434,952 results match your criteria reactive astrocytic


Male Sex Is a Significant Predictor of All-cause Mortality in Patients with Antineutrophil Cytoplasmic Antibody-associated Vasculitis.

J Korean Med Sci 2021 May 10;36(18):e120. Epub 2021 May 10.

Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.

Background: We investigated and compared the initial clinical features at diagnosis and the poor outcomes during follow-up in Korean patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) based on sex.

Methods: The medical records of 223 immunosuppressive drug-naïve patients with AAV were reviewed. Age, body mass index (BMI), smoking history, AAV subtypes, ANCA positivity, clinical manifestations, Birmingham vasculitis activity score (BVAS), five-factor score (FFS), erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) at diagnosis were collected. Read More

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Lycopene and Caffeic Acid Phenethyl Ester Affect Caspase-3 Activity, but Do Not Alter the NO Pathway in Lung Tissue Damage Induced by Cisplatin.

Pharmacology 2021 May 11:1-9. Epub 2021 May 11.

Department of biochemistry, Faculty of Medicine, University of Niš, Niš, Serbia.

Introduction: Antioxidants such as lycopene (LCP) and caffeic acid phenethyl ester (CAPE) represent ideal molecules for the treatment of different reactive oxygen species (ROS) associated disorders. Cisplatin is a chemotherapeutic agent, causing an increase in ROS and DNA damage, with numerous side effects, which include lung toxicity. In the presents study, we evaluated and mutually compared the potential of LCP and CAPE in preventing cisplatin-induced rat lung damage. Read More

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CHA2DS2-VASc Score as a Predictor of Cardiovascular and All-Cause Mortality in Chronic Kidney Disease Patients.

Am J Nephrol 2021 May 11:1-8. Epub 2021 May 11.

Department of Nephrology, Clinic for Internal Medicine, University Medical Centre Maribor, Maribor, Slovenia.

Introduction: Chronic kidney disease (CKD) is a risk factor for cardiovascular and all-cause mortality. Recognition of high-risk patients is important and could lead to a different approach and better treatment. The CHA2DS2-VASc score was originally used to predict cerebral infarction in patients with atrial fibrillation (AF), but it is also a useful predictor of outcome in other cardiovascular conditions, independent of AF. Read More

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Cerebral Venous Thrombosis Associated with COVID-19 Infection: An Observational, Multicenter Study.

Cerebrovasc Dis Extra 2021 May 11;11(2):55-60. Epub 2021 May 11.

Rashid Hospital, Dubai, United Arab Emirates.

Background And Purpose: Coronavirus disease 2019 (CO-VID-19) has an increased propensity for systemic hypercoagulability and thromboembolism. An association with cerebrovascular diseases, especially cerebral venous thrombosis (CVT), has been reported among these patients. The objective of the present study was to identify risk factors for CVT as well as its presentation and outcome in COVID-19 patients. Read More

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Visible light-activated ZnO nanoparticles for microbial control of wheat crop.

J Photochem Photobiol B 2021 May 5;219:112206. Epub 2021 May 5.

Vilnius University, Institute of Photonics and Nanotechnology, Sauletekio 10, Vilnius 10223, Lithuania. Electronic address:

Every year 15-50% of cereals all around the world are lost due to fungal contamination and deterioration. In addition, 25% of crops, which are used for human and animal consumption, are contaminated with mycotoxins. It is obvious, that more effective and sustainable technologies for better microbial control of crops are required. Read More

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Bimetal (Fe/Zn) doped BiOI photocatalyst: An effective photodegradation of tetracycline and bacteria.

Chemosphere 2021 May 5;280:130803. Epub 2021 May 5.

Advanced Ceramics and Nanotechnology Laboratory, Department of Materials Engineering, Faculty of Engineering, University of Concepción, Concepción, 4070409, Chile. Electronic address:

Tetracycline (TC) is one of the most commonly used broad-spectrum antibiotics to treat the bacterial infection. TC antibiotics enter into the environment because of partial metabolism in the humans and animals, thereby increasing the environmental toxicity. Therefore, it is highly needed to treat TC antibiotics from the water system. Read More

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Developmental neurotoxicity of antimony (Sb) in the early life stages of zebrafish.

