20,652 results match your criteria real-life


Awareness of Forensic Cases Among Nurses: A Descriptive, Cross-Sectional Study.

J Forensic Nurs 2021 Apr 9. Epub 2021 Apr 9.

Istanbul University Faculty of Health Sciences, Healthcare Management Marmara University School of Medicine, Internal Medical Sciences.

Purpose: This study reports the knowledge, experience, and attitudes of nurses toward forensic cases in Turkey; critically evaluates the appropriateness of current practices in the collection and preservation of evidence; and assesses nurses' level of awareness on the law enforcement perspective of forensic cases. The study, thereby, seeks to offer solutions to some practical difficulties faced by nurses in clinical practice in Turkey.

Methods: The study involved 178 nurses of 202 employed in three healthcare centers operated by the same private healthcare group located in Istanbul, Turkey. Read More

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Performance of the 2017 American College of Rheumatology/European League Against Rheumatism Provisional Classification Criteria for Antineutrophil Cytoplasmic Antibody-Associated Vasculitis in a Peruvian Tertiary Care Center.

J Clin Rheumatol 2021 Apr 9. Epub 2021 Apr 9.

From the Department of Rheumatology, Hospital Nacional Guillermo Almenara Irigoyen, EsSalud, Lima Universidad Científica del Sur, Villa El Salvador Unidad de Investigación para la Generación y Síntesis de Evidencias en Salud, Universidad San Ignacio de Loyola Universidad Nacional Mayor de San Marcos, Lima, Peru Division of Clinical Immunology and Rheumatology, Department of Medicine, School of Medicine, The University of Alabama at Birmingham, Birmingham, AL Department of Medicine, School of Medicine, Universidad Peruana Cayetano Heredia, Lima, Peru.

Aim: To validate the new classification criteria for antineutrophil cytoplasmic antibody-associated vasculitis in a real-life Peruvian cohort of antineutrophil cytoplasmic antibody-associated vasculitis patients.

Methods: We reviewed medical records from a Peruvian tertiary care center from January 1990 to December 2019. Antineutrophil cytoplasmic antibody-associated vasculitis was diagnosed based on the 1990 American College of Rheumatology (ACR) criteria, the 2012 Chapel Hill Consensus Conference definitions, the European Medicines Agency (EMEA) algorithm, and the clinical acumen of the treating rheumatologists. Read More

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Seven Years-Experience of adalimumab therapy for hidradenitis suppurativa in a real-life dermatologic setting.

J Dermatolog Treat 2021 Apr 12:1-10. Epub 2021 Apr 12.

Department of Medical Sciences, Section of Dermatology and Infectious Diseases, University of Ferrara, Ferrara, Italy.

Introduction: Hidradenitis Suppurativa (HS) often causes severe impairment of the quality of life of patients affected, as it is characterized by recurrent relapses of inflammation and predisposes to retractive scars, with severe alteration of anatomy of the affected regions. Adalimumab is currently the only approved long-term biological therapy for this disease.

Material And Method: we retrospectively review the data of HS patients treated with Adalimumab at the "Hidradenitis Suppurativa Clinic", University of Ferrara, Italy since the drug was first available to October 2020. Read More

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Perceiving dynamic emotions expressed simultaneously in the face and body minimizes perceptual differences between young and older adults.

J Gerontol B Psychol Sci Soc Sci 2021 Apr 12. Epub 2021 Apr 12.

Department of Psychology, The Hebrew University of Jerusalem.

Objectives: It is commonly argued that older adults show difficulties in standardized tasks of emotional expression perception, yet most previous works relied on classic sets of static, decontextualized, and stereotypical facial expressions. In real-life, facial expressions are dynamic and embedded in a rich context, two key factors that may aid emotion perception. Specifically, body language provides important affective cues that may disambiguate facial movements. Read More

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An Automated Correction Algorithm (ALPACA) for ddPCR Data Using Adaptive Limit of Blank and Correction of False Positive Events Improves Specificity of Mutation Detection.

Clin Chem 2021 Apr 11. Epub 2021 Apr 11.

Department of Laboratory Medicine, Netherlands Cancer Institute, Amsterdam, the Netherlands.

