442,023 results match your criteria reactive


The cross-talk between tumor cells and activated fibroblasts mediated by lactate/BDNF/TrkB signaling promotes acquired resistance to anlotinib in human gastric cancer.

Redox Biol 2021 Jul 20;46:102076. Epub 2021 Jul 20.

Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. Electronic address:

Acquired resistance to tyrosine kinase inhibitors (TKIs) is the major obstacle to improve clinical efficacy in cancer patients. The epithelial-stromal interaction in tumor microenvironment influences cancer drug response to TKIs. Anlotinib is a novel oral multi-targeted TKI, and has recently been proven to be effective and safe for several tumors. Read More

View Article and Full-Text PDF

CCL5 via GPX1 activation protects hippocampal memory function after mild traumatic brain injury.

Redox Biol 2021 Jul 17;46:102067. Epub 2021 Jul 17.

Ph.D. Program for Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University and National Health Research, Taiwan; Graduate Institute of Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan. Electronic address:

Traumatic brain injury (TBI) is a prevalent head injury worldwide which increases the risk of neurodegenerative diseases. Increased reactive oxygen species (ROS) and inflammatory chemokines after TBI induces secondary effects which damage neurons. Targeting NADPH oxidase or increasing redox systems are ways to reduce ROS and damage. Read More

View Article and Full-Text PDF

Low levels of TiO-nanoparticles interact antagonistically with Al and Pb alleviating their toxicity.

Plant Physiol Biochem 2021 Jul 21;167:1-10. Epub 2021 Jul 21.

LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, Campus Universitário de Santiago, 3810-193, Aveiro, Portugal. Electronic address:

The contamination and bioavailability of deleterious metals in arable soils significantly limits crop development and yield. Aiming at mitigating Pb- and Al-induced phytotoxicity, this work explores the use of P25 titanium dioxide nanoparticles (nTiO) in soil amendments. For that, Lactuca sativa L. Read More

View Article and Full-Text PDF

Magnetically separable ZnFeO/AgPO/g-CN photocatalyst for inactivation of Microcystis aeruginosa: Characterization, performance and mechanism.

J Hazard Mater 2021 Jul 21;421:126703. Epub 2021 Jul 21.

Fujian Jinhuang Environmental Sci-Tech Co., Ltd, 350002 Fujian, China.

Water eutrophication leads to increasingly serious harmful algal blooms (HABs), which poses tremendous threats on aquatic environment and human health. In this work, a novel magnetically separable ZnFeO/AgPO/g-CN (ZFO/AP/CN) photocatalyst with double Z-scheme was constructed for Microcystis aeruginosa (M. aeruginosa) inactivation and Microcystin-LR (MC-LR) degradation under visible light. Read More

View Article and Full-Text PDF

INR and COVID-19 severity and mortality: A systematic review with meta-analysis and meta-regression.

Adv Med Sci 2021 Jul 21;66(2):372-380. Epub 2021 Jul 21.

Discipline of Clinical Pharmacology, College of Medicine and Public Health, Flinders University, Adelaide, Australia; Department of Clinical Pharmacology, Flinders Medical Centre, Southern Adelaide Local Health Network, Adelaide, Australia. Electronic address:

Objectives: D-dimer elevations, suggesting a pro-thrombotic state and coagulopathy, predict adverse outcomes in coronavirus disease 2019 (COVID-19). However, the clinical significance of other coagulation markers, particularly the international normalized ratio (INR), is not well established. We conducted a systematic review and meta-analysis of the INR in COVID-19. Read More

View Article and Full-Text PDF

MICAL1 regulates actin cytoskeleton organization, directional cell migration and the growth of human breast cancer cells as orthotopic xenograft tumours.

Cancer Lett 2021 Jul 24. Epub 2021 Jul 24.

Department of Chemistry and Biology, Ryerson University, Toronto, ON, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada. Electronic address:

The Molecule Interacting with CasL 1 (MICAL1) monooxygenase has emerged as an important regulator of cytoskeleton organization via actin oxidation. Although filamentous actin (F-actin) increases MICAL1 monooxygenase activity, hydrogen peroxide (HO) is also generated in the absence of F-actin, suggesting that diffusible HO might have additional functions. MICAL1 gene disruption by CRISPR/Cas9 in MDA MB 231 human breast cancer cells knocked out (KO) protein expression, which affected F-actin organization, cell size and motility. Read More

View Article and Full-Text PDF

Reduction of oxidative stress and inflammatory signaling in the commissural nucleus of the solitary tract (commNTS) and rostral ventrolateral medulla (RVLM) in treadmill trained rats.