Ecotoxicol Environ Saf 2021 May 8;218:112308. Epub 2021 May 8.

Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing 400030, China. Electronic address:

Accumulating studies have revealed the toxicity of antimony (Sb) to soil-dwelling and aquatic organisms at the individual level. However, little is known about the neurotoxic effects of antimony and its underlying mechanisms. To assess this issue, we investigated the neurotoxicity of antimony (0, 200, 400, 600 and 800 mg/L) in zebrafish embryos. Read More

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Effects of ultrasound-assisted vacuum tumbling on the oxidation and physicochemical properties of pork myofibrillar proteins.

Ultrason Sonochem 2021 May 4;74:105582. Epub 2021 May 4.

Key Laboratory of Meat Processing and Quality Control, Jiangsu Synergetic Innovation Center of Meat Processing and Quality Control, College of Food Science and Technology, Nanjing Agricultural University, Nanjing, Jiangsu 210095, China. Electronic address:

The present research aimed to investigate the effects of high-intensity ultrasound (HIU, 20 kHz, 0 W, 100 W, 300 W and 500 W)-assisted vacuum tumbling (UVT) for 60 min and 120 min on the oxidation and physicochemical properties of the pork myofibrillar proteins (MPs). Compared with the vacuum tumbling (VT) groups without the HIU assistance, the carbonyl content increased, while the total sulfhydryl (SH) content was reduced with the increase of HIU power and treatment time (P < 0.05). Read More

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Selenium nanoparticles ameliorate Brassica napus L. cadmium toxicity by inhibiting the respiratory burst and scavenging reactive oxygen species.

J Hazard Mater 2021 Apr 16;417:125900. Epub 2021 Apr 16.

Shandong Key Laboratory of Water Pollution Control and Resource Reuse, School of Environmental Science and Engineering, Shandong University, Qingdao 266237, China. Electronic address:

Cadmium (Cd) is a widely distributed soil contaminant which induces oxidative damage and is therefore toxic to plants. Although selenium oxyanions such as selenite (SeO) and selenate (SeO) can alleviate Cd stress to plants, it is not known whether selenium nanoparticles (SeNPs) are able to do the same. The present study demonstrated the positive impact of both SeNPs and SeO on Brassica napus L. Read More

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Assessment of the effect of long-term exposure to microplastics and depuration period in Sparus aurata Linnaeus, 1758: Liver and blood biomarkers.

Sci Total Environ 2021 May 3;786:147479. Epub 2021 May 3.

Instituto Español de Oceanografía, Centro Oceanográfico de Baleares, Muelle de Poniente s/n, E-07015 Palma de Mallorca, Balearic Islands, Spain. Electronic address:

The constant increase in plastic pollution has attracted great attention in recent years due to its potential detrimental effects on organisms and ecosystems. While the consequences of ingestion of large plastic litter are mostly understood, the impacts resulting from a long-term exposure and a recovery period of microplastics (MPs) are still limited. The aims were to monitor oxidative stress, detoxification and inflammatory biomarkers in liver, plasma and erythrocytes of Sparus aurata exposed during 90 days to low-density polyethylene (LDPE)-MPs enriched diet (10% by weight) followed by 30 days of depuration. Read More

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Transformation of tetracycline antibiotics with goethite: Mechanism, kinetic modeling and toxicity evaluation.

Water Res 2021 Apr 29;199:117196. Epub 2021 Apr 29.

School of Environmental Science and Engineering, Tianjin University, Tianjin 300072, China. Electronic address:

Tetracycline antibiotics (TCs) are a group of the top selling and widely used antibiotics that have been frequently detected in various environments. The interaction between TCs and goethite (α-FeOOH), one of the most common crystalline oxide minerals in aqueous environment and soil, is unclear. Apart from adsorption, this study firstly demonstrated that transformation of tetracycline (TTC) occurred in the presence of goethite. Read More

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How to interpret and use COVID-19 serology and immunology tests.

