283,265 results match your criteria reactive protein

Establishment and Validation of Nomogram Based on Combination of Pretreatment C-Reactive Protein/Albumin Ratio-EBV DNA Grade in Nasopharyngeal Carcinoma Patients Who Received Concurrent Chemoradiotherapy.

Front Oncol 2021 15;11:583283. Epub 2021 Jul 15.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China.

Background: A higher ratio of pretreatment C-reactive protein/albumin ratio (CAR) is associated with poor prognosis in nasopharyngeal carcinoma (NPC), and Epstein-Barr virus (EBV) DNA level is known to not only participate in the occurrence of nasopharyngeal carcinoma but also affect the development and prognosis of the disease. Herein, we proposed that a combination of both these markers could improve the predictive prognostic ability.

Methods: In all, 842 NPC patients who received concurrent chemoradiotherapy (CCRT) were entered in this study. Read More

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Roles and Interplay of SARS-CoV-2 Serology With Clinical Stages of Disease in COVID-19.

Cureus 2021 Jun 27;13(6):e15953. Epub 2021 Jun 27.

Infectious Diseases, Saint Michael's Medical Center, Newark, USA.

Background Currently, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serology is recommended only for seroprevalence. We think it could be useful in differentiating coronavirus disease 2019 (COVID-19) stages, which could in terms of helping improve our therapeutic interventions. Methods The medical records of adult patients admitted to the hospital with probable COVID-19 were extracted and analyzed. Read More

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Mechanisms and Potential Treatment Options of Heart Failure in Patients With Multiple Myeloma.

Cureus 2021 Jun 26;13(6):e15943. Epub 2021 Jun 26.

Psychiatry, Psychotherapy and Research Field, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.

Multiple myeloma is a pathology of plasma cells, with one of the most common side effects of its treatment is heart failure. In addition, cardiac amyloidosis could cause heart failure by itself. Even though mechanisms of cardiac amyloidosis are known, and they involve lysosomal dysfunction, reactive oxygen species (ROS) accumulation, and infiltrative effect by fibrils, there is no specific agent that could protect from these effects. Read More

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Coronavirus Disease 2019-Related Multisystem Inflammatory Syndrome in Children: A Systematic Review and Meta-Analysis.

Biochem Res Int 2021 15;2021:5596727. Epub 2021 Jul 15.

Pediatrics Department, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.

Background: This study aimed to describe the clinical symptoms, laboratory findings, treatment, and outcomes of coronavirus disease 2019-related multisystem inflammatory syndrome in children to provide a reference for clinical practice.

Methods: We employed a literature search of databases such as PubMed, Web of Science, EMBASE, and Johns Hopkins University for articles on COVID-19-related multisystem inflammatory syndrome in children published between April 1, 2020, and January 15, 2021. High-quality articles were selected for analysis on the basis of their quality standard scores. Read More

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Evaluation of Invasive Ventilation Rate and Comorbidities, Clinical Signs and Lab Findings among COVID 19 Patients.

New Microbes New Infect 2021 Jul 24:100925. Epub 2021 Jul 24.

Emergency Medicine Department, Student Research development center, Qom university of medical sciences, Qom, Iran.

The severity of COVID-19 has been to be associated with the comorbidities. It is defined as the presentation of severe respiratory dysfunction or failure, leading to the need of ventilation and mortality. The aim of this study is the evaluate the factors predicting the rate of invasive ventilation among these patients. Read More

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A case of seat belt-induced small bowel rupture and Chance fracture accompanied by elevated serum amylase.

J Surg Case Rep 2021 Jul 26;2021(7):rjab315. Epub 2021 Jul 26.

Department of Pediatric Surgery, Saku Central Hospital Advanced Care Center, Nagano, Japan.

We report herein our experience with a 10-year-old girl who incurred injuries consistent with seat belt syndrome. The patient was involved in a low-speed motor vehicle accident while restrained in a three-point belt (shoulder and lap belts). She complained of abdominal pain and developed tenderness and abdominal guarding. Read More

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Synergistic Antioxidant Effects of Araloside A and L-Ascorbic Acid on HO-Induced HEK293 Cells: Regulation of Cellular Antioxidant Status.

Oxid Med Cell Longev 2021 9;2021:9996040. Epub 2021 Jul 9.

College of Food Science, Northeast Agricultural University, Harbin, Heilongjiang 150030, China.

