18,056 results match your criteria reactive amine

Understanding the Effect of Water on CO Adsorption.

Chem Rev 2021 May 11. Epub 2021 May 11.

Centre for Catalysis Research and Innovation, Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Ontario K1N 6N5, Canada.

Carbon capture from large sources and ambient air is one of the most promising strategies to curb the deleterious effect of greenhouse gases. Among different technologies, CO adsorption has drawn widespread attention mostly because of its low energy requirements. Considering that water vapor is a ubiquitous component in air and almost all CO-rich industrial gas streams, understanding its impact on CO adsorption is of critical importance. Read More

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A metastasis suppressor Pt-dendrimer nanozyme for the alleviation of glioblastoma.

J Mater Chem B 2021 May 6. Epub 2021 May 6.

Department of Biomedical Science, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea. and KHU-KIST Department of Converging Science and Technology, Kyung Hee University, Seoul 02447, Republic of Korea and Department of Anatomy and Neurobiology, College of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea and Center for Converging Humanities, Kyung Hee University, Seoul 02447, Republic of Korea and Medical Research Center for Bioreaction to Reactive Oxygen Species and Biomedical Science Institute, School of Medicine, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea.

Nanozymes are nanostructure-based materials which mimic the enzymatic characteristics of natural enzymes. Biological applications of nanozymes have been highlighted in basic research, industry, and translational medicine as a new cutting-edge tool. In this work, and for the first time, we disclose a tumor alleviation property of a nanozyme that is made up of amine-terminated sixth-generation polyamidoamine dendrimers with encapsulated tiny platinum nanoparticles. Read More

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[Controlling Cell Dynamics by Cell-surface Modification].

Yakugaku Zasshi 2021 ;141(5):661-665

Faculty of Medicine, Kindai University.

Although the concept of a drug delivery system (DDS) is usually applied to conventional drug therapy, it is also important for cell-based therapy. The surface manipulation of living cells represents a powerful tool for controlling cell behaviors in the body, such as enhancement of cell-cell interactions, targeted delivery of cells, and protection from immunological rejection. Functional groups, including amines, thiols, and carbonyls, offer excellent opportunities for chemical modification through the formation of covalent bonds with exogenous molecules. Read More

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January 2021

Enantioselective, Catalytic Multicomponent Synthesis of Homoallylic Amines Enabled by Hydrogen-Bonding and Dispersive Interactions.

J Am Chem Soc 2021 May 5. Epub 2021 May 5.

Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, United States.

We report a one-step catalytic, enantioselective method for the preparation of homoallylic -Boc amines directly from acetals. Reactive iminium ion intermediates are generated through the combination of an acetal, a chiral thiourea catalyst, trialkylsilyl triflate, and -Boc carbamate and are subsequently trapped by a variety of allylsilane nucleophiles. No homoallylic ether byproducts are detected, consistent with allylation of the iminium intermediate being highly favored over allylation of the intermediate oxocarbenium ion. Read More

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Photocross-Linked Antimicrobial Amino-Siloxane Elastomers.

ACS Appl Mater Interfaces 2021 May 4. Epub 2021 May 4.

Department of Chemistry, 2036 Main Mall, University of British Columbia, Vancouver, British Columbia V6T 1Z1, Canada.

Mechanically robust bulk antimicrobial polymers are one way to address disease transmission via contaminated surfaces. Here, we demonstrate the visible light photo-oxidative cross-linking of amine-containing PDMS using a single-component, solvent-free system where amines have a dual role as antimicrobial functionalities and cross-linking sites. Rose Bengal, a xanthene dye used as a fluorescent stain, is thermally reacted with the polymer to give a solvent-free liquid siloxane that can generate reactive singlet oxygen upon aerobic green light irradiation, coupling the amine functionalities into imine cross-links. Read More

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Functional Polymer Zwitterions as Reactive Surfactants for Nanoparticle Capture.

ACS Appl Mater Interfaces 2021 May 4. Epub 2021 May 4.

Polymer Science & Engineering Department Conte Center for Polymer Research, University of Massachusetts, 120 Governors Drive, Amherst 01003, Massachusetts, United States.