Clin Microbiol Infect 2021 May 8. Epub 2021 May 8.

Institute of Laboratory Medicine, Universities of Giessen and Marburg Lung Centre (UGMLC), Philipps University Marburg, German Centre for Lung Research (DZL) Marburg, Germany.

Background: Although molecular tests are considered the gold standard for coronavirus disease 2019 (COVID-19) diagnostics, serological and immunological tests may be useful in specific settings.

Objectives: This review summarises the underlying principles and performance of COVID-19 serological and immunological testing.

Sources: Selected peer-reviewed publications on COVID-19 related serology and immunology published between December 2019 and March 2021. Read More

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The role of sex and inflammation in cardiovascular outcomes and mortality in COVID-19.

Int J Cardiol 2021 May 8. Epub 2021 May 8.

Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA. Electronic address:

Objective: Higher mortality in COVID-19 in men compared to women is recognized, but sex differences in cardiovascular events are less well established. We aimed to determine the independent contribution of sex to stroke, myocardial infarction and death in the setting of COVID-19 infection.

Methods: We performed a retrospective cohort study of hospitalized COVID-19 patients in a racially/ethnically diverse population. Read More

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Shenqi Yizhi Granule attenuates Aβ induced cognitive dysfunction via inhibiting JAK2/STAT3 activated astrocyte reactivity.

Exp Gerontol 2021 May 8:111400. Epub 2021 May 8.

Institute of Meterial Medica Integration and Transformation for Brain Disorders, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, PR China; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, PR China. Electronic address:

Shenqi Yizhi Granule (SYG), a modern preparation herbs based on the theory of traditional Chinese medicine, has been proved to be effective against Alzheimer's disease in clinical trials, APP/PS1 mice and 5XFAD transgenic mice. But the underlying mechanism remains ambiguous. Increasing evidence supports the crucial role of astrocyte reactivity in the pathogenesis of Alzheimer's disease (AD). Read More

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Effects of sacrificial coordination bonds on the mechanical performance of lignin-based thermoplastic elastomer composites.

Int J Biol Macromol 2021 May 8. Epub 2021 May 8.

School of Chemistry and Chemical Engineering, Guangdong Engineering Research Center for Green Fine Chemicals, South China University of Technology, Wushan Road 381, Guangzhou, Guangdong 510640, China.

The coordination-based energy sacrificial bonds have been constructed in the interphase between lignin and polyolefin elastomer which has been demonstrated as an effective method to prepare high performance lignin-based thermoplastic elastomers (TPEs). Here, we proposed a strategy of adjusting the strength and toughness of lignin-based TPEs by using different nitrogen heterocyclic compounds as reactive assistants and Fe or Zn as metal coordination centers to construct coordination bonds between lignin and polyethylene elastomer matrix. It was demonstrated that 3-Amino-1,2,4-triazole with three nitrogen atoms in the heterocyclic ring and one nitrogen branch chain could form the most efficient coordination bond system which generated the best mechanical performance. Read More

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Assessment of Anti-inflammatory-like, Antioxidant activities and Molecular docking of three Alkynyl-substituted 3-ylidenedihydrobenzo[d] isothiazole 1,1-dioxide derivatives.

Chem Biol Interact 2021 May 8:109513. Epub 2021 May 8.

Center for Oxygen, Research and Development (CORD) and Center for Interdisciplinary Research on Medicine (CIRM) Institute of Chemistry University of Liège, Sart-Tilman (B.6a), 4000 Liège, Belgium.

The presence of enyne and benzoisothiazole functions in the molecular architecture of compounds 1, 2 and 3 were expected to provide biochemical activities. In the present work, we first examined the molecular surface contact of three alkynyl-substituted 3-ylidenedihydrobenzo[d] isothiazole 1,1-dioxides. The analysis of the Hirshfeld surfaces reveals that only compound 3 exhibited a well-defined red spots, indicating intermolecular interactions identified as S-O···H, C-H···O and C-O···H contacts. Read More

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Elucidating of oxidative distress in COVID-19 and methods of its prevention.

Chem Biol Interact 2021 May 8:109501. Epub 2021 May 8.