Araloside A is a pentacyclic triterpenoid saponin, and L-ascorbic acid is a globally recognized antioxidant. In this study, coadministered araloside A and L-ascorbic acid were found to have a strong synergistic antioxidant effect, and correlations between cellular antioxidant indexes and free radical scavenging ability were found. Individual and combined pretreatment with araloside A and L-ascorbic acid increased both cell viability and antioxidant enzyme activity and inhibited the release of lactate dehydrogenase (LDH); the accumulation of malondialdehyde (MDA), lipid peroxidation (LPO) products, and HO; and the production of intracellular reactive oxygen species (ROS), protein carbonyls, and 8-hydroxy-2-deoxy guanosine (8-OHdG). Read More

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Oxidative Stress Markers among Obstructive Sleep Apnea Patients.

Oxid Med Cell Longev 2021 19;2021:9681595. Epub 2021 Jul 19.

Chair and Department of Internal Medicine, Medical University of Lublin, Staszica 16 St., 20-081 Lublin, Poland.

Obstructive sleep apnea (OSA) is a chronic respiratory disorder, which can be present in up to 50% of the population, depending on the country. OSA is characterized by recurrent episodes of partial or complete obstruction of the upper airways with consistent movement of the respiratory musculature during sleep. Apneas and hypopneas can lead to a decrease in oxygen saturation, an increase in carbon dioxide in the blood, and subsequent arousals and sleep fragmentation caused by repetitive activation of the central nervous system. Read More

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1-Nitropyrene Induced Reactive Oxygen Species-Mediated Apoptosis in Macrophages through AIF Nuclear Translocation and AMPK/Nrf-2/HO-1 Pathway Activation.

Oxid Med Cell Longev 2021 13;2021:9314342. Epub 2021 Jul 13.

Department of Pharmacology, School of Medicine, Chung Shan Medical University, Taichung, Taiwan.

1-Nitropyrene (1-NP), one of the most abundant nitropolycyclic aromatic hydrocarbons (nitro-PAHs), is generated from the incomplete combustion of carbonaceous organic compounds. 1-NP is a specific marker of diesel exhaust and is an environmental pollutant and a probable carcinogen. Macrophages participate in immune defense against the invasive pathogens in heart, lung, and kidney infection diseases. Read More

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Antiepileptic Effects of Cicadae Periostracum on Mice and Its Antiapoptotic Effects in HO-Stimulated PC12 Cells via Regulation of PI3K/Akt/Nrf2 Signaling Pathways.

Oxid Med Cell Longev 2021 20;2021:5598818. Epub 2021 Jul 20.

School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611130, China.

Cicadae Periostracum (CPM), a commonly used animal traditional Chinese medicine (TCM), possesses antifebrile, spasmolytic, antiasthmatic, and antiphlogistic effects. In our present paper, we aimed to systemically investigate the antiepileptic effects of CPM in epileptic mice and explore the related molecular mechanism. Pentylenetetrazole- (PTZ) and strychnine-induced convulsion mice were established, and the results showed CPM could prolong the latency of convulsion and death and improve the neuronal damage in the hippocampus of PTZ-induced mice. Read More

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Reactive Oxygen Species as a Link between Antioxidant Pathways and Autophagy.

Oxid Med Cell Longev 2021 21;2021:5583215. Epub 2021 Jul 21.

Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, China.

Reactive oxygen species (ROS) are highly reactive molecules that can oxidize proteins, lipids, and DNA. Under physiological conditions, ROS are mainly generated in the mitochondria during aerobic metabolism. Under pathological conditions, excessive ROS disrupt cellular homeostasis. Read More

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A Clinical Monitoring Program of COVID-19 Outpatients: A Prospective Cohort Study.

Can J Infect Dis Med Microbiol 2021 20;2021:6644570. Epub 2021 Jul 20.

Department of Biostatistic, Ibne Sina Medical and Educational Center, Mazandaran University of Medical Sciences, Sari, Mazandaran, Iran.

Purpose: Coronavirus disease 2019 (COVID-19) has been associated with a high rate of mortality and morbidity. While a high portion of COVID-19 patients have mild symptoms, a limited number of clinical trials have evaluated the clinical course of this large group of patients. This study was designed to investigate the demographics and clinical characteristics and comorbidity of nonhospitalized COVID-19 patients. Read More

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Effects of experimental colitis in rats on incretin levels, inflammatory markers, and enteric neuronal function.