We describe the synthesis of sulfothetin (ST)-containing polymer zwitterions and their use as polymer surfactants for stabilizing emulsion droplets and for capturing and transporting nanoparticles (NPs) through a flowing aqueous fluid. In contrast to conventional zwitterions, which are chemically inert, the multifunctional ST-containing copolymers we describe both participate in droplet stabilization and embed reactive functionality directly into the zwitterionic framework. Advantageously including these ST zwitterions in phosphorylcholine (PC)-containing copolymers proved particularly useful for producing surfactants that contributed characteristics of droplet stabilization and interfacial reactivity. Read More

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Detecting Sex-Related Changes to the Metabolome of a Critically Endangered Freshwater Crayfish During the Mating Season.

Front Mol Biosci 2021 16;8:650839. Epub 2021 Apr 16.

Centre for Ecosystem Management, Edith Cowan University, Perth, WA, Australia.

Captive breeding is a vital tool in the conservation of highly endangered species, as it is for the Margaret River hairy marron, , from the south west of Australia. A close relative, , has almost completely displaced in the wild and is a successful aquaculture species, whereas has performed poorly in captivity. We used untargeted liquid chromatography-mass spectrometry to obtain metabolomic profiles of female and male held in controlled aquarium conditions during their reproductive period. Read More

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Differential colorimetric nanobiosensor array as bioelectronic tongue for discrimination and quantitation of multiple foodborne carcinogens.

Food Chem 2021 Apr 20;357:129801. Epub 2021 Apr 20.

Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia; Centre for Innovation in Medical Engineering, Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur, Malaysia. Electronic address:

Foodborne amides, specifically acrylamide, are vitally important for food safety and security, as they are the most common food toxicants and suspected human carcinogens. A facile and novel differential-based colorimetric nanobiosensor array composed of three surface-bioengineered gold nanoparticles (AuNPs) was developed for the rapid detection, differentiation, and quantification of acrylamide and six analogues. Diverse cross-reactive receptors demonstrated differential binding affinities toward target analytes, resulting in distinctive AuNP aggregation behaviors and distinguishable response patterns. Read More

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Decorating sdAbs with Chelators: Effect of Conjugation on Biodistribution and Functionality.

Pharmaceuticals (Basel) 2021 Apr 25;14(5). Epub 2021 Apr 25.

Department of Medical Imaging (MIMA), Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090 Brussels, Belgium.

Single domain antibodies (sdAbs) have proven to be valuable probes for molecular imaging. In order to produce such probes, one strategy is the functionalization of the reactive amine side chain of lysines with a chelator, resulting in a mixture of compounds with a different degree of conjugation. In this study, we implemented anion exchange chromatography (AEX) to separate the different compounds or fractions that were further characterized and evaluated to study the impact of the conjugation degree on pharmacokinetic properties and functionality. Read More

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A New Pyrimidine Schiff Base with Selective Activities against and Gastric Adenocarcinoma.

Molecules 2021 Apr 15;26(8). Epub 2021 Apr 15.

Screening Laboratory of Biological Activity Tests and Collection of Biological Material, Faculty of Pharmacy, Wroclaw Medical University, 211A Borowska, 50-556 Wroclaw, Poland.

is known as a significant nosocomial pathogen due to its natural resistance to many antibacterial drugs. Moreover, it was found that infection causes inflammation, production of reactive oxygen species, and DNA damage to human gastric cancer cells, which can induce cancer. In this study, we synthesized and tested the biological activity of a new Schiff base, 5-[(4-ethoxyphenyl)imino]methyl--(4-fluorophenyl)-6-methyl-2-phenylpyrimidin-4-amine (), and compared its properties with an analogous amine (). Read More

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Ratiometric Near-Infrared Fluorescent Probes Based on Hemicyanine Dyes Bearing Dithioacetal and Formal Residues for pH Detection in Mitochondria.

Molecules 2021 Apr 6;26(7). Epub 2021 Apr 6.

Department of Chemistry, Michigan Technological University, Houghton, MI 49931, USA.