Intraoperative Imaging Unit, Chair and Department of Neurosurgery and Neurotraumatology, Karol Marcinkowski University of Medical Sciences, Przybyszewskiego 49, 60-355, Poznan, Poland; Department of Neurosurgery and Neurotraumatology, Heliodor Swiecicki Clinical Hospital, Przybyszewskiego 49, 60-355, Poznan, Poland. Electronic address:

The pandemic of SARS-CoV-2 stimulates significant efforts and approaches to understand its global spread. Although the recent introduction of the vaccine is a crucial prophylactic step, the effective treatment for SARS-CoV-2 is still undiscovered. An in-depth analysis of symptoms and clinical parameters, as well as molecular changes, is necessary to comprehend COVID-19 and propose a remedy for affected people to fight that disease. Read More

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Copper biology.

Curr Biol 2021 May;31(9):R421-R427

Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

Metals are vital for life as they are necessary for essential biological processes. Traditionally, metals are categorized as either dynamic signals or static cofactors. Redox-inactive metals such as calcium (Ca), potassium (K), sodium (Na), and zinc (Zn) signal through large fluctuations in their metal-ion pools. Read More

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Understanding the Effect of Water on CO Adsorption.

Chem Rev 2021 May 11. Epub 2021 May 11.

Centre for Catalysis Research and Innovation, Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Ontario K1N 6N5, Canada.

Carbon capture from large sources and ambient air is one of the most promising strategies to curb the deleterious effect of greenhouse gases. Among different technologies, CO adsorption has drawn widespread attention mostly because of its low energy requirements. Considering that water vapor is a ubiquitous component in air and almost all CO-rich industrial gas streams, understanding its impact on CO adsorption is of critical importance. Read More

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Glutathione-Depleting Nanomedicines for Synergistic Cancer Therapy.

ACS Nano 2021 May 11. Epub 2021 May 11.

State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, 2 Sipailou Road, Nanjing 210096, P.R. China.

Cancer cells frequently exhibit resistance to various molecular and nanoscale drugs, which inevitably affects the drugs' therapeutic outcomes. Overexpression of glutathione (GSH) has been observed in many cancer cells, and solid evidence has corroborated the resulting tumor resistance to a variety of anticancer therapies, suggesting that this biochemical characteristic of cancer cells can be developed as a potential target for cancer treatments. The single treatment of GSH-depleting agents can potentiate the responses of the cancer cells to different cell death stimuli; therefore, as an adjunctive strategy, GSH depletion is usually combined with mainstream cancer therapies for enhancing the therapeutic outcomes. Read More

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Regulation of plasmodesmata in leaves of Arabidopsis: ATP, NADPH and chlorophyll b levels matter.

J Exp Bot 2021 May 11. Epub 2021 May 11.

Laboratory of Molecular and Ecological Physiology, Komarov Botanical Institute, Russian Academy of Sciences, ul. Professora Popova 2, 197376 St.-Petersburg, Russia.

In mature leaves, cell-to-cell transport via plasmodesmata (PD) between mesophyll cells links assimilate production in photosynthesis with their export to sink organs. This study addresses the question how signals derived from chloroplasts and photosynthesis influence PD permeability. Cell-to-cell transport was analyzed in leaves of Arabidopsis chlorophyll b-less ch1-3 mutant, the same mutant complemented with a cyanobacterial CAO gene (PhCAO) over-accumulating chlorophyll b, the trxm3 mutant lacking plastidial thioredoxin m3, and the ntrc mutant lacking functional NADPH : thioredoxin reductase C. Read More

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Two-year follow-up after a six-week high-intensity training intervention study with breast cancer patients: physiological, psychological and immunological differences.

Disabil Rehabil 2021 May 11:1-8. Epub 2021 May 11.

Division of Sports and Rehabilitation Medicine, Ulm University Hospital, Ulm, Germany.

Purpose: Previously we demonstrated the feasibility of a six-week-long combination of high-intensity interval endurance and strength training (HIT/HIRT) for women with nonmetastatic breast cancer leading to improvements in psychological well-being and performance. Now we report results of a 24-month follow-up.