Brain Res 2021 Jul 24:147582. Epub 2021 Jul 24.

Dept. Morphology and Physiology, Faculdade de Medicina do ABC, Centro Universitario FMABC, Santo Andre, SP, Brazil.

Inflammation has been associated with cardiovascular diseases and the key point is the generation of reactive oxygen species (ROS). Exercise modulates medullary neurons involved in cardiovascular control. We investigated the effect of chronic exercise training (Tr) in treadmill running on gene expression (GE) of ROS and inflammation in commNTS and RVLM neurons. Read More

View Article and Full-Text PDF

Availability of neuregulin-1beta1 protects neurons in spinal cord injury and against glutamate toxicity through caspase dependent and independent mechanisms.

Exp Neurol 2021 Jul 24:113817. Epub 2021 Jul 24.

Department of Physiology and Pathophysiology, Regenerative Medicine Program, Spinal Cord Research Centre, Children's Hospital Research Institute of Manitoba, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada. Electronic address:

Spinal cord injury (SCI) causes sensorimotor and autonomic impairment that partly reflects extensive, permanent loss of neurons at the epicenter and penumbra of the injury. Strategies aimed at enhancing neuronal protection are critical to attenuate neurodegeneration and improve neurological recovery after SCI. In rat SCI, we previously uncovered that the tissue levels of neuregulin-1beta 1 (Nrg-1β1) are acutely and persistently downregulated in the injured spinal cord. Read More

View Article and Full-Text PDF

Neurobiology: Resetting the axon's batteries.

Curr Biol 2021 Jul;31(14):R914-R917

Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.

Neuronal injury can cause mitochondrial damage, leading to reduced energy production, decreased Ca storage capacity, and increased reactive oxygen species. A new study reveals a mechanism to trigger the axonal transport of previously anchored mitochondria and promote neuroprotection and axon regeneration by replacing damaged with functional mitochondria. Read More

View Article and Full-Text PDF

Sequential oncogenic mutations influence cell competition.

Curr Biol 2021 Jul 16. Epub 2021 Jul 16.

Department of Molecular Oncology, Kyoto University Graduate School of Medicine, Kyoto, Japan; Division of Molecular Oncology, Institute for Genetic Medicine, Hokkaido University Graduate School of Chemical Sciences and Engineering, Sapporo, Japan. Electronic address:

At the initial stage of carcinogenesis, newly emerging transformed cells are often eliminated from epithelial layers via cell competition with the surrounding normal cells. For instance, when surrounded by normal cells, oncoprotein RasV12-transformed cells are extruded into the apical lumen of epithelia. During cancer development, multiple oncogenic mutations accumulate within epithelial tissues. Read More

View Article and Full-Text PDF

Inhibition of iNOS protects against the deleterious effects of sub-lethal sepsis and ethanol in the cardiorenal system.

Can J Physiol Pharmacol 2021 Jul 27. Epub 2021 Jul 27.

Universidade de São Paulo, Av. Bandeirantes 3900, Ribeirão Preto, Brazil, 14040120;

We tested the hypothesis that ethanol would aggravate the deleterious effects of sub-lethal cecal ligation and puncture (SL-CLP) sepsis in the cardiorenal system and that inhibition of iNOS would prevent such response. Male C57BL/6 mice were treated with ethanol for 12 weeks. One hour before SL-CLP surgery, mice were treated with N6-(1-Iminoethyl)-lysine (L-NIL, 5 mg/kg, i. Read More

View Article and Full-Text PDF

Substituent Effect in the Reactions between Criegee Intermediates and 3-Aminopropanol.

J Phys Chem A 2021 Jul 27. Epub 2021 Jul 27.

Institute of Atomic and Molecular Sciences, Academia Sinica, Taipei 10617, Taiwan.

Via intramolecular H atom transfer, 3-aminopropanol is more reactive toward Criegee intermediates, in comparison with amines or alcohols. Here we accessed the substituent effect of Criegee intermediates in their reactions with 3-aminopropanol. Through real-time monitoring the concentrations of two Criegee intermediates with their strong UV absorption at 340 nm, the experimental rate coefficients at 298 K (100-300 Torr) were determined to be (1. Read More

View Article and Full-Text PDF

SARS-CoV-2 spike glycoprotein-reactive T cells can be readily expanded from COVID-19 vaccinated donors.

Immun Inflamm Dis 2021 Jul 27. Epub 2021 Jul 27.

Department of Immunology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic.