Ratiometric near-infrared fluorescent probes ( and ) have been prepared for pH determination in mitochondria by attaching dithioacetal and formal residues onto a hemicyanine dye. The reactive formyl group on probe allows for retention inside mitochondria as it can react with a protein primary amine residue to form an imine under slightly basic pH 8.0. Read More

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Biogenic copper nanoparticles produced by using the Klebsiella pneumoniae strain NST2 curtailed salt stress effects in maize by modulating the cellular oxidative repair mechanisms.

Ecotoxicol Environ Saf 2021 Jul 27;217:112264. Epub 2021 Apr 27.

Department of Bioscience and Technology, Khwaja Farid University of Engineering and Information Technology, Rahim Yar Khan, Pakistan.

The negative effects of salinity on plant growth and physiology are well-established, which is one of the major threats to food security in semi-arid and arid regions of the world. The current research focuses on biosynthesis of copper nanoparticles (CuNPs) from a bacterial strain NST2, which was genetically identified as Klebsiella pneumoniae based on taxonomic identity of 16S rRNA gene. The strain was selected for bioprospecting of CuNPs owing to its Cu tolerance potential. Read More

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Metal Cation-Driven Dynamic Covalent Formation of Imine and Hydrazone Ligands Displaying Synergistic Co-catalysis and Auxiliary Amine Effects.

Chemistry 2021 Apr 28. Epub 2021 Apr 28.

Laboratoire de Chimie Supramoléculaire, Institut de Science et d'Ingénierie Supramoléculaires, Université de Strasbourg, 8 allée Gaspard Monge, 67000, Strasbourg, France.

Optimizing C=N bond formation and C/N component exchange has major significance in Dynamic Covalent Chemistry (DCC). Imine and hydrazone generation from their aldehyde, amine and hydrazine components showed large accelerations in presence of AgOTf or Zn(OTf) , up to 10 for the Zn(II)-(p-anisidine)imine complex. Zn(OTf) and auxiliary p-anisidine together accelerated 630 times the formation of the Zn(II)-hydrazone complex, revealing a strong synergistic effect, traced to very fast initial formation of the reactive Zn(II)-imine complex presenting a C=N bond metallo-activated towards reaction with the hydrazine component. Read More

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Improvement of phosphorus release from sludge by combined electrochemical-EDTA treatment.

Water Sci Technol 2021 Apr;83(8):1824-1833

School of Environmental and Chemical Engineering, Shanghai University, No. 99, Shangda Rd, Shanghai 200444, China E-mail:

In this paper, combined with the addition of ethylenediaminetetraacetic acid (EDTA), the electrochemical treatment of waste activated sludge (WAS) was investigated to explore its effect on the release of phosphorus (P) from WAS. The results showed that during the electrochemical treatment, the addition of EDTA could significantly promote the release of P from the WAS to the supernatant, the optimal amount of EDTA was 0.4 g/g total suspended solids (TSS), when the release of total dissolved phosphorus (TDP), organic phosphorus (OP) and molybdate reactive phosphorus (PO-P) were 187. Read More

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Iron-Catalysed Remote C(sp³)-H Azidation of -Acyl Oximes and -Acyloxy Imidates.

Chimia (Aarau) 2021 Apr;75(4):329-332

Laboratory of Synthesis and Natural Products, Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne, EPFL-SB-ISIC-LSPN, BCH 5304, CH-1015 Lausanne, Switzerland;, Email:

The azido group occupies an important position in modern organic chemistry, broadly used as amine surrogates and as anchors in bioconjugation. Despite their importance, examples of selective direct azidation of inert C(sp³)-H bonds remain limited and often require strong oxidative conditions. Herein, we highlight the use of -acyl oximes and -acyloxy imidates as directing groups for the selective iron-catalysed azidation of C(sp³)-H bond with trimethylsilyl azide, giving access to various γ-azido ketones and β-azido alcohols in moderate to excellent yields. Read More

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Asynchronous Double Schiff Base Formation of Pyrazole Porous Polymers for Selective Pd Recovery.

Adv Sci (Weinh) 2021 Apr 2;8(8):2001676. Epub 2021 Mar 2.

Department of Chemical and Biomolecular Engineering Korea Advanced Institute of Science and Technology (KAIST) 291 Daehak-ro, Yuseong-gu Daejeon 34141 Korea.

