-level data were obtained from the Dairy Herd Improvement Association (AgriTech, Visalia, CA) and individual dairy herds in California. Logistic regression models were used to predict the incidence risk of subclinical and clinical mastitis in the subsequent lactation for 96 last test-day somatic cell score categories. Read More

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Randomized controlled field trial comparing quarter and cow level selective dry cow treatment using the California Mastitis Test.

J Dairy Sci 2021 Apr 29. Epub 2021 Apr 29.

Quality Milk Management Services Ltd., Cedar Barn, Easton Hill, Easton, Wells, Somerset, BA5 1DU, United Kingdom; School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Sutton Bonington, LE12 5RD, United Kingdom.

Selective use of antibiotic dry cow treatment can be implemented at the cow or quarter level, with the latter having the potential to further reduce antibiotic use. Our objective was to compare these 2 approaches in 6 herds in the United Kingdom in which environmental mastitis predominated. Eight hundred seven cows were enrolled and categorized as having a high cell count (n = 401) or low cell count (n = 406) in the last 3 mo of lactation and clinical mastitis history. Read More

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The role of magnesium in the management of acute and long-term symptoms caused by tetanus in two dogs.

Top Companion Anim Med 2021 Apr 29:100535. Epub 2021 Apr 29.

Companion Animal Clinic, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Tetanus in dogs is a relatively uncommon neurological disease caused by the sporogenic bacillus Clostridium tetani. This disease is associated with prolonged hospitalization and mortality rates from 8-50%. A 2-year-old, neutered male King Charles Spaniel and an approximately 8- months-old female Mongrel dog presented to Companion Animal Clinic with symptoms of muscle rigidity and generalized stiffness. Read More

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The effect of intestinal microbiota dysbiosis on growth and detection of carbapenemase-producing Enterobacterales within an in vitro gut model.

J Hosp Infect 2021 Apr 28. Epub 2021 Apr 28.

Heath care associated infection research group, Leeds Institute of Medical Research, Faculty of Medicine and Health, University of Leeds, Leeds, LS1 LEX, United Kingdom. Electronic address:

Background: Carbapenemase-producing Enterobacterales (CPE) can colonise the gut and are of major clinical concern. Identification of CPE colonisation is problematic; there is no gold-standard detection method, and the effects of antibiotic exposure and microbiota dysbiosis on detection are unknown.

Aim: Based on a national survey we selected four CPE screening assays in common use. Read More

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Can Topical Vancomycin Prevent Periprosthetic Joint Infection in Hip and Knee Arthroplasty? A Systematic Review.

Clin Orthop Relat Res 2021 04 30. Epub 2021 Apr 30.

M. T. Wong, S. S. Sridharan, E. M. Davison, R. Ng, N. M. Desy, University of Calgary, Calgary, AB, Canada.

Background: Periprosthetic joint infection (PJI) after hip and knee arthroplasty is a leading cause of revision surgery, inferior function, complications, and death. The administration of topical, intrawound vancomycin (vancomycin powder) has appeared promising in some studies, but others have found it ineffective in reducing infection risk; for that reason, a high-quality systematic review of the best-available evidence is needed.

Questions/purposes: In this systematic review, we asked: (1) Does topical vancomycin (vancomycin powder) reduce PJI risk in hip and knee arthroplasty? (2) Does topical vancomycin lead to an increased risk of complications after hip and knee arthroplasty?

Methods: A search of Embase, MEDLINE, and PubMed databases as of June 2020 was performed according to Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. Read More

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