Am J Surg Pathol 2021 Sep 6. Epub 2021 Sep 6.
Division of Pathology Pathology Project for Molecular Targets, Cancer Institute Department of Pathology Breast Oncology Center, Cancer Institute Hospital, Japanese Foundation for Cancer Research Department of Pathology, Mita Hospital, International University of Health and Welfare, Tokyo Departments of Pathology Breast Surgery, Saku Central Hospital Advanced Care Center Department of Pathology, Saku Central Hospital, Saku, Nagano Prefecture, Japan.
Anaplastic lymphoma kinase (ALK)-positive histiocytosis is a rare emerging entity characterized by systemic or localized proliferation of histiocytes harboring ALK rearrangements. Breasts are reportedly affected by ALK-positive histiocytosis. Here, we evaluated 2 localized cases of breast ALK-positive histiocytosis through a comprehensive clinicopathologic, molecular, and genomic analysis to further delineate this entity and better understand its pathogenesis. Read More