Introduction: The COVID-19 vaccine was designed to provide protection against infection by the severe respiratory coronavirus 2 (SARS-CoV-2) and coronavirus disease 2019 (COVID-19). However, the vaccine's efficacy can be compromised in patients with immunodeficiencies or the vaccine-induced immunoprotection suppressed by other comorbidity treatments, such as chemotherapy or immunotherapy. To enhance the protective role of the COVID-19 vaccine, we have investigated a combination of the COVID-19 vaccination with ex vivo enrichment and large-scale expansion of SARS-CoV-2 spike glycoprotein-reactive CD4 and CD8 T cells. Read More

View Article and Full-Text PDF

Diagnostic accuracy of C-reactive protein, procalcitonin and neutrophils for the early detection of anastomotic leakage after colorectal resection. A multicentric, prospective study.

Colorectal Dis 2021 Jul 27. Epub 2021 Jul 27.

Hospital Universitario y Politecnico la Fe, Colorectal Surgery Unit, Valencia, Spain.

Aim: To determine the accuracy of C-reactive protein, procalcitonin and neutrophils in the early detection (fourth postoperative day) of anastomotic leak (AL) after colorectal surgery.

Methods: We conducted a multicentre, prospective study that included a consecutive series of patients who underwent colorectal resection with anastomosis without ostomy (September 2015 to December 2017). CRP, procalcitonin and neutrophils values on the fourth postoperative day after colorectal resection along with the postoperative outcome (60-day anastomotic leak, morbidity and mortality) were prospectively included in an online, anonymous database. Read More

View Article and Full-Text PDF

{BiW8O30} Exerts Antitumor Effect by Triggering Pyroptosis and Upregulating Reactive Oxygen Species.

Angew Chem Int Ed Engl 2021 Jul 27. Epub 2021 Jul 27.

Harbin Medical University, Department of Biochemisty and Molecular Biology, 157 Baojian Road, 150081, Harbin, CHINA.

We successfully synthesized {BiW8}, a 10-nuclear heteroatom cluster modified {BiW8O30}. At 24 h post-incubation, the IC50 values of {BiW8} against HUVEC, MG63, RD, Hep3B, HepG2, and MCF7 cells were 895.8, 127. Read More

View Article and Full-Text PDF

Transient astrocyte-like NG2 glia subpopulation emerges solely following permanent brain ischemia.

Glia 2021 Jul 27. Epub 2021 Jul 27.

Department of Cellular Neurophysiology, Institute of Experimental Medicine, Czech Academy of Sciences, Prague, Czech Republic.

NG2 glia display wide proliferation and differentiation potential under physiological and pathological conditions. Here, we examined these two features following different types of brain disorders such as focal cerebral ischemia (FCI), cortical stab wound (SW), and demyelination (DEMY) in 3-month-old mice, in which NG2 glia are labeled by tdTomato under the Cspg4 promoter. To compare NG2 glia expression profiles following different CNS injuries, we employed single-cell RT-qPCR and self-organizing Kohonen map analysis of tdTomato-positive cells isolated from the uninjured cortex/corpus callosum and those after specific injury. Read More

View Article and Full-Text PDF

Can Wolf Spider Mothers Detect Insecticides in Environment? Does the Silk of the Egg-Sac Protect Juveniles from Insecticides?

Environ Toxicol Chem 2021 Jul 27. Epub 2021 Jul 27.

Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner" (INIBIOLP), La Plata, Argentina.

The use of pesticides for plague control in agroecosystems generates a threat to wildlife and a major problem for human health. Pesticide compounds are also an important source of water and atmosphere contamination. Although insecticides are effective on their target organisms, they often affect organisms that are not their target The aim of the present study was to research the effects of three types of neurotoxic insecticides-a pyrethroid (cypermethrin), a neonicotinoid (imidacloprid) and an organophosphate (chlorpyrifos)-on behavioral and physiological parameters of Pardosa saltans spider (Lycosidae). Read More

View Article and Full-Text PDF

The Knockdown of Mitochondrial Uncoupling Proteins 1 and 2 (AtUCP1 and 2) in Arabidopsis thaliana Impacts Vegetative Development and Fertility.

Plant Cell Physiol 2021 Jul 28. Epub 2021 Jul 28.

Instituto de Biociências de Botucatu, Departamento de Ciências Químicas e Biológicas, UNESP, Botucatu, SP, Brazil.