Arch Med Sci 2021 18;17(4):1087-1092. Epub 2019 Jul 18.

Department of Internal Medicine and Therapeutics, Section of Pharmacology, University of Pavia, Pavia, Italy.

Introduction: The aim of the study was to assess the effects of chronic inflammation on incretin levels, inflammatory markers, and enteric neuronal function measured in isolated preparations of smooth muscle of rat.

Material And Methods: We induced experimental colitis using 2,4-dinitrobenzenesulfonic acid (DNBS) in 17 Albino male Sprague-Dawley rats, while 16 rats were used as a control. They were housed in temperature-controlled rooms in a 12-h light/dark cycle at 22-24°C and 50 to 60% humidity. Read More

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Ischemia-Modified Albumin: Origins and Clinical Implications.

Dis Markers 2021 19;2021:9945424. Epub 2021 Jul 19.

Oles Honchar Dnipro National University, 72 Gagarin Ave, Dnipro 49010, Ukraine.

Albumin is one of the most abundant proteins in the body of mammals: about 40% of its pool is located in the intravascular space and the remainder is found in the interstitial space. The content of this multifunctional protein in blood is about 60-65% of total plasma proteins. A decrease in its synthesis or changes of functional activity can destabilize oncotic blood pressure, cause a violation of transporting hormones, fatty acids, metals, and drugs. Read More

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Orthogonal targeting of osteoclasts and myeloma cells for radionuclide stimulated dynamic therapy induces multidimensional cell death pathways.

Theranostics 2021 22;11(16):7735-7754. Epub 2021 Jun 22.

Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Multiple myeloma (MM) is a multifocal malignancy of bone marrow plasma cells, characterized by vicious cycles of remission and relapse that eventually culminate in death. The disease remains mostly incurable largely due to the complex interactions between the bone microenvironment (BME) and MM cells (MMC). In the "vicious cycle" of bone disease, abnormal activation of osteoclasts (OCs) by MMC causes severe osteolysis, promotes immune evasion, and stimulates the growth of MMC. Read More

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Histone Deacetylase Inhibitor-Induced CDKN2B and CDKN2D Contribute to G2/M Cell Cycle Arrest Incurred by Oxidative Stress in Hepatocellular Carcinoma Cells via Forkhead Box M1 Suppression.

J Cancer 2021 22;12(17):5086-5098. Epub 2021 Jun 22.

Medical Research Center for Bioreaction to Reactive Oxygen Species and Biomedical Science Institute, School of Medicine, Graduate School, Kyung Hee University, Seoul, Republic of Korea.

Forkhead box protein M1 (FOXM1) is a pivotal regulator of G2/M cell cycle progression in many types of cancer. Previously, our study demonstrated that histone deacetylase inhibition (HDACi) sensitizes hepatocellular carcinoma cells (HCC) to oxidative stress through FOXM1 suppression. However, the mechanism underlying its suppression by HDACi still requires elucidation. Read More

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Tongxinluo Capsule Combined with Atorvastatin for Coronary Heart Disease: A Systematic Review and Meta-Analysis.

Evid Based Complement Alternat Med 2021 17;2021:9413704. Epub 2021 Jul 17.

Shaanxi University of Chinese Medicine, Xianyang 712046, China.

Introduction: Coronary heart disease (CHD) is a common clinical cardiovascular disease, and its morbidity and mortality rates are increasing, which brings a serious burden to the family and society. Dyslipidemia is one of the most important risk factors for CHD. However, it is difficult to reduce blood lipids to an ideal state with the administration of a statin alone. Read More

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Effectiveness and Safety of Chinese Medicine Decoctions for Behcet's Disease: A Systematic Review and Meta-Analysis.

Evid Based Complement Alternat Med 2021 17;2021:8202512. Epub 2021 Jul 17.

Department of Oral Medicine, Peking University School and Hospital of Stomatology, Beijing 100081, China.

Background: Behcet's disease (BD) is an autoimmune disease of systemic vasculitis with an unclear pathogenesis. Although western medicines remain the mainstay interventions, effectiveness and safety are significant challenges. Complementary and alternative medicine, including herbal medicine, are gaining more attention. Read More

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FERONIA Confers Resistance to Photooxidative Stress in Arabidopsis.

Front Plant Sci 2021 15;12:714938. Epub 2021 Jul 15.