Pyrazole-linked covalent organic polymer is synthesized using an asynchronous double Schiff base from readily available monomers. The one-pot reaction features no metals as a building block or reagent, hence facilitating the structural purity and industrial scalability of the design. Through a single-crystal study on a model compound, the double Schiff base formation is found to follow addition, a kinetically favored product, suggesting that reactivity of the amine and carbonyls dictate the order and geometry of the framework building. Read More

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C Fullerene Catalyzed Photoinduced Aerobic Oxidation of Benzylamines to Imines and Aldehydes.

J Org Chem 2021 May 22;86(9):6449-6457. Epub 2021 Apr 22.

Chemical Technology Division, CSIR-Institute of Himalayan Bioresource and Technology, Palampur 176061, India.

C fullerene catalyzed photoinduced oxidation of benzylic amines at ambient conditions has been explored here. The developed strategy's main feature includes the additive/oxidant-free conversion of benzylic amine to corresponding imine and aldehydes. The reaction manifests broad substrate scope with excellent function group leniency and is applicable up to the gram scale. Read More

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Visible-Light-Mediated Synthesis of Substituted Phenazine and Phenoxazinone Using Eosin Y as a Photoredox Catalyst.

Org Lett 2021 May 21;23(9):3269-3273. Epub 2021 Apr 21.

Department of Chemistry, School of Natural Sciences, Shiv Nadar University, Gautam Buddha Nagar, Dadri, Uttar Pradesh 201314, India.

This paper describes an efficient, sustainable, one-step procedure for synthesizing substituted phenazines and phenoxazinones from commercially available -substituted aromatic amines with very good yield (≥80%) in water. The procedure uses eosin Y (EY) as a photoredox catalyst at room temperature (RT). The highly reactive -quinone-diimine or -quinone-imine intermediate was characterized by the HR-MS technique. Read More

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Delivery of Ferulic Acid with PEGylated DiphenylalanineBased Nanoparticles for the Treatment of Arthritis in Early Stage.

J Biomed Nanotechnol 2021 Mar;17(3):357-368

Ferulic acid (FA), an active component extracted from Chinese medicine, shows excellent anti-inflammatory properties and favorable safety in various animal models. However, the application of FA as an anti-inflammatory drug is hindered by its instability and short half-life in vivo . In this paper, we synthesize PEGylated diphenylalanine nanoparticles by using glutaraldehyde (GTA) as a cross-linker of diphenylalanine NH₂ -Phe-Phe-COOH and poly(ethylene glycol) methyl ether amine (PEG -NH₂). Read More

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In vitro toxic synergistic effects of exogenous pollutants-trimethylamine and its metabolites on human respiratory tract cells.

Sci Total Environ 2021 Apr 6;783:146915. Epub 2021 Apr 6.

Guangdong-Hong Kong-Macao Joint Laboratory for Contaminants Exposure and Health, Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control, Institute of Environmental Health and Pollution control, Guangdong University of Technology, Guangzhou 510006, China; Guangzhou Key Laboratory of Environmental Catalysis and Pollution Control, Key Laboratory of City Cluster Environmental Safety and Green Development (Department of Education, China), School of Environmental Science and Engineering, Guangdong University of Technology, Guangzhou 510006, China.

The wide presence of volatile organic amines in atmosphere has been clarified to relate to adverse effects on human respiratory health. However, toxic effects of them on human respiratory tract and their metabiotic mechanism of in vivo transformation have not been elucidated yet. Herein, cell viability and production of reactive oxygen species (ROSs) were first investigated during acute exposure of trimethylamine (TMA) to bronchial epithelial cells (16HBE), along with identification of toxic metabolites and metabolic mechanisms of TMA from headspace atmosphere and cell culture. Read More

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Smart Layer-by-Layer Polymeric Microreactors: pH-Triggered Drug Release and Attenuation of Cellular Oxidative Stress as Prospective Combination Therapy.

ACS Appl Mater Interfaces 2021 Apr 16;13(16):18511-18524. Epub 2021 Apr 16.