Background: Bio-Rad droplet-digital PCR is a highly sensitive method that can be used to detect tumor mutations in circulating cell-free DNA (cfDNA) of patients with cancer. Correct interpretation of ddPCR results is important for optimal sensitivity and specificity. Despite its widespread use, no standardized method to interpret ddPCR data is available, nor have technical artifacts affecting ddPCR results been widely studied. Read More

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A Bayesian Disease Progression Model for Clinical Trajectories.

Graphs Biomed Image Anal Integr Med Imaging Nonimaging Modalities (2018) 2018 Sep 16;11044:57-65. Epub 2018 Sep 16.

Schools of ECE and BME, Cornell University, Ithaca, USA.

In this work, we consider the problem of predicting the course of a progressive disease, such as cancer or Alzheimer's. Progressive diseases often start with mild symptoms that might precede a diagnosis, and each patient follows their own trajectory. Patient trajectories exhibit wild variability, which can be associated with many factors such as geno-type, age, or sex. Read More

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September 2018

Can a monologue-style ECA more effectively motivate eHealth users in initial distress than textual guidance?

Heliyon 2021 Mar 21;7(3):e06509. Epub 2021 Mar 21.

Department of Psychology, Health and Technology, Centre for eHealth and Wellbeing Research, University of Twente, Enschede, Netherlands.

Stress is a prevalent issue amongst patients with chronic conditions. As eHealth interventions are gaining importance, it becomes more relevant to invoke the possibilities from the eHealth technology itself to provide motivational acts during experiences of stress as to enhance adherence to the intervention. Embodied Conversational Agents (ECA's) also known as 'robots on screen' can potentially provide a remedy. Read More

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A review of machine learning experiments in equity investment decision-making: why most published research findings do not live up to their promise in real life.

Int J Data Sci Anal 2021 Apr 5:1-22. Epub 2021 Apr 5.

University of Cambridge, Cambridge, UK.

The numerical nature of financial markets makes market forecasting and portfolio construction a good use case for machine learning (ML), a branch of artificial intelligence (AI). Over the past two decades, a number of academics worldwide (mostly from the field of computer science) produced a sizeable body of experimental research. Many publications claim highly accurate forecasts or highly profitable investment strategies. Read More

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IRAK-M knockout promotes allergic airway inflammation, but not airway hyperresponsiveness, in house dust mite-induced experimental asthma model.

J Thorac Dis 2021 Mar;13(3):1413-1426

Departments of Pulmonary and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Background: IL-1 receptor associated-kinase (IRAK)-M, expressed by airway epithelium and macrophages, was shown to regulate acute and chronic airway inflammation exhibiting a biphasic response in an OVA-based animal model. House dust mite (HDM) is a common real-life aeroallergen highly relevant to asthma pathogenesis. The role of IRAK-M in HDM-induced asthma remains unknown. Read More

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What influences the information exchange during self-medication consultations in community pharmacies? A non-participant observation study.

Res Social Adm Pharm 2021 Apr 2. Epub 2021 Apr 2.

Department of Clinical Pharmacy, Institute of Pharmacy, Faculty of Medicine, Leipzig University, Leipzig, Germany; Drug Safety Center, University Hospital Leipzig and Leipzig University, Leipzig, Germany.

Background: Although pharmaceutical staff consider guideline-compliant information exchange during self-medication consultations as crucial, they have not fully integrated it into practice. It is unclear what prevents pharmaceutical staff from implementing their positive intentions into their actual everyday practice. To improve the information exchange during the current consultation practice, a deeper understanding of its implementation is needed. Read More

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[Neovascular recurrences in 42 treatment-naive eyes with neovascular age-related macular degeneration (AMD) followed for over 2 years].

J Fr Ophtalmol 2021 Apr 8. Epub 2021 Apr 8.

Clinique ophtalmologique, CHU de Nantes, 1, place Alexis-Ricordeau, 44000 Nantes, France.

Introduction: The objective of this study was to analyze the reproducibility or variability of the time period to exudative recurrences in patients who were treated with intravitreal injections (IVT) of anti-VEGF (ranibizumab, aflibercept) for exudative age-related macular degeneration (AMD). The data studied included the number of recurrences per year, the time between the last IVT and the recurrence, fluctuation over time in the same patient, and changes in the therapeutic management of these exudative recurrences with regard to repeat induction therapy of three IVT, changes in monitoring protocols, and switches in anti-VEGF molecules.