Methods: Previous intervention (IG,  = 10; 58. Read More

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Purposefulness and daily life in a pandemic: Predicting daily affect and physical symptoms during the first weeks of the COVID-19 response.

Psychol Health 2021 May 11:1-17. Epub 2021 May 11.

Department of Psychology, University of British Columbia, Vancouver, BC, Canada.

Objective: Sense of purpose has been associated with greater health and well-being, even in daily contexts. However, it is unclear whether effects would hold in daily life during COVID-19, when people may have difficulty seeing a path towards their life goals.

Design: The current study investigated whether purposefulness predicted daily positive affect, negative affect, and physical symptoms. Read More

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Highly Stable 1,2-Dicarbonyl Radical Cations Derived from N-Heterocyclic Carbenes.

J Am Chem Soc 2021 May 11. Epub 2021 May 11.

Department of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang 37673, Republic of Korea.

Stable organic radicals have been of great academic interest not only in the context of fundamental understanding of reactive intermediates but also because of their numerous applications as functional materials. Apart from the early examples of triphenylmethyl and TEMPO derivatives, reports on air- and water-stable organic radicals are scarce, and their development remains a challenge. Herein, we present the design and synthesis of a novel organic radical based on a 1,2-dicarbonyl scaffold supported by -heterocyclic carbenes (NHCs). Read More

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Representation of Multiphase OH Oxidation of Amorphous Organic Aerosol for Tropospheric Conditions.

Environ Sci Technol 2021 May 11. Epub 2021 May 11.

School of Marine and Atmospheric Sciences, Stony Brook University, Stony Brook, New York 11794, United States.

Organic aerosol (OA) is ubiquitous in the atmosphere and, during transport, can experience chemical transformation with consequences for air quality and climate. Prediction of the chemical evolution of OA depends on its reactivity with atmospheric oxidants such as the OH radical. OA particles undergo amorphous phase transitions from liquid to solid (glassy) states in response to temperature changes, which, in turn, will impact its reactivity toward OH oxidation. Read More

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Synchronization of Nanoparticle Sensitization and Radiosensitizing Chemotherapy through Cell Cycle Arrest Achieving Ultralow X-ray Dose Delivery to Pancreatic Tumors.

ACS Nano 2021 May 11. Epub 2021 May 11.

Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan.

Pancreatic cancer is among the leading causes of cancer-related death and remains a formidable therapeutic challenge. To date, surgical resection and chemotherapy have been the standards of care. Methotrexate (MTX), which is recognized as a refractory drug for pancreatic cells, was conjugated to the surface of LiYF:Ce nanoparticles (NP-MTX) through a photocleavable linker molecule. Read More

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HBCD, TBECH, and BTBPE exhibit cytotoxic effects in human vascular endothelial cells by regulating mitochondria function and ROS production.

Environ Toxicol 2021 May 11. Epub 2021 May 11.

Division of Cardiology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Brominated flame retardants (BFRs), such as, 1,2,5,6-tetrabromocyclooctane (HBCD), 1,2-dibromo-4-(1,2-dibromopropyl)cyclohexane (TBECH), and 1 1,2-bis-(2,4,6-tribromophenoxy)ethane (BTBPE), have garnered increasing attention due to their potent biological effects. In the present study, the toxicity of HBCD, TBECH, and BTBPE in human vascular endothelial cells (ECs) was explored. The data showed that HBCD, TBECH, and BTBPE induced cytotoxicity, namely dose-dependent cell viability reduction, cell membrane permeability and apoptosis increase, migration, and lumen formation inhibition. Read More

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[Identification and pedigree analysis for an A(W)37B subtype due to c.940A>G variant of ABO gene].

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2021 May;38(5):496-498

School of Medical Laboratory, Weifang Medical University, Weifang, Shandong 261053, China.

Objective: To delineate the serological and molecular profiles of a patient with A(w)37B subtype.

Methods: The ABO bloodtypes of the proband, his wife and daughter were determined with a standard serological method. Their ABO genotypes were determined by sequence-specific primer polymerase chain reaction (PCR-SSP). Read More

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