Department of Mining-Metallurgy Engineering and Materials Science, POLYMAT, Faculty of Engineering in Bilbao, University of the Basque Country (UPV/EHU), Plaza Torres Quevedo 1, 48013 Bilbao, Spain.

Polymer capsules fabricated the layer-by-layer (LbL) approach have emerged as promising biomedical systems for the release of a wide variety of therapeutic agents, owing to their tunable and controllable structure and the possibility to include several functionalities in the polymeric membrane during the fabrication process. However, the limitation of the capsules with a single functionality to overcome the challenges involved in the treatment of complex pathologies denotes the need to develop multifunctional capsules capable of targeting several mediators and/or mechanisms. Oxidative stress is caused by the accumulation of reactive oxygen species [, hydrogen peroxide (HO), hydroxyl radicals (OH), and superoxide anion radicals (O)] in the cellular microenvironment and is a key modulator in the pathology of a broad range of inflammatory diseases. Read More

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Development of continuous flow systems to access secondary amines through previously incompatible biocatalytic cascades.

Angew Chem Int Ed Engl 2021 Apr 15. Epub 2021 Apr 15.

The University of Manchester, chemistry, UNITED KINGDOM.

A key aim of biocatalysis is to mimic the ability of eukaryotic cells to carry out multistep cascades in a controlled and selective way. As biocatalytic cascades get more complex, reactions become unattainable under typical batch conditions. Here a number of continuous flow systems were used to overcome batch incompatibility, thus allowing for successful biocatalytic cascades. Read More

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Amine oxidase copper-containing 3 (AOC3) inhibition: a potential novel target for the management of diabetic retinopathy.

Int J Retina Vitreous 2021 Apr 12;7(1):30. Epub 2021 Apr 12.

Byers Eye Institute, Stanford University, Palo Alto, CA, USA.

Background: Diabetic retinopathy (DR), a microvascular complication of diabetes, is the leading cause of visual impairment in people aged 20-65 years and can go undetected until vision is irreversibly lost. There is a need for treatments for non-proliferative diabetic retinopathy (NPDR) which, in comparison with current intravitreal (IVT) injections, offer an improved risk-benefit ratio and are suitable for the treatment of early stages of disease, during which there is no major visual impairment. Efficacious systemic therapy for NPDR, including oral treatment, would be an important and convenient therapeutic approach for patients and physicians and would reduce treatment burden. Read More

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Overview of the Neuroprotective Effects of the MAO-Inhibiting Antidepressant Phenelzine.

Cell Mol Neurobiol 2021 Apr 10. Epub 2021 Apr 10.

Department of Psychiatry (Neurochemical Research Unit), University of Alberta, 12-105B Clinical Sciences Building, Edmonton, AB, T6G 2G3, Canada.

Phenelzine (PLZ) is a monoamine oxidase (MAO)-inhibiting antidepressant with anxiolytic properties. This multifaceted drug has a number of pharmacological and neurochemical effects in addition to inhibition of MAO, and findings on these effects have contributed to a body of evidence indicating that PLZ also has neuroprotective/neurorescue properties. These attributes are reviewed in this paper and include catabolism to the active metabolite β-phenylethylidenehydrazine (PEH) and effects of PLZ and PEH on the GABA-glutamate balance in brain, sequestration of reactive aldehydes, and inhibition of primary amine oxidase. Read More

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Design, synthesis and in-vitro evaluation of fluorinated triazoles as multi-target directed ligands for Alzheimer disease.

Bioorg Med Chem Lett 2021 Apr 9;42:127999. Epub 2021 Apr 9.

Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER) Ahmedabad, Opposite Air Force Station, Palaj, Gandhinagar, Gujarat 382355, India. Electronic address:

Alzheimer disease is multi-factorial and inflammation plays a major role in the disease progression and severity. Metals and reactive oxygen species (ROS) are the key mediators for inflammatory conditions associated with Alzheimer's. Along multi-factorial nature, major challenge for developing new drug is the ability of the molecule to cross blood brain barrier (BBB). Read More

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Modular synthesis of chiral 1,2-dihydropyridines via Mannich/Wittig/cycloisomerization sequence that internally reuses waste.

Nat Commun 2021 04 8;12(1):2219. Epub 2021 Apr 8.

Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, Shanghai Key Laboratory of Green Chemistry and Chemical Processes, East China Normal University, Shanghai, 200062, China.

1,2-Dihydropyridines are valuable and reactive synthons, and particularly useful precursors to synthesize piperidines and pyridines that are among the most common structural components of pharmaceuticals. However, the catalytic enantioselective synthesis of structurally diverse 1,2-dihydropyridines is limited to enantioselective addition of nucleophiles to activated pyridines. Here, we report a modular organocatalytic Mannich/Wittig/cycloisomerization sequence as a flexible strategy to access chiral 1,2-dihydropyridines from N-Boc aldimines, aldehydes, and phosphoranes, using a chiral amine catalyst. Read More

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Mechanistic Diversity of Low-Valent Chromium Catalysis: Cross-Coupling and Hydrofunctionalization.

Acc Chem Res 2021 Apr 8;54(8):2014-2026. Epub 2021 Apr 8.

Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu, Sichuan 610064, P. R. China.

ConspectusTransition-metal catalysis has traditionally been dominated by precious metals because of their high reactivity toward chemical transformations. As a cost-effective alternative, catalysis by earth-abundant group 6 metal chromium is underdeveloped, and its reactivity remains largely unexplored, although the industrially important Phillips catalyst, which is composed of Cr as the active metal, is currently used to supply almost 40% of the total world demand for high-density polyethylene. Cr has traditionally served in organoreagents with high-valent states (≥2+), which are typified by reactions involving Nozaki-Hiyama-Kishi (NHK) and Takai-Utimoto one-electron transfer processes. Read More

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Cyclometalated iridium(III) complexes as mitochondria-targeted anticancer and antibacterial agents to induce both autophagy and apoptosis.

J Inorg Biochem 2021 Jun 29;219:111450. Epub 2021 Mar 29.

School of Pharmacy, Guangdong Medical University, Dongguan 523808, China. Electronic address:

Mitochondrial damage will hinder the energy production of cells and produce excessive ROS (reactive oxygen species), resulting in cell death through autophagy or apoptosis. In this paper, four cyclometalated iridium(III) complexes (Ir1: [Ir(piq)L]PF; Ir2: [Ir(bzq)L]PF; Ir3: [Ir(dfppy)L]PF; Ir4: [Ir(thpy)L]PF; piq = 1-phenylisoquinoline; bzq = benzo[h]quinoline; dfppy = 2-(2,4-difluorophenyl)pyridine;thpy = 2-(2-thienyl)pyridine; L = 1,10-phenanthroline-5-amine) were synthesized and characterized. Cytotoxicity tests show that these complexes have excellent cytotoxicity to cancer cells, and mechanism studies indicatethat these complexes can specifically target mitochondria. Read More

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Attenuation of the Reaction of Michael Acceptors with Biologically Important Nucleophiles.

Bioconjug Chem 2021 04 6;32(4):794-800. Epub 2021 Apr 6.

ProLynx, 455 Mission Bay Boulevard South, Suite 341, San Francisco, California 94158, United States.

β-Elimination of drugs tethered to macromolecular carbamates provides a platform for drug half-life extension. However, the macromolecular Michael acceptor products formed upon drug release can potentially react with biological amines and thiols and may raise concerns about safety. We desired to mitigate this possibility by developing linkers that have predictable rates of β-elimination but suppressed rates of nucleophilic addition to their Michael acceptor products. Read More

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Kinetic assessment of Michael addition reactions of alpha, beta-unsaturated carbonyl compounds to amino acid and protein thiols.

Free Radic Biol Med 2021 Apr 2;169:1-11. Epub 2021 Apr 2.

Department of Biomedical Sciences, Panum Institute, University of Copenhagen, Copenhagen, 2200, Denmark. Electronic address:

Humans have extensive adverse exposure to alpha,beta-unsaturated carbonyl compounds (ABuCs) as these are major toxins in smoke and exhaust fumes, as well as products of lipid peroxidation. In contrast, another ABuC, dimethylfumarate, is used to treat psoriasis and multiple sclerosis. ABuCs undergo Michael adduction with amine, imidazole and thiol groups, with reaction at Cys residues predominating. Read More

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