Plant Systems Engineering Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, South Korea.

Plants absorb light energy required for photosynthesis, but excess light can damage plant cells. To protect themselves, plants have developed diverse signaling pathways which are activated under high-intensity light. Plant photoprotection mechanisms have been mainly investigated under conditions of extremely high amount of light; thus, it is largely unknown how plants manage photooxidative damage under moderate light intensities. Read More

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Mapping Autoantibodies in Children With Acute Rheumatic Fever.

Front Immunol 2021 15;12:702877. Epub 2021 Jul 15.

School of Medical Sciences, The University of Auckland, Auckland, New Zealand.

Background: Acute rheumatic fever (ARF) is a serious sequela of Group A (GAS) infection associated with significant global mortality. Pathogenesis remains poorly understood, with the current prevailing hypothesis based on molecular mimicry and the notion that antibodies generated in response to GAS infection cross-react with cardiac proteins such as myosin. Contemporary investigations of the broader autoantibody response in ARF are needed to both inform pathogenesis models and identify new biomarkers for the disease. Read More

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Administration of Multivalent Influenza Virus Recombinant Hemagglutinin Vaccine in Combination-Adjuvant Elicits Broad Reactivity Beyond the Vaccine Components.

Front Immunol 2021 14;12:692151. Epub 2021 Jul 14.

Vaccine Research and Development Center, Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, Irvine, CA, United States.

Combining variant antigens into a multivalent vaccine is a traditional approach used to provide broad coverage against antigenically variable pathogens, such as polio, human papilloma and influenza viruses. However, strategies for increasing the breadth of antibody coverage beyond the vaccine are not well understood, but may provide more anticipatory protection. Influenza virus hemagglutinin (HA) is a prototypic variant antigen. Read More

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Targeting Tristetraprolin Expression or Functional Activity Regulates Inflammatory Response Induced by MSU Crystals.

Front Immunol 2021 16;12:675534. Epub 2021 Jul 16.

Institute of Rheumatology and Immunology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.

The RNA-binding protein tristetraprolin (TTP) is an anti-inflammatory factor that prompts the mRNA decay of target mRNAs and is involved in inflammatory diseases such as rheumatoid arthritis (RA). TTP is regulated by phosphorylation, and protein phosphatase 2A (PP2A) can dephosphorylate TTP to activate its mRNA-degrading function. Some small molecules can enhance PP2A activation. Read More

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Targeting Neoepitopes to Treat Solid Malignancies: Immunosurgery.

Front Immunol 2021 15;12:592031. Epub 2021 Jul 15.

ImmunoSurgery Unit, Champalimaud Centre for the Unknown, Lisbon, Portugal.

Successful outcome of immune checkpoint blockade in patients with solid cancers is in part associated with a high tumor mutational burden (TMB) and the recognition of private neoantigens by T-cells. The quality and quantity of target recognition is determined by the repertoire of 'neoepitope'-specific T-cell receptors (TCRs) in tumor-infiltrating lymphocytes (TIL), or peripheral T-cells. Interferon gamma (IFN-γ), produced by T-cells and other immune cells, is essential for controlling proliferation of transformed cells, induction of apoptosis and enhancing human leukocyte antigen (HLA) expression, thereby increasing immunogenicity of cancer cells. Read More

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Management Based on Multimodal Brain Monitoring May Improve Functional Connectivity and Post-operative Neurocognition in Elderly Patients Undergoing Spinal Surgery.

Front Aging Neurosci 2021 15;13:705287. Epub 2021 Jul 15.

Department of Anesthesiology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Disease, Beijing, China.

Perioperative neurocognitive disorder (PND) is a common condition in elderly patients undergoing surgery. Sedation, analgesia, regional cerebral oxygen saturation (rSO), and body temperature are known to be associated with PND, but few studies have examined the contribution of these factors combined in detail. This prospective, randomized, controlled, double-blinded study investigated whether anesthesia management based on multimodal brain monitoring-an anesthesia management algorithm designed by our group-could improve the post-operative cognitive function and brain functional connectivity (FC) in elderly patients undergoing elective spinal surgery with general anesthesia. Read More

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Predictive Ability of Serum IL-27 Level for Assessing Activity of Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.

Mediators Inflamm 2021 19;2021:6668884. Epub 2021 Jul 19.

Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.

