Crit Care Med 2021 Jun 24. Epub 2021 Jun 24.
Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China. Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN. Division of Intensive Care Unit, Department of Critical Care Medicine, the First Affiliated Hospital of UTSC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China. Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN. Mayo Clinic Library, Evidence-based Practice Center, Mayo Clinic, Rochester, MN. Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, MN. Unidad de Conocimiento y Evidencia, CONEVID, Universidad Peruana Cayetano Heredia, Lima, Peru. Division of Critical Care, Department of Medicine, Mayo Clinic Health System, Mankato, MN.
Objectives: To evaluate the efficacy of the simultaneous hypertonic saline solution and IV furosemide (HSS+Fx) for patients with fluid overload compared with IV furosemide alone (Fx).
Data Sources: Electronic databases (MEDLINE, EMBASE, CENTRAL, Cochrane Database of Systematic Reviews, PsycINFO, Scopus, and WOS) were searched from inception to March 2020.
Study Selection: Randomized controlled trials on the use of HSS+Fx in adult patients with fluid overload versus Fx were included. Read More