Materials And Methods: We conducted a retrospective, single center, "real-life" study at the Nantes University Hospital, including 33 patients (42 eyes) between March 2012 and March 2017. Read More

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Burden of allergic rhinitis and impact of MP-AzeFlu from the patient perspective: pan European patient survey.

Curr Med Res Opin 2021 Apr 12. Epub 2021 Apr 12.

Power Project GmbH, Vienna Challenge Chamber, Vienna, Austria.

The aims of this survey were to (1) assess the burden of allergic rhinitis (AR) from the patient perspective, (2) investigate MP-AzeFlu use in real life and its impact on patients' lives and (3) explore factors associated with treatment satisfaction. A cross-sectional, quantitative, online, questionnaire-based survey was conducted in 7 European countries (March-June 2019). Questions explored AR burden and treatment satisfaction. Read More

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Reduced listener-speaker neural coupling underlies speech understanding difficulty in older adults.

Brain Struct Funct 2021 Apr 11. Epub 2021 Apr 11.

State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University & IDG, McGovern Institute for Brain Research, Beijing, 100875, China.

An increasing number of studies have highlighted the importance of listener-speaker neural coupling in successful verbal communication. Whether the brain-to-brain coupling changes with healthy aging and the possible role of this change in the speech comprehension of older adults remain unexplored. In this study, we scanned with fMRI a young and an older speaker telling real-life stories and then played the audio recordings to a group of young (N = 28, aged 19-27 year) and a group of older adults during scanning (N = 27, aged 53-75 year), respectively. Read More

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A combined stimuli presentation for assessing facial emotion related N170, N250 and visual mismatch negativity in neuropsychiatric disorders.

Asian J Psychiatr 2021 Apr 2;59:102639. Epub 2021 Apr 2.

Department of Physiology, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, India; Department of Medical Education, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, India.

Event-related potential (ERP) is a useful approach to assess the neurophysiological correlates of facial emotion processing. Previous studies examined the facial emotion recognition (FER) related ERPs (N170, N250, visual MisMatch Negativity) individually using ERP specific paradigms. This approach can be time-consuming and may not resemble real-life scenarios where an individual must process multiple stimuli simultaneously. Read More

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Safety and tolerability of the SQ HDM SLIT-tablet in real-life: A non-interventional, open-label study.

J Allergy Clin Immunol Pract 2021 Apr 8. Epub 2021 Apr 8.

ALK-Abelló Arzneimittel GmbH, Medical Department, D-22763 Hamburg, Germany;; Universitätsklinikum Carl Gustav Carus, Clinic for Otorhinolaryngology, D-01307 Dresden, Germany.

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Real-world outcomes with different technology modalities in type 1 diabetes.

Nutr Metab Cardiovasc Dis 2021 Mar 3. Epub 2021 Mar 3.

Endocrinology and Nutrition Department. Badajoz University Hospital, Badajoz, Spain.

Background And Aims: Several treatment modalities are available for type 1 diabetes (T1D), including continuous glucose monitoring (CGM) and flash glucose monitoring (FGM) with MDI, sensor-augmented pumps with predictive low-glucose suspend function (SAP-PLGS) and hybrid closed-loop systems (HCL). The aim of the study was to evaluate the real-world benefits obtained with these treatment modalities.

Methods And Results: A cross-sectional study was performed, selecting 4 groups of T1D subjects, regarding their treatment modalities, paired by age, sex and diabetes duration. Read More

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Dose-optimization for loss-of-response to vedolizumab - pharmacokinetics and immune mechanisms.

J Crohns Colitis 2021 Apr 10. Epub 2021 Apr 10.

Gastroenterology Institute, Sheba Medical Center Tel Hashomer, Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel.

Background: Real-life-data regarding pharmacokinetics of vedolizumab in patients needing dose-optimization are scarce. We set to examine whether pre-optimization vedolizumab-levels associate with therapy-outcomes and which mechanisms explain the associations.

Methods: A multi-center observational study assessed the outcome of dose-increase in association with pre-escalation levels in vedolizumab-treated patients. Read More

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Feasibility and Effectiveness of Norepinephrine Outside the Intensive Care Setting for Treatment of Hepatorenal Syndrome.

Liver Transpl 2021 Apr 10. Epub 2021 Apr 10.