Mitochondrial Uncoupling Proteins (UCPs) are mitochondrial inner membrane proteins that dissipate the proton electrochemical gradient generated by the respiratory chain complexes. In plants, these proteins are crucial for maintaining mitochondrial reactive oxygen species (ROS) homeostasis. In this study, single T-DNA insertion mutants for two (AtUCP1and AtUCP2) out of the three UCP genes present in Arabidopsis thaliana were employed to elucidate their potential roles in planta. Read More

View Article and Full-Text PDF

Use of fourth-generation rapid combined antigen and antibody diagnostic tests for the detection of acute HIV infection in a community centre for men who have sex with men, between 2016 and 2019.

PLoS One 2021 27;16(7):e0255065. Epub 2021 Jul 27.

Tuberculosis Research Unit of Barcelona (UITB) Foundation, Barcelona, Spain.

Objective: To assess the use of fourth-generation rapid diagnostic tests in identifying acute infection of Human Immunodeficiency Virus (HIV).

Methods: BCN Checkpoint promotes sexual health among men who have sex with men (MSM), with a focus on diagnosing HIV early, initiating combined antiretroviral treatment (cART) promptly, and recommending regular repeat testing for those who have tested negative. This cross-sectional study included all test results obtained at the centre between 25 March 2016 and 24 March 2019. Read More

View Article and Full-Text PDF

Hematological abnormalities and comorbidities are associated with COVID-19 severity among hospitalized patients: Experience from Bangladesh.

PLoS One 2021 27;16(7):e0255379. Epub 2021 Jul 27.

Department of Pharmaceutical Sciences, North South University, Bashundhara, Dhaka, Bangladesh.

Background: The hematological abnormalities are assumed to be involved in the disease progression of COVID-19. However, the actual associations between specific blood parameters and COVID-19 are not well understood. Here we aimed to assess the correlations between hematological parameters and the severity of COVID-19. Read More

View Article and Full-Text PDF

Effect of sugar metabolite methylglyoxal on equine lamellar explants: An ex vivo model of laminitis.

PLoS One 2021 27;16(7):e0253840. Epub 2021 Jul 27.

Department of Veterinary Science, University of Turin, Grugliasco (TO), Italy.

Laminitis is one of the most devastating diseases in equine medicine, and although several etiopathogenetic mechanisms have been proposed, few clear answers have been identified to date. Several lines of evidence point towards its underlying pathology as being metabolism-related. In the carbonyl stress pathway, sugars are converted to methylglyoxal (MG)-a highly reactive α-oxoaldehyde, mainly derived during glycolysis in eukaryotic cells from the triose phosphates: D-glyceraldehyde-3-phosphate and dihydroxyacetone phosphate. Read More

View Article and Full-Text PDF

Illuminating Invisible Grain Boundaries in Coalesced Single-Orientation WS Monolayer Films.

Nano Lett 2021 Jul 27. Epub 2021 Jul 27.

Department of Materials Science and Engineering, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.

Engineering atomic-scale defects is crucial for realizing wafer-scale, single-crystalline transition metal dichalcogenide monolayers for electronic devices. However, connecting atomic-scale defects to larger morphologies poses a significant challenge. Using electron microscopy and ReaxFF reactive force field-based molecular dynamics simulations, we provide insights into WS crystal growth mechanisms, providing a direct link between synthetic conditions and microstructure. Read More

View Article and Full-Text PDF

Total Synthesis of the ssp. 3240 Zwitterionic Trisaccharide Repeating Unit.

Org Lett 2021 Jul 27. Epub 2021 Jul 27.

Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37235, United States.

Zwitterionic carbohydrate modifications, such as phosphoethanolamine (PEtN), govern host-pathogen interactions. Whereas it is recognized that these modifications stimulate the host immune system, the purpose of PEtN modification remains largely descriptive. As an enabling step toward studying this carbohydrate modification, we report a synthesis of the zwitterionic trisaccharide repeating unit. Read More

View Article and Full-Text PDF

Interconvertible Living Radical and Cationic Polymerization using a Dual Photoelectrochemical Catalyst.

J Am Chem Soc 2021 Jul 27. Epub 2021 Jul 27.

Department of Chemistry and Biochemistry, University of California at Santa Barbara, Santa Barbara, California 93106, United States.

The necessity of well-tuned reactivity for successful controlled polymer synthesis often comes with the price of limited monomer substrate scope. We demonstrate here the on-demand interconversion between living radical and cationic polymerization using two orthogonal stimuli and a dual responsive single catalyst. The dual photo- and electrochemical reactivity of 10-phenylphenothiazine catalyst provides control of the polymer's molar mass and composition by orthogonally activating the common dormant species toward two distinct chemical routes. Read More

View Article and Full-Text PDF

Nanoparticulate β-Cyclodextrin with Gallium Tetraphenylporphyrin Demonstrates in Vitro and in Vivo Antimicrobial Efficacy against and .