Serum interleukin- (IL-) 27 level has been reported to increase in patients with several autoimmune diseases; however, its significance in patients with antineutrophil cytoplasmic antibody- (ANCA-) associated vasculitis (AAV) is unknown. In this study, we investigated the associations between serum IL-27, laboratory features, and activity of AAV and evaluate the predictive ability of serum IL-27 level for disease activity. This study included 77 AAV patients, and we collected clinical and laboratory data at blood sampling. Read More

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Short Sleep Duration and Its Association with Obesity and Other Metabolic Risk Factors in Kuwaiti Urban Adults.

Nat Sci Sleep 2021 24;13:1225-1241. Epub 2021 Jul 24.

Immunology & Microbiology Department, Dasman Diabetes Institute, Dasman, Kuwait.

Background: Efficient sleep duration and its quality are increasingly recognized as important contributors for maintaining normal body weight. However, lifestyle and social structure within the Arab-gulf region differ compared to those in the western world. This study was specifically conducted in Kuwait's population to investigate the link between sleep quality (SQ) and obesity in the absence of sleep apnea (SA) onset. Read More

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Effects of Photobiomodulation Therapy Combined with Static Magnetic Field in Severe COVID-19 Patients Requiring Intubation: A Pragmatic Randomized Placebo-Controlled Trial.

J Inflamm Res 2021 24;14:3569-3585. Epub 2021 Jul 24.

Laboratory of Phototherapy and Innovative Technologies in Health (LaPIT), Post-graduate Program in Rehabilitation Sciences, Nove de Julho University, São Paulo, Brazil.

Purpose: We aimed to investigate the effects of photobiomodulation therapy combined with static magnetic field (PBMT-sMF) on the length of intensive care unit (ICU) stay and mortality rate of severe COVID-19 patients requiring invasive mechanical ventilation and assess its role in preserving respiratory muscles and modulating inflammatory processes.

Patients And Methods: We conducted a prospectively registered, triple-blinded, randomized, placebo-controlled trial of PBMT-sMF in severe COVID-19 ICU patients requiring invasive mechanical ventilation. Patients were randomly assigned to receive either PBMT-sMF or a placebo daily throughout their ICU stay. Read More

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Impact of Covid-19 pandemic on arthroplasty services and early experience after resuming surgeries at a 'non Covid' center.

J Clin Orthop Trauma 2021 Oct 26;21:101515. Epub 2021 Jul 26.

Max Institute of Musculoskeletal Sciences (Department of Orthopaedic Surgery), Max Super Speciality Hospital, Mandir marg, Press Enclave Road, Saket, New Delhi, 110017, India.

Background: The aim of this study is to assess the impact of Covid-19 crisis on hip and knee joint replacement surgeries at a high volume tertiary care hospital in the Indian National Capital Region and to evaluate the early experience of resumption of arthroplasty services.

Methods: Institutional records of the arthroplasty cases, operated between 1st March to 31 August of 2019 (Group A, pre-Covid) and 2020 (Group B, pandemic year) were compared retrospectively over numerous parameters including the complications within six weeks of surgery.

Results: There was a significant drop (by 82. Read More

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October 2021

Hydroxyl Radical Generation Through the Fenton-Like Reaction of Hematin- and Catechol-Functionalized Microgels.

Chem Mater 2020 Oct 4;32(19):8182-8194. Epub 2020 Sep 4.

Department of Biomedical Engineering, Michigan Technological University, Houghton, MI 49931, USA.

Hydroxyl radical (OH) is a potent reactive oxygen species with the ability to degrade hazardous organic compounds, kill bacteria, and inactivate viruses. However, an off-the-shelf, portable, and easily activated biomaterial for generating OH does not exist. Here, microgels were functionalized with catechol, an adhesive moiety found in mussel adhesive proteins, and hematin (HEM), a hydroxylated Fe ion-containing porphyrin derivative. Read More

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October 2020

Effects of utilization on physochemical and microbiological properties of Turkish dry fermented sausage.

J Food Sci Technol 2021 Jul 24:1-12. Epub 2021 Jul 24.

Department of Food Engineering, Suleyman Demirel University, Isparta, Turkey.

The study aimed to determine the minimum inhibitory concentration of extracts obtained by different extraction methods on eight strains from five different pathogens (, , spp., and ) in the first phase and utilize extract in sausage processing in the second phase. Sausages were evaluated for thiobarbituric acid reactive substances (TBARS), physicochemical and microbiological properties. Read More

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