Stanford University, Division of Nephrology.

Background & Aims: Vasoconstrictors are the treatment of choice for hepatorenal syndrome (HRS), a potentially lethal complication of end-stage liver disease. We evaluate the real-life effectiveness of a sequential vasoconstrictor regimen of midodrine-octreotide followed by norepinephrine in a non-ICU setting in the United States, where terlipressin is not available.

Approach & Results: Adult patients diagnosed with HRS were treated with oral midodrine and subcutaneous octreotide in conjunction with albumin. Read More

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Therapeutic efficacy of lenvatinib as third line treatment following regorafenib for unresectable hepatocellular carcinoma progression.

Hepatol Res 2021 Apr 10. Epub 2021 Apr 10.

Department of Gastroenterology and Hepatology, Kindai University, Osaka, Japan.

Background/aim: Multiple molecular agents (MTAs) have been developed for treating unresectable hepatocellular carcinoma (u-HCC). This study aimed to elucidate the clinical efficacy of sequential treatment with lenvatinib after regorafenib failure.

Materials/methods: From June 2017 to October 2020, 63 patients with Child-Pugh A and treated with regorafenib followed by sorafenib were enrolled (median age 71 years, males 52, BCLC B:C=23:40). Read More

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Use of 360° virtual reality video in medical obstetrical education: a quasi-experimental design.

BMC Med Educ 2021 Apr 10;21(1):202. Epub 2021 Apr 10.

Spaarne Gasthuis Academie, Spaarne Gasthuis Hospital, SpaarnePoort 1, 2134, TM, Hoofddorp, the Netherlands.

Background: Video-based teaching has been part of medical education for some time but 360° videos using a virtual reality (VR) device are a new medium that offer extended possibilities. We investigated whether adding a 360° VR video to the internship curriculum leads to an improvement of long-term recall of specific knowledge on a gentle Caesarean Sections (gCS) and on general obstetric knowledge.

Methods: Two weeks prior to their Obstetrics and Gynaecology (O&G) internship, medical students were divided in teaching groups, that did or did not have access to a VR-video of a gCS. Read More

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Acute gastrointestinal bleeding: results from the prospective German electronic registry of nearly 11 000 endoscopies (ALGK GI-bleeding registry).

Z Gastroenterol 2021 Apr 9. Epub 2021 Apr 9.

ALGK (Arbeitsgemeinschaft Leitende Gastroenterologische Krankenhausärzte; Working Group of Leading German Gastroenterologists in Hospitals).

Background And Study Aims:  Gastrointestinal bleeding is frequently observed in the German population. However, recent epidemiological data are not available. This study aimed to elucidate gastrointestinal bleeds under real-life conditions in 3 German hospitals. Read More

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A real-life study of the positive response to DAA-based therapies for hepatitis C in Brazil.

Braz J Infect Dis 2021 Apr 6:101573. Epub 2021 Apr 6.

University of Brasília (UnB), Faculty of Medicine, Center for Tropical Medicine, Brasília, DF, Brazil; National Institute for Science and Technology for Health Technology Assessment, Porto Alegre, RS, Brazil; University of Brasília (UnB), Faculty of Ceilândia, Brasília, DF, Brazil.

A retrospective cohort of 11,308 chronic hepatitis C infected patients treated with regimens that included Sofosbuvir (SOF), Daclatasvir (DCV), Simeprevir (SMV), or an association of Ombitasvir, Veruprevir/Ritonavir and Dasabuvir (3D) with or without Ribavirin (RBV) were assessed for sustained virologic response (SVR) or viral cure after a 12-week treatment. Logistic regression analyses were used to identify factors independently associated with positive response to direct-acting antivirals (DAA)-based therapies. Overall 57. Read More

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Oral immunotherapy in severe cow's milk allergic patients treated with omalizumab: real life survey from a Spanish registry.

Pediatr Allergy Immunol 2021 Apr 9. Epub 2021 Apr 9.

Department of Allergy, Hospital Infantil Universitario Niño Jesús and ARADyAL- RETICs network RD16, Instituto de Salud Carlos III, IIS-P, FibHNJ, 0006/0026, Madrid, Spain.