ACS Infect Dis 2021 Jul 27. Epub 2021 Jul 27.

Department of Pathology and Microbiology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States.

The emergence of drug-resistant pathogens causes the greatest challenge for drug development research. Recently, gallium(III)-based compounds have received great attention as novel antimicrobial agents against drug-resistant pathogens. Here, we synthesized a new β-cyclodextrin Ga nanoparticle (CDGaTP) using Ga tetraphenylporphyrin (GaTP, a hemin analogue) and β-cyclodextrin. Read More

View Article and Full-Text PDF

Evaluation of predictors of severe-moderate COVID-19 infections at children: a review of 292 children.

J Med Virol 2021 Jul 27. Epub 2021 Jul 27.

Department of Pediatric Infectious Diseases, Dr. Behçet Uz Children's Diseases and Surgery Training and Research Hospital, İzmir, Turkey.

Background: Although underlying disease is associated with a severe course in adults and laboratory abnormalities have been widely reported, there are not sufficient data on the clinical course of COVID-19 in children with pre-existing comorbid conditions and on laboratory findings. We aimed to describe the independent risk factors for estimating the severity of the COVID-19 in children METHODS: All children between one month to 18 years old who were hospitalized during the period of March 11 - December 31, 2020 resulting from COVID-19 were included in the study. Patients were categorized into mild (group 1) and moderate+severe/critically (group 2) of severity based on the criteria. Read More

View Article and Full-Text PDF

The Antioxidant Effect of Small Extracellular Vesicles Derived from Aloe vera Peels for Wound Healing.

Tissue Eng Regen Med 2021 Jul 27. Epub 2021 Jul 27.

Exostemtech Inc., Education Research Industry Collaboration Complex (ERICC), Hanyang University, 55 Hanyangdaehak-ro, Sangnok-gu, Ansan, 15588, Republic of Korea.

Background: Extracellular vesicles (EVs) derived from plants have emerged as potential candidates for cosmetic and therapeutic applications. In this study, we isolated EVs from Aloe vera peels (A-EVs) and investigated the antioxidant and wound healing potential of A-EVs.

Methods: A-EVs were isolated by ultracentrifugation and tangential flow filtration and were characterized using transmission electron microscopy, nanoparticle tracking analysis. Read More

View Article and Full-Text PDF

Ecotoxicological Effects of Bimetallic PdNi/MWCNT and PdCu/MWCNT Nanoparticles onto DNA Damage and Oxidative Stress in Earthworms.

Biol Trace Elem Res 2021 Jul 27. Epub 2021 Jul 27.

Department of Medical Services and Techniques, Tuzluca Vocational School, University of Igdır, Igdır, Turkey.

Bimetallic nanoparticles are synthesized using two different metal elements and used recently in many fields. However, limited studies related to the ecotoxic effects of nanoparticles available in the literature. The purpose of this study is to synthesize and characterize bimetallic PdCu/MWCNT and PdNi/MWCNT NPs and investigate their ecotoxic effects on earthworms. Read More

View Article and Full-Text PDF

Antiproliferative and Oxidative Damage Protection Activities of Endophytic Fungi Aspergillus fumigatus and Chaetomium globosum from Moringa oleifera Lam.

Appl Biochem Biotechnol 2021 Jul 27. Epub 2021 Jul 27.

Department of Botanical and Environmental Sciences, Guru Nanak Dev University, Amritsar, Punjab, 143005, India.

The current study was conducted to evaluate the antiproliferative and oxidative damage protection potential of endophytic fungi Aspergillus fumigatus and Chaetomium globosum isolated from Moringa oleifera. The chloroformic extract (CE) of both the fungi showed dose dependent antiproliferative activity against human prostate adenocarcinoma (PC-3) cell line with (IC) value of 0.055 mg/ml and 0. Read More

View Article and Full-Text PDF

Systemic burden and cardiovascular risk to Porphyromonas species in apical periodontitis.

Clin Oral Investig 2021 Jul 27. Epub 2021 Jul 27.

Laboratory of Periodontal Biology, Faculty of Dentistry, Universidad de Chile, Santiago, Chile.

Objective: Porphyromonas (P.) species (spp.) are a major etiological agent of apical periodontitis (AP), which in turn represents a risk factor for cardiovascular diseases. Read More

View Article and Full-Text PDF