Background: Oral immunotherapy is a frequent treatment for the management of food allergies, but adverse events (AE) are common. This study assessed the outcome of cow's milk oral immunotherapy (MOIT) in severe cow`s milk allergic patients treated with omalizumab in a real-life setting.

Methods: OmaBASE was a national, multicenter, open and observational registry that collected clinical, immunological and treatment data from patients with food allergy receiving omalizumab. Read More

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Real-life outcomes after artificial urinary sphincter explantation in women suffering from severe stress incontinence.

World J Urol 2021 Apr 9. Epub 2021 Apr 9.

Department of Urology, Nouvel Hôpital Civil, Hôpitaux Universitaire de Strasbourg, 1 place de l'Hôpital, 67000, Strasbourg, France.

Purpose: Artificial urinary sphincter (AUS) implantation in female patients results in high satisfaction rates and high functional outcomes, but implantation can be challenging and explantation of the device is fairly common. The objective of this study was to review outcomes after AUS explantation in women.

Methods: This is a retrospective, monocentric study of all women who underwent open or laparoscopic AUS implantation between November 1994 and July 2019, and patients with AUS explantation were included. Read More

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Substances of abuse consumption among patients seeking medical help for uro-andrological purposes: a sociobehavioral survey in the real-life scenario.

Asian J Androl 2021 Apr 6. Epub 2021 Apr 6.

Division of Experimental Oncology/Unit of Urology, URI, IRCCS Ospedale San Raffaele, via Olgettina 60, Milan 20131, Italy.

Substances of abuse (SoA), as well as smoking and alcohol consumption, are well known for their impact on male fertility status, erectile function, and ejaculation. We assessed SoA consumption habits in a cohort of men seeking medical attention for uro-andrological purposes. Data from 7447 men seeking medical attention for the first time for uro-andrological purposes were analyzed. Read More

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Alpha and theta mechanisms operating in internal-external attention competition.

J Integr Neurosci 2021 Mar;20(1):1-19

Department of Electrical, Electronic and Information Engineering "Guglielmo Marconi", University of Bologna-Campus of Cesena, 47521 Cesena, Italy.

Attention is the ability to prioritize a set of information at expense of others and can be internally- or externally-oriented. Alpha and theta oscillations have been extensively implicated in attention. However, it is unclear how these oscillations operate when sensory distractors are presented continuously during task-relevant internal processes, in close-to-real-life conditions. Read More

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Good tolerance of hyaluronic acid injections during the period of the Covid-19 pandemic: observing a cohort of 1093 patients in a prospective, observational real-life study.

J Eur Acad Dermatol Venereol 2021 Apr 8. Epub 2021 Apr 8.

Centre Laser MD, Strasbourg, France.

Dermatologists have questioned the possibility of continuing hyaluronic acid (HA) injections during the Covid-19 pandemic period, fearing especially an increase in immune complications. Therefore, the Group for Aesthetic and Corrective Dermatology of the French Society of Dermatology (gDEC) decided to set up a prospective, clincal study over the period May to July 2020 to follow a large patient cohort being injected with HA during the Covid-19 pandemic. Read More

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Advanced feature selection to study the internationalization strategy of enterprises.

PeerJ Comput Sci 2021 25;7:e403. Epub 2021 Mar 25.

Departamento de Economia y Administración de Empresas, Universidad de Burgos, Burgos, Spain.

Firms face an increasingly complex economic and financial environment in which the access to international networks and markets is crucial. To be successful, companies need to understand the role of internationalization determinants such as bilateral psychic distance, experience, etc. Cutting-edge feature selection methods are applied in the present paper and compared to previous results to gain deep knowledge about strategies for Foreign Direct Investment. Read More

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Time-dependent heterogeneity leads to transient suppression of the COVID-19 epidemic, not herd immunity.

Proc Natl Acad Sci U S A 2021 04;118(17)

Department of Physics, University of Illinois at Urbana-Champaign, Urbana, IL 61801.

Epidemics generally spread through a succession of waves that reflect factors on multiple timescales. On short timescales, superspreading events lead to burstiness and overdispersion, whereas long-term persistent heterogeneity in susceptibility is expected to lead to a reduction in both the infection peak and the herd immunity threshold (HIT). Here, we develop a general approach to encompass both timescales, including time variations in individual social activity, and demonstrate how to incorporate them phenomenologically into a wide class of epidemiological models through reparameterization